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Volumn 88, Issue Part B, 2015, Pages 302-313

Mechanisms and functions of Nrf2 signaling in Drosophila

Author keywords

Aging; Drosophila; Free radicals; Keap1; Maf S; Nrf2; Oxidative stress

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; MYC PROTEIN; PROTEIN P62; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; CAP-N-COLLAR PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; REPRESSOR PROTEIN;

EID: 84969796361     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.06.020     Document Type: Review
Times cited : (89)

References (111)
  • 1
    • 84924953006 scopus 로고    scopus 로고
    • Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila
    • E.T. Ables, K.E. Bois, C.A. Garcia, and D. Drummond-Barbosa Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila Dev. Biol. 400 2015 33 42
    • (2015) Dev. Biol. , vol.400 , pp. 33-42
    • Ables, E.T.1    Bois, K.E.2    Garcia, C.A.3    Drummond-Barbosa, D.4
  • 2
    • 70449674487 scopus 로고    scopus 로고
    • Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)
    • A. Arlt, I. Bauer, C. Schafmayer, J. Tepel, S.S. Muerkoster, M. Brosch, C. Roder, H. Kalthoff, J. Hampe, M.P. Moyer, and et al. Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2) Oncogene 28 2009 3983 3996
    • (2009) Oncogene , vol.28 , pp. 3983-3996
    • Arlt, A.1    Bauer, I.2    Schafmayer, C.3    Tepel, J.4    Muerkoster, S.S.5    Brosch, M.6    Roder, C.7    Kalthoff, H.8    Hampe, J.9    Moyer, M.P.10
  • 3
    • 0015268582 scopus 로고
    • Patterns of puffing activity in the salivary gland chromosomes of Drosophila. VII. Homology of puffing patterns on chromosome arm 3L in D. Melanogaster and D. Yakuba, with notes on puffing in D. Teissieri
    • M. Ashburner, and F. Lemeunier Patterns of puffing activity in the salivary gland chromosomes of Drosophila. VII. Homology of puffing patterns on chromosome arm 3L in D. melanogaster and D. yakuba, with notes on puffing in D. teissieri Chromosoma 38 1972 283 295
    • (1972) Chromosoma , vol.38 , pp. 283-295
    • Ashburner, M.1    Lemeunier, F.2
  • 4
    • 84884338770 scopus 로고    scopus 로고
    • Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
    • L. Baird, D. Lleres, S. Swift, and A.T. Dinkova-Kostova Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex Proc. Natl. Acad. Sci. USA 110 2013 15259 15264
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 15259-15264
    • Baird, L.1    Lleres, D.2    Swift, S.3    Dinkova-Kostova, A.T.4
  • 5
    • 80052277569 scopus 로고    scopus 로고
    • Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.
    • M.C. Barone, G.P. Sykiotis, and D. Bohmann Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease. Dis. Model. Mech. 4 2011 701 707
    • (2011) Dis. Model. Mech. , vol.4 , pp. 701-707
    • Barone, M.C.1    Sykiotis, G.P.2    Bohmann, D.3
  • 6
    • 61649121516 scopus 로고    scopus 로고
    • The UPS and autophagy in chronic neurodegenerative disease: Six of one and half a dozen of the other - Or not?
    • L. Bedford, S. Paine, N. Rezvani, M. Mee, J. Lowe, and R.J. Mayer The UPS and autophagy in chronic neurodegenerative disease: six of one and half a dozen of the other - or not? Autophagy 5 2009 224 227
    • (2009) Autophagy , vol.5 , pp. 224-227
    • Bedford, L.1    Paine, S.2    Rezvani, N.3    Mee, M.4    Lowe, J.5    Mayer, R.J.6
  • 8
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. Elegans
    • N.A. Bishop, and L. Guarente Two neurons mediate diet-restriction-induced longevity in C. elegans Nature 447 2007 545 549
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 9
    • 52949093944 scopus 로고    scopus 로고
    • JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
    • B. Biteau, C.E. Hochmuth, and H. Jasper JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut Cell Stem Cell 3 2008 442 455
    • (2008) Cell Stem Cell , vol.3 , pp. 442-455
    • Biteau, B.1    Hochmuth, C.E.2    Jasper, H.3
  • 10
    • 0028104274 scopus 로고
    • Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements
    • T.K. Blackwell, B. Bowerman, J.R. Priess, and H. Weintraub Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements Science 266 1994 621 628
    • (1994) Science , vol.266 , pp. 621-628
    • Blackwell, T.K.1    Bowerman, B.2    Priess, J.R.3    Weintraub, H.4
  • 11
    • 39049129643 scopus 로고    scopus 로고
    • Small Maf proteins in mammalian gene control: Mere dimerization partners or dynamic transcriptional regulators?
