Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo

Journal of Controlled Release

Volumn 170, Issue 1, 2013, Pages 51-63

  Desai, Pinaki R ^a   Marepally, Srujan ^a,c   Patel, Apurva R ^a   Voshavar, Chandrashekhar ^b,c   Chaudhuri, Arabinda ^c   Singh, Mandip ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Gene therapy; Hybrid nanoparticles; Percutaneous delivery; Psoriasis like mouse model; SIRNA; Skin inflammation

Indexed keywords

COLLECTOR EFFICIENCY; FUNCTIONAL POLYMERS; GENE EXPRESSION; GENES; NANOPARTICLES; PATHOLOGY; POLYMERS;

ANTI-INFLAMMATORIES; HYBRID NANOPARTICLE; INFLAMMATORY DISEASE; MOUSE MODELS; PERCUTANEOUS DELIVERIES; PHYSICO-CHEMICAL CHARACTERIZATION; SIRNA; THERAPEUTIC EFFICACY;

GENE THERAPY;

CAPSAICIN; CYCLIC CATIONIC HEAD LIPID POLYMER HYBRID NANOCARRIER; FLUORESCEIN ISOTHIOCYANATE; IMIQUIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 23; KI 67 ANTIGEN; NANOCARRIER; POLYMER; SMALL INTERFERING RNA; SOLID LIPID NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DERMATITIS; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENTIATION; DRUG RETENTION; DRUG UPTAKE; GENE EXPRESSION; HYDRODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; MALE; NANOENCAPSULATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PSORIASIS VULGARIS; RAT; SKIN PERMEABILITY; SURFACE PROPERTY;

EID: 84878387681     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.04.021     Document Type: Article

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