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Volumn 9, Issue 8, 2013, Pages

Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; PROTEIN P62; TRANSCRIPTION FACTOR NRF2;

EID: 84884636654     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003664     Document Type: Article
Times cited : (79)

References (50)
  • 1
    • 77951227871 scopus 로고    scopus 로고
    • TOR-dependent control of autophagy: biting the hand that feeds
    • Neufeld TP, (2010) TOR-dependent control of autophagy: biting the hand that feeds. Curr Opin Cell Biol 22: 157-168.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 157-168
    • Neufeld, T.P.1
  • 2
    • 33845874899 scopus 로고    scopus 로고
    • Direct induction of autophagy by atg1 inhibits cell growth and induces apoptotic cell death
    • Scott RC, Juhasz G, Neufeld TP, (2007) Direct induction of autophagy by atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol 17: 1-11.
    • (2007) Curr Biol , vol.17 , pp. 1-11
    • Scott, R.C.1    Juhasz, G.2    Neufeld, T.P.3
  • 3
    • 33646204392 scopus 로고    scopus 로고
    • Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size
    • Hosokawa N, Hara Y, Mizushima N, (2007) Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 581: 2623-2629.
    • (2007) FEBS Lett , vol.581 , pp. 2623-2629
    • Hosokawa, N.1    Hara, Y.2    Mizushima, N.3
  • 4
    • 36849021043 scopus 로고    scopus 로고
    • Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    • Juhasz G, Erdi B, Sass M, Neufeld TP, (2007) Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev 21: 3061-3066.
    • (2007) Genes Dev , vol.21 , pp. 3061-3066
    • Juhasz, G.1    Erdi, B.2    Sass, M.3    Neufeld, T.P.4
  • 5
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, et al. (2008) Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4: 176-184.
    • (2008) Autophagy , vol.4 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5
  • 6
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ, (2008) Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 7
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White E, (2012) Deconvoluting the context-dependent role for autophagy in cancer. Nature Rev Cancer 12: 401-410.
    • (2012) Nature Rev Cancer , vol.12 , pp. 401-410
    • White, E.1
  • 8
    • 84863661689 scopus 로고    scopus 로고
    • Therapeutic targets in cancer cell metabolism and autophagy
    • Cheong H, Lu C, Lindsten T, Thompson CB, (2012) Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol 30: 671-678.
    • (2012) Nat Biotechnol , vol.30 , pp. 671-678
    • Cheong, H.1    Lu, C.2    Lindsten, T.3    Thompson, C.B.4
  • 9
    • 54349087788 scopus 로고    scopus 로고
    • Myc's broad reach
    • Eilers M, Eisenman RN, (2008) Myc's broad reach. Genes Dev 22: 2755-2766.
    • (2008) Genes Dev , vol.22 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 11
    • 75849131117 scopus 로고    scopus 로고
    • The ups and downs of Myc biology
    • Soucek L, Evan GI, (2010) The ups and downs of Myc biology. Curr Opin Genet Dev 20: 91-95.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 91-95
    • Soucek, L.1    Evan, G.I.2
  • 14
    • 3042796953 scopus 로고    scopus 로고
    • dMyc is required for larval growth and endoreplication in Drosophila
    • Pierce SB, Yost C, Britton JS, Loo LW, Flynn EM, et al. (2004) dMyc is required for larval growth and endoreplication in Drosophila. Development 131: 2317-2327.
    • (2004) Development , vol.131 , pp. 2317-2327
    • Pierce, S.B.1    Yost, C.2    Britton, J.S.3    Loo, L.W.4    Flynn, E.M.5
  • 15
    • 44149127993 scopus 로고    scopus 로고
    • The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
    • Juhasz G, Hill JH, Yan Y, Sass M, Baehrecke EH, et al. (2008) The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol 181: 655-666.
    • (2008) J Cell Biol , vol.181 , pp. 655-666
    • Juhasz, G.1    Hill, J.H.2    Yan, Y.3    Sass, M.4    Baehrecke, E.H.5
  • 17
    • 84865623676 scopus 로고    scopus 로고
    • Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila
    • Pircs K, Nagy P, Varga A, Venkei Z, Erdi B, et al. (2012) Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PloS one 7: e44214.
    • (2012) PloS One , vol.7
    • Pircs, K.1    Nagy, P.2    Varga, A.3    Venkei, Z.4    Erdi, B.5
  • 18
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • Scott RC, Schuldiner O, Neufeld TP, (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7: 167-178.
    • (2004) Dev Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 19
    • 84878615771 scopus 로고    scopus 로고
    • Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila
    • Takats S, Nagy P, Varga A, Pircs K, Karpati M, et al. (2013) Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol 201: 531-539.
