Effect of HPβCD on solubility and transdermal delivery of capsaicin through rat skin

International Journal of Pharmaceutics

Volumn 358, Issue 1-2, 2008, Pages 151-158

  Zi, Peng ^a   Yang, Xinghao ^a   Kuang, Huifen ^a   Yang, Yanshuang ^a   Yu, Lili ^b  

^a NANJING NORMAL UNIVERSITY   (China)

^b Nanjing C and O Pharmaceutical Technology Company   (China)

Author keywords

Capsaicin; Histological analysis; Hydrogel; Hydroxypropyl cyclodextrin; In vitro percutaneous studies

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CAPSAICIN; CARBOMER; SOLUBILIZER; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; EXCIPIENT; POLYVINYL DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG SOLUBILITY; HISTOLOGY; HYDROGEL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN ABSORPTION; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION; ANIMAL; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFECT; FEMALE; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRADERMAL DRUG ADMINISTRATION; MALE; SOLUBILITY; SOLUTION AND SOLUBILITY; SPRAGUE DAWLEY RAT; SUSPENSION; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

ADMINISTRATION, CUTANEOUS; ANIMALS; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CAPSAICIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXCIPIENTS; FEMALE; FREEZE DRYING; HYDROGELS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; PHARMACEUTICAL SOLUTIONS; POLYVINYLS; RATS; RATS, SPRAGUE-DAWLEY; SKIN ABSORPTION; SOLUBILITY; SUSPENSIONS; X-RAY DIFFRACTION;

EID: 44449134556     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.03.001     Document Type: Article

References (28)

1. Babu R.J., and Pandit J.K. Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin. Int. J. Pharm. 271 (2004) 155-165
2. Bentley M.V., Vianna R.F., Wilson S., and Collett J.H. Characterization of the influence of some cyclodextrins on the stratum corneum from the hairless mouse. J. Pharm. Pharmacol. 49 (1997) 397-402
3. Degim I.T., Uslu A., Hadgraft J., Atay T., Akay C., and Cevheroglu S. The effects of Azone and capsaicin on the permeation of naproxen through human skin. Int. J. Pharm. 179 (1999) 21-25
4. Donnerer J., Amann R., Schuligoi R., and Lembeck F. Absorption and metabolism of capsaicinoids following intragastric administration in rats. Naunyn Schmiedebergs Arch. Pharmacol. 342 (1990) 357-361
5. Fang J.Y., Wu P.C., Huang Y.B., and Tsai Y.H. In vitro permeation study of capsaicin and its synthetic derivatives from ointment bases using various skin types. Int. J. Pharm. 126 (1995) 119-128
6. Fang J.Y., Wu P.C., Huang Y.B., and Tsai Y.H. In vivo percutaneous absorption of capsaicin, nonivamide and sodium nonivamide acetate from ointment bases: skin erythema test and non-invasive surface recovery technique in humans. Int. J. Pharm. 131 (1996) 143-151
7. Fang J.Y., Wu P.C., Huang Y.B., and Tsai Y.H. Percutaneous absorption of capsaicin, nonivamide and sodium nonivamide acetate from gel and ointment bases: in vitro formulation evaluations in pigs and in vivo bioengineering methods in humans. Int. J. Pharm. 130 (1996) 121-135
8. Fang J.Y., Fang C.L., Hong C.T., Chen H.Y., Lin T.Y., and Wei H.M. Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin. Eur. J. Pharm. Sci. 12 (2001) 195-203
9. Fusco M.B., and Giacovazzo M. Peppers and pain: the promise of capsaicin. Drugs 53 (1997) 909-914
10. Hayes A.G., Skingle M., and Tyers M.B. Effects of single doses of capsaicin on nociceptive thresholds in the rodent. Neuropharmacology 20 (1981) 505-511
11. Higuchi T., and Connors K.A. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4 (1965) 117-212
12. Kawada T., Watanabe T., Katsura K., Takami H., and Iwai K. Formation and metabolism of pungent principle of capsicum fruits. XV. Microdetermination of capsaicin by high-performance liquid chromatography with electrochemical detection. J. Chromatogr. 329 (1985) 99-105
13. Legendre J.Y., Rault I., Petit A., Luijten W., Demuynck I., Horvath S., Ginot Y.M., and Cuine A. Effects of β-cyclodextrins on skin: implications for the transdermal delivery of piribedil and a novel cognition enhancing-drug, S-9977. Eur. J. Pharm. Sci. 3 (1995) 311-322
14. Loftsson T., and Masson M. Cyclodextrins in topical drug formulations: theory and practice. Int. J. Pharm. 225 (2001) 15-30
15. Loftsson T., Konrádsdóttir F., and Másson M. Influence of aqueous diffusion layer on passive drug diffusion from cyclodextrin solutions through biological membranes. Pharmazie 61 (2006) 83-89
16. Magnusson B.M., and Koskinen L.O.D. In vitro percutaneous penetration of topically applied capsaicin in relation to in vivo sensation responses. Int. J. Pharm. 195 (2000) 55-62
17. Másson M., Loftsson T., Másson G., and Stefánsson E. Cyclodextrins as permeation enhancers: some theoretical evaluations and in vitro testing. J. Controlled Release 59 (1999) 107-118
18. Másson M., Sigurdardottir B.V., Matthíasson K., and Loftsson T. Investigation of drug-cyclodextrin complexes by a phase-distribution method: some theoretical and practical considerations. Chem. Pharm. Bull. 53 (2005) 958-964
19. Miro A., Quaglia F., Sorrentino U., La Rotonda M.I., D'Emmanuele Di Villa Bianca R., and Sorrentino R. Improvement of gliquidone hypoglycaemic effect in rats by cyclodextrin formulations. Eur. J. Pharm. Sci. 23 (2004) 57-64
20. Monsereenusorn Y., Kongsamut S., and Pezalla P.D. Capsaicin-a literature survey. Crit. Rev. Toxicol. 10 (1982) 321-339
21. Rao V.M., and Stella V.J. When can cyclodextrins be considered for solubilizing purposes?. J. Pharm. Sci. 92 (2003) 927-932
22. Shaker D.S., Ghanem A.H., Li S.K., Warner K.S., Hashem F.M., and Higuchi W.I. Mechanistic studies of the effect of hydroxypropyl-β-cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin. Int. J. Pharm. 253 (2003) 1-11
23. Sietsema W.K., Berman E.F., Farmer R.W., and Maddin C.S. The antinociceptive effect and pharmacokinetics of olvanil following oral and subcutaneous dosing in the mouse. Life Sci. 43 (1988) 1385-1391
24. Simeoni S., Scalia S., and Benson H.A. Influence of cyclodextrins on in vitro human skin absorption of the sunscreen, butyl-methoxydibenzoylmethane. Int. J. Pharm. 280 (2004) 163-171
25. Ventura C.A., Tommasini S., Falcone A., Giannone I., Paolino D., Sdrafkakis V., Mondello M.R., and Puglisi G. Influence of modified cyclodextrins on solubility and percutaneous absorption of celecoxib through human skin. Int. J. Pharm. 314 (2006) 37-45
26. Wang J.P., Hsu M.F., and Teng C.M. Antiplatelet effect of capsaicin. Thromb. Res. 36 (1984) 497-507
27. Wang Y.Y., Hong C.T., Chiu W.T., and Fang J.Y. In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. Int. J. Pharm. 224 (2001) 89-104
28. Williams A.C., and Barry B.W. Penetration enhancers. Adv. Drug Deliv. Rev. 56 (2004) 603-618