메뉴 건너뛰기




Volumn 13, Issue 1, 2016, Pages 27-39

Infringement of the barriers of cancer via dietary phytoconstituents capsaicin through novel drug delivery system

Author keywords

Bioavailability; Cancer; Capsaicin; Drug delivery; Nanotechnology; Novel drug carrier

Indexed keywords

ANTINEOPLASTIC AGENT; CAPSAICIN; DRUG CARRIER; NANOPARTICLE;

EID: 84964037971     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/1567201812666150603151250     Document Type: Article
Times cited : (26)

References (122)
  • 1
    • 78649315943 scopus 로고    scopus 로고
    • To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    • Danhier, F.; Feron, O.; Preat, V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J. Controlled Release, 2010, 148, 135-146.
    • (2010) J. Controlled Release , vol.148 , pp. 135-146
    • Danhier, F.1    Feron, O.2    Preat, V.3
  • 2
    • 33748513702 scopus 로고    scopus 로고
    • Traditional chinese medicine in cancer care: Perspectives and experiences of patients and professionals in china
    • Xu, W.; Towers, A.D.; Li, P.; Collet, J.P. Traditional chinese medicine in cancer care: perspectives and experiences of patients and professionals in china. Eur. J. Cancer. Care, 2006, 15, 397-403.
    • (2006) Eur. J. Cancer. Care , vol.15 , pp. 397-403
    • Xu, W.1    Towers, A.D.2    Li, P.3    Collet, J.P.4
  • 3
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod., 2007, 70, 461-477.
    • (2007) J. Nat. Prod. , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 4
    • 33947304343 scopus 로고    scopus 로고
    • TRPV6 mediates capsaicin- induced apoptosis in gastric cancer cells-mechanisms behind a possible new “hot” cancer treatment
    • Chow, J.; Norng, M.; Zhang, J.; Chai, J. TRPV6 mediates capsaicin- induced apoptosis in gastric cancer cells-mechanisms behind a possible new “hot” cancer treatment. Biochim. Biophys. Acta., 2007, 1773, 565-576.
    • (2007) Biochim. Biophys. Acta. , vol.1773 , pp. 565-576
    • Chow, J.1    Norng, M.2    Zhang, J.3    Chai, J.4
  • 5
    • 0028913539 scopus 로고
    • Capsaicin, a double-edged sword: Toxicity, metabolism, and chemopreventive potential
    • Surh, Y.J.; Lee, S.S. Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential. Life Sci., 1995, 56, 1845-1855.
    • (1995) Life Sci. , vol.56 , pp. 1845-1855
    • Surh, Y.J.1    Lee, S.S.2
  • 6
    • 0032813348 scopus 로고    scopus 로고
    • Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
    • Surh, Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mut. Res., 1999, 428, 305-327.
    • (1999) Mut. Res. , vol.428 , pp. 305-327
    • Surh, Y.1
  • 8
    • 0022419355 scopus 로고
    • Formation and metabolism of pungent principle of capsicum fruits. XV. Microdetermination of capsaicin by high-performance liquid chromatography with electrochemical detection
    • Kawada, T.; Watanabe, T.; Katsura, K.; Takami, H.; Iwai, K. Formation and metabolism of pungent principle of capsicum fruits. XV. Microdetermination of capsaicin by high-performance liquid chromatography with electrochemical detection. J. Chromatogr., 1985, 329, 99-105.
    • (1985) J. Chromatogr. , vol.329 , pp. 99-105
    • Kawada, T.1    Watanabe, T.2    Katsura, K.3    Takami, H.4    Iwai, K.5
  • 9
    • 37349070280 scopus 로고    scopus 로고
    • Transdermal delivery of capsaicin derivative-sodium nonivamide acetate using microemulsions as vehicles
    • Huang, Y.B.; Lin, Y.H.; Lu, T.M.; Wang, R.J.; Tsai, Y.H.; Wu, P.C. Transdermal delivery of capsaicin derivative-sodium nonivamide acetate using microemulsions as vehicles. Int. J. Pharm., 2008, 349, 206-11.
    • (2008) Int. J. Pharm. , vol.349 , pp. 206-211
    • Huang, Y.B.1    Lin, Y.H.2    Lu, T.M.3    Wang, R.J.4    Tsai, Y.H.5    Wu, P.C.6
  • 11
    • 84882760791 scopus 로고    scopus 로고
    • Preparation and evaluation of rapidly disintegrating fast release tablet of diazepam-hydroxypropyl-β-cyclodextrin inclusion complex
    • Giri, T.K.; Sa, B. Preparation and evaluation of rapidly disintegrating fast release tablet of diazepam-hydroxypropyl-β-cyclodextrin inclusion complex. Pharmacol. Pharm., 2010, 1, 18-26.
    • (2010) Pharmacol. Pharm. , vol.1 , pp. 18-26
    • Giri, T.K.1    Sa, B.2
  • 12
    • 79960317135 scopus 로고    scopus 로고
    • The botany, chemistry, pharmacological and therapeutic application of Oxalis corniculata Linna- a review
    • Badwaik, H.; Singh, M.; Thakur, D.; Giri, T.K.; Tripathi, D.K. The botany, chemistry, pharmacological and therapeutic application of Oxalis corniculata Linna- a review. Int. J. Phytomed., 2011, 3, 1-8.
    • (2011) Int. J. Phytomed. , vol.3 , pp. 1-8
    • Badwaik, H.1    Singh, M.2    Thakur, D.3    Giri, T.K.4    Tripathi, D.K.5
  • 13
    • 79960140081 scopus 로고    scopus 로고
    • Physicochemical classification and formulation development of solid dispersion of poorly water soluble drugs: An updated review
    • Giri, T.K.; Alexander, A.; Tripathi, D.K. Physicochemical classification and formulation development of solid dispersion of poorly water soluble drugs: An updated review. Int. J. Pharm. Biol. Arch., 2010, 1, 309-324.
    • (2010) Int. J. Pharm. Biol. Arch. , vol.1 , pp. 309-324
    • Giri, T.K.1    Alexander, A.2    Tripathi, D.K.3
  • 15
    • 56949104715 scopus 로고    scopus 로고
    • Capsaicin: A review of its pharmacology and clinical applications
    • Hayman, M.; Kam, P. Capsaicin: a review of its pharmacology and clinical applications. Curr. Anaesth. Crit. Care, 2008, 19, 338-343.
