-
3
-
-
0007374771
-
-
Verlag von Gustav Fisher, Jena, Germany. Jena, Gustav Fischer
-
Weismann A. Über Leben und Tod. Verlag von Gustav Fisher, Jena, Germany. Jena, Gustav Fischer: 1892.
-
(1892)
Über Leben und Tod
-
-
Weismann, A.1
-
4
-
-
0002134284
-
Old age and natural death
-
Medawar PB. Old age and natural death. Modern Quarterly 1946; 1:30-56
-
(1946)
Modern Quarterly
, vol.1
, pp. 30-56
-
-
Medawar, P.B.1
-
6
-
-
0000055057
-
Pleiotropy, natural selection and the evolution of senescence
-
Williams GC. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957; 11:398-411; http://dx.doi.org/10.2307/2406060
-
(1957)
Evolution
, vol.11
, pp. 398-411
-
-
Williams, G.C.1
-
7
-
-
0012278503
-
Evolutionary theories of aging and longevity
-
PMID:12806021
-
Gavrilov LA, Gavrilova NS. Evolutionary theories of aging and longevity. ScientificWorldJournal 2002; 2:339-56; PMID:12806021; http://dx.doi.org/10.1100/ tsw.2002.96
-
(2002)
ScientificWorldJournal
, vol.2
, pp. 339-356
-
-
Gavrilov, L.A.1
Gavrilova, N.S.2
-
8
-
-
58549086780
-
Evolution of ageing since Darwin
-
PMID:19147926
-
Rose MR, Burke MK, Shahrestani P, Mueller LD. Evolution of ageing since Darwin. J Genet 2008; 87:363-71; PMID:19147926; http://dx.doi.org/10.1007/ s12041-008-0059-6
-
(2008)
J Genet
, vol.87
, pp. 363-371
-
-
Rose, M.R.1
Burke, M.K.2
Shahrestani, P.3
Mueller, L.D.4
-
9
-
-
0017782437
-
Evolution of ageing
-
PMID:593350
-
Kirkwood TB. Evolution of ageing. Nature 1977; 270:301-4; PMID:593350; http://dx.doi.org/10.1038/270301a0
-
(1977)
Nature
, vol.270
, pp. 301-304
-
-
Kirkwood, T.B.1
-
10
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
PMID:11089983
-
Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000; 408:255-62; PMID:11089983; http://dx.doi.org/10.1038/ 35041700
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
11
-
-
0029123058
-
Thermotolerance and extended lifespan conferred by single-gene mutations and induced by thermal stress
-
PMID:7638227
-
Lithgow GJ, White TM, Melov S, Johnson TE. Thermotolerance and extended lifespan conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A 1995; 92:7540-4; PMID:7638227; http://dx.doi.org/10.1073/ pnas.92.16.7540
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7540-7544
-
-
Lithgow, G.J.1
White, T.M.2
Melov, S.3
Johnson, T.E.4
-
12
-
-
33644669837
-
Programmed and altruistic ageing
-
PMID:16304601
-
Longo VD, Mitteldorf J, Skulachev VP. Programmed and altruistic ageing. Nat Rev Genet 2005; 6:866- 72; PMID:16304601; http://dx.doi.org/10.1038/nrg1706
-
(2005)
Nat Rev Genet
, vol.6
, pp. 866-872
-
-
Longo, V.D.1
Mitteldorf, J.2
Skulachev, V.P.3
-
13
-
-
0030014296
-
A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
-
PMID:8807294
-
Murakami S, Johnson TE. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 1996; 143:1207-18; PMID:8807294
-
(1996)
Genetics
, vol.143
, pp. 1207-1218
-
-
Murakami, S.1
Johnson, T.E.2
-
14
-
-
13944282128
-
Sex and death: What is the connection?
-
PMID:15734679
-
Partridge L, Gems D, Withers DJ. Sex and death: what is the connection? Cell 2005; 120:461-72; PMID:15734679; http://dx.doi.org/10.1016/j.cell.2005.01. 026
-
(2005)
Cell
, vol.120
, pp. 461-472
-
-
Partridge, L.1
Gems, D.2
Withers, D.J.3
-
15
-
-
84874065131
-
A genetic program promotes C. Elegans longevity at cold temperatures via a thermosensitive TRP channel
-
PMID:23415228
-
Xiao R, Zhang B, Dong Y, Gong J, Xu T, Liu J, Xu XZ. A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell 2013; 152:806-17; PMID:23415228; http://dx.doi.org/10.1016/j.cell. 2013.01.020
-
(2013)
Cell
, vol.152
, pp. 806-817
-
-
Xiao, R.1
Zhang, B.2
Dong, Y.3
Gong, J.4
Xu, T.5
Liu, J.6
Xu, X.Z.7
-
16
-
-
84864868691
-
Can ageing be slowed?: Hormetic and redox perspectives
-
PMID:22514565
-
Gaman L, Stoian I, Atanasiu V. Can ageing be slowed?: Hormetic and redox perspectives. J Med Life 2011; 4:346-51; PMID:22514565
-
(2011)
J Med Life
, vol.4
, pp. 346-351
-
-
Gaman, L.1
Stoian, I.2
Atanasiu, V.3
-
17
-
-
39649110574
-
Stress-response hormesis and aging: "that which does not kill us makes us stronger"
-
PMID:18316025
-
Gems D, Partridge L. Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell Metab 2008; 7:200-3; PMID:18316025; http://dx.doi.org/10.1016/j.cmet.2008.01.001
-
(2008)
Cell Metab
, vol.7
, pp. 200-203
-
-
Gems, D.1
Partridge, L.2
-
18
-
-
84876958820
-
Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a "chi"
-
PMID:23618527
-
Cornelius C, Perrotta R, Graziano A, Calabrese EJ, Calabrese V. Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a "chi". Immun Ageing 2013; 10:15; PMID:23618527; http://dx.doi.org/10.1186/1742-4933-10-15
-
(2013)
Immun Ageing
, vol.10
, pp. 15
-
-
Cornelius, C.1
Perrotta, R.2
Graziano, A.3
Calabrese, E.J.4
Calabrese, V.5
-
19
-
-
37749029855
-
Hormesis in aging
-
PMID:17964227
-
Rattan SI. Hormesis in aging. Ageing Res Rev 2008; 7:63-78; PMID:17964227; http://dx.doi.org/10.1016/j.arr.2007.03.002
-
(2008)
Ageing Res Rev
, vol.7
, pp. 63-78
-
-
Rattan, S.I.1
-
20
-
-
34548458640
-
Radiation-induced lifespan alteration of Drosophila lines with genotype differences
-
PMID:17380421
-
Moskalev A. Radiation-induced lifespan alteration of Drosophila lines with genotype differences. Biogerontology 2007; 8:499-504; PMID:17380421; http://dx.doi.org/10.1007/s10522-007-9090-x
-
(2007)
Biogerontology
, vol.8
, pp. 499-504
-
-
Moskalev, A.1
-
21
-
-
79958152231
-
Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: The role of cellular stress-resistance mechanisms
-
PMID:21234801
-
Moskalev AA, Plyusnina EN, Shaposhnikov MV. Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. Biogerontology 2011; 12:253-63; PMID:21234801; http://dx.doi.org/10.1007/s10522-011-9320-0
-
(2011)
Biogerontology
, vol.12
, pp. 253-263
-
-
Moskalev, A.A.1
Plyusnina, E.N.2
Shaposhnikov, M.V.3
-
22
-
-
79958084497
-
Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system
-
PMID:21153055
-
Plyusnina EN, Shaposhnikov MV, Moskalev AA. Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system. Biogerontology 2011; 12:211-26; PMID:21153055; http://dx.doi.org/10.1007/s10522- 010-9311-6
-
(2011)
Biogerontology
, vol.12
, pp. 211-226
-
-
Plyusnina, E.N.1
Shaposhnikov, M.V.2
Moskalev, A.A.3
-
23
-
-
84878864199
-
The hallmarks of aging
-
PMID:23746838
-
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013; 153:1194-217; PMID:23746838; http://dx.doi.org/10.1016/j.cell.2013.05.039
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
López-Otín, C.1
