Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 5, 2011, Pages

  Rizza, Stefano ^b   Muniyappa, Ranganath ^a   Iantorno, Micaela ^a   Kim, Jeong A ^d   Chen, Hui ^a   Pullikotil, Philomena ^a   Senese, Nicoletta ^b   Tesauro, Manfredi ^b   Lauro, Davide ^b   Cardillo, Carmine ^c   Quon, Michael J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d and Clinical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRINOGEN; HESPERIDIN; HOMOCYSTEINE; HYDROGEN PEROXIDE; NITRIC OXIDE; PLACEBO; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SERUM AMYLOID A; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; BRACHIAL ARTERY; CELL ADHESION; CELL STIMULATION; CELL STRAIN U937; CLINICAL ARTICLE; CONTROLLED STUDY; COW; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; EXPLORATORY RESEARCH; FEMALE; HUMAN; INFLAMMATION; MALE; METABOLIC SYNDROME X; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION;

ADENYLATE KINASE; ANIMALS; CATTLE; CELL ADHESION; CELLS, CULTURED; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HESPERIDIN; HUMANS; INFLAMMATION; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MONOCYTES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; ONCOGENE PROTEIN V-AKT; SIGNAL TRANSDUCTION; STIMULATION, CHEMICAL; TUMOR NECROSIS FACTOR-ALPHA; VASODILATION;

BOVINAE; CITRUS;

EID: 79955655412     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-2879     Document Type: Article

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