    • (2008) Curr. Anaesth. Crit. Care , vol.19 , pp. 338-343
    • Hayman, M.1    Kam, P.2
  • 17
    • 84890125300 scopus 로고    scopus 로고
    • Mechanisms and clinical uses of capsaicin
    • Sharma, S.K.; Vij, A.S.; Sharma, M. Mechanisms and clinical uses of capsaicin. Eur. J. Pharmacol., 2013, 720, 55-62.
    • (2013) Eur. J. Pharmacol. , vol.720 , pp. 55-62
    • Sharma, S.K.1    Vij, A.S.2    Sharma, M.3
  • 18
    • 4644363137 scopus 로고    scopus 로고
    • Effects of vehicle on the uptake and elimination kinetics of capsaicinoids in human skin in vivo
    • Pershing, L.K.; Reilly, C.A.; Corlett, J.L.; Crouch, D.J. Effects of vehicle on the uptake and elimination kinetics of capsaicinoids in human skin in vivo. Toxicol. Appl. Pharmacol., 2004, 200, 73-81.
    • (2004) Toxicol. Appl. Pharmacol. , vol.200 , pp. 73-81
    • Pershing, L.K.1    Reilly, C.A.2    Corlett, J.L.3    Crouch, D.J.4
  • 19
    • 77952379134 scopus 로고    scopus 로고
    • Tissue distribution and elimination of capsaicin, piperine and curcumin following oral intake in rats
    • Suresh, D.; Srinivasan, K. Tissue distribution and elimination of capsaicin, piperine and curcumin following oral intake in rats. Indian. J. Med. Res., 2010, 131, 682-691.
    • (2010) Indian. J. Med. Res. , vol.131 , pp. 682-691
    • Suresh, D.1    Srinivasan, K.2
  • 20
    • 0019799194 scopus 로고
    • Determination of capsaicin in tissues and separation of capsaicin analogues by high-performance liquid chromatography
    • Saria, A.; Lembeck, F.; Skofitsch, G. Determination of capsaicin in tissues and separation of capsaicin analogues by high-performance liquid chromatography. J. Chromatogr., 1981, 208, 41-46.
    • (1981) J. Chromatogr. , vol.208 , pp. 41-46
    • Saria, A.1    Lembeck, F.2    Skofitsch, G.3
  • 21
    • 33847785854 scopus 로고    scopus 로고
    • Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin
    • Johnson, W.J. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Int. J. Toxicol., 2007, 26(1), 3-106.
    • (2007) Int. J. Toxicol. , vol.26 , Issue.1 , pp. 3-106
    • Johnson, W.J.1
  • 22
  • 24
    • 0021932668 scopus 로고
    • In vivo and in vitro metabolism of dihydrocapsaicin, a pungent principle of hot pepper, in rats
    • Kawada, T.; Iwai, K. In vivo and in vitro metabolism of dihydrocapsaicin, a pungent principle of hot pepper, in rats. Agric. Biol. Chem., 1985, 49, 441-448.
    • (1985) Agric. Biol. Chem. , vol.49 , pp. 441-448
    • Kawada, T.1    Iwai, K.2
  • 25
    • 2442696310 scopus 로고    scopus 로고
    • Biochemical pharmacology of the vanilloid receptor TRPV1
    • Cortright, D.N.; Szallasi, A. Biochemical pharmacology of the vanilloid receptor TRPV1. Eur. J. Biochem., 2004, 271, 1814-1819.
    • (2004) Eur. J. Biochem. , vol.271 , pp. 1814-1819
    • Cortright, D.N.1    Szallasi, A.2
  • 27
    • 26444511606 scopus 로고    scopus 로고
    • Structure and function of TRPV1
    • Tominaga, M.; Tominaga, T. Structure and function of TRPV1. Pflugers Arch., 2005, 451, 143-150.
    • (2005) Pflugers Arch. , vol.451 , pp. 143-150
    • Tominaga, M.1    Tominaga, T.2
  • 28
    • 0025758541 scopus 로고
    • Topical capsaicin in dermatological and peripheral pain disorder
    • Rumsfield, J.A.; West, D. Topical capsaicin in dermatological and peripheral pain disorder. DICP. Ann. Pharmacother., 1991, 25, 381-387.
    • (1991) DICP. Ann. Pharmacother. , vol.25 , pp. 381-387
    • Rumsfield, J.A.1    West, D.2
  • 29
    • 0024351831 scopus 로고
    • Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin
    • Simone, D.A.; Baumann, T.K.; LaMotte, R.H. Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain., 1989, 38, 99-107.
    • (1989) Pain. , vol.38 , pp. 99-107
    • Simone, D.A.1    Baumann, T.K.2    Lamotte, R.H.3
  • 32
    • 0029799076 scopus 로고    scopus 로고
    • Acute oral toxicity of capsaicin in mice and rats
    • Satio, A.; Yamamato, M. Acute oral toxicity of capsaicin in mice and rats. J. Toxicol. Sci., 1996, 21, 195-200.
    • (1996) J. Toxicol. Sci. , vol.21 , pp. 195-200
    • Satio, A.1    Yamamato, M.2
  • 33
    • 0025985683 scopus 로고
    • Capsicum - production, technology, chemistry, and quality. Part V. Impact on the physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences
    • Govindarajan, V.S.; Sathyanarayana, M.N. “Capsicum - production, technology, chemistry, and quality. part V. Impact on the physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences”. Crit. Rev. Food Sci. Nutr., 1991, 29, 435-474.
    • (1991) Crit. Rev. Food Sci. Nutr. , vol.29 , pp. 435-474
    • Govindarajan, V.S.1    Sathyanarayana, M.N.2
  • 35
    • 0002379291 scopus 로고    scopus 로고
    • Colorectal tumors
    • In: Vogelstein B, Kinzler KW, eds., 2nd ed. New York: McGraw-Hill
    • Kinzler, K.W.; Vogelstein, B. Colorectal tumors. In: Vogelstein B, Kinzler KW, eds. The genetic basis of human cancer. 2nd ed. New York: McGraw-Hill, 2002, 583-612.
    • (2002) The Genetic Basis of Human Cancer , pp. 583-612
    • Kinzler, K.W.1    Vogelstein, B.2
  • 36
    • 0032871895 scopus 로고    scopus 로고
    • APC: The plot thickens
    • Bienz, M. APC: the plot thickens. Curr. Opin. Genet. Dev., 1999, 9, 595-603.