    • V. Blank Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators? J. Mol. Biol 376 2008 913 925
    • (2008) J. Mol. Biol , vol.376 , pp. 913-925
    • Blank, V.1
  • 12
    • 27144522538 scopus 로고    scopus 로고
    • Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release
    • P.E. Caldwell, M. Walkiewicz, and M. Stern Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release Curr. Biol. 15 2005 1785 1795
    • (2005) Curr. Biol. , vol.15 , pp. 1785-1795
    • Caldwell, P.E.1    Walkiewicz, M.2    Stern, M.3
  • 14
    • 0032536783 scopus 로고    scopus 로고
    • Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    • J.Y. Chan, M. Kwong, R. Lu, J. Chang, B. Wang, T.S. Yen, and Y.W. Kan Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice EMBO J. 17 1998 1779 1787
    • (1998) EMBO J. , vol.17 , pp. 1779-1787
    • Chan, J.Y.1    Kwong, M.2    Lu, R.3    Chang, J.4    Wang, B.5    Yen, T.S.6    Kan, Y.W.7
  • 15
    • 0030451213 scopus 로고    scopus 로고
    • Nrf2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • K. Chan, R. Lu, J.C. Chang, and Y.W. Kan Nrf2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development Proc. Natl. Acad. Sci. USA 93 1996 13943 13948
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 16
    • 84859592613 scopus 로고    scopus 로고
    • A versatile PhiC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture
    • N. Chatterjee, and D. Bohmann A versatile PhiC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture PLoS One 7 2012 e34063
    • (2012) PLoS One , vol.7 , pp. e34063
    • Chatterjee, N.1    Bohmann, D.2
  • 17
    • 0038382987 scopus 로고    scopus 로고
    • Nrf1 is critical for redox balance and survival of liver cells during development
    • L. Chen, M. Kwong, R. Lu, D. Ginzinger, C. Lee, L. Leung, and J.Y. Chan Nrf1 is critical for redox balance and survival of liver cells during development Mol. Cell. Biol. 23 2003 4673 4686
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 4673-4686
    • Chen, L.1    Kwong, M.2    Lu, R.3    Ginzinger, D.4    Lee, C.5    Leung, L.6    Chan, J.Y.7
  • 18
    • 66349105688 scopus 로고    scopus 로고
    • The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans
    • K.P. Choe, A.J. Przybysz, and K. Strange The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans Mol. Cell. Biol. 29 2009 2704 2715
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 2704-2715
    • Choe, K.P.1    Przybysz, A.J.2    Strange, K.3
  • 19
    • 84881476323 scopus 로고    scopus 로고
    • Nrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
    • S. Chowdhry, Y. Zhang, M. McMahon, C. Sutherland, A. Cuadrado, and J.D. Hayes Nrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity Oncogene 32 2013 3765 3781
    • (2013) Oncogene , vol.32 , pp. 3765-3781
    • Chowdhry, S.1    Zhang, Y.2    McMahon, M.3    Sutherland, C.4    Cuadrado, A.5    Hayes, J.D.6
  • 20
    • 53149123284 scopus 로고    scopus 로고
    • Structure of the human 26S proteasome: Subunit radial displacements open the gate into the proteolytic core
    • P.C. da Fonseca, and E.P. Morris Structure of the human 26S proteasome: subunit radial displacements open the gate into the proteolytic core J. Biol. Chem. 283 2008 23305 23314
    • (2008) J. Biol. Chem. , vol.283 , pp. 23305-23314
    • Da Fonseca, P.C.1    Morris, E.P.2
  • 21
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • C.V. Dang MYC on the path to cancer Cell 149 2012 22 35
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 22
    • 84874764624 scopus 로고    scopus 로고
    • Regulation of Drosophila metamorphosis by xenobiotic response regulators
    • H. Deng, and T.K. Kerppola Regulation of Drosophila metamorphosis by xenobiotic response regulators PLoS Genet. 9 2013 e1003263
    • (2013) PLoS Genet. , vol.9 , pp. e1003263
    • Deng, H.1    Kerppola, T.K.2
  • 23
    • 84905483278 scopus 로고    scopus 로고
    • Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation
    • H. Deng, and T.K. Kerppola Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation Development 141 2014 3277 3288
    • (2014) Development , vol.141 , pp. 3277-3288
    • Deng, H.1    Kerppola, T.K.2
  • 25