Blasco, M.A.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
25
-
-
77951176737
-
Extending healthy lifespan - From yeast to humans
-
PMID:20395504
-
Fontana L, Partridge L, Longo VD. Extending healthy lifespan - from yeast to humans. Science 2010; 328:321-6; PMID:20395504; http://dx.doi.org/10.1126/ science.1172539
-
(2010)
Science
, vol.328
, pp. 321-326
-
-
Fontana, L.1
Partridge, L.2
Longo, V.D.3
-
26
-
-
77950200010
-
The genetics of ageing
-
PMID:20336132
-
Kenyon CJ. The genetics of ageing. Nature 2010; 464:504-12; PMID:20336132; http://dx.doi.org/10.1038/nature08980
-
(2010)
Nature
, vol.464
, pp. 504-512
-
-
Kenyon, C.J.1
-
27
-
-
75449088805
-
The new biology of ageing
-
PMID:20008392
-
Partridge L. The new biology of ageing. Philos Trans R Soc Lond B Biol Sci 2010; 365:147-54; PMID:20008392; http://dx.doi.org/10.1098/rstb.2009.0222
-
(2010)
Philos Trans R Soc Lond B Biol Sci
, vol.365
, pp. 147-154
-
-
Partridge, L.1
-
28
-
-
70449859148
-
Prospective trends in genetics of aging and longevity
-
PMID:19827680
-
Moskalev AA. [Prospective trends in genetics of aging and longevity]. Adv Gerontol 2009; 22:92-103; PMID:19827680
-
(2009)
Adv Gerontol
, vol.22
, pp. 92-103
-
-
Moskalev, A.A.1
-
29
-
-
84884212849
-
Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases
-
(Berl) PMID:23090008
-
Zhavoronkov A, Smit-McBride Z, Guinan KJ, Litovchenko M, Moskalev A. Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases. J Mol Med (Berl) 2012; 90:1361-89; PMID:23090008; http://dx.doi.org/10.1007/s00109-012-0962-4
-
(2012)
J Mol Med
, vol.90
, pp. 1361-1389
-
-
Zhavoronkov, A.1
Smit-McBride, Z.2
Guinan, K.J.3
Litovchenko, M.4
Moskalev, A.5
-
30
-
-
84861885929
-
The critical role of metabolic pathways in aging
-
PMID:22618766
-
Barzilai N, Huffman DM, Muzumdar RH, Bartke A. The critical role of metabolic pathways in aging. Diabetes 2012; 61:1315-22; PMID:22618766; http://dx.doi.org/10.2337/db11-1300
-
(2012)
Diabetes
, vol.61
, pp. 1315-1322
-
-
Barzilai, N.1
Huffman, D.M.2
Muzumdar, R.H.3
Bartke, A.4
-
31
-
-
34249748303
-
Common aging pathways in worms, flies, mice and humans
-
PMID:17449826
-
Kim SK. Common aging pathways in worms, flies, mice and humans. J Exp Biol 2007; 210:1607-12; PMID:17449826; http://dx.doi.org/10.1242/jeb.004887
-
(2007)
J Exp Biol
, vol.210
, pp. 1607-1612
-
-
Kim, S.K.1
-
32
-
-
17144415603
-
Role of insulin/ insulin-like growth factor 1 signaling pathway in longevity
-
PMID:15800976
-
Cheng CL, Gao TQ, Wang Z, Li DD. Role of insulin/ insulin-like growth factor 1 signaling pathway in longevity. World J Gastroenterol 2005; 11:1891-5; PMID:15800976
-
(2005)
World J Gastroenterol
, vol.11
, pp. 1891-1895
-
-
Cheng, C.L.1
Gao, T.Q.2
Wang, Z.3
Li, D.D.4
-
33
-
-
55849132493
-
Insulin and aging
-
PMID:18948730
-
Bartke A. Insulin and aging. Cell Cycle 2008; 7:3338-43; PMID:18948730; http://dx.doi.org/10.4161/cc.7.21.7012
-
(2008)
Cell Cycle
, vol.7
, pp. 3338-3343
-
-
Bartke, A.1
-
34
-
-
77749316176
-
Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: From yeast to the mammalian brain
-
PMID:20098959
-
Parrella E, Longo VD. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal 2010; 10:161-77; PMID:20098959; http://dx.doi.org/10. 1100/tsw.2010.8
-
(2010)
ScientificWorldJournal
, vol.10
, pp. 161-177
-
-
Parrella, E.1
Longo, V.D.2
-
35
-
-
42149141146
-
Functionally significant insulin-like growth factor I receptor mutations in centenarians
-
PMID:18316725
-
Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A 2008; 105:3438-42; PMID:18316725; http://dx.doi.org/10.1073/pnas.0705467105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 3438-3442
-
-
Suh, Y.1
Atzmon, G.2
Cho, M.O.3
Hwang, D.4
Liu, B.5
Leahy, D.J.6
Barzilai, N.7
Cohen, P.8
-
36
-
-
66149147947
-
Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance
-
PMID:19360094
-
Tazearslan C, Ayyadevara S, Bharill P, Shmookler Reis RJ. Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance. PLoS Genet 2009; 5:e1000452; PMID:19360094; http://dx.doi.org/10.1371/journal.pgen.1000452
-
(2009)
PLoS Genet
, vol.5
-
-
Tazearslan, C.1
Ayyadevara, S.2
Bharill, P.3
Shmookler Reis, R.J.4
-
37
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
PMID:12483226
-
Holzenberger M, Dupont J, Ducos B, Leneuve P, Géloën A, Even PC, Cervera P, Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003; 421:182-7; PMID:12483226; http://dx.doi.org/10.1038/nature01298
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Géloën, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
38
-
-
0035815414
-
Extension of lifespan by loss of CHICO, a Drosophila insulin receptor substrate protein
-
PMID:11292874
-
Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L. Extension of lifespan by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 2001; 292:104-6; PMID:11292874; http://dx.doi.org/10.1126/science.1057991
-
(2001)
Science
, vol.292
, pp. 104-106
-
-
Clancy, D.J.1
Gems, D.2
Harshman, L.G.3
Oldham, S.4
Stocker, H.5
Hafen, E.6
Leevers, S.J.7
Partridge, L.8
-
39
-
-
40449142493
-
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
-
PMID:17928362
-
Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J 2008; 22:807-18; PMID:17928362; http://dx.doi.org/10.1096/fj. 07-9261com
-
(2008)
FASEB J
, vol.22
, pp. 807-818
-
-
Selman, C.1
Lingard, S.2
Choudhury, A.I.3
Batterham, R.L.4
Claret, M.5
Clements, M.6
Ramadani, F.7
Okkenhaug, K.8
Schuster, E.9
Blanc, E.10
-
40
-
-
34547097247
-
Brain IRS2 signaling coordinates lifespan and nutrient homeostasis
-
PMID:17641201
-
Taguchi A, Wartschow LM, White MF. Brain IRS2 signaling coordinates lifespan and nutrient homeostasis. Science 2007; 317:369-72; PMID:17641201; http://dx.doi.org/10.1126/science.1142179
-
(2007)
Science
, vol.317
, pp. 369-372
-
-
Taguchi, A.1
Wartschow, L.M.2
White, M.F.3
-
41
-
-
38349093613
-
Remarkable longevity and stress resistance of nematode PI3K-null mutants
-
PMID:17996009
-
Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell 2008; 7:13-22; PMID:17996009; http://dx.doi.org/10.1111/j.1474-9726.2007.00348.x
-
(2008)
Aging Cell
, vol.7
, pp. 13-22
-
-
Ayyadevara, S.1
Alla, R.2
Thaden, J.J.3
Shmookler Reis, R.J.4
-
42
-
-
68149136449
-
Converging pathways in lifespan regulation
-
PMID:19674551
-
Narasimhan SD, Yen K, Tissenbaum HA. Converging pathways in lifespan regulation. Curr Biol 2009; 19:R657-66; PMID:19674551; http://dx.doi.org/10. 1016/j.cub.2009.06.013
-
(2009)
Curr Biol
, vol.19
-
-
Narasimhan, S.D.1
Yen, K.2
Tissenbaum, H.A.3
-
43
-
-
26944461217
-
Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
-
PMID:16230533
-
Puig O, Tjian R. Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev 2005; 19:2435-46; PMID:16230533; http://dx.doi.org/10. 1101/gad.1340505
-
(2005)
Genes Dev
, vol.19
, pp. 2435-2446
-
-
Puig, O.1
Tjian, R.2
-
44
-
-
44449133522
-
Born to run; the story of the PEPCK-Cmus mouse
-
PMID:18394430
-
Hanson RW, Hakimi P. Born to run; the story of the PEPCK-Cmus mouse. Biochimie 2008; 90:838-42; PMID:18394430; http://dx.doi.org/10.1016/j.biochi. 2008.03.009
-
(2008)
Biochimie
, vol.90
, pp. 838-842
-
-
Hanson, R.W.1
Hakimi, P.2
-
45
-
-
67649185223
-
Hsps and aging
-
PMID:19394247
-
Tower J. Hsps and aging. Trends Endocrinol Metab 2009; 20:216-22; PMID:19394247; http://dx.doi. org/10.1016/j.tem.2008.12.005
-
(2009)
Trends Endocrinol Metab
, vol.20
, pp. 216-222
-
-
Tower, J.1
-
46
-
-
84869459118
-
The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance
-
PMID:23095639
-
Moskalev A, Plyusnina E, Shaposhnikov M, Shilova L, Kazachenok A, Zhavoronkov A. The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance. Cell Cycle 2012; 11:4222-41; PMID:23095639; http://dx.doi.org/10. 4161/cc.22545
-
(2012)
Cell Cycle
, vol.11
, pp. 4222-4241
-
-
Moskalev, A.1
Plyusnina, E.2
Shaposhnikov, M.3
Shilova, L.4
Kazachenok, A.5
Zhavoronkov, A.6
-
47
-
-
83855164048
-
Gadd45 proteins: Relevance to aging, longevity and age-related pathologies
-
PMID:21986581
-
Moskalev AA, Smit-McBride Z, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Tacutu R, Fraifeld VE. Gadd45 proteins: relevance to aging, longevity and age-related pathologies. Ageing Res Rev 2012; 11:51-66; PMID:21986581; http://dx.doi.org/10.1016/j.arr.2011.09.003
-
(2012)
Ageing Res Rev
, vol.11
, pp. 51-66
-
-
Moskalev, A.A.1
Smit-McBride, Z.2
Shaposhnikov, M.V.3
Plyusnina, E.N.4
Zhavoronkov, A.5
Budovsky, A.6
Tacutu, R.7
Fraifeld, V.E.8
-
48
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
PMID:16123266
-
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, et al. Suppression of aging in mice by the hormone Klotho. Science 2005; 309:1829-33; PMID:16123266; http://dx.doi.org/10.1126/science.1112766
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
Pastor, J.V.4
Nandi, A.5
Gurnani, P.6
McGuinness, O.P.7
Chikuda, H.8
Yamaguchi, M.9
Kawaguchi, H.10
-
49
-
-
20044393471
-
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
-
PMID:15708981
-
Broughton SJ, Piper MD, Ikeya T, Bass TM, Jacobson J, Driege Y, Martinez P, Hafen E, Withers DJ, Leevers SJ, et al. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A 2005; 102:3105-10; PMID:15708981; http://dx.doi.org/10.1073/pnas.0405775102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 3105-3110
-
-
Broughton, S.J.1
Piper, M.D.2
Ikeya, T.3
Bass, T.M.4
Jacobson, J.5
Driege, Y.6
Martinez, P.7
Hafen, E.8
Withers, D.J.9
Leevers, S.J.10
-
50
-
-
47049090142
-
Adiponectin levels and genotype: A potential regulator of lifespan in humans
-
PMID:18511746
-
Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, Scherer PE, Rincon M, Siegel G, Katz M, Lipton RB, et al. Adiponectin levels and genotype: a potential regulator of lifespan in humans. J Gerontol A Biol Sci Med Sci 2008; 63:447-53; PMID:18511746; http://dx.doi.org/10.1093/gerona/63.5.447
-
(2008)
J Gerontol a Biol Sci Med Sci
, vol.63
, pp. 447-453
-
-
Atzmon, G.1
Pollin, T.I.2
Crandall, J.3
Tanner, K.4
Schechter, C.B.5
Scherer, P.E.6
Rincon, M.7
Siegel, G.8
Katz, M.9
Lipton, R.B.10
-
51
-
-
80052900602
-
Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice
-
PMID:21810600
-
Naito M, Fujikura J, Ebihara K, Miyanaga F, Yokoi H, Kusakabe T, Yamamoto Y, Son C, Mukoyama M, Hosoda K, et al. Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice. Diabetes 2011; 60:2265-73; PMID:21810600; http://dx.doi.org/10.2337/db10- 1795
-
(2011)
Diabetes
, vol.60
, pp. 2265-2273
-
-
Naito, M.1
Fujikura, J.2
Ebihara, K.3
Miyanaga, F.4
Yokoi, H.5
Kusakabe, T.6
Yamamoto, Y.7
Son, C.8
Mukoyama, M.9
Hosoda, K.10
-
52
-
-
81755173582
-
Physiological roles revealed by ghrelin and ghrelin receptor deficient mice
-
PMID:21781995
-
Albarran-Zeckler RG, Sun Y, Smith RG. Physiological roles revealed by ghrelin and ghrelin receptor deficient mice. Peptides 2011; 32:2229-35; PMID:21781995; http://dx.doi.org/10.1016/j.peptides.2011.07.003
-
(2011)
Peptides
, vol.32
, pp. 2229-2235
-
-
Albarran-Zeckler, R.G.1
Sun, Y.2
Smith, R.G.3
-
53
-
-
78650006092
-
Correlation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients
-
PMID:20739208
-
Gharibeh MY, Al Tawallbeh GM, Abboud MM, Radaideh A, Alhader AA, Khabour OF. Correlation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients. Diabetes Metab 2010; 36:443-9; PMID:20739208; http://dx.doi.org/10.1016/j.diabet.2010.05.003
-
(2010)
Diabetes Metab
, vol.36
, pp. 443-449
-
-
Gharibeh, M.Y.1
Al Tawallbeh, G.M.2
Abboud, M.M.3
Radaideh, A.4
Alhader, A.A.5
Khabour, O.F.6
-
54
-
-
84865405029
-
Therapies in inborn errors of oxidative metabolism
-
PMID:22633959
-
Schiff M, Bénit P, Jacobs HT, Vockley J, Rustin P. Therapies in inborn errors of oxidative metabolism. Trends Endocrinol Metab 2012; 23:488-95; PMID:22633959; http://dx.doi.org/10.1016/j.tem.2012.04.006
-
(2012)
Trends Endocrinol Metab
, vol.23
, pp. 488-495
-
-
Schiff, M.1
Bénit, P.2
Jacobs, H.T.3
Vockley, J.4
Rustin, P.5
-
55
-
-
74249092870
-
Ppargamma2 is a key driver of longevity in the mouse
-
PMID:19997628
-
Argmann C, Dobrin R, Heikkinen S, Auburtin A, Pouilly L, Cock TA, Koutnikova H, Zhu J, Schadt EE, Auwerx J. Ppargamma2 is a key driver of longevity in the mouse. PLoS Genet 2009; 5:e1000752; PMID:19997628; http://dx.doi.org/10.1371/journal.pgen.1000752
-
(2009)
PLoS Genet
, vol.5
-
-
Argmann, C.1
Dobrin, R.2
Heikkinen, S.3
Auburtin, A.4
Pouilly, L.5
Cock, T.A.6
Koutnikova, H.7
Zhu, J.8
Schadt, E.E.9
Auwerx, J.10
-
56
-
-
0037379744
-
The age-related inverse relationship between ob and lipogenic enzymes genes expression in rat white adipose tissue
-
PMID:12670628
-
Nogalska A, Pankiewicz A, Goyke E, Swierczynski J. The age-related inverse relationship between ob and lipogenic enzymes genes expression in rat white adipose tissue. Exp Gerontol 2003; 38:415-22; PMID:12670628; http://dx.doi.org/10.1016/S0531-5565(02)00210-3
-
(2003)
Exp Gerontol
, vol.38
, pp. 415-422
-
-
Nogalska, A.1
Pankiewicz, A.2
Goyke, E.3
Swierczynski, J.4
-
57
-
-
9644309911
-
PTH and phospholipase A2 in the aging process of intestinal cells
-
PMID:15368358
-
