-
1
-
-
84913594397
-
Genome editing. The new frontier of genome engineering with CRISPR-Cas9
-
Doudna, J. A., Charpentier, E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science 346, 1258096, doi: 10.1126/science.1258096 (2014).
-
(2014)
Science
, vol.346
, pp. 1258096
-
-
Doudna, J.A.1
Charpentier, E.2
-
2
-
-
84928205754
-
High-throughput functional genomics using CRISPR-Cas9
-
Shalem, O., Sanjana, N. E., Zhang, F. High-throughput functional genomics using CRISPR-Cas9. Nat Rev Genet 16, 299-311, doi: 10.1038/nrg3899 (2015).
-
(2015)
Nat Rev Genet
, vol.16
, pp. 299-311
-
-
Shalem, O.1
Sanjana, N.E.2
Zhang, F.3
-
3
-
-
84929666410
-
Expanding the Biologist's Toolkit with CRISPR-Cas9
-
Sternberg, S. H., Doudna, J. A. Expanding the Biologist's Toolkit with CRISPR-Cas9. Mol Cell 58, 568-574, doi: 10.1016/j. molcel.2015.02.032 (2015).
-
(2015)
Mol Cell
, vol.58
, pp. 568-574
-
-
Sternberg, S.H.1
Doudna, J.A.2
-
4
-
-
84923096541
-
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
-
Konermann, S. et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517, 583-588, doi: 10.1038/nature14136 (2015).
-
(2015)
Nature
, vol.517
, pp. 583-588
-
-
Konermann, S.1
-
5
-
-
84880571335
-
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
-
Gilbert, L. A. et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154, 442-451, doi: 10.1016/j.cell.2013.06.044 (2013).
-
(2013)
Cell
, vol.154
, pp. 442-451
-
-
Gilbert, L.A.1
-
6
-
-
84897134020
-
CRISPRs and epigenome editing
-
Rusk, N. CRISPRs and epigenome editing. Nat Methods 11, 28 (2014).
-
(2014)
Nat Methods
, vol.11
, pp. 28
-
-
Rusk, N.1
-
7
-
-
84929135130
-
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
-
Hilton, I. B. et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat Biotechnol 33, 510-517, doi: 10.1038/nbt.3199 (2015).
-
(2015)
Nat Biotechnol
, vol.33
, pp. 510-517
-
-
Hilton, I.B.1
-
8
-
-
84913568580
-
Programmable RNA recognition and cleavage by CRISPR/Cas9
-
O'Connell, M. R. et al. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature 516, 263-266, doi: 10.1038/nature13769 (2014).
-
(2014)
Nature
, vol.516
, pp. 263-266
-
-
O'Connell, M.R.1
-
9
-
-
79956157571
-
Evolution and classification of the CRISPR-Cas systems
-
Makarova, K. S. et al. Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol 9, 467-477, doi: 10.1038/nrmicro2577 (2011).
-
(2011)
Nat Rev Microbiol
, vol.9
, pp. 467-477
-
-
Makarova, K.S.1
-
10
-
-
84902096048
-
Development and applications of CRISPR-Cas9 for genome engineering
-
Hsu, P. D., Lander, E. S., Zhang, F. Development and applications of CRISPR-Cas9 for genome engineering. Cell 157, 1262-1278, doi: 10.1016/j.cell.2014.05.010 (2014).
-
(2014)
Cell
, vol.157
, pp. 1262-1278
-
-
Hsu, P.D.1
Lander, E.S.2
Zhang, F.3
-
11
-
-
84902095351
-
Classification and evolution of type II CRISPR-Cas systems
-
Chylinski, K., Makarova, K. S., Charpentier, E., Koonin, E. V. Classification and evolution of type II CRISPR-Cas systems. Nucleic Acids Res 42, 6091-6105, doi: 10.1093/nar/gku241 (2014).
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 6091-6105
-
-
Chylinski, K.1
Makarova, K.S.2
Charpentier, E.3
Koonin, E.V.4
-
12
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816-821, doi: 10.1126/science.1225829 (2012).
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
-
13
-
-
84922535144
-
Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector
-
Kabadi, A. M., Ousterout, D. G., Hilton, I. B., Gersbach, C. A. Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector. Nucleic Acids Res 42, e147, doi: 10.1093/nar/gku749 (2014).