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • A.T. Dinkova-Kostova, W.D. Holtzclaw, R.N. Cole, K. Itoh, N. Wakabayashi, Y. Katoh, M. Yamamoto, and P. Talalay Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Proc. Natl. Acad. Sci. USA 99 2002 11908 11913
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3    Itoh, K.4    Wakabayashi, N.5    Katoh, Y.6    Yamamoto, M.7    Talalay, P.8
  • 27
  • 28
    • 84937763512 scopus 로고    scopus 로고
    • New FDA-approved disease-modifying therapies for multiple sclerosis
    • C. English, and J.J. Aloi New FDA-approved disease-modifying therapies for multiple sclerosis Clin. Ther 2015
    • (2015) Clin. Ther
    • English, C.1    Aloi, J.J.2
  • 29
    • 84893840509 scopus 로고    scopus 로고
    • Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1
    • T. Fukutomi, K. Takagi, T. Mizushima, N. Ohuchi, and M. Yamamoto Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1 Mol. Cell. Biol. 34 2014 832 846
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 832-846
    • Fukutomi, T.1    Takagi, K.2    Mizushima, T.3    Ohuchi, N.4    Yamamoto, M.5
  • 30
    • 84873633910 scopus 로고    scopus 로고
    • Genetics of longevity in model organisms: Debates and paradigm shifts
    • D. Gems, and L. Partridge Genetics of longevity in model organisms: debates and paradigm shifts Annu. Rev. Physiol. 75 2013 621 644
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 621-644
    • Gems, D.1    Partridge, L.2
  • 31
    • 79251559085 scopus 로고    scopus 로고
    • Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome
    • K.B. Grimberg, A. Beskow, D. Lundin, M.M. Davis, and P. Young Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome Mol. Cell. Biol. 31 2011 897 909
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 897-909
    • Grimberg, K.B.1    Beskow, A.2    Lundin, D.3    Davis, M.M.4    Young, P.5
  • 32
    • 0028978186 scopus 로고
    • A screen for modifiers of Deformed function in Drosophila
    • K.W. Harding, G. Gellon, N. McGinnis, and W. McGinnis A screen for modifiers of Deformed function in Drosophila Genetics 140 1995 1339 1352
    • (1995) Genetics , vol.140 , pp. 1339-1352
    • Harding, K.W.1    Gellon, G.2    McGinnis, N.3    McGinnis, W.4
  • 33
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • D. Harman Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 34
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • J.D. Hayes, and A.T. Dinkova-Kostova The Nrf2 regulatory network provides an interface between redox and intermediary metabolism Trends Biochem. Sci 39 2014 199 218
    • (2014) Trends Biochem. Sci , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 35
    • 63549121490 scopus 로고    scopus 로고
    • Nrf2 and Keap1 mutations: Permanent activation of an adaptive response in cancer
    • J.D. Hayes, and M. McMahon Nrf2 and Keap1 mutations: permanent activation of an adaptive response in cancer Trends Biochem. Sci. 34 2009 176 188
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 36
    • 84866774510 scopus 로고    scopus 로고
    • Ecology: Insecticide resistance after silent spring
    • D.G. Heckel Ecology: insecticide resistance after silent spring Science 337 2012 1612 1614
    • (2012) Science , vol.337 , pp. 1612-1614
    • Heckel, D.G.1
  • 37
    • 79551610653 scopus 로고    scopus 로고
    • Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
    • C.E. Hochmuth, B. Biteau, D. Bohmann, and H. Jasper Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila Cell Stem Cell 8 2011 188 199
    • (2011) Cell Stem Cell , vol.8 , pp. 188-199
    • Hochmuth, C.E.1    Biteau, B.2    Bohmann, D.3    Jasper, H.4
  • 38
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev. 13 1999 76 86
    • (1999) Genes Dev. , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 39
    • 84885944468 scopus 로고    scopus 로고
    • The emerging role of the Nrf2-Keap1 signaling pathway in cancer
    • M.C. Jaramillo, and D.D. Zhang The emerging role of the Nrf2-Keap1 signaling pathway in cancer Genes Dev. 27 2013 2179 2191
    • (2013) Genes Dev. , vol.27 , pp. 2179-2191
    • Jaramillo, M.C.1    Zhang, D.D.2
  • 41
    • 0034752461 scopus 로고    scopus 로고
    • Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
    • Y. Katoh, K. Itoh, E. Yoshida, M. Miyagishi, A. Fukamizu, and M. Yamamoto Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription Genes Cells 6 2001 857 868
    • (2001) Genes Cells , vol.6 , pp. 857-868
    • Katoh, Y.1    Itoh, K.2    Yoshida, E.3    Miyagishi, M.4    Fukamizu, A.5    Yamamoto, M.6
  • 43
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • T.W. Kensler, N. Wakabayashi, and S. Biswal Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu. Rev. Pharmacol. Toxicol. 47 2007 89 116
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 44
    • 80053634368 scopus 로고    scopus 로고
    • The dynamic nature of autophagy in cancer
    • A.C. Kimmelman The dynamic nature of autophagy in cancer Genes Dev. 25 2011 1999 2010
    • (2011) Genes Dev. , vol.25 , pp. 1999-2010
    • Kimmelman, A.C.1
  • 46
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • T.B. Kirkwood Understanding the odd science of aging Cell 120 2005 437 447
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 50
    • 0020520516 scopus 로고
    • Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
    • H. Land, L.F. Parada, and R.A. Weinberg Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes Nature 304 1983 596 602
    • (1983) Nature , vol.304 , pp. 596-602
    • Land, H.1    Parada, L.F.2    Weinberg, R.A.3
  • 51
    • 84904251656 scopus 로고    scopus 로고
    • Comparison of D. Melanogaster and C. Elegans developmental stages, tissues, and cells by modENCODE RNA-seq data
    • J.J. Li, H. Huang, P.J. Bickel, and S.E. Brenner Comparison of D. melanogaster and C. elegans developmental stages, tissues, and cells by modENCODE RNA-seq data Genome Res. 24 2014 1086 1101
    • (2014) Genome Res. , vol.24 , pp. 1086-1101
    • Li, J.J.1    Huang, H.2    Bickel, P.J.3    Brenner, S.E.4
  • 52
    • 79952136166 scopus 로고    scopus 로고
    • Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
    • R.A. Linker, D.H. Lee, S. Ryan, A.M. van Dam, R. Conrad, P. Bista, W. Zeng, X. Hronowsky, A. Buko, S. Chollate, and et al. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway Brain 134 2011 678 692
    • (2011) Brain , vol.134 , pp. 678-692
    • Linker, R.A.1    Lee, D.H.2    Ryan, S.3    Van Dam, A.M.4    Conrad, R.5    Bista, P.6    Zeng, W.7    Hronowsky, X.8    Buko, A.9    Chollate, S.10
  • 54
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: Oncogene and non-oncogene addiction
    • J. Luo, N.L. Solimini, and S.J. Elledge Principles of cancer therapy: oncogene and non-oncogene addiction Cell 136 2009 823 837
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 55
    • 0034595389 scopus 로고    scopus 로고
    • Factors on the third chromosome affect the level of cyp6a2 and cyp6a8 expression in Drosophila melanogaster
    • S. Maitra, S.M. Dombrowski, M. Basu, O. Raustol, L.C. Waters, and R. Ganguly Factors on the third chromosome affect the level of cyp6a2 and cyp6a8 expression in Drosophila melanogaster Gene 248 2000 147 156
    • (2000) Gene , vol.248 , pp. 147-156
    • Maitra, S.1    Dombrowski, S.M.2    Basu, M.3    Raustol, O.4    Waters, L.C.5    Ganguly, R.6
  • 56
    • 0031646521 scopus 로고    scopus 로고
    • A cap 'n' collar protein isoform contains a selective Hox repressor function
    • N. McGinnis, E. Ragnhildstveit, A. Veraksa, and W. McGinnis A cap 'n' collar protein isoform contains a selective Hox repressor function Development 125 1998 4553 4564
    • (1998) Development , vol.125 , pp. 4553-4564
    • McGinnis, N.1    Ragnhildstveit, E.2    Veraksa, A.3    McGinnis, W.4
  • 57
    • 33747728194 scopus 로고    scopus 로고
    • Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: A two-site interaction model for the Nrf2-Keap1 complex
    • M. McMahon, N. Thomas, K. Itoh, M. Yamamoto, and J.D. Hayes Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex J. Biol. Chem 281 2006 24756 24768
    • (2006) J. Biol. Chem , vol.281 , pp. 24756-24768
    • McMahon, M.1    Thomas, N.2    Itoh, K.3    Yamamoto, M.4    Hayes, J.D.5
  • 60
    • 80052452088 scopus 로고    scopus 로고
    • Transcriptional regulation of xenobiotic detoxification in Drosophila
