The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men

International Journal of Obesity

Volumn 38, Issue 3, 2014, Pages 470-473

  Konings, E ^a   Timmers, S ^a,b   Boekschoten, M V ^b,c   Goossens, G H ^a   Jocken, J W ^a   Afman, L A ^b,c   Muller M ^b,c   Schrauwen, P ^a,b   Mariman, E C ^a   Blaak, E E ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

adipose tissue; microarray; resveratrol

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; NOTCH RECEPTOR; NOTCH4 RECEPTOR; PLACEBO; RESVERATROL; SMAD4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; WNT PROTEIN; ENZYME INHIBITOR; STILBENE DERIVATIVE;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ADULT; AGED; ARTICLE; AUTOPHAGY; CELL CYCLE REGULATION; CELL SIZE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIPID METABOLISM; LYSOSOME; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; MORPHOLOGY; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PHAGOSOME; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SUPPLEMENTATION; UPREGULATION; WNT SIGNALING PATHWAY; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; ADULT; AGED; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; OBESITY; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STILBENES; TREATMENT OUTCOME; WNT SIGNALING PATHWAY;

EID: 84896314683     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2013.155     Document Type: Article

References (20)

1. Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey 1988-1994. Diabetes Care 1998; 21: 518-524
2. Szkudelska K, Szkudelski T. Resveratrol, obesity and diabetes. Eur J Pharmacol 2010; 635: 1-8
3. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444: 337-342
4. Kim S, Jin Y, Choi Y, Park T. Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochem Pharmacol 2011; 81: 1343-1351
5. McLaughlin T, Sherman A, Tsao P, Gonzalez O, Yee G, Lamendola C et al. Enhanced proportion of small adipose cells in insulin-resistant vs insulinsensitive obese individuals implicates impaired adipogenesis. Diabetologia 2007; 50: 1707-1715
6. Poulsen MM, Vestergaard PF, Clasen BF, Radko Y, Christensen LP, Stodkilde-Jorgensen H et al. High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes 2013; 62: 1186-1195
7. Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB et al. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab 2012; 16: 658-664
8. Timmers S, Konings E, Bilet L, Houtkooper RH. van De Weijer T, Goossens GH et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011; 14: 612-622
9. Goossens GH, Bizzarri A, Venteclef N, Essers Y, Cleutjens JP, Konings E et al. Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation 2011; 124: 67-76
10. Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S et al. TFEB links autophagy to lysosomal biogenesis. Science 2011; 332: 1429-1433
11. Goossens GH. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav 2008; 94: 206-218
12. Christodoulides C, Laudes M, Cawthorn WP, Schinner S, Soos M, O?Rahilly S et al. The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis. J Cell Sci 2006; 119(Pt 12): 2613-2620
13. Garces C, Ruiz-Hidalgo MJ, Font De Mora J, Park C, Miele L, Goldstein J et al. Notch-1 controls the expression of fatty acid-Activated transcription factors and is required for adipogenesis. J Biol Chem 1997; 272: 29729-29734
14. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPARgamma. Nature 2004; 429: 771-776
15. Fischer-Posovszky P, Kukulus V, Tews D, Unterkircher T, Debatin KM, Fulda S et al. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr 2010; 92: 5-15
16. He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. Regulation of HIF-1{alpha} activity in adipose tissue by obesity-Associated factors: Adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab 2011; 300: E877-E885
17. Brakenhielm E, Cao R, Cao Y. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J 2001; 15: 1798-1800
18. Singh R, Cuervo AM. Lipophagy: Connecting autophagy and lipid metabolism. Int J Cell Biol 2012; 2012: 282041
19. Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK et al. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 2009; 119: 3329-3339
20. Siklova-Vitkova M, Klimcakova E, Polak J, Kovacova Z, Tencerova M, Rossmeislova L et al. Adipose tissue secretion and expression of adipocyte-produced and stromavascular fraction-produced adipokines vary during multiple phases of weight-reducing dietary intervention in obese women. J Clin Endocrinol Metab 2012; 97: E1176-E1181