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 595-603
    • Bienz, M.1
  • 39
    • 84860887229 scopus 로고    scopus 로고
    • Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells
    • Lee, S.H.; Richardson, R.L.; Dashwood, R.H.; Baek, S.J. Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells. J. Nutr. Biochem., 2012, 23, 646–655.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 646-655
    • Lee, S.H.1    Richardson, R.L.2    Dashwood, R.H.3    Baek, S.J.4
  • 40
    • 78650380318 scopus 로고    scopus 로고
    • Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo
    • Lu, H.F.; Chen, Y.L.; Yang, J.S.; Yang, Y.Y.; Liu, J.Y.; Hsu, S.C.; Lai, K.C.; Chung, J.G. Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo. J. Agric. Food Chem., 2010, 58, 12999-3005.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 12999-13005
    • Lu, H.F.1    Chen, Y.L.2    Yang, J.S.3    Yang, Y.Y.4    Liu, J.Y.5    Hsu, S.C.6    Lai, K.C.7    Chung, J.G.8
  • 41
    • 70349570949 scopus 로고    scopus 로고
    • Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines
    • Yang, K.M.; Pyo, J.O.; Kim, G.Y.; Yu, R.; Han, I.S.; Ju, S.A.; Kim, W.H.; Kim, B.S. Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines. Cell. Mol. Biol. Lett., 2009, 14, 497-510.
    • (2009) Cell. Mol. Biol. Lett. , vol.14 , pp. 497-510
    • Yang, K.M.1    Pyo, J.O.2    Kim, G.Y.3    Yu, R.4    Han, I.S.5    Ju, S.A.6    Kim, W.H.7    Kim, B.S.8
  • 42
    • 79957465966 scopus 로고    scopus 로고
    • Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells
    • Pramanik, K.C.; Boreddy, S.R.; Srivastava, S.K. Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PloS. One., 2011, 6, e20151, doi:10.1371/journal.pone.0020151.
    • (2011) Plos. One. , vol.6
    • Pramanik, K.C.1    Boreddy, S.R.2    Srivastava, S.K.3
  • 43
    • 56349151331 scopus 로고    scopus 로고
    • Srivastava, S.K. In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
    • Zhang, R.; Humphreys, I.; Sahu, R.P.; Shi, Y.; Srivastava, S.K. In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis., 2008, 13, 1465-78.
    • (2008) Apoptosis. , vol.13 , pp. 1465-1478
    • Zhang, R.1    Humphreys, I.2    Sahu, R.P.3    Shi, Y.4
  • 45
    • 84869053446 scopus 로고    scopus 로고
    • Involvement of the phosphoinositide 3-kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1
    • Zhang, J.H.; Lai, F.J.; Chen, H.; Luo, J.; Zhang, R.Y.; Bu, H.Q.; Wang, Z.H.; Lin, H.H.; Lin, S.Z. Involvement of the phosphoinositide 3-kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1. Oncol. Lett., 2013, 5, 43-48.
    • (2013) Oncol. Lett. , vol.5 , pp. 43-48
    • Zhang, J.H.1    Lai, F.J.2    Chen, H.3    Luo, J.4    Zhang, R.Y.5    Bu, H.Q.6    Wang, Z.H.7    Lin, H.H.8    Lin, S.Z.9
  • 46
    • 74449084136 scopus 로고    scopus 로고
    • Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and - negative breast cancer cells by modulating the EGFR/HER-2 pathway
    • Thoennissen, N.H.; Kelly, J.O.; Lu, D.; Iwanski, G.B.; La, D.T.; Abbassi, S.; Leiter, A.; Karlan, B.; Mehta, R.; Koeffler, H.P. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and - negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene, 2010, 29, 285-96.
    • (2010) Oncogene , vol.29 , pp. 285-296
    • Thoennissen, N.H.1    Kelly, J.O.2    Lu, D.3    Iwanski, G.B.4    La, D.T.5    Abbassi, S.6    Leiter, A.7    Karlan, B.8    Mehta, R.9    Koeffler, H.P.10
  • 47
    • 84904539783 scopus 로고    scopus 로고
    • Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression
    • Wu, T.T.L.; Peters, A.A.; Tan, P.T.; Roberts-Thomson, S.J.; Monteith, G.R. Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression. Cell. Calcium., 2014, 56, 5659-67.
    • (2014) Cell. Calcium. , vol.56 , pp. 5659-5667
    • Wu, T.T.L.1    Peters, A.A.2    Tan, P.T.3    Roberts-Thomson, S.J.4    Monteith, G.R.5
  • 49
    • 80054869554 scopus 로고    scopus 로고
    • Capsaicin may induce breast cancer cell death through apoptosis- inducing factor involving mitochondrial dysfunction
    • Chang, H.C.; Chen, S.T.; Chien, S.Y.; Kuo, S.J.; Tsai, H.T.; Chen, D.R. Capsaicin may induce breast cancer cell death through apoptosis- inducing factor involving mitochondrial dysfunction. Hum. Exp. Toxicol., 2011, 30, 1657-65.
    • (2011) Hum. Exp. Toxicol. , vol.30 , pp. 1657-1665
    • Chang, H.C.1    Chen, S.T.2    Chien, S.Y.3    Kuo, S.J.4    Tsai, H.T.5    Chen, D.R.6
  • 50
    • 64849094943 scopus 로고    scopus 로고
    • Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway
    • Chou, C.C.; Wu, Y.C.; Wang, Y.F.; Chou, M.J.; Kuo, S.J.; Chen, D.R. Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncol. Rep., 2009, 21, 665-71.
    • (2009) Oncol. Rep. , vol.21 , pp. 665-671
    • Chou, C.C.1    Wu, Y.C.2    Wang, Y.F.3    Chou, M.J.4    Kuo, S.J.5    Chen, D.R.6
  • 52
    • 78149460936 scopus 로고    scopus 로고
    • Effect of capsaicin on prostate cancer cells
    • Diaz-Laviada, I. Effect of capsaicin on prostate cancer cells. Future. Oncol., 2010, 6, 1545-50.
    • (2010) Future. Oncol. , vol.6 , pp. 1545-1550
    • Diaz-Laviada, I.1
  • 53
    • 0031570783 scopus 로고    scopus 로고
    • NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients
    • Morre, D.J.; Caldwell, S.; Mayorga, A.; Wu, L.Y.; Morre, D.M. NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients. Arch. Biochem. Biophys., 1997, 342, 224-30.