    • (2013) J Cell Biol , vol.201 , pp. 531-539
    • Takats, S.1    Nagy, P.2    Varga, A.3    Pircs, K.4    Karpati, M.5
  • 20
    • 79955854666 scopus 로고    scopus 로고
    • Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis
    • Barth JM, Szabad J, Hafen E, Kohler K, (2011) Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis. Cell Death Differ 18: 915-924.
    • (2011) Cell Death Differ , vol.18 , pp. 915-924
    • Barth, J.M.1    Szabad, J.2    Hafen, E.3    Kohler, K.4
  • 21
    • 41549151641 scopus 로고    scopus 로고
    • Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
    • Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, et al. (2008) Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol 180: 1065-1071.
    • (2008) J Cell Biol , vol.180 , pp. 1065-1071
    • Nezis, I.P.1    Simonsen, A.2    Sagona, A.P.3    Finley, K.4    Gaumer, S.5
  • 22
    • 0036778129 scopus 로고    scopus 로고
    • Why size matters: altering cell size
    • Saucedo LJ, Edgar BA, (2002) Why size matters: altering cell size. Curr Opin Genet Dev 12: 565-571.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 565-571
    • Saucedo, L.J.1    Edgar, B.A.2
  • 23
    • 65249155441 scopus 로고    scopus 로고
    • An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation
    • Chang YY, Neufeld TP, (2009) An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell 20: 2004-2014.
    • (2009) Mol Biol Cell , vol.20 , pp. 2004-2014
    • Chang, Y.Y.1    Neufeld, T.P.2
  • 24
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima N, Yoshimori T, (2007) How to interpret LC3 immunoblotting. Autophagy 3: 542-545.
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 25
    • 77955903343 scopus 로고    scopus 로고
    • Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
    • Nezis IP, Shravage BV, Sagona AP, Lamark T, Bjorkoy G, et al. (2010) Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol 190: 523-531.
    • (2010) J Cell Biol , vol.190 , pp. 523-531
    • Nezis, I.P.1    Shravage, B.V.2    Sagona, A.P.3    Lamark, T.4    Bjorkoy, G.5
  • 26
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura S, Noda T, Yoshimori T, (2007) Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3: 452-460.
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 28
    • 84861939463 scopus 로고    scopus 로고
    • p62: a versatile multitasker takes on cancer
    • Moscat J, Diaz-Meco MT, (2012) p62: a versatile multitasker takes on cancer. Trends Biochem Sci 37: 230-236.
    • (2012) Trends Biochem Sci , vol.37 , pp. 230-236
    • Moscat, J.1    Diaz-Meco, M.T.2
  • 29
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, et al. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137: 1062-1075.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3    Vuong, N.4    Chen, G.5
  • 30
    • 79955492012 scopus 로고    scopus 로고
    • Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
    • Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, et al. (2011) Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol 193: 275-284.
    • (2011) J Cell Biol , vol.193 , pp. 275-284
    • Inami, Y.1    Waguri, S.2    Sakamoto, A.3    Kouno, T.4    Nakada, K.5
  • 31
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, et al. (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12: 213-223.
    • (2010) Nat Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3    Taguchi, K.4    Kobayashi, A.5
  • 32
    • 79955377420 scopus 로고    scopus 로고
    • Autophagy-deficient mice develop multiple liver tumors
    • Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, et al. (2011) Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25: 795-800.
    • (2011) Genes Dev , vol.25 , pp. 795-800
    • Takamura, A.1    Komatsu, M.2    Hara, T.3    Sakamoto, A.4    Kishi, C.5
  • 33
    • 77954599053 scopus 로고    scopus 로고
    • p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    • Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, et al. (2010) p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 285: 22576-22591.
    • (2010) J Biol Chem , vol.285 , pp. 22576-22591
    • Jain, A.1    Lamark, T.2    Sjottem, E.3    Larsen, K.B.4    Awuh, J.A.5
  • 34
    • 84861743338 scopus 로고    scopus 로고
    • Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress
    • Liu XD, Ko S, Xu Y, Fattah EA, Xiang Q, et al. (2012) Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J Biol Chem 287: 19687-19698.
    • (2012) J Biol Chem , vol.287 , pp. 19687-19698
    • Liu, X.D.1    Ko, S.2    Xu, Y.3    Fattah, E.A.4    Xiang, Q.5
  • 35
    • 77956941992 scopus 로고    scopus 로고
    • Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response
    • Malzer E, Daly ML, Moloney A, Sendall TJ, Thomas SE, et al. (2010) Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. J Cell Sci 123: 2892-2900.