    • J.R. Misra, M.A. Horner, G. Lam, and C.S. Thummel Transcriptional regulation of xenobiotic detoxification in Drosophila Genes Dev. 25 2011 1796 1806
    • (2011) Genes Dev. , vol.25 , pp. 1796-1806
    • Misra, J.R.1    Horner, M.A.2    Lam, G.3    Thummel, C.S.4
  • 61
    • 84885990241 scopus 로고    scopus 로고
    • Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila
    • J.R. Misra, G. Lam, and C.S. Thummel Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila Insect Biochem. Mol. Biol. 43 2013 1116 1124
    • (2013) Insect Biochem. Mol. Biol. , vol.43 , pp. 1116-1124
    • Misra, J.R.1    Lam, G.2    Thummel, C.S.3
  • 62
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • N. Mizushima Autophagy: process and function Genes Dev. 21 2007 2861 2873
    • (2007) Genes Dev. , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 63
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • N. Mizushima, and M. Komatsu Autophagy: renovation of cells and tissues Cell 147 2011 728 741
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 65
    • 0028795364 scopus 로고
    • Control of Drosophila head segment identity by the bZIP homeotic gene cnc
    • J. Mohler, J.W. Mahaffey, E. Deutsch, and K. Vani Control of Drosophila head segment identity by the bZIP homeotic gene cnc Development 121 1995 237 247
    • (1995) Development , vol.121 , pp. 237-247
    • Mohler, J.1    Mahaffey, J.W.2    Deutsch, E.3    Vani, K.4
  • 66
    • 0025868833 scopus 로고
    • Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis
    • J. Mohler, K. Vani, S. Leung, and A. Epstein Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis Mech. Dev. 34 1991 3 9
    • (1991) Mech. Dev. , vol.34 , pp. 3-9
    • Mohler, J.1    Vani, K.2    Leung, S.3    Epstein, A.4
  • 67
    • 84901364818 scopus 로고    scopus 로고
    • Resources for functional genomics studies in Drosophila melanogaster
    • S.E. Mohr, Y. Hu, K. Kim, B.E. Housden, and N. Perrimon Resources for functional genomics studies in Drosophila melanogaster Genetics 197 2014 1 18
    • (2014) Genetics , vol.197 , pp. 1-18
    • Mohr, S.E.1    Hu, Y.2    Kim, K.3    Housden, B.E.4    Perrimon, N.5
  • 68
    • 0027163005 scopus 로고
    • Evolution of Drosophila insecticide resistance
    • R.A. Morton Evolution of Drosophila insecticide resistance Genome 36 1993 1 7
    • (1993) Genome , vol.36 , pp. 1-7
    • Morton, R.A.1
  • 70
    • 2342511435 scopus 로고    scopus 로고
    • Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway
    • H. Motohashi, F. Katsuoka, J.D. Engel, and M. Yamamoto Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway Proc. Natl. Acad. Sci. USA 101 2004 6379 6384
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6379-6384
    • Motohashi, H.1    Katsuoka, F.2    Engel, J.D.3    Yamamoto, M.4
  • 72
    • 84908108248 scopus 로고    scopus 로고
    • Widespread pyrethroid and DDT resistance in the major malaria vector Anopheles funestus in East Africa is driven by metabolic resistance mechanisms
    • C. Mulamba, J.M. Riveron, S.S. Ibrahim, H. Irving, K.G. Barnes, L.G. Mukwaya, J. Birungi, and C.S. Wondji Widespread pyrethroid and DDT resistance in the major malaria vector Anopheles funestus in East Africa is driven by metabolic resistance mechanisms PLoS One 9 2014 e110058
    • (2014) PLoS One , vol.9 , pp. e110058
    • Mulamba, C.1    Riveron, J.M.2    Ibrahim, S.S.3    Irving, H.4    Barnes, K.G.5    Mukwaya, L.G.6    Birungi, J.7    Wondji, C.S.8
  • 73
    • 84884636654 scopus 로고    scopus 로고
    • Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster
    • P. Nagy, A. Varga, K. Pircs, K. Hegedus, and G. Juhasz Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster PLoS Genet. 9 2013 e1003664
    • (2013) PLoS Genet. , vol.9 , pp. e1003664
    • Nagy, P.1    Varga, A.2    Pircs, K.3    Hegedus, K.4    Juhasz, G.5
  • 74
    • 41549151641 scopus 로고    scopus 로고
    • Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
    • I.P. Nezis, A. Simonsen, A.P. Sagona, K. Finley, S. Gaumer, D. Contamine, T.E. Rusten, H. Stenmark, and A. Brech Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain J. Cell Biol. 180 2008 1065 1071