Gentili C, Morelli S, de Boland AR. PTH and phospholipase A2 in the aging process of intestinal cells. J Cell Biochem 2004; 93:312-26; PMID:15368358; http://dx.doi.org/10.1002/jcb.20158
-
(2004)
J Cell Biochem
, vol.93
, pp. 312-326
-
-
Gentili, C.1
Morelli, S.2
De Boland, A.R.3
-
58
-
-
0030936949
-
Impairment of signal transduction in T cells from old mice
-
PMID:9089578
-
Utsuyama M, Wakikawa A, Tamura T, Nariuchi H, Hirokawa K. Impairment of signal transduction in T cells from old mice. Mech Ageing Dev 1997; 93:131-44; PMID:9089578; http://dx.doi.org/10.1016/S0047-6374(96)01837-4
-
(1997)
Mech Ageing Dev
, vol.93
, pp. 131-144
-
-
Utsuyama, M.1
Wakikawa, A.2
Tamura, T.3
Nariuchi, H.4
Hirokawa, K.5
-
59
-
-
84867356065
-
Overexpression of fatty-acid-β-oxidation-related genes extends the lifespan of Drosophila melanogaster
-
PMID:22997544
-
Lee SH, Lee SK, Paik D, Min KJ. Overexpression of fatty-acid-β- oxidation-related genes extends the lifespan of Drosophila melanogaster. Oxid Med Cell Longev 2012; 2012:854502; PMID:22997544; http://dx.doi.org/10.1155/ 2012/854502
-
(2012)
Oxid Med Cell Longev
, vol.2012
, pp. 854502
-
-
Lee, S.H.1
Lee, S.K.2
Paik, D.3
Min, K.J.4
-
60
-
-
33646251112
-
Lipoprotein genotype and conserved pathway for exceptional longevity in humans
-
PMID:16602826
-
Atzmon G, Rincon M, Schechter CB, Shuldiner AR, Lipton RB, Bergman A, Barzilai N. Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol 2006; 4:e113; PMID:16602826; http://dx.doi.org/10.1371/ journal.pbio.0040113
-
(2006)
PLoS Biol
, vol.4
-
-
Atzmon, G.1
Rincon, M.2
Schechter, C.B.3
Shuldiner, A.R.4
Lipton, R.B.5
Bergman, A.6
Barzilai, N.7
-
61
-
-
74649085042
-
Apolipoprotein E and its role in aging and survival
-
PMID:19941948
-
Bonomini F, Filippini F, Hayek T, Aviram M, Keidar S, Rodella LF, Coleman R, Rezzani R. Apolipoprotein E and its role in aging and survival. Exp Gerontol 2010; 45:149-57; PMID:19941948; http://dx.doi.org/10.1016/j.exger.2009.11.006
-
(2010)
Exp Gerontol
, vol.45
, pp. 149-157
-
-
Bonomini, F.1
Filippini, F.2
Hayek, T.3
Aviram, M.4
Keidar, S.5
Rodella, L.F.6
Coleman, R.7
Rezzani, R.8
-
62
-
-
74949122722
-
Apolipoprotein D: An overview of its role in aging and age-related diseases
-
Apolipoprotein D. PMID:20023409
-
Muffat J, Walker DW, Apolipoprotein D. Apolipoprotein D: an overview of its role in aging and age-related diseases. Cell Cycle 2010; 9:269-73; PMID:20023409; http://dx.doi.org/10.4161/cc.9.2.10433
-
(2010)
Cell Cycle
, vol.9
, pp. 269-273
-
-
Muffat, J.1
Walker, D.W.2
-
63
-
-
44349118767
-
Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila
-
Human Apo D. PMID:18458334
-
Muffat J, Walker DW, Benzer S, Human Apo D. Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. Proc Natl Acad Sci U S A 2008; 105:7088-93; PMID:18458334; http://dx.doi.org/10.1073/pnas.0800896105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 7088-7093
-
-
Muffat, J.1
Walker, D.W.2
Benzer, S.3
-
64
-
-
33645882217
-
Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan
-
PMID:16581512
-
Walker DW, Muffat J, Rundel C, Benzer S. Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol 2006; 16:674-9; PMID:16581512; http://dx.doi.org/10.1016/j. cub.2006.01.057
-
(2006)
Curr Biol
, vol.16
, pp. 674-679
-
-
Walker, D.W.1
Muffat, J.2
Rundel, C.3
Benzer, S.4
-
65
-
-
54749114466
-
It's not how fat you are, it's what you do with it that counts
-
PMID:18816166
-
Virtue S, Vidal-Puig A. It's not how fat you are, it's what you do with it that counts. PLoS Biol 2008; 6:e237; PMID:18816166; http://dx.doi.org/10. 1371/journal.pbio.0060237
-
(2008)
PLoS Biol
, vol.6
-
-
Virtue, S.1
Vidal-Puig, A.2
-
66
-
-
68649105257
-
AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity
-
PMID:19686213
-
Greer EL, Banko MR, Brunet A. AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity. Ann N Y Acad Sci 2009; 1170:688-92; PMID:19686213; http://dx.doi.org/10.1111/j.1749-6632.2009. 04019.x
-
(2009)
Ann N Y Acad Sci
, vol.1170
, pp. 688-692
-
-
Greer, E.L.1
Banko, M.R.2
Brunet, A.3
-
67
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
PMID:19587680
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460:392-5; PMID:19587680
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
-
68
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan
-
PMID:19797661
-
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan. Science 2009; 326:140-4; PMID:19797661; http://dx.doi.org/10.1126/science.1177221
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
Claret, M.7
Al-Qassab, H.8
Carmignac, D.9
Ramadani, F.10
-
69
-
-
34249888736
-
PHA-4/Foxa mediates diet-restriction- induced longevity of C. elegans
-
PMID:17476212
-
Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction- induced longevity of C. elegans. Nature 2007; 447:550-5; PMID:17476212; http://dx.doi.org/10.1038/nature05837
-
(2007)
Nature
, vol.447
, pp. 550-555
-
-
Panowski, S.H.1
Wolff, S.2
Aguilaniu, H.3
Durieux, J.4
Dillin, A.5
-
70
-
-
84866544628
-
The endoplasmic reticulum stress response in aging and age-related diseases
-
PMID:22934019
-
Brown MK, Naidoo N. The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 2012; 3:263; PMID:22934019; http://dx.doi.org/10.3389/fphys.2012.00263
-
(2012)
Front Physiol
, vol.3
, pp. 263
-
-
Brown, M.K.1
Naidoo, N.2
-
71
-
-
34347375071
-
On why decreasing protein synthesis can increase lifespan
-
PMID:17452047
-
Hipkiss AR. On why decreasing protein synthesis can increase lifespan. Mech Ageing Dev 2007; 128:412-4; PMID:17452047; http://dx.doi.org/10.1016/j.mad. 2007.03.002
-
(2007)
Mech Ageing Dev
, vol.128
, pp. 412-414
-
-
Hipkiss, A.R.1
-
72
-
-
77249166017
-
Molecular mechanisms of proteasome plasticity in aging
-
PMID:20080121
-
Rodriguez KA, Gaczynska M, Osmulski PA. Molecular mechanisms of proteasome plasticity in aging. Mech Ageing Dev 2010; 131:144-55; PMID:20080121; http://dx.doi.org/10.1016/j.mad.2010.01.002
-
(2010)
Mech Ageing Dev
, vol.131
, pp. 144-155
-
-
Rodriguez, K.A.1
Gaczynska, M.2
Osmulski, P.A.3
-
73
-
-
56349168452
-
Autophagy and aging: Keeping that old broom working
-
PMID:18992957
-
Cuervo AM. Autophagy and aging: keeping that old broom working. Trends Genet 2008; 24:604-12; PMID:18992957; http://dx.doi.org/10.1016/j.tig.2008.10. 002
-
(2008)
Trends Genet
, vol.24
, pp. 604-612
-
-
Cuervo, A.M.1
-
74
-
-
59449095881
-
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process
-
PMID:19075009
-
Tonoki A, Kuranaga E, Tomioka T, Hamazaki J, Murata S, Tanaka K, Miura M. Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol 2009; 29:1095-106; PMID:19075009; http://dx.doi.org/10.1128/MCB.01227-08