    • (1997) Arch. Biochem. Biophys. , vol.342 , pp. 224-230
    • Morre, D.J.1    Caldwell, S.2    Mayorga, A.3    Wu, L.Y.4    Morre, D.M.5
  • 55
    • 57749188229 scopus 로고    scopus 로고
    • Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells
    • Malagarie-Cazenave, S.; Olea-Herrero, N.; Vara, D.; Diaz-Laviada, I. Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells. FEBS. Lett., 2009, 583, 141-7.
    • (2009) FEBS. Lett. , vol.583 , pp. 141-147
    • Malagarie-Cazenave, S.1    Olea-Herrero, N.2    Vara, D.3    Diaz-Laviada, I.4
  • 57
    • 34848895758 scopus 로고    scopus 로고
    • Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation
    • Sanchez, A.M.; Malagarie-Cazenave, S.; Olea, N.; Vara, D.; Chiloeches, A.; Diaz-Laviada, I. Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis., 2007, 12, 2013-24.
    • (2007) Apoptosis. , vol.12 , pp. 2013-2024
    • Sanchez, A.M.1    Malagarie-Cazenave, S.2    Olea, N.3    Vara, D.4    Chiloeches, A.5    Diaz-Laviada, I.6
  • 58
    • 31444437266 scopus 로고    scopus 로고
    • Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin
    • Sanchez, A.M.; Sanchez, M.G.; Malagarie-Cazenave, S.; Olea, N.; Diaz-Laviada, I. Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin. Apoptosis., 2006, 11, 89-99.
    • (2006) Apoptosis. , vol.11 , pp. 89-99
    • Sanchez, A.M.1    Sanchez, M.G.2    Malagarie-Cazenave, S.3    Olea, N.4    Diaz-Laviada, I.5
  • 60
    • 34848828574 scopus 로고    scopus 로고
    • Mechanisms of capsaicininduced apoptosis of human melanoma A375-S2 cells
    • Gong, X.F.; Wang, M.W.; Ikejima, T. Mechanisms of capsaicininduced apoptosis of human melanoma A375-S2 cells. Zhonghua. Zhong. Liu. Za. Zhi., 2005, 27, 401-3.
    • (2005) Zhonghua. Zhong. Liu. Za. Zhi. , vol.27 , pp. 401-403
    • Gong, X.F.1    Wang, M.W.2    Ikejima, T.3
  • 61
    • 0035953182 scopus 로고    scopus 로고
    • Capsaicin suppresses phorbol ester-induced activation of NFkappaB/ Rel and AP-1 transcription factors in mouse epidermis
    • Han, S.S.; Keum, Y.S.; Seo, H.J.; Chun, K.S.; Lee, S.S.; Surh, Y.J. Capsaicin suppresses phorbol ester-induced activation of NFkappaB/ Rel and AP-1 transcription factors in mouse epidermis. Cancer Lett., 2001, 164, 119-26.
    • (2001) Cancer Lett. , vol.164 , pp. 119-126
    • Han, S.S.1    Keum, Y.S.2    Seo, H.J.3    Chun, K.S.4    Lee, S.S.5    Surh, Y.J.6
  • 62
    • 0842304283 scopus 로고    scopus 로고
    • Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress
    • Ito, K.; Nakazato, T.; Yamato, K.; Miyakawa, T.; Yamada, T.; Hozumi, N.; Segawa, K.; Ikeda, Y.; Kizaki, M. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress. Cancer Res., 2004, 64, 1071-1078.
    • (2004) Cancer Res. , vol.64 , pp. 1071-1078
    • Ito, K.1    Nakazato, T.2    Yamato, K.3    Miyakawa, T.4    Yamada, T.5    Hozumi, N.6    Segawa, K.7    Ikeda, Y.8    Kizaki, M.9
  • 63
    • 33745621050 scopus 로고    scopus 로고
    • Involvement of Bax, Bcl-2, Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells
    • Tsou, M.F.; Lu, H.F.; Chen, S.C.; Wu, L.T.; Chen, Y.S.; Kuo, H.M.; Lin, S.S.; Chung, J.G. Involvement of Bax, Bcl-2, Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells. Anticancer Res., 2006, 26, 1965-71.
    • (2006) Anticancer Res. , vol.26 , pp. 1965-1971
    • Tsou, M.F.1    Lu, H.F.2    Chen, S.C.3    Wu, L.T.4    Chen, Y.S.5    Kuo, H.M.6    Lin, S.S.7    Chung, J.G.8
  • 64
    • 22344440437 scopus 로고    scopus 로고
    • Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells
    • Zheng, X.; Ryan, A.; Patel, N.; Klemons, S.; Hansson, A.; Shih, W.J.; Lin, Y.; Huberman, E.; Chang, R.L.; Conney, A.H. Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells. Int. J. Oncol., 2005, 26, 441-8.
    • (2005) Int. J. Oncol. , vol.26 , pp. 441-448
    • Zheng, X.1    Ryan, A.2    Patel, N.3    Klemons, S.4    Hansson, A.5    Shih, W.J.6    Lin, Y.7    Huberman, E.8    Chang, R.L.9    Conney, A.H.10
  • 65
    • 0037355052 scopus 로고    scopus 로고
    • Capsaicin inhibits growth of adult T-cell leukemia cells
    • Zhang, J.; Nagasaki, M.; Tanaka, Y.; Morikawa, S. Capsaicin inhibits growth of adult T-cell leukemia cells. Leuk. Res., 2003, 27, 275-83.
    • (2003) Leuk. Res. , vol.27 , pp. 275-283
    • Zhang, J.1    Nagasaki, M.2    Tanaka, Y.3    Morikawa, S.4
  • 66
    • 16644391529 scopus 로고    scopus 로고
    • Capsaicin-induced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells
    • Lee, J.S.; Chang, J.S.; Lee, J.Y.; Kim, J.A. Capsaicin-induced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells. Arch. Pharmacal. Res., 2004, 27, 1147-1153.
    • (2004) Arch. Pharmacal. Res. , vol.27 , pp. 1147-1153
    • Lee, J.S.1    Chang, J.S.2    Lee, J.Y.3    Kim, J.A.4
  • 67
    • 84862769400 scopus 로고    scopus 로고
    • Capsaicin induces cycle arrest by inhibiting cyclin-dependent-kinase in bladder carcinoma cells
    • Chen, D.; Yang, Z.; Wang, Y.; Zhu, G.; Wang, X. Capsaicin induces cycle arrest by inhibiting cyclin-dependent-kinase in bladder carcinoma cells. Int. J. Urol., 2012, 19, 662-8.