-
(2014)
Nucleic Acids Res
, vol.42
, pp. e147
-
-
Kabadi, A.M.1
Ousterout, D.G.2
Hilton, I.B.3
Gersbach, C.A.4
-
14
-
-
84873729095
-
Multiplex Genome Engineering Using CRISPR/Cas Systems
-
Cong, L. et al. Multiplex Genome Engineering Using CRISPR/Cas Systems. Science 339, 819-823, doi: DOI 10.1126/science.1231143 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
15
-
-
84866859751
-
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
-
Gasiunas, G., Barrangou, R., Horvath, P., Siksnys, V. Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci USA 109, E2579-2586, doi: 10.1073/pnas.1208507109 (2012).
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E2579-2586
-
-
Gasiunas, G.1
Barrangou, R.2
Horvath, P.3
Siksnys, V.4
-
16
-
-
84884155038
-
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
-
Pattanayak, V. et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat Biotechnol 31, 839-843, doi: 10.1038/nbt.2673 (2013).
-
(2013)
Nat Biotechnol
, vol.31
, pp. 839-843
-
-
Pattanayak, V.1
-
17
-
-
84896733529
-
Crystal structure of Cas9 in complex with guide RNA and target DNA
-
Nishimasu, H. et al. Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell 156, 935-949, doi: 10.1016/j. cell.2014.02.001 (2014).
-
(2014)
Cell
, vol.156
, pp. 935-949
-
-
Nishimasu, H.1
-
18
-
-
84884165315
-
DNA targeting specificity of RNA-guided Cas9 nucleases
-
Hsu, P. D. et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol 31, 827-832, doi: 10.1038/nbt.2647 (2013).
-
(2013)
Nat Biotechnol
, vol.31
, pp. 827-832
-
-
Hsu, P.D.1
-
19
-
-
84922671463
-
Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9
-
Mandal, P. K. et al. Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell 15, 643-652, doi: 10.1016/j.stem.2014.10.004 (2014).
-
(2014)
Cell Stem Cell
, vol.15
, pp. 643-652
-
-
Mandal, P.K.1
-
20
-
-
84892749369
-
Genetic screens in human cells using the CRISPR-Cas9 system
-
Wang, T., Wei, J. J., Sabatini, D. M., Lander, E. S. Genetic screens in human cells using the CRISPR-Cas9 system. Science 343, 80-84, doi: 10.1126/science.1246981 (2014).
-
(2014)
Science
, vol.343
, pp. 80-84
-
-
Wang, T.1
Wei, J.J.2
Sabatini, D.M.3
Lander, E.S.4
-
21
-
-
84921540377
-
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
-
Doench, J. G. et al. Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. Nat Biotechnol 32, 1262-1267, doi: 10.1038/nbt.3026 (2014).
-
(2014)
Nat Biotechnol
, vol.32
, pp. 1262-1267
-
-
Doench, J.G.1
-
22
-
-
84938829555
-
Sequence determinants of improved CRISPR sgRNA design
-
Xu, H. et al. Sequence determinants of improved CRISPR sgRNA design. Genome Res 25, 1147-1157, doi: 10.1101/gr.191452.115 (2015).
-
(2015)
Genome Res
, vol.25
, pp. 1147-1157
-
-
Xu, H.1
-
23
-
-
84959123021
-
CRISPRscan: Designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
-
Moreno-Mateos, M. A. et al. CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nat Methods 12, 982-988, doi: 10.1038/nmeth.3543 (2015).
-
(2015)
Nat Methods
, vol.12
, pp. 982-988
-
-
Moreno-Mateos, M.A.1
-
24
-
-
84940501210
-
Unraveling CRISPR-Cas9 genome engineering parameters via a library-onlibrary approach
-
Chari, R., Mali, P., Moosburner, M., Church, G. M. Unraveling CRISPR-Cas9 genome engineering parameters via a library-onlibrary approach. Nat Methods 12, 823-826, doi: 10.1038/nmeth.3473 (2015).
-
(2015)
Nat Methods
, vol.12
, pp. 823-826
-
-
Chari, R.1
Mali, P.2
Moosburner, M.3
Church, G.M.4
-
25
-
-
84919762182
-
Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila
-
Ren, X. et al. Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila. Cell Rep 9, 1151-1162, doi: 10.1016/j.celrep.2014.09.044 (2014).