    • (2008) J. Cell Biol. , vol.180 , pp. 1065-1071
    • Nezis, I.P.1    Simonsen, A.2    Sagona, A.P.3    Finley, K.4    Gaumer, S.5    Contamine, D.6    Rusten, T.E.7    Stenmark, H.8    Brech, A.9
  • 75
    • 0042330074 scopus 로고    scopus 로고
    • Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: Reassessment of the ARE consensus sequence
    • P. Nioi, M. McMahon, K. Itoh, M. Yamamoto, and J.D. Hayes Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence Biochem. J. 374 2003 337 348
    • (2003) Biochem. J. , vol.374 , pp. 337-348
    • Nioi, P.1    McMahon, M.2    Itoh, K.3    Yamamoto, M.4    Hayes, J.D.5
  • 76
    • 28544450507 scopus 로고    scopus 로고
    • The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
    • P. Nioi, T. Nguyen, P.J. Sherratt, and C.B. Pickett The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation Mol. Cell. Biol. 25 2005 10895 10906
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10895-10906
    • Nioi, P.1    Nguyen, T.2    Sherratt, P.J.3    Pickett, C.B.4
  • 78
    • 57749120460 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
    • M. Ohtsuji, F. Katsuoka, A. Kobayashi, H. Aburatani, J.D. Hayes, and M. Yamamoto Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes J. Biol. Chem. 283 2008 33554 33562
    • (2008) J. Biol. Chem. , vol.283 , pp. 33554-33562
    • Ohtsuji, M.1    Katsuoka, F.2    Kobayashi, A.3    Aburatani, H.4    Hayes, J.D.5    Yamamoto, M.6
  • 79
    • 47849083585 scopus 로고    scopus 로고
    • Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
    • W.O. Osburn, and T.W. Kensler Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults Mutat. Res 659 2008 31 39
    • (2008) Mutat. Res , vol.659 , pp. 31-39
    • Osburn, W.O.1    Kensler, T.W.2
  • 80
    • 84858972249 scopus 로고    scopus 로고
    • Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress
    • A.M. Pickering, R.A. Linder, H. Zhang, H.J. Forman, and K.J. Davies Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress J. Biol. Chem. 287 2012 10021 10031
    • (2012) J. Biol. Chem. , vol.287 , pp. 10021-10031
    • Pickering, A.M.1    Linder, R.A.2    Zhang, H.3    Forman, H.J.4    Davies, K.J.5
  • 81
    • 84865623676 scopus 로고    scopus 로고
    • Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila
    • K. Pircs, P. Nagy, A. Varga, Z. Venkei, B. Erdi, K. Hegedus, and G. Juhasz Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila PLoS One 7 2012 e44214
    • (2012) PLoS One , vol.7 , pp. e44214
    • Pircs, K.1    Nagy, P.2    Varga, A.3    Venkei, Z.4    Erdi, B.5    Hegedus, K.6    Juhasz, G.7
  • 82
    • 0030661627 scopus 로고    scopus 로고
    • Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides
    • B. Pittendrigh, R. Reenan, R.H. ffrench-Constant, and B. Ganetzky Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides Mol. Gen. Genet. 256 1997 602 610
    • (1997) Mol. Gen. Genet. , vol.256 , pp. 602-610
    • Pittendrigh, B.1    Reenan, R.2    Ffrench-Constant, R.H.3    Ganetzky, B.4
  • 83
    • 79952256187 scopus 로고    scopus 로고
    • SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
    • P. Rada, A.I. Rojo, S. Chowdhry, M. McMahon, J.D. Hayes, and A. Cuadrado SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner Mol. Cell. Biol. 31 2011 1121 1133
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 1121-1133
    • Rada, P.1    Rojo, A.I.2    Chowdhry, S.3    McMahon, M.4    Hayes, J.D.5    Cuadrado, A.6
  • 84
    • 77950366349 scopus 로고    scopus 로고
    • Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
    • S.K. Radhakrishnan, C.S. Lee, P. Young, A. Beskow, J.Y. Chan, and R.J. Deshaies Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells Mol. Cell 38 2010 17 28
    • (2010) Mol. Cell , vol.38 , pp. 17-28
    • Radhakrishnan, S.K.1    Lee, C.S.2    Young, P.3    Beskow, A.4    Chan, J.Y.5    Deshaies, R.J.6
  • 85
    • 84880514122 scopus 로고    scopus 로고
    • Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes
    • M.M. Rahman, G.P. Sykiotis, M. Nishimura, R. Bodmer, and D. Bohmann Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes Aging Cell. 2013
    • (2013) Aging Cell.
