Capsaicin can alter the expression of tumor forming-related genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1

Cancer Letters

Volumn 120, Issue 2, 1997, Pages 235-241

  Kim, Jung Dae ^a   Kim, Jung Mi ^a   Pyo, Jong Oak ^a   Kim, Sun Young ^b   Kim, Byung Sam ^a   Yu, Rina ^a   Han, In Seob ^a  

^a University of Ulsan   (South Korea)

^b Dong Gang Hospital 680 749   (South Korea)

Author keywords

Apoptosis; c erbB 2; c jun; c myc; Capsaicin; NIH 3T3; p53; SNU 1

Indexed keywords

CAPSAICIN; DNA FRAGMENT; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KOREA; MOUSE; NONHUMAN; ONCOGENE C ERB; ONCOGENE C H RAS; ONCOGENE C MYC; PRIORITY JOURNAL; PROTO ONCOGENE; STOMACH CANCER; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; RAS PROTEINS; RECEPTOR, ERBB-2; RNA, MESSENGER; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0030713333     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)00321-2     Document Type: Article

References (26)

1. Jang J.J., Kim S.H., Yun T.K. Inhibitory effect of capsaicin on mouse lung tumor development, in vivo. J. Korean Med. Sci. 3:1989;49-53.
2. Jang J.J., Cho K.J., Lee Y.S., Bae J.H. Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat. J. Korean Med. 6:1991;31-36.
3. Marchetti M., Arico B., Burroni D., Figura N., Rappuoli R., Ghiara P. Development of a mouse model of Helicobacter phlori infection that mimics human disease. Science. 267:1995;1655-1658.
4. Flack V.G., Gullick W.J. c-erbB-2 oncogene product staining in gastric adenocarcinoma, an immunohistochemical study. J. Pathol. 159:1989;107-111.
5. Houldswurth J., Cordon-Cardo C., Ladanyi M. Gene amplification in gastric and esophageal adenocarcinomas. Cancer Res. 50:1990;6417-6422.
6. Jain S., Isabel Filipe M., Gullick W.J. c-erbB-2 proto-oncogene expression and its relationship to survival in gastric carcinoma: an immunohistochemical study on archival material. Int. J. Cancer. 48:1991;668-671.
7. Joypatal B.V., Newman E.L., Hopwood D., Grant A., Qureshi S., Lane D.P., Cuschieri A.A.D. Expression of p53 protein in normal, cysplastic, and malignant gastric mucosa: an immunohistochemical study. J. Pathol. 170:1993;279-283.
8. Iwai K., Suzuki T., Fujiwake H. Formation and accumulation of pungent principle of hot pepper fruits, capsaicin and its analogues, in Capsicum annuum var.annuum cv. Karayatsubusa at different growth stages after flowering. Agric. Biol. Chem. 43:1979;2493-2498.
9. T. Suzuki, K. Iwai, Constitution of red pepper species: chemistry, biochemistry, pharmacology, and food science of the pungent principle of Capsicum species, in: A. Brosi (Ed.), The Alkaloids, Vol. 23, Academic Press, New York, 1984, pp. 227-299.
10. Cordell G.A., Araujo O.E. Capsaicin: identification, nomenclature, and pharmacotherapy. Ann. Pharmacother. 27:1993;330-336.
11. Teel R.W. Effects of capsaicin on rat liver S9-mediated metabolism and DNA binding of aflatoxin. Nutr. Cancer. 15:1991;27-32.
12. Teel R.W. Effect of phytochemicals on the mutagenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Salmonella typhimurium strain TA1535. Phytother. Res. 7:1993;248-251.
13. Zang Z., Hamilton S.M., Stewart C., Strother A., Teel R.W. Inhibition of liver microsomal cytochrome P-450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid. Anticancer Res. 13:1993;2341-2346.
14. Morre D.J., Chueh P.-J., Morre D.M. Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture. Proc. Natl. Acad. Sci. USA. 92:1995;1831-1835.
15. Ogretmen B., Ratajczak H., Gendel S.M., Stark B.C. Effects of sodium saccharin and linoleic acid on mRNA levels of Her/neu and p53 in a human breast epithelial cell line. Cancer Lett. 102:1996;91-99.
16. Bae C.D., Park S.E., Seong Y.S., Kimm S.W., Park J.B. The mechanism of c-erbB-2 gene product increase in stomach cancer cell lines. J. Korean Med. Sci. 8:1993;153-159.
17. J. Sambrook, E.F. Fritsch, T. Maniatis, Extraction of RNA with guanidine thiocyanate followed by centrifugation in cesium chloride, in: Molecular Cloning, second ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989, pp. 7.19-7.22.
18. Yanagihara K., Seyama T., Tsumuraya M., Kamada N., Yokoro K. Establishment and characterization of human signet ring cell gastric carcinoma cell lines with amplification of the c-myc oncogene. Cancer Res. 51:1991;381-386.
19. Surh Y.-J., Lee R.C.-J., Park K.-K., Mayne S.T., Liem A., Miller J.A. Chemoprotective effects of capsaicin and dially sulfide against mutagenesis of tumorigenesis by vinyl carbamate and N-nitrosodimethylamine. Carcinogenesis. 16:1995;2467-2471.
20. Sher C.J. Cancer cell cycles. Science. 274:1996;1672-1677.
21. Singh S., Natarajan K., Aggarwal B.B. Capsaicin is a potent inhibitor of TNF-κB activation by diverse agents. J. Immunol. 22:1996;4412-4420.
22. Sasano H., Date F., Imatani A., Asaki S., Nagura H. Double immunostaining for c-erbB-2 and p53 in human stomach cancer cells. Hum. Pathol. 24:1993;584-589.
23. Di Fiore P., Pierce J.H., Kraus M.H., Segatto O., King C.R., Aaronson S.A. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science. 237:1987;178-180.
24. Chien C.H., Chow S.N. Point mutation of the ras oncogene in human ovarian cancer. DNA Cell Biol. 12:1993;623-627.
25. Dole M., Nunez G., Merchant A.K., Maybaum J., Rode C.K., Bloch C.A., Castle V.P. Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res. 54:1994;3253-3259.
26. Allsopp T.E., Wyatt S., Paterson H.F., Davies A.M. The proto-oncogene bcl-2 can selectively rescue neutrophic factor-dependent neurons from apoptosis. Cell. 73:1993;295-307.