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1095-1106
-
-
Tonoki, A.1
Kuranaga, E.2
Tomioka, T.3
Hamazaki, J.4
Murata, S.5
Tanaka, K.6
Miura, M.7
-
75
-
-
38949099761
-
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
-
PMID:18059160
-
Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2008; 4:176-84; PMID:18059160
-
(2008)
Autophagy
, vol.4
, pp. 176-184
-
-
Simonsen, A.1
Cumming, R.C.2
Brech, A.3
Isakson, P.4
Schubert, D.R.5
Finley, K.D.6
-
76
-
-
67651004289
-
A conserved ubiquitination pathway determines longevity in response to diet restriction
-
PMID:19553937
-
Carrano AC, Liu Z, Dillin A, Hunter T. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 2009; 460:396-9; PMID:19553937
-
(2009)
Nature
, vol.460
, pp. 396-399
-
-
Carrano, A.C.1
Liu, Z.2
Dillin, A.3
Hunter, T.4
-
77
-
-
33846596646
-
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination
-
PMID:17276341
-
Li W, Gao B, Lee SM, Bennett K, Fang D. RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev Cell 2007; 12:235-46; PMID:17276341; http://dx.doi.org/10.1016/j.devcel.2006.12.002
-
(2007)
Dev Cell
, vol.12
, pp. 235-246
-
-
Li, W.1
Gao, B.2
Lee, S.M.3
Bennett, K.4
Fang, D.5
-
78
-
-
2442649342
-
Overexpression of the small mitochondrial Hsp22 extends Drosophila lifespan and increases resistance to oxidative stress
-
PMID:14734639
-
Morrow G, Samson M, Michaud S, Tanguay RM. Overexpression of the small mitochondrial Hsp22 extends Drosophila lifespan and increases resistance to oxidative stress. FASEB J 2004; 18:598-9; PMID:14734639
-
(2004)
FASEB J
, vol.18
, pp. 598-599
-
-
Morrow, G.1
Samson, M.2
Michaud, S.3
Tanguay, R.M.4
-
79
-
-
67650091290
-
Increasing organismal healthspan by enhancing mitochondrial protein quality control
-
PMID:19543272
-
Luce K, Osiewacz HD. Increasing organismal healthspan by enhancing mitochondrial protein quality control. Nat Cell Biol 2009; 11:852-8; PMID:19543272; http://dx.doi.org/10.1038/ncb1893
-
(2009)
Nat Cell Biol
, vol.11
, pp. 852-858
-
-
Luce, K.1
Osiewacz, H.D.2
-
80
-
-
58149296387
-
The signaling hubs at the crossroad of longevity and age- related disease networks
-
PMID:18793745
-
Wolfson M, Budovsky A, Tacutu R, Fraifeld V. The signaling hubs at the crossroad of longevity and age- related disease networks. Int J Biochem Cell Biol 2009; 41:516-20; PMID:18793745; http://dx.doi.org/10.1016/j.biocel.2008.08. 026
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 516-520
-
-
Wolfson, M.1
Budovsky, A.2
Tacutu, R.3
Fraifeld, V.4
-
81
-
-
34547924424
-
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
-
PMID:17690295
-
Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 2007; 317:807-10; PMID:17690295; http://dx.doi.org/10.1126/science. 1144090
-
(2007)
Science
, vol.317
, pp. 807-810
-
-
Brack, A.S.1
Conboy, M.J.2
Roy, S.3
Lee, M.4
Kuo, C.J.5
Keller, C.6
Rando, T.A.7
-
82
-
-
84861233634
-
Age-related changes in gene expression in tissues of the sea urchin Strongylocentrotus purpuratus
-
PMID:22475988
-
Loram J, Bodnar A. Age-related changes in gene expression in tissues of the sea urchin Strongylocentrotus purpuratus. Mech Ageing Dev 2012; 133:338-47; PMID:22475988; http://dx.doi.org/10.1016/j.mad.2012.03.012
-
(2012)
Mech Ageing Dev
, vol.133
, pp. 338-347
-
-
Loram, J.1
Bodnar, A.2
-
83
-
-
70349142170
-
RAS in cellular transformation and senescence
-
PMID:19775620
-
DeNicola GM, Tuveson DA. RAS in cellular transformation and senescence. Eur J Cancer 2009; 45(Suppl 1):211-6; PMID:19775620; http://dx.doi.org/10.1016/ S0959-8049(09)70036-X
-
(2009)
Eur J Cancer
, vol.45
, Issue.SUPPL. 1
, pp. 211-216
-
-
DeNicola, G.M.1
Tuveson, D.A.2
-
84
-
-
80054722470
-
A muscle-specific p38 MAPK/Mef2/ MnSOD pathway regulates stress, motor function, and lifespan in Drosophila
-
PMID:22014527
-
Vrailas-Mortimer A, del Rivero T, Mukherjee S, Nag S, Gaitanidis A, Kadas D, Consoulas C, Duttaroy A, Sanyal S. A muscle-specific p38 MAPK/Mef2/ MnSOD pathway regulates stress, motor function, and lifespan in Drosophila. Dev Cell 2011; 21:783-95; PMID:22014527; http://dx.doi.org/10.1016/j.devcel.2011.09.002
-
(2011)
Dev Cell
, vol.21
, pp. 783-795
-
-
Vrailas-Mortimer, A.1
Del Rivero, T.2
Mukherjee, S.3
Nag, S.4
Gaitanidis, A.5
Kadas, D.6
Consoulas, C.7
Duttaroy, A.8
Sanyal, S.9
-
85
-
-
33947199706
-
Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation
-
PMID:17339447
-
King AM, Van der Put E, Blomberg BB, Riley RL. Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation. J Immunol 2007; 178:3521-9; PMID:17339447
-
(2007)
J Immunol
, vol.178
, pp. 3521-3529
-
-
King, A.M.1
Van Der Put, E.2
Blomberg, B.B.3
Riley, R.L.4
-
86
-
-
0242362732
-
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
-
PMID:14602080
-
Wang MC, Bohmann D, Jasper H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell 2003; 5:811-6; PMID:14602080; http://dx.doi.org/10.1016/S1534-5807(03)00323-X
-
(2003)
Dev Cell
, vol.5
, pp. 811-816
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
87
-
-
77955293654
-
Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence
-
PMID:20649541
-
Kim YM, Seo YH, Park CB, Yoon SH, Yoon G. Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence. Ann N Y Acad Sci 2010; 1201:65-71; PMID:20649541; http://dx.doi. org/10.1111/j.1749-6632.2010.05617.x
-
(2010)
Ann N Y Acad Sci
, vol.1201
, pp. 65-71
-
-
Kim, Y.M.1
Seo, Y.H.2
Park, C.B.3
Yoon, S.H.4
Yoon, G.5
-
88
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and lifespan in mammals
-
PMID:10580504
-
Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG. The p66shc adaptor protein controls oxidative stress response and lifespan in mammals. Nature 1999; 402:309-13; PMID:10580504; http://dx.doi.org/10.1038/46311
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
Giorgio, M.2
Mele, S.3
Pelicci, G.4
Reboldi, P.5
Pandolfi, P.P.6
Lanfrancone, L.7
Pelicci, P.G.8
-
89
-
-
54449091329
-
Early mitochondrial dysfunction in long-lived Mclk1+/- mice
-
PMID:18635541
-
Lapointe J, Hekimi S. Early mitochondrial dysfunction in long-lived Mclk1+/- mice. J Biol Chem 2008; 283:26217-27; PMID:18635541; http://dx.doi.org/10.1074/jbc.M803287200
-
(2008)
J Biol Chem
, vol.283
, pp. 26217-26227
-
-
Lapointe, J.1
Hekimi, S.2
-
90
-
-
47349099980
-
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
-
PMID:18505478
-
Caldeira da Silva CC, Cerqueira FM, Barbosa LF, Medeiros MH, Kowaltowski AJ. Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging Cell 2008; 7:552-60; PMID:18505478; http://dx.doi.org/10.1111/j.1474-9726.2008.00407.x
