Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome

Molecular Therapy

Volumn 24, Issue 3, 2016, Pages 636-644

  Müller, Maximilian ^a,b   Lee, Ciaran M ^c,d   Gasiunas, Giedrius ^e   Davis, Timothy H ^c,d   Cradick, Thomas J ^c,f   Siksnys, Virginijus ^e   Bao, Gang ^c,d   Cathomen, Toni ^a   Mussolino, Claudio ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Emory University   (United States)

^d Rice University   (United States)

^e VILNIUS UNIVERSITY   (Lithuania)

^f CRISPR THERAPEUTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CRISPR ASSOCIATED PROTEIN; ENDONUCLEASE; GUIDE RNA; PROTEIN BINDING;

ANALYTICAL PARAMETERS; ARTICLE; CARD11 GENE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; GENE; GENE ACTIVITY; GENE LOCUS; GENOME ANALYSIS; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; PRKDC GENE; PROTOSPACER ADJACENT MOTIF; STREPTOCOCCUS THERMOPHILUS; BINDING SITE; CELL LINE; CRISPR CAS SYSTEM; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENE EDITING; GENE VECTOR; GENETICS; HUMAN GENOME; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; BINDING SITES; CELL LINE; CRISPR-CAS SYSTEMS; ENDONUCLEASES; ENZYME ACTIVATION; GENE EDITING; GENETIC VECTORS; GENOME, HUMAN; HUMANS; PROTEIN BINDING; RNA, GUIDE; STREPTOCOCCUS THERMOPHILUS; SUBSTRATE SPECIFICITY;

EID: 84960467897     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2015.218     Document Type: Article

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