-
(2014)
Cell Rep
, vol.9
, pp. 1151-1162
-
-
Ren, X.1
-
26
-
-
84902141229
-
Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of singleguide RNAs
-
Gagnon, J. A. et al. Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of singleguide RNAs. PLoS One 9, e98186, doi: 10.1371/journal.pone.0098186 (2014).
-
(2014)
PLoS One
, vol.9
, pp. e98186
-
-
Gagnon, J.A.1
-
27
-
-
84908508061
-
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
-
Anders, C., Niewoehner, O., Duerst, A., Jinek, M. Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease. Nature 513, 569-573, doi: 10.1038/nature13579 (2014).
-
(2014)
Nature
, vol.513
, pp. 569-573
-
-
Anders, C.1
Niewoehner, O.2
Duerst, A.3
Jinek, M.4
-
28
-
-
84983752643
-
Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
-
Singh, R., Kuscu, C., Quinlan, A., Qi, Y., Adli, M. Cas9-chromatin binding information enables more accurate CRISPR off-target prediction. Nucleic Acids Res 43, e118, doi: 10.1093/nar/gkv575 (2015).
-
(2015)
Nucleic Acids Res
, vol.43
, pp. e118
-
-
Singh, R.1
Kuscu, C.2
Quinlan, A.3
Qi, Y.4
Adli, M.5
-
29
-
-
84902095352
-
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
-
Wu, X. et al. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat Biotechnol 32, 670-676, doi: 10.1038/nbt.2889 (2014).
-
(2014)
Nat Biotechnol
, vol.32
, pp. 670-676
-
-
Wu, X.1
-
30
-
-
84893157352
-
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
-
Jinek, M. et al. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science 343, 1247997, doi: 10.1126/science.1247997 (2014).
-
(2014)
Science
, vol.343
, pp. 1247997
-
-
Jinek, M.1
-
31
-
-
84865121188
-
An encyclopedia of mouse DNA elements (Mouse ENCODE)
-
Mouse, E. C. et al. An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol 13, 418, doi: 10.1186/gb-2012-13-8-418 (2012).
-
(2012)
Genome Biol
, vol.13
, pp. 418
-
-
Mouse, E.C.1
-
32
-
-
84865755978
-
The accessible chromatin landscape of the human genome
-
Thurman, R. E. et al. The accessible chromatin landscape of the human genome. Nature 489, 75-82, doi: 10.1038/nature11232 (2012).
-
(2012)
Nature
, vol.489
, pp. 75-82
-
-
Thurman, R.E.1
-
33
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823, doi: 10.1126/science.1231143 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
34
-
-
84884929362
-
SFARI Gene 2.0: A community-driven knowledgebase for the autism spectrum disorders (ASDs
-
Abrahams, B. S. et al. SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs). Mol Autism 4, 36, doi: 10.1186/2040-2392-4-36 (2013).
-
(2013)
Mol Autism
, vol.4
, pp. 36
-
-
Abrahams, B.S.1
-
35
-
-
84855199947
-
-
R Foundation for Statistical Computing, Vienna, Austria. URL
-
R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org/(2013).
-
(2013)
A Language and Environment for Statistical Computing
-
-
-
36
-
-
77952567987
-
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
-
Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38, 576-589, doi: 10.1016/j.molcel.2010.05.004 (2010).
-
(2010)
Mol Cell
, vol.38
, pp. 576-589
-
-
Heinz, S.1
-
37
-
-
82055164092
-
ViennaRNA Package 2.0
-
Lorenz, R. et al. ViennaRNA Package 2.0. Algorithms Mol Biol 6, 26, doi: 10.1186/1748-7188-6-26 (2011).
-
(2011)
Algorithms Mol Biol
, vol.6
, pp. 26
-
-
Lorenz, R.1
-
38
-
-
77952687104
-
Predicting in vivo binding sites of RNA-binding proteins using mRNA secondary structure
-
Li, X., Quon, G., Lipshitz, H. D., Morris, Q. Predicting in vivo binding sites of RNA-binding proteins using mRNA secondary structure. RNA 16, 1096-1107, doi: 10.1261/rna.2017210 (2010).
-
(2010)
RNA
, vol.16
, pp. 1096-1107
-
-
Li, X.1
Quon, G.2
Lipshitz, H.D.3
Morris, Q.4
|