-
(2008)
Aging Cell
, vol.7
, pp. 552-560
-
-
Caldeira Da Silva, C.C.1
Cerqueira, F.M.2
Barbosa, L.F.3
Medeiros, M.H.4
Kowaltowski, A.J.5
-
92
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
-
PMID:18358814
-
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 2008; 132:1025-38; PMID:18358814; http://dx.doi.org/10.1016/j.cell.2008.01.030
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
93
-
-
70350398226
-
JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends lifespan
-
PMID:19720829
-
Lee KS, Iijima-Ando K, Iijima K, Lee WJ, Lee JH, Yu K, Lee DS. JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends lifespan. J Biol Chem 2009; 284:29454-61; PMID:19720829; http://dx.doi.org/10.1074/jbc.M109.028027
-
(2009)
J Biol Chem
, vol.284
, pp. 29454-29461
-
-
Lee, K.S.1
Iijima-Ando, K.2
Iijima, K.3
Lee, W.J.4
Lee, J.H.5
Yu, K.6
Lee, D.S.7
-
94
-
-
64249103993
-
Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila
-
PMID:19128239
-
Radyuk SN, Michalak K, Klichko VI, Benes J, Rebrin I, Sohal RS, Orr WC. Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila. Biochem J 2009; 419:437-45; PMID:19128239; http://dx.doi.org/10.1042/BJ20082003
-
(2009)
Biochem J
, vol.419
, pp. 437-445
-
-
Radyuk, S.N.1
Michalak, K.2
Klichko, V.I.3
Benes, J.4
Rebrin, I.5
Sohal, R.S.6
Orr, W.C.7
-
95
-
-
33846345418
-
Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase
-
PMID:17129739
-
Hu D, Cao P, Thiels E, Chu CT, Wu GY, Oury TD, Klann E. Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol Learn Mem 2007; 87:372-84; PMID:17129739; http://dx.doi.org/10.1016/j.nlm.2006.10.003
-
(2007)
Neurobiol Learn Mem
, vol.87
, pp. 372-384
-
-
Hu, D.1
Cao, P.2
Thiels, E.3
Chu, C.T.4
Wu, G.Y.5
Oury, T.D.6
Klann, E.7
-
96
-
-
0033659765
-
Targeted neuronal gene expression and longevity in Drosophila
-
PMID:11113599
-
Phillips JP, Parkes TL, Hilliker AJ. Targeted neuronal gene expression and longevity in Drosophila. Exp Gerontol 2000; 35:1157-64; PMID:11113599; http://dx.doi.org/10.1016/S0531-5565(00)00117-0
-
(2000)
Exp Gerontol
, vol.35
, pp. 1157-1164
-
-
Phillips, J.P.1
Parkes, T.L.2
Hilliker, A.J.3
-
97
-
-
67649204729
-
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
-
PMID:19451351
-
Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, et al. Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation 2009; 119:2789-97; PMID:19451351; http://dx.doi.org/10.1161/CIRCULATIONAHA.108.822403
-
(2009)
Circulation
, vol.119
, pp. 2789-2797
-
-
Dai, D.F.1
Santana, L.F.2
Vermulst, M.3
Tomazela, D.M.4
Emond, M.J.5
MacCoss, M.J.6
Gollahon, K.7
Martin, G.M.8
Loeb, L.A.9
Ladiges, W.C.10
-
98
-
-
0347991998
-
Age- associated activation of epigenetically repressed genes in the mouse
-
PMID:14704185
-
Bennett-Baker PE, Wilkowski J, Burke DT. Age- associated activation of epigenetically repressed genes in the mouse. Genetics 2003; 165:2055-62; PMID:14704185
-
(2003)
Genetics
, vol.165
, pp. 2055-2062
-
-
Bennett-Baker, P.E.1
Wilkowski, J.2
Burke, D.T.3
-
99
-
-
84864946547
-
Postnatal development- and age-related changes in DNA-methylation patterns in the human genome
-
PMID:22495928
-
Salpea P, Russanova VR, Hirai TH, Sourlingas TG, Sekeri-Pataryas KE, Romero R, Epstein J, Howard BH. Postnatal development- and age-related changes in DNA-methylation patterns in the human genome. Nucleic Acids Res 2012; 40:6477-94; PMID:22495928; http://dx.doi.org/10.1093/nar/gks312
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 6477-6494
-
-
Salpea, P.1
Russanova, V.R.2
Hirai, T.H.3
Sourlingas, T.G.4
Sekeri-Pataryas, K.E.5
Romero, R.6
Epstein, J.7
Howard, B.H.8
-
100
-
-
84860572791
-
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
-
MuTHER Consortium. PMID:22532803
-
Bell JT, Tsai PC, Yang TP, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al.; MuTHER Consortium. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 2012; 8:e1002629; PMID:22532803; http://dx.doi.org/10.1371/journal.pgen.1002629
-
(2012)
PLoS Genet
, vol.8
-
-
Bell, J.T.1
Tsai, P.C.2
Yang, T.P.3
Pidsley, R.4
Nisbet, J.5
Glass, D.6
Mangino, M.7
Zhai, G.8
Zhang, F.9
Valdes, A.10
-
101
-
-
23044514669
-
Epigenetic differences arise during the lifetime of monozygotic twins
-
PMID:16009939
-
Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 2005; 102:10604-9; PMID:16009939; http://dx.doi.org/10.1073/pnas.0500398102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 10604-10609
-
-
Fraga, M.F.1
Ballestar, E.2
Paz, M.F.3
Ropero, S.4
Setien, F.5
Ballestar, M.L.6
Heine-Suñer, D.7
Cigudosa, J.C.8
Urioste, M.9
Benitez, J.10
-
102
-
-
84867484739
-
The second international conference "genetics of aging and longevity"
-
(Albany NY) PMID:22661237
-
Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, et al. The second international conference "genetics of aging and longevity". Aging (Albany NY) 2012; 4:305-17; PMID:22661237
-
(2012)
Aging
, vol.4
, pp. 305-317
-
-
Anisimov, V.N.1
Bartke, A.2
Barzilai, N.3
Batin, M.A.4
Blagosklonny, M.V.5
Brown-Borg, H.6
Budovskaya, Y.7
Campisi, J.8
Friguet, B.9
Fraifeld, V.10
-
103
-
-
0036606768
-
Epigenetic regulation of an IAP retrotransposon in the aging mouse: Progressive demethylation and de-silencing of the element by its repetitive induction
-
PMID:12034823
-
Barbot W, Dupressoir A, Lazar V, Heidmann T. Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction. Nucleic Acids Res 2002; 30:2365-73; PMID:12034823; http://dx.doi.org/10.1093/nar/30.11.2365
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 2365-2373
-
-
Barbot, W.1
Dupressoir, A.2
Lazar, V.3
Heidmann, T.4
-
104
-
-
0033822681
-
Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts
-
PMID:10973920
-
Machwe A, Orren DK, Bohr VA. Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts. FASEB J 2000; 14:1715-24; PMID:10973920; http://dx.doi.org/10.1096/fj.99-0926com
-
(2000)
FASEB J
, vol.14
, pp. 1715-1724
-
-
Machwe, A.1
Orren, D.K.2
Bohr, V.A.3
-
105
-
-
0025043570
-
Age-related increase in methylation of ribosomal genes and inactivation of chromosome- specific rRNA gene clusters in mouse
-
PMID:1700292
-
Swisshelm K, Disteche CM, Thorvaldsen J, Nelson A, Salk D. Age-related increase in methylation of ribosomal genes and inactivation of chromosome- specific rRNA gene clusters in mouse. Mutat Res 1990; 237:131-46; PMID:1700292; http://dx.doi.org/10.1016/0921-8734(90)90019-N
-
(1990)
Mutat Res
, vol.237
, pp. 131-146
-
-
Swisshelm, K.1
Disteche, C.M.2
Thorvaldsen, J.3