    • (2012) Int. J. Urol. , vol.19 , pp. 662-668
    • Chen, D.1    Yang, Z.2    Wang, Y.3    Zhu, G.4    Wang, X.5
  • 68
    • 77649187285 scopus 로고    scopus 로고
    • Capsaicin mediates cell death in bladder cancer T24 cells through reactive oxygen species production and mitochondrial depolarization
    • Yang, Z.H.; Wangemail, X.H.; Wang, H.P.; Hu, L.Q.; Zheng, X.M.; Li, S.W. Capsaicin mediates cell death in bladder cancer T24 cells through reactive oxygen species production and mitochondrial depolarization. Urology, 2010, 75, 735-741.
    • (2010) Urology , vol.75 , pp. 735-741
    • Yang, Z.H.1    Wangemail, X.H.2    Wang, H.P.3    Hu, L.Q.4    Zheng, X.M.5    Li, S.W.6
  • 70
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan 2000
    • Parkin, D.M; Bray, F; Ferlay, J.; Pisani, P. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer, 2001, 94, 153-156.
    • (2001) Int. J. Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 71
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular cancer in the United States
    • El-Serag, H.B.; Mason, A.C. Rising incidence of hepatocellular cancer in the United States. N. Engl. J. Med., 1999, 340, 745-750.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 73
    • 35848954977 scopus 로고    scopus 로고
    • Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:Quinone oxidoreductase as a potential target
    • Joung, E.J.; Li, M.H.; Lee, H.G.; Somparn, N.; Jung, Y.S.; Na, H.K.; Kim, S.H.; Cha, Y.N.; Surh, Y.J. Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target. Antioxid. Redox. Signal., 2007, 9, 2087-98.
    • (2007) Antioxid. Redox. Signal. , vol.9 , pp. 2087-2098
    • Joung, E.J.1    Li, M.H.2    Lee, H.G.3    Somparn, N.4    Jung, Y.S.5    Na, H.K.6    Kim, S.H.7    Cha, Y.N.8    Surh, Y.J.9
  • 74
    • 1842431016 scopus 로고    scopus 로고
    • Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells
    • Lee, Y.S.; Kang, Y.S.; Lee, J.S.; Nicolova, S.; Kim, J.A. Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells. Free. Radic. Res., 2004, 38, 405-12.
    • (2004) Free. Radic. Res. , vol.38 , pp. 405-412
    • Lee, Y.S.1    Kang, Y.S.2    Lee, J.S.3    Nicolova, S.4    Kim, J.A.5
  • 75
    • 0035953849 scopus 로고    scopus 로고
    • Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation
    • Jung, M.Y.; Kang, H.J.; Moon, A. Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation. Cancer Lett., 2001, 165, 139-45.
    • (2001) Cancer Lett. , vol.165 , pp. 139-145
    • Jung, M.Y.1    Kang, H.J.2    Moon, A.3
  • 76
    • 33947304343 scopus 로고    scopus 로고
    • TRPV6 mediates capsaicin- induced apoptosis in gastric cancer cells—Mechanisms behind a possible new “hot” cancer treatment
    • Chow, J.; Norng, M.; Zhang, J.; Chai, J. TRPV6 mediates capsaicin- induced apoptosis in gastric cancer cells—Mechanisms behind a possible new “hot” cancer treatment. Biochimic. Biophysic. Acta, 2007, 1773, 565-576.
    • (2007) Biochimic. Biophysic. Acta , vol.1773 , pp. 565-576
    • Chow, J.1    Norng, M.2    Zhang, J.3    Chai, J.4
  • 77
    • 0030713333 scopus 로고    scopus 로고
    • Capsaicin can alter the expression of tumor formingrelated genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1
    • Kim, J.D.; Kim, J.M.; Pyo, J.O.; Kim, S.Y.; Kim, B.S.; Yu, R.; Han, I.S. Capsaicin can alter the expression of tumor formingrelated genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1. Cancer Lett., 1997, 120, 235-241.
    • (1997) Cancer Lett. , vol.120 , pp. 235-241
    • Kim, J.D.1    Kim, J.M.2    Pyo, J.O.3    Kim, S.Y.4    Kim, B.S.5    Yu, R.6    Han, I.S.7
  • 78
    • 84874128795 scopus 로고    scopus 로고
    • Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells
    • Lin, C.H.; Lu, W.C.; Wang, C.W.; Chan, Y.C.; Chen, M.K. Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells. BMC Complem. Altern. M., 2013, 13, 46-54.
    • (2013) BMC Complem. Altern. M. , vol.13 , pp. 46-54
    • Lin, C.H.1    Lu, W.C.2    Wang, C.W.3    Chan, Y.C.4    Chen, M.K.5
  • 79
    • 84880182793 scopus 로고    scopus 로고
    • Capsaicin provokes apoptosis and restricts benzo(A)pyrene induced lung tumorigenesis in Swiss albino mice
    • Anandakumar, P.; Kamaraj, S.; Jagan, S.; Ramakrishnan, G.; Devaki, T. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int. Imunopharmacol., 2013, 17, 254-259.
    • (2013) Int. Imunopharmacol. , vol.17 , pp. 254-259
    • Anandakumar, P.1    Kamaraj, S.2    Jagan, S.3    Ramakrishnan, G.4    Devaki, T.5
  • 80
    • 84892855289 scopus 로고    scopus 로고
    • Evaluating the role of substance P in the growth of brain tumors
    • Harford-Wright, E.; Lewis, K.M.; Vink, R.; Ghabriel, M.N. Evaluating the role of substance P in the growth of brain tumors. Neuroscience, 2014, 261, 85-94.
    • (2014) Neuroscience , vol.261 , pp. 85-94
    • Harford-Wright, E.1    Lewis, K.M.2    Vink, R.3    Ghabriel, M.N.4
  • 81
    • 63349085786 scopus 로고    scopus 로고
    • Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress
    • Lee, H.K.; Seo, I.A.; Shin, Y.K.; Park, J.W.; Suh, D.J.; Park, H.T. Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress. Biochem. Biophys. Res. Commun., 2009, 382, 445-450.
