Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides

Molecular and General Genetics

Volumn 256, Issue 6, 1997, Pages 602-610

  Pittendrigh, B ^a   Reenan, R ^a   Ffrench Constant, R H ^a   Ganetzky, B ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

DDT pyrethroids; Drosophila melanogaster; Insecticide resistance; para; Voltage gated sodium channel

Indexed keywords

CHLORPHENOTANE; INSECTICIDE; PROTEIN SUBUNIT; PYRETHROID; SODIUM CHANNEL;

ARTICLE; DROSOPHILA; DROSOPHILA MELANOGASTER; HOUSE FLY; INSECTICIDE RESISTANCE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; COCKROACHES; DDT; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; DRUG RESISTANCE, MULTIPLE; GENES, DOMINANT; GENES, INSECT; HOUSEFLIES; INSECT PROTEINS; INSECTICIDE RESISTANCE; INSECTICIDES; MOLECULAR SEQUENCE DATA; PARALYSIS; POINT MUTATION; PYRETHRINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; SPECIES SPECIFICITY; TEMPERATURE;

EID: 0030661627     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050608     Document Type: Article

References (36)

1. Cannon SC, Brown RH, Corey DP (1991) A sodium channel defect in hyperkalemic periodic paralysis: potassium induced failure of inactivation. Neuron 6:619-626
2. Catterall WA (1988) Structure and function of voltage-sensitive ion channels. Science 242:50-61
3. Cohen E, Casida JE (1986) Effects of insecticides and GABAergic agents on a housefly [35S]t-butylbicyclophosphorothionate binding site. Pestic Biochem Physiol 25:63-72
4. Dapkus D (1992) Genetic localization of DDT resistance in Drosophila melanogaster (Diptera: Drosophilidae). J Econ Entomol 85:340-347
5. Dong K (1997) A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. Insect Biochem Mol Biol 27:93-100
6. Dong K, Scott JG (1994) Linkage of kdr-type resistance and the para-homologous sodium channel gene in German cockroaches. Insect Mol Biochem Mol Biol 24:647-654
7. Feng G, Deak P, Chopra M, Hall LM (1995) Cloning and functional analysis of Tip-E, a novel membrane protein that enhances Drosophila para sodium channel function. Cell 82:1001 1011
8. ffrench-Constant RH, Roush RT, Mortlock D, Dively GP (1990) Isolation of dieldrin resistance from field populations of Drosophila melanogaster (Diptera: Drosophilidae). J Econ Entomol 83:1733-1737
9. Ganetzky B (1984) Genetic studies of membrane excitability in Drosophila: lethal interaction between two temperature-sensitive paralytic mutations. Genetics 108:897-911
10. Grigliatti T, Hall L, Rosenbluth R, Suzuki DT (1973) Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults. Mol Gen Genet 120:107-114
11. Hong C-S, Ganetzky B (1994) Spatial and temporal expression patterns of two sodium channel genes in Drosophila. J Neurosci 14:5160-5169
12. + channel. Nature 353:86 90
13. Knipple DC, Doyle KE, Marsella Herrick PA, Soderlund DM (1994) Tight genetic linkage between the kdr insecticide resistance trait and a voltage-sensitive sodium channel gene in the house fly. Proc Natl Acad Sci USA 91:2483 2487
14. Kohrman DC, Smith MR, Goldin AL, Harris J, Meisler MH (1996) A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. J Neurosci 16:5993-5999
15. Lilly M, Kreber R, Ganetzky B, Carlson J (1994) Evidence that the Drosophila olfactory mutant smellblind defines a novel class of sodium channel mutation. Genetics 136:1087-1096
16. Lindsley DL, Zimm G (1985) The genome of Drosophila melanogaster. Part 1: Genes A-K (Progress report). Drosophila Inf Serv 62:1-227
17. Loughney K, Kreber R, Ganetzky B (1989) Molecular analysis of the para locus, a sodium channel gene in Drosophila. Cell 58:1143-1154
18. McClatchey AI, McKennayasek D, Cros D, Worthen HG, Kuncl RW, DeSilva SM, Cornblath DR, Gusella JF, Brown RH (1992) Novel mutations in families with unusual and variable disorders of the skeletal muscle sodium channel. Nature Genet 2:148-152
19. Miyazaki M, Ohyama K, Dunlap DY, Matsumura F (1996) Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant German cockroaches (Blatella germanica) and the house fly (Musca domestica). Mol Gen Genet 252:61-68
20. Ptacek LJ, George AL, Griggs RC, Tawil R, Kallen RG, Barchi RL, Robertson M, Leppert MF (1991) Identification of a mutation in the gene causing hyperkalemic periodic paralysis. Cell 67:1021-1027
21. Robertson JL, Russell RM, Savin NE (1980) POLO: a user's guide to probit or logic analysis. US Forestry Service Technical Report PSW
22. + channel alpha subunit in hyperkalemic periodic paralysis. Nature 354:387-389
23. Sawicki RM (1978) Unusual response of DDT-resistant houseflies to carbinol analogues of DDT. Nature 275:443-444
24. Siddiqi O, Benzer S (1976) Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster. Proc Natl Acad Sci USA 73:3253-3257
25. Soderlund DM, Bloomquist JR (1989) Neurotoxic actions of pyrethroid insecticides. Annu Rev Entomol 34:77-96
26. Stern M, Kreber R, Ganetzky B (1990) Effects of para gene dosage on behavior and axonal excitability in Drosophila. Genetics 124:133 143
27. Sundseth SS, Nix CE, Waters LC (1990) Isolation of insecticide resistance-related forms of cytochrome P-450 from Drosophila melanogaster. Biochem J 265:213 7
28. ts) causing reversible adult paralysis. Proc Natl Acad Sci USA 68:890-893
29. Taylor MFJ, Heckel DG, Brown TM, Kreitman ME, Black B (1993) Linkage of pyrethroid insecticide resistance to a sodium channel locus in the tobacco budworm. Insect Biochem Mol Biol 23:763 775
30. Thackeray JR, Ganetzky B (1994) Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms. J Neurosci 14:2569 2578
31. Wang Q, Shen J, Li Z, Timothy K, Vincent GM, Priori SG, Schwartz PJ, Keating MT (1995) Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arhythmia. Human Mol Genet 4:1603 1607
32. Warmke JW, Reenan RAG, Wang P, Qian S, Arena JP, Wang J, Wunderler D, Liu K, Kaczorowski GJ, Van der ploeg LHT, Ganetzky B, Cohen CJ (1997) Functional expression of Drosophila para sodium channels: Modulation by the membrane protein Tip E and toxin pharmacology. J Gen Physiol 110: 119-133
33. Waters LC, Nix CE (1988) Regulation of insecticide resistance-related cytochrome P-450 expression in Drosophila melanogaster. Pestic Biochem Physiol 30:214-227
34. Williamson MS, Denholm I, Bell CA, Devonshire AL (1993) Knockdown resistance (kdr) to DDT and pyrethroid insecticides maps to a sodium channel gene locus in the housefly (Musca domestica). Mol Gen Genet 240:17 22
35. Williamson MS, Martinez-Torres D, Hick CA, Devonshire AL (1996) Identification of mutations in the housefly paratype sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides. Mol Gen Genet 252:51-60
36. Yang N, Ji J, Zhou M, Ptacek LJ, Barchi RL, Horn R, George AL (1994) Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro. Proc Natl Acad Sci US 91:12785-12789