    • Rahman, M.M.1    Sykiotis, G.P.2    Nishimura, M.3    Bodmer, R.4    Bohmann, D.5
  • 86
    • 33750729203 scopus 로고    scopus 로고
    • Theories of biological aging: Genes, proteins, and free radicals
    • S.I. Rattan Theories of biological aging: genes, proteins, and free radicals Free Radic. Res. 40 2006 1230 1238
    • (2006) Free Radic. Res. , vol.40 , pp. 1230-1238
    • Rattan, S.I.1
  • 87
    • 71549168637 scopus 로고    scopus 로고
    • The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis
    • K.F. Rewitz, N. Yamanaka, L.I. Gilbert, and M.B. O'Connor The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis Science 326 2009 1403 1405
    • (2009) Science , vol.326 , pp. 1403-1405
    • Rewitz, K.F.1    Yamanaka, N.2    Gilbert, L.I.3    O'Connor, M.B.4
  • 88
    • 0025322840 scopus 로고
    • Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3
    • E. Siegfried, L.A. Perkins, T.M. Capaci, and N. Perrimon Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3 Nature 345 1990 825 829
    • (1990) Nature , vol.345 , pp. 825-829
    • Siegfried, E.1    Perkins, L.A.2    Capaci, T.M.3    Perrimon, N.4
  • 89
    • 0033083158 scopus 로고    scopus 로고
    • Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP
    • E. Spencer, J. Jiang, and Z.J. Chen Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP Genes Dev. 13 1999 284 294
    • (1999) Genes Dev. , vol.13 , pp. 284-294
    • Spencer, E.1    Jiang, J.2    Chen, Z.J.3
  • 90
    • 37749024370 scopus 로고    scopus 로고
    • Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
    • G.P. Sykiotis, and D. Bohmann Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila Dev. Cell 14 2008 76 85
    • (2008) Dev. Cell , vol.14 , pp. 76-85
    • Sykiotis, G.P.1    Bohmann, D.2
  • 91
    • 77953012548 scopus 로고    scopus 로고
    • Stress-activated Cap'n'collar transcription factors in aging and human disease
    • re3
    • G.P. Sykiotis, and D. Bohmann Stress-activated Cap'n'collar transcription factors in aging and human disease Sci. Signaling 3 2010 re3
    • (2010) Sci. Signaling , vol.3
    • Sykiotis, G.P.1    Bohmann, D.2
  • 92
    • 84899671764 scopus 로고    scopus 로고
    • Lysosomal function is involved in 17beta-estradiol-induced estrogen receptor alpha degradation and cell proliferation
    • P. Totta, V. Pesiri, M. Marino, and F. Acconcia Lysosomal function is involved in 17beta-estradiol-induced estrogen receptor alpha degradation and cell proliferation PLoS One 9 2014 e94880
    • (2014) PLoS One , vol.9 , pp. e94880
    • Totta, P.1    Pesiri, V.2    Marino, M.3    Acconcia, F.4
  • 93
    • 77951543964 scopus 로고    scopus 로고
    • Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an Nrf2-dependent mechanism
    • K. Trinh, L. Andrews, J. Krause, T. Hanak, D. Lee, M. Gelb, and L. Pallanck Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an Nrf2-dependent mechanism J. Neurosci. 30 2010 5525 5532
    • (2010) J. Neurosci. , vol.30 , pp. 5525-5532
    • Trinh, K.1    Andrews, L.2    Krause, J.3    Hanak, T.4    Lee, D.5    Gelb, M.6    Pallanck, L.7
  • 95
    • 84878764019 scopus 로고    scopus 로고
    • Differential regulation of proteasome functionality in reproductive vs. Somatic tissues of Drosophila during aging or oxidative stress
    • E.N. Tsakiri, G.P. Sykiotis, I.S. Papassideri, V.G. Gorgoulis, D. Bohmann, and I.P. Trougakos Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress FASEB J. 27 2013 2407 2420
    • (2013) FASEB J. , vol.27 , pp. 2407-2420
    • Tsakiri, E.N.1    Sykiotis, G.P.2    Papassideri, I.S.3    Gorgoulis, V.G.4    Bohmann, D.5    Trougakos, I.P.6
  • 96
    • 84883750565 scopus 로고    scopus 로고
    • Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
    • E.N. Tsakiri, G.P. Sykiotis, I.S. Papassideri, E. Terpos, M.A. Dimopoulos, V.G. Gorgoulis, D. Bohmann, and I.P. Trougakos Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging Aging Cell 12 2013 802 813
    • (2013) Aging Cell , vol.12 , pp. 802-813
    • Tsakiri, E.N.1    Sykiotis, G.P.2    Papassideri, I.S.3    Terpos, E.4    Dimopoulos, M.A.5    Gorgoulis, V.G.6    Bohmann, D.7    Trougakos, I.P.8
  • 98
    • 0033792944 scopus 로고    scopus 로고
    • Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head