Nelson, A.4
Salk, D.5
-
106
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
PMID:12809602
-
Narita M, Nũnez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003; 113:703-16; PMID:12809602; http://dx.doi.org/10.1016/S0092-8674(03)00401-X
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
Nũnez, S.2
Heard, E.3
Narita, M.4
Lin, A.W.5
Hearn, S.A.6
Spector, D.L.7
Hannon, G.J.8
Lowe, S.W.9
-
107
-
-
0141839825
-
Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts
-
PMID:14577574
-
Casillas MA Jr., Lopatina N, Andrews LG, Tollefsbol TO. Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts. Mol Cell Biochem 2003; 252:33-43; PMID:14577574; http://dx.doi.org/10.1023/A:1025548623524
-
(2003)
Mol Cell Biochem
, vol.252
, pp. 33-43
-
-
Casillas Jr., M.A.1
Lopatina, N.2
Andrews, L.G.3
Tollefsbol, T.O.4
-
108
-
-
78049268948
-
Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats
-
PMID:20467811
-
Marton O, Koltai E, Nyakas C, Bakonyi T, Zenteno-Savin T, Kumagai S, Goto S, Radak Z. Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats. Biogerontology 2010; 11:679-86; PMID:20467811; http://dx.doi.org/10.1007/s10522-010-9279-2
-
(2010)
Biogerontology
, vol.11
, pp. 679-686
-
-
Marton, O.1
Koltai, E.2
Nyakas, C.3
Bakonyi, T.4
Zenteno-Savin, T.5
Kumagai, S.6
Goto, S.7
Radak, Z.8
-
109
-
-
77950602854
-
Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
-
PMID:20049504
-
Jung JW, Lee S, Seo MS, Park SB, Kurtz A, Kang SK, Kang KS. Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3. Cell Mol Life Sci 2010; 67:1165-76; PMID:20049504; http://dx.doi.org/10.1007/s00018-009-0242-9
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 1165-1176
-
-
Jung, J.W.1
Lee, S.2
Seo, M.S.3
Park, S.B.4
Kurtz, A.5
Kang, S.K.6
Kang, K.S.7
-
110
-
-
80053203114
-
The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence
-
PMID:21980403
-
Nijwening JH, Geutjes EJ, Bernards R, Beijersbergen RL. The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence. PLoS One 2011; 6:e25235; PMID:21980403; http://dx.doi.org/10.1371/journal.pone.0025235
-
(2011)
PLoS One
, vol.6
-
-
Nijwening, J.H.1
Geutjes, E.J.2
Bernards, R.3
Beijersbergen, R.L.4
-
111
-
-
84857997174
-
Cancer cell senescence: A new frontier in drug development
-
PMID:22314100
-
Cairney CJ, Bilsland AE, Evans TR, Roffey J, Bennett DC, Narita M, Torrance CJ, Keith WN. Cancer cell senescence: a new frontier in drug development. Drug Discov Today 2012; 17:269-76; PMID:22314100; http://dx.doi.org/10.1016/j.drudis.2012.01.019
-
(2012)
Drug Discov Today
, vol.17
, pp. 269-276
-
-
Cairney, C.J.1
Bilsland, A.E.2
Evans, T.R.3
Roffey, J.4
Bennett, D.C.5
Narita, M.6
Torrance, C.J.7
Keith, W.N.8
-
112
-
-
84876576773
-
MicroRNA and senescence: The senectome, integration and distributed control
-
PMID:23614622
-
Bilsland AE, Revie J, Keith W. MicroRNA and senescence: the senectome, integration and distributed control. Crit Rev Oncog 2013; 18:373-90; PMID:23614622; http://dx.doi.org/10.1615/CritRevOncog.2013007197
-
(2013)
Crit Rev Oncog
, vol.18
, pp. 373-390
-
-
Bilsland, A.E.1
Revie, J.2
Keith, W.3
-
113
-
-
84874700585
-
MicroRNA-34a regulates cardiac ageing and function
-
PMID:23426265
-
Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, et al. MicroRNA-34a regulates cardiac ageing and function. Nature 2013; 495:107-10; PMID:23426265; http://dx.doi.org/10.1038/nature11919
-
(2013)
Nature
, vol.495
, pp. 107-110
-
-
Boon, R.A.1
Iekushi, K.2
Lechner, S.3
Seeger, T.4
Fischer, A.5
Heydt, S.6
Kaluza, D.7
Tréguer, K.8
Carmona, G.9
Bonauer, A.10
-
114
-
-
84898011848
-
MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro
-
(Dordr) PMID:23818104
-
Mehi SJ, Maltare A, Abraham CR, King GD. MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro. Age (Dordr) 2014; 36:141-9; PMID:23818104
-
(2014)
Age
, vol.36
, pp. 141-149
-
-
Mehi, S.J.1
Maltare, A.2
Abraham, C.R.3
King, G.D.4
-
115
-
-
84883496441
-
Circulating inflamma-miRs in aging and age-related diseases
-
PMID:23805154
-
Olivieri F, Rippo MR, Procopio AD, Fazioli F. Circulating inflamma-miRs in aging and age-related diseases. Front Genet 2013; 4:121; PMID:23805154; http://dx.doi.org/10.3389/fgene.2013.00121
-
(2013)
Front Genet
, vol.4
, pp. 121
-
-
Olivieri, F.1
Rippo, M.R.2
Procopio, A.D.3
Fazioli, F.4
-
116
-
-
84872598678
-
Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: A pilot study
-
PMID:22931923
-
Chang AL, Bitter PH Jr., Qu K, Lin M, Rapicavoli NA, Chang HY. Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study. J Invest Dermatol 2013; 133:394-402; PMID:22931923; http://dx.doi.org/10.1038/jid.2012.287
-
(2013)
J Invest Dermatol
, vol.133
, pp. 394-402
-
-
Chang, A.L.1
Bitter Jr., P.H.2
Qu, K.3
Lin, M.4
Rapicavoli, N.A.5
Chang, H.Y.6
-
117
-
-
84883794528
-
SAL-RNAs: Senescence-associated long non-coding RNAs
-
Abdelmohsen K, Panda A, Kang MJ, Xu J, Selimyan R, Yoon JH, Martindale JL, De S, Wood WH, Becker KG, et al. SAL-RNAs: Senescence-associated long non-coding RNAs. Aging Cell 2013; http://dx.doi.org/10.1111/acel.12115
-
(2013)
Aging Cell
-
-
Abdelmohsen, K.1
Panda, A.2
Kang, M.J.3
Xu, J.4
Selimyan, R.5
Yoon, J.H.6
Martindale, J.L.7
De, S.8
Wood, W.H.9
Becker, K.G.10
-
118
-
-
21144460742
-
Analysis of long- lived C. elegans daf-2 mutants using serial analysis of gene expression
-
PMID:15837805
-
Halaschek-Wiener J, Khattra JS, McKay S, Pouzyrev A, Stott JM, Yang GS, Holt RA, Jones SJ, Marra MA, Brooks-Wilson AR, et al. Analysis of long- lived C. elegans daf-2 mutants using serial analysis of gene expression. Genome Res 2005; 15:603-15; PMID:15837805; http://dx.doi.org/10.1101/gr.3274805
-
(2005)
Genome Res
, vol.15
, pp. 603-615
-
-
Halaschek-Wiener, J.1
Khattra, J.S.2
McKay, S.3
Pouzyrev, A.4
Stott, J.M.5
Yang, G.S.6
Holt, R.A.7
Jones, S.J.8
Marra, M.A.9
Brooks-Wilson, A.R.10
-
119
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
-
PMID:18282106
-
Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 2008; 4:e24; PMID:18282106; http://dx.doi.org/10.1371/journal.pgen. 0040024
-
(2008)
PLoS Genet
, vol.4
-
-
Hansen, M.1
Chandra, A.2
Mitic, L.L.3
Onken, B.4
Driscoll, M.5
Kenyon, C.6
-
120
-
-
0742323000
-
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
-
PMID:14668486
-
Morley JF, Morimoto RI. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell 2004; 15:657-64; PMID:14668486; http://dx.doi.org/10.1091/mbc.E03-07-0532
-
(2004)
Mol Biol Cell
, vol.15
, pp. 657-664
-
-
Morley, J.F.1
Morimoto, R.I.2
-
121
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