    • (2009) Biochem. Biophys. Res. Commun. , vol.382 , pp. 445-450
    • Lee, H.K.1    Seo, I.A.2    Shin, Y.K.3    Park, J.W.4    Suh, D.J.5    Park, H.T.6
  • 82
    • 0034624342 scopus 로고    scopus 로고
    • Induction of apoptosis by capsaicin in A172 human glioblastoma cells
    • Lee, Y.S.; Nam, D.H.; Kim, J.A. Induction of apoptosis by capsaicin in A172 human glioblastoma cells. Cancer Lett., 2000, 161, 121-130.
    • (2000) Cancer Lett. , vol.161 , pp. 121-130
    • Lee, Y.S.1    Nam, D.H.2    Kim, J.A.3
  • 83
    • 42649124636 scopus 로고    scopus 로고
    • Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells
    • Gil, Y.G.; Kang, M.K. Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells. Life Sci., 2008, 82, 997-1003.
    • (2008) Life Sci. , vol.82 , pp. 997-1003
    • Gil, Y.G.1    Kang, M.K.2
  • 84
    • 12844280531 scopus 로고    scopus 로고
    • Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells
    • Qiao, S.; Li, W.; Tsubouchi, R.; Haneda, M.; Murakami, K.; Yoshino, M. Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells. Neurosci. Res., 2005, 51, 175-183.
    • (2005) Neurosci. Res. , vol.51 , pp. 175-183
    • Qiao, S.1    Li, W.2    Tsubouchi, R.3    Haneda, M.4    Murakami, K.5    Yoshino, M.6
  • 86
    • 84875806870 scopus 로고    scopus 로고
    • Prospective of pharmaceuticals and biopharmaceuticals loaded microparticles prepared by double emulsion technique for controlled delivery
    • Giri, T.K.; Choudhary, C.; Ajazuddin; Alexander, A.; Badwaik, H.; Tripathi, D.K. Prospective of pharmaceuticals and biopharmaceuticals loaded microparticles prepared by double emulsion technique for controlled delivery. Saudi. Pharm. J., 2013, 21, 125-141.
    • (2013) Saudi. Pharm. J. , vol.21 , pp. 125-141
    • Giri, T.K.1    Choudhary, C.2    Ajazuddinalexander, A.3    Badwaik, H.4    Tripathi, D.K.5
  • 88
    • 84897122013 scopus 로고    scopus 로고
    • Xanthan Gum and its Derivatives as a Potential Bio- Polymeric Carrier for Drug Delivery System
    • Badwaik, H.; Giri, T.K.; Nakhate, K.T.; Kashyap, P.; Tripathi, D.K. Xanthan Gum and its Derivatives as a Potential Bio- Polymeric Carrier for Drug Delivery System. Curr. Drug Deliv., 2013, 10, 587-600.
    • (2013) Curr. Drug Deliv. , vol.10 , pp. 587-600
    • Badwaik, H.1    Giri, T.K.2    Nakhate, K.T.3    Kashyap, P.4    Tripathi, D.K.5
  • 90
    • 84946483462 scopus 로고    scopus 로고
    • Grafting of vinyl monomer onto gellan gum using microwave:Synthesis and characterization of grafted copolymer
    • Giri, T.K.; Verma, P.; Tripathi, D.K. Grafting of vinyl monomer onto gellan gum using microwave:synthesis and characterization of grafted copolymer. Adv. Compos. Mater., 2014, DOI:10.1080/09243046.2014.906977.
    • (2014) Adv. Compos. Mater.
    • Giri, T.K.1    Verma, P.2    Tripathi, D.K.3
  • 91
    • 84863895298 scopus 로고    scopus 로고
    • An exhaustive review on recent advancement in pharmaceutical bioadhesive used for systemic drug delivery through oral mucosa for achieving maximum pharmacological response and effect
    • Behra, A.; Giri, T.K.; Tripathi, D.K.; Ajazuddin.; Alexander, A. An exhaustive review on recent advancement in pharmaceutical bioadhesive used for systemic drug delivery through oral mucosa for achieving maximum pharmacological response and effect. Int. J. Pharmacol., 2012, 8, 283-305.
    • (2012) Int. J. Pharmacol. , vol.8 , pp. 283-305
    • Behra, A.1    Giri, T.K.2    Tripathi, D.K.3    Ajazuddinalexander, A.4
  • 92
    • 84930766589 scopus 로고    scopus 로고
    • Effect of adsorption parameters on biosorption of Pb++ ions from aqueous solution by poly (Acrylamide)-grafted kappa-carrageenan
    • Giri, T.K.; Verma, D.; Tripathi, D.K. Effect of adsorption parameters on biosorption of Pb++ ions from aqueous solution by poly (acrylamide)-grafted kappa-carrageenan. Polym. Bull., 2015. DOI 10.1007/s00289-015-1357-9.
    • (2015) Polym. Bull
    • Giri, T.K.1    Verma, D.2    Tripathi, D.K.3
  • 93
    • 84870203532 scopus 로고    scopus 로고
    • Alginate based Hydrogel as a Potential Biopolymeric Carrier for Drug Delivery and Cell Delivery Systems: Present Status and Applications
    • Giri, T.K.; Thakur, D.; Alexander, A.; Ajazuddin; Badwaik, H.; Tripathi, D.K. Alginate based Hydrogel as a Potential Biopolymeric Carrier for Drug Delivery and Cell Delivery Systems: Present Status and Applications. Curr. Drug Deliv., 2012, 9, 539-555.
    • (2012) Curr. Drug Deliv. , vol.9 , pp. 539-555
    • Giri, T.K.1    Thakur, D.2    Alexander, A.3    Ajazuddinbadwaik, H.4    Tripathi, D.K.5
  • 94
    • 84861219159 scopus 로고    scopus 로고
    • A Review on Novel Therapeutic Strategies for the Enhancement of Solubility for Hydrophobic Drugs through Lipid and Surfactant Based Self-Micro Emulsifying Drug Delivery System: A Novel Approach
    • Agrawal, S.; Giri, T.K.; Tripathi, D.K.; Ajazuddin.; Alexander, A. A Review on Novel Therapeutic Strategies for the Enhancement of Solubility for Hydrophobic Drugs through Lipid and Surfactant Based Self-Micro Emulsifying Drug Delivery System: A Novel Approach. Am. J. Drug Discov. Develop., 2012, 2, 143-183.