    • (2010) J Cell Sci , vol.123 , pp. 2892-2900
    • Malzer, E.1    Daly, M.L.2    Moloney, A.3    Sendall, T.J.4    Thomas, S.E.5
  • 36
    • 84877833331 scopus 로고    scopus 로고
    • A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development
    • Sone M, Zeng X, Larese J, Ryoo HD, (2013) A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development. Cell Stress Chaperones 18: 307-319.
    • (2013) Cell Stress Chaperones , vol.18 , pp. 307-319
    • Sone, M.1    Zeng, X.2    Larese, J.3    Ryoo, H.D.4
  • 37
    • 84863740827 scopus 로고    scopus 로고
    • The impact of the unfolded protein response on human disease
    • Wang S, Kaufman RJ, (2012) The impact of the unfolded protein response on human disease. J Cell Biol 197: 857-867.
    • (2012) J Cell Biol , vol.197 , pp. 857-867
    • Wang, S.1    Kaufman, R.J.2
  • 38
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, et al. (2007) Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117: 326-336.
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3    Bui, T.4    Christophorou, M.A.5
  • 39
    • 38149141767 scopus 로고    scopus 로고
    • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
    • Maclean KH, Dorsey FC, Cleveland JL, Kastan MB, (2008) Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 118: 79-88.
    • (2008) J Clin Invest , vol.118 , pp. 79-88
    • Maclean, K.H.1    Dorsey, F.C.2    Cleveland, J.L.3    Kastan, M.B.4
  • 40
    • 84870546460 scopus 로고    scopus 로고
    • ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
    • Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, et al. (2012) ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest 122: 4621-4634.
    • (2012) J Clin Invest , vol.122 , pp. 4621-4634
    • Hart, L.S.1    Cunningham, J.T.2    Datta, T.3    Dey, S.4    Tameire, F.5
  • 41
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: oncogene and non-oncogene addiction
    • Luo J, Solimini NL, Elledge SJ, (2009) Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136: 823-837.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 42
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, et al. (2004) The role of autophagy during the early neonatal starvation period. Nature 432: 1032-1036.
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1    Hatano, M.2    Matsui, M.3    Yamamoto, A.4    Nakaya, H.5
  • 43
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: renovation of cells and tissues
    • Mizushima N, Komatsu M, (2011) Autophagy: renovation of cells and tissues. Cell 147: 728-741.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 44
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, et al. (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131: 1149-1163.
    • (2007) Cell , vol.131 , pp. 1149-1163
    • Komatsu, M.1    Waguri, S.2    Koike, M.3    Sou, Y.S.4    Ueno, T.5
  • 45
    • 0030451213 scopus 로고    scopus 로고
    • NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • Chan K, Lu R, Chang JC, Kan YW, (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci USA 93: 13943-13948.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 46
    • 0034717329 scopus 로고    scopus 로고
    • Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
    • Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, et al. (2000) Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275: 16023-16029.
    • (2000) J Biol Chem , vol.275 , pp. 16023-16029
    • Ishii, T.1    Itoh, K.2    Takahashi, S.3    Sato, H.4    Yanagawa, T.5
  • 47
    • 0034968330 scopus 로고    scopus 로고
    • Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
    • Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, et al. (2001) Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 7: 1153-1163.
    • (2001) Mol Cell , vol.7 , pp. 1153-1163
    • Harding, H.P.1    Zeng, H.2    Zhang, Y.3    Jungries, R.4    Chung, P.5
  • 48
    • 0345714991 scopus 로고    scopus 로고
    • Chemotherapy-induced secondary malignancies
    • Vega-Stromberg T, (2003) Chemotherapy-induced secondary malignancies. J Infus Nurs 26: 353-361.
    • (2003) J Infus Nurs , vol.26 , pp. 353-361
    • Vega-Stromberg, T.1
  • 49
    • 58949092542 scopus 로고    scopus 로고
    • Acute leukemia as a secondary malignancy in children and adolescents: current findings and issues
    • Hijiya N, Ness KK, Ribeiro RC, Hudson MM, (2009) Acute leukemia as a secondary malignancy in children and adolescents: current findings and issues. Cancer 115: 23-35.
    • (2009) Cancer , vol.115 , pp. 23-35
    • Hijiya, N.1    Ness, K.K.2    Ribeiro, R.C.3    Hudson, M.M.4
  • 50
    • 37749024370 scopus 로고    scopus 로고
    • Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
    • Sykiotis GP, Bohmann D, (2008) Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell 14: 76-85.
    • (2008) Dev Cell , vol.14 , pp. 76-85
    • Sykiotis, G.P.1    Bohmann, D.2


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