PMID:14668850
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Müller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620; PMID:14668850; http://dx.doi.org/10.1038/426620a
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Müller, F.6
-
122
-
-
11144355021
-
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and lifespan
-
PMID:15068796
-
Hertweck M, Göbel C, Baumeister R. C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and lifespan. Dev Cell 2004; 6:577-88; PMID:15068796; http://dx.doi.org/10.1016/S1534- 5807(04)00095-4
-
(2004)
Dev Cell
, vol.6
, pp. 577-588
-
-
Hertweck, M.1
Göbel, C.2
Baumeister, R.3
-
123
-
-
80053460544
-
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
-
PMID:21909281
-
Rizki G, Iwata TN, Li J, Riedel CG, Picard CL, Jan M, Murphy CT, Lee SS. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet 2011; 7:e1002235; PMID:21909281; http://dx.doi.org/10.1371/journal.pgen.1002235
-
(2011)
PLoS Genet
, vol.7
-
-
Rizki, G.1
Iwata, T.N.2
Li, J.3
Riedel, C.G.4
Picard, C.L.5
Jan, M.6
Murphy, C.T.7
Lee, S.S.8
-
124
-
-
15444371989
-
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF- 16
-
PMID:15767565
-
Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF- 16. Proc Natl Acad Sci U S A 2005; 102:4494-9; PMID:15767565; http://dx.doi.org/10.1073/pnas.0500749102
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 4494-4499
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Svrzikapa, N.3
Jiang, F.4
Davis, R.J.5
Tissenbaum, H.A.6
-
125
-
-
84860390185
-
Increased lifespan from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage
-
PMID:21839827
-
Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, Braeckman BP, Gems D. Increased lifespan from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med 2011; 51:1575-82; PMID:21839827; http://dx.doi.org/10.1016/j. freeradbiomed.2011.07.020
-
(2011)
Free Radic Biol Med
, vol.51
, pp. 1575-1582
-
-
Cabreiro, F.1
Ackerman, D.2
Doonan, R.3
Araiz, C.4
Back, P.5
Papp, D.6
Braeckman, B.P.7
Gems, D.8
-
126
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
PMID:15520384
-
Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A 2004; 101:15998-6003; PMID:15520384; http://dx.doi.org/10.1073/pnas.0404184101
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
127
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends lifespan and impairs neuroendocrine function
-
PMID:11292875
-
Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends lifespan and impairs neuroendocrine function. Science 2001; 292:107-10; PMID:11292875; http://dx.doi.org/10.1126/science.1057987
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.P.4
Yin, C.M.5
Garofalo, R.S.6
-
128
-
-
2942563805
-
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
-
PMID:15175753
-
Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004; 429:562-6; PMID:15175753; http://dx.doi.org/10.1038/nature02549
-
(2004)
Nature
, vol.429
, pp. 562-566
-
-
Hwangbo, D.S.1
Gershman, B.2
Tu, M.P.3
Palmer, M.4
Tatar, M.5
-
129
-
-
27444442915
-
Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila
-
PMID:15954861
-
Bayne AC, Mockett RJ, Orr WC, Sohal RS. Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila. Biochem J 2005; 391:277-84; PMID:15954861; http://dx.doi.org/10.1042/BJ20041872
-
(2005)
Biochem J
, vol.391
, pp. 277-284
-
-
Bayne, A.C.1
Mockett, R.J.2
Orr, W.C.3
Sohal, R.S.4
-
130
-
-
0031864164
-
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
-
PMID:9620775
-
Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet 1998; 19:171-4; PMID:9620775; http://dx.doi.org/10.1038/ 534
-
(1998)
Nat Genet
, vol.19
, pp. 171-174
-
-
Parkes, T.L.1
Elia, A.J.2
Dickinson, D.3
Hilliker, A.J.4
Phillips, J.P.5
Boulianne, G.L.6
-
131
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
PMID:15186745
-
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14:885-90; PMID:15186745; http://dx.doi.org/10.1016/j.cub.2004.03. 059
-
(2004)
Curr Biol
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
132
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway
-
PMID:17637672
-
Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 2007; 448:375-9; PMID:17637672; http://dx.doi.org/10.1038/nature05949
-
(2007)
Nature
, vol.448
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
Flores, J.M.7
Viña, J.8
Blasco, M.A.9
Serrano, M.10
-
133
-
-
84858000209
-
The sirtuin SIRT6 regulates lifespan in male mice
-
PMID:22367546
-
Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY. The sirtuin SIRT6 regulates lifespan in male mice. Nature 2012; 483:218-21; PMID:22367546; http://dx.doi.org/10.1038/nature10815
-
(2012)
Nature
, vol.483
, pp. 218-221
-
-
Kanfi, Y.1
Naiman, S.2
Amir, G.3
Peshti, V.4
Zinman, G.5
Nahum, L.6
Bar-Joseph, Z.7
Cohen, H.Y.8
-
134
-
-
24344447780
-
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
-
PMID:16107615
-
Keyes WM, Wu Y, Vogel H, Guo X, Lowe SW, Mills AA. p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 2005; 19:1986-99; PMID:16107615; http://dx.doi.org/10.1101/gad.342305
-
(2005)
Genes Dev
, vol.19
, pp. 1986-1999
-
-
Keyes, W.M.1
Wu, Y.2
Vogel, H.3
Guo, X.4
Lowe, S.W.5
Mills, A.A.6
-
135
-
-
34347354474
-
Brca1 heterozygous mice have shortened lifespan and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation
-
PMID:17420720
-
Jeng YM, Cai-Ng S, Li A, Furuta S, Chew H, Chen PL, Lee EY, Lee WH. Brca1 heterozygous mice have shortened lifespan and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. Oncogene 2007; 26:6160-6; PMID:17420720; http://dx.doi.org/10.1038/sj.onc.1210451
-
(2007)
Oncogene
, vol.26
, pp. 6160-6166
-
-
Jeng, Y.M.1
Cai-Ng, S.2
Li, A.3
Furuta, S.4
Chew, H.5
Chen, P.L.6
Lee, E.Y.7
Lee, W.H.8
-
136
-
-
79960673725
-
Methods for structuring scientific knowledge from many areas related to aging research
-
PMID:21799912
-
Zhavoronkov A, Cantor CR. Methods for structuring scientific knowledge from many areas related to aging research. PLoS One 2011; 6:e22597; PMID:21799912; http://dx.doi.org/10.1371/journal.pone.0022597
-
(2011)
PLoS One
, vol.6
-
-
Zhavoronkov, A.1
Cantor, C.R.2
-
137
-
-
84855521160
-
-
Science: St Petersburg
-
Moskalev A. Aging and genes. Science: St Petersburg, 2008; p 358.
-
(2008)
Aging and Genes
, pp. 358
-
-
Moskalev, A.1
-
138
-
-
84873655526
-
Evolutionary ideas on the nature of aging
-
Moskalev AA. Evolutionary ideas on the nature of aging. Adv Gerontol 2011; 1:112-21; http://dx.doi.org/10.1134/S207905701102010X
-
(2011)
Adv Gerontol
, vol.1
, pp. 112-121
-
-
Moskalev, A.A.1
|