    • (2012) Am. J. Drug Discov. Develop. , vol.2 , pp. 143-183
    • Agrawal, S.1    Giri, T.K.2    Tripathi, D.K.3    Ajazuddinalexander, A.4
  • 95
    • 84878892472 scopus 로고    scopus 로고
    • Crosslinked biodegradable hydrogel floating beads for stomach site specific controlled delivery of metronidazole
    • Giri, T.K.; Verma, S.; Alexander, A.; Ajazuddin; Badwaik, H.; Tripathy, M.; Tripathi, D.K. Crosslinked biodegradable hydrogel floating beads for stomach site specific controlled delivery of metronidazole. FARMACIA., 2013, 61, 533-550.
    • (2013) FARMACIA. , vol.61 , pp. 533-550
    • Giri, T.K.1    Verma, S.2    Alexander, A.3    Ajazuddinbadwaik, H.4    Tripathy, M.5    Tripathi, D.K.6
  • 97
    • 44449134556 scopus 로고    scopus 로고
    • Effect of HPCD on solubility and transdermal delivery of capsaicin through rat skin
    • Zi, P.; Yang, X.; Kuang, H.; Yang, Y.; Yu, L. Effect of HPCD on solubility and transdermal delivery of capsaicin through rat skin. Int. J. Pharm., 2008, 358, 151-158.
    • (2008) Int. J. Pharm. , vol.358 , pp. 151-158
    • Zi, P.1    Yang, X.2    Kuang, H.3    Yang, Y.4    Yu, L.5
  • 98
    • 0035859975 scopus 로고    scopus 로고
    • In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels
    • Wang, Y.Y.; Hong, C.T.; Chiu, W.T.; Fang, J.U. In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. Int. J. Pharm., 2001, 224, 89-104.
    • (2001) Int. J. Pharm. , vol.224 , pp. 89-104
    • Wang, Y.Y.1    Hong, C.T.2    Chiu, W.T.3    Fang, J.U.4
  • 99
    • 78649907878 scopus 로고    scopus 로고
    • Design and in vitro evaluation of capsaicin transdermal controlled release cubic phase gels
    • Peng, X.; Wen, X.; Pan, X.; Wang, R.; Chen, B.; Wu, C. Design and in vitro evaluation of capsaicin transdermal controlled release cubic phase gels. AAPS. Pharm. Sci. Tech., 2010, 11, 1405-1410.
    • (2010) AAPS. Pharm. Sci. Tech. , vol.11 , pp. 1405-1410
    • Peng, X.1    Wen, X.2    Pan, X.3    Wang, R.4    Chen, B.5    Wu, C.6
  • 100
    • 0031573919 scopus 로고    scopus 로고
    • Percutaneous absorption and histopathology of a poloxamer-based formulation of capsaicin analog
    • Lee, B.J.; Lee, T.S.; Cha, B.J.; Kim, S.H.; Kim, W.B. Percutaneous absorption and histopathology of a poloxamer-based formulation of capsaicin analog. Int. J. Pharm., 1997, 159, 105–114.
    • (1997) Int. J. Pharm. , vol.159 , pp. 105-114
    • Lee, B.J.1    Lee, T.S.2    Cha, B.J.3    Kim, S.H.4    Kim, W.B.5
  • 102
    • 79953007356 scopus 로고    scopus 로고
    • Design and evaluation of flexible membrane vesicles (FMVs) for enhanced topical delivery of capsaicin
    • Raza, K.; Singh, B.; Mahajan, A.; Negi, P.; Bhatia, A.; Katare, O.P. Design and evaluation of flexible membrane vesicles (FMVs) for enhanced topical delivery of capsaicin. J. Drug Target, 2011, 19, 293-302.
    • (2011) J. Drug Target , vol.19 , pp. 293-302
    • Raza, K.1    Singh, B.2    Mahajan, A.3    Negi, P.4    Bhatia, A.5    Katare, O.P.6
  • 104
    • 84949548952 scopus 로고    scopus 로고
    • Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats
    • Kumar, S.K.; Rudrapal, M.; Mazumder, B. Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats. Drug Deliv., 2014, DOI: 10.3109/10717544.2013.861041.
    • (2014) Drug Deliv.
    • Kumar, S.K.1    Rudrapal, M.2    Mazumder, B.3
  • 105
    • 0019946911 scopus 로고
    • Distribution of capsaicin in rat tissues after systemic administration
    • Saria, A.; Skofitch, O.; Lembeck, F. Distribution of capsaicin in rat tissues after systemic administration. J. Pharm. Pharmacol., 1982, 34, 273-5.
    • (1982) J. Pharm. Pharmacol. , vol.34 , pp. 273-275
    • Saria, A.1    Skofitch, O.2    Lembeck, F.3
  • 106
    • 77957684525 scopus 로고    scopus 로고
    • Enhanced aqueous solubility and bioavailability of capsaicin by the preparation of an inclusion complex
    • Chen, X.; Sun, X.; Ren, K.; Zhang, X.; Zhang, Z.; Gong, T. Enhanced aqueous solubility and bioavailability of capsaicin by the preparation of an inclusion complex. Arzneim. Forsc., 2010, 60, 571-574.
    • (2010) Arzneim. Forsc. , vol.60 , pp. 571-574
    • Chen, X.1    Sun, X.2    Ren, K.3    Zhang, X.4    Zhang, Z.5    Gong, T.6
  • 108
    • 84890410137 scopus 로고    scopus 로고
    • The preparation of capsaicin-chitosan microspheres (CCMS) enteric coated tablets
    • Chen, J.; Huang, G.D.; Tan, S.R.; Guo, J.; Su, Z.Q. The preparation of capsaicin-chitosan microspheres (CCMS) enteric coated tablets. Int. J. Mol. Sci., 2013, 14, 24305-24319.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 24305-24319
    • Chen, J.1    Huang, G.D.2    Tan, S.R.3    Guo, J.4    Su, Z.Q.5
  • 109
    • 84878387681 scopus 로고    scopus 로고
    • Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo
    • Desai, P.R.; Marepally, S.; Patel, A.R.; Voshavar, C.; Chaudhuri, A.; Singh, M. Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo. J. Controlled Release, 2013, 170, 51-63.
    • (2013) J. Controlled Release , vol.170 , pp. 51-63
    • Desai, P.R.1    Marepally, S.2    Patel, A.R.3    Voshavar, C.4    Chaudhuri, A.5    Singh, M.6
  • 110
    • 79952586373 scopus 로고    scopus 로고
    • Development of a novel method for fabrication of solid lipid nanoparticles: Using high shear homogenization and ultrasonication
    • Sharma, A.; Jindal, M.; Aggarwal, G.; Jain, S. Development of a novel method for fabrication of solid lipid nanoparticles: using high shear homogenization and ultrasonication. Res. J. Pharm. Biol. Chem. Sci., 2010, 1, 265-274.