    • A. Veraksa, N. McGinnis, X. Li, J. Mohler, and W. McGinnis Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head Development 127 2000 4023 4037
    • (2000) Development , vol.127 , pp. 4023-4037
    • Veraksa, A.1    McGinnis, N.2    Li, X.3    Mohler, J.4    McGinnis, W.5
  • 100
    • 33745807575 scopus 로고    scopus 로고
    • Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain: Inhibition of nuclear translocation and transacting function
    • W. Wang, and J.Y. Chan Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain: inhibition of nuclear translocation and transacting function J. Biol. Chem 281 2006 19676 19687
    • (2006) J. Biol. Chem , vol.281 , pp. 19676-19687
    • Wang, W.1    Chan, J.Y.2
  • 101
    • 84928796551 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate adipocyte differentiation of mesenchymal stem cells in hematopoietic stress induced by arabinosylcytosine
    • W. Wang, Y. Zhang, W. Lu, and K. Liu Mitochondrial reactive oxygen species regulate adipocyte differentiation of mesenchymal stem cells in hematopoietic stress induced by arabinosylcytosine PLoS One 10 2015 e0120629
    • (2015) PLoS One , vol.10 , pp. e0120629
    • Wang, W.1    Zhang, Y.2    Lu, W.3    Liu, K.4
  • 102
    • 77957821749 scopus 로고    scopus 로고
    • Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer
    • X. Wang, B.N. Chorley, G.S. Pittman, S.R. Kleeberger, J. Brothers 2nd, G. Liu, A. Spira, and D.A. Bell Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer PLoS One 5 2010 e11934
    • (2010) PLoS One , vol.5 , pp. e11934
    • Wang, X.1    Chorley, B.N.2    Pittman, G.S.3    Kleeberger, S.R.4    Brothers, J.5    Liu, G.6    Spira, A.7    Bell, D.A.8
  • 103
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • E. White Deconvoluting the context-dependent role for autophagy in cancer Nat. Rev. Cancer 12 2012 401 410
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 401-410
    • White, E.1
  • 104
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    • D.D. Zhang, and M. Hannink Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress Mol. Cell. Biol. 23 2003 8137 8151
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 105
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • D.D. Zhang, S.C. Lo, J.V. Cross, D.J. Templeton, and M. Hannink Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex Mol. Cell. Biol. 24 2004 10941 10953
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5
  • 106
    • 33750543308 scopus 로고    scopus 로고
    • Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum
    • Y. Zhang, D.H. Crouch, M. Yamamoto, and J.D. Hayes Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum Biochem. J 399 2006 373 385
    • (2006) Biochem. J , vol.399 , pp. 373-385
    • Zhang, Y.1    Crouch, D.H.2    Yamamoto, M.3    Hayes, J.D.4
  • 107
    • 4444315787 scopus 로고    scopus 로고
    • A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway
    • Y. Zhang, and G.B. Gordon A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway Mol. Cancer Ther. 3 2004 885 893
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 885-893
    • Zhang, Y.1    Gordon, G.B.2
  • 108
    • 36749013169 scopus 로고    scopus 로고
    • The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
    • Y. Zhang, J.M. Lucocq, M. Yamamoto, and J.D. Hayes The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation Biochem. J. 408 2007 161 172
    • (2007) Biochem. J. , vol.408 , pp. 161-172
    • Zhang, Y.1    Lucocq, J.M.2    Yamamoto, M.3    Hayes, J.D.4
  • 110
    • 84898850319 scopus 로고    scopus 로고
    • Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains
    • Y. Zhang, Y. Ren, S. Li, and J.D. Hayes Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domains PLoS One 9 2014 e93458
    • (2014) PLoS One , vol.9 , pp. e93458
    • Zhang, Y.1    Ren, Y.2    Li, S.3    Hayes, J.D.4
  • 111
    • 84922627875 scopus 로고    scopus 로고
    • Mitochondrial effectors of cellular senescence: Beyond the free radical theory of aging
    • D.V. Ziegler, C.D. Wiley, and M.C. Velarde Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging Aging Cell 14 2015 1 7
    • (2015) Aging Cell , vol.14 , pp. 1-7
    • Ziegler, D.V.1    Wiley, C.D.2    Velarde, M.C.3


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