    • (2010) Res. J. Pharm. Biol. Chem. Sci. , vol.1 , pp. 265-274
    • Sharma, A.1    Jindal, M.2    Aggarwal, G.3    Jain, S.4
  • 111
    • 78649499043 scopus 로고    scopus 로고
    • Chitosan hydrogel containing capsaicinoids-loaded nanocapsules: An innovative formulation for topical delivery
    • Contri, R.V.; Katzer, T.; Pohlmann, A.R.; Guterres, S.S. Chitosan hydrogel containing capsaicinoids-loaded nanocapsules: an innovative formulation for topical delivery. Soft. Mater., 2010, 8, 370-385.
    • (2010) Soft. Mater. , vol.8 , pp. 370-385
    • Contri, R.V.1    Katzer, T.2    Pohlmann, A.R.3    Guterres, S.S.4
  • 113
    • 79958294765 scopus 로고    scopus 로고
    • Characterization of capsaicin-loaded nanoemulsions stabilized with alginate and chitosan by self-assembly
    • Choi, A.J.; Kim, C.J.; Cho, Y.J.; Hwang, J.K.; Kim, C.T. Characterization of capsaicin-loaded nanoemulsions stabilized with alginate and chitosan by self-assembly. Food Bioprocess. Technol., 2011, 4, 1119-1126.
    • (2011) Food Bioprocess. Technol. , vol.4 , pp. 1119-1126
    • Choi, A.J.1    Kim, C.J.2    Cho, Y.J.3    Hwang, J.K.4    Kim, C.T.5
  • 114
    • 84874886577 scopus 로고    scopus 로고
    • Pharmacokinetic characteristics of capsaicinloaded nanoemulsions fabricated with alginate and chitosan
    • Choi, A.Y.; Kim, C.T.; Park, H.Y.; Kim, H.O.; Lee, N.R.; Lee, K.E.; Gwak, H.S. Pharmacokinetic characteristics of capsaicinloaded nanoemulsions fabricated with alginate and chitosan. J. Agric. Food Chem., 2013, 61, 2096-102.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 2096-2102
    • Choi, A.Y.1    Kim, C.T.2    Park, H.Y.3    Kim, H.O.4    Lee, N.R.5    Lee, K.E.6    Gwak, H.S.7
  • 115
    • 84878396266 scopus 로고    scopus 로고
    • Polysaccharide-based micelles for drug delivery
    • Zhang, N.; Wardwell, P.R.; Bader, R.A. Polysaccharide-based micelles for drug delivery. Pharmaceutics, 2013, 5, 329-352.
    • (2013) Pharmaceutics , vol.5 , pp. 329-352
    • Zhang, N.1    Wardwell, P.R.2    Bader, R.A.3
  • 116
    • 84899969642 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation
    • Zhu, Y.; Peng, W.; Zhang, J.; Wang, M.; Firempong, C.B.; Feng, C.; Liu, H.; Xu, X.; Yu, J. Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: preparation, in vitro and in vivo evaluation. J. Funct. Foods, 2014, 8, 358-366.
    • (2014) J. Funct. Foods , vol.8 , pp. 358-366
    • Zhu, Y.1    Peng, W.2    Zhang, J.3    Wang, M.4    Firempong, C.B.5    Feng, C.6    Liu, H.7    Xu, X.8    Yu, J.9
  • 117
    • 84882798654 scopus 로고    scopus 로고
    • Ajazuddin.; Badwaik, H.; Tripathy, M.; Tripathi, D.K. Novel controlled release solid dispersion for the delivery of diclofenac sodium
    • Giri, T.K.; Kumar, K.; Alexander, A.; Ajazuddin.; Badwaik, H.; Tripathy, M.; Tripathi, D.K. Novel controlled release solid dispersion for the delivery of diclofenac sodium. Curr. Drug Deliv., 2013, 10, 435-443.
    • (2013) Curr. Drug Deliv. , vol.10 , pp. 435-443
    • Giri, T.K.1    Kumar, K.2    Alexander, A.3
  • 119
    • 84892683143 scopus 로고    scopus 로고
    • Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads based on Pectin and modified Xanthan Gum
    • Giri, T.K.; Choudhary, C.; Alexander, A.; Ajazuddin Badwaik H.; Tripathy, M.; Tripathi, D.K. Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads based on Pectin and modified Xanthan Gum. Indian. J. Pharm. Sci., 2013, 75, 619-627.
    • (2013) Indian. J. Pharm. Sci. , vol.75 , pp. 619-627
    • Giri, T.K.1    Choudhary, C.2    Alexander, A.3    Ajazuddin Badwaik, H.4    Tripathy, M.5    Tripathi, D.K.6
  • 121
    • 84964006548 scopus 로고    scopus 로고
    • Prospective and new findings of Hydroxypropyl methylcellulose (HPMC) as a potential carrier for gastrorententive drug delivery systems
    • Giri, T.K.; Verma, S.; Ajazuddin.; Alexander, A.; Badwaik, H.; Tripathi, D.K. Prospective and new findings of Hydroxypropyl methylcellulose (HPMC) as a potential carrier for gastrorententive drug delivery systems. Drug. Deliv. Lett., 2012, 2, 98-107.
    • (2012) Drug. Deliv. Lett. , vol.2 , pp. 98-107
    • Giri, T.K.1    Verma, S.2    Ajazuddinalexander, A.3    Badwaik, H.4    Tripathi, D.K.5
  • 122
    • 84874436914 scopus 로고    scopus 로고
    • Optimization of preparation process of floating sustained-release pellets of capsaicin based on nanometer CaCO3 by central composite design-response surface method
    • Chen, X.Y.; Zhang, Z.H.; Jin, X.; Jia, X.B. Optimization of preparation process of floating sustained-release pellets of capsaicin based on nanometer CaCO3 by central composite design-response surface method. Zhongguo. Zhong. Yao. Za. Zhi., 2012, 37, 3400-5.
    • (2012) Zhongguo. Zhong. Yao. Za. Zhi. , vol.37 , pp. 3400-3405
    • Chen, X.Y.1    Zhang, Z.H.2    Jin, X.3    Jia, X.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.