메뉴 건너뛰기




Volumn 271, Issue 1, 2016, Pages 127-140

Autoimmune regulator and self-tolerance - molecular and clinical aspects

Author keywords

Autoantibodies; Autoimmune polyendocrine syndrome type 1; Autoimmune regulator; Autoimmunity; Medullary thymic epithelial cell; T regulatory cell

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; DNA; PROTEIN KINASE; RAG1 PROTEIN; RAG2 PROTEIN; SIRTUIN 1; TRANSCRIPTION FACTOR FOXP3; AUTOANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 84963569487     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12419     Document Type: Article
Times cited : (75)

References (110)
  • 1
    • 71649086164 scopus 로고    scopus 로고
    • Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases
    • Cooper GS, Bynum ML, Somers EC. Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun 2009;33:197-207.
    • (2009) J Autoimmun , vol.33 , pp. 197-207
    • Cooper, G.S.1    Bynum, M.L.2    Somers, E.C.3
  • 3
    • 64249161198 scopus 로고    scopus 로고
    • Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I
    • Husebye ES, Perheentupa J, Rautemaa R, Kampe O. Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J Intern Med 2009;265:514-529.
    • (2009) J Intern Med , vol.265 , pp. 514-529
    • Husebye, E.S.1    Perheentupa, J.2    Rautemaa, R.3    Kampe, O.4
  • 4
    • 77149147477 scopus 로고    scopus 로고
    • Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines
    • Kisand K, et al. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J Exp Med 2010;207:299-308.
    • (2010) J Exp Med , vol.207 , pp. 299-308
    • Kisand, K.1
  • 5
    • 77149124612 scopus 로고    scopus 로고
    • Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
    • Puel A, et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J Exp Med 2010;207:291-297.
    • (2010) J Exp Med , vol.207 , pp. 291-297
    • Puel, A.1
  • 6
    • 84937598338 scopus 로고    scopus 로고
    • Dominant mutations in the autoimmune regulator AIRE are associated with common organ-specific autoimmune diseases
    • Oftedal BE, et al. Dominant mutations in the autoimmune regulator AIRE are associated with common organ-specific autoimmune diseases. Immunity 2015;42:1185-1196.
    • (2015) Immunity , vol.42 , pp. 1185-1196
    • Oftedal, B.E.1
  • 7
    • 0346599403 scopus 로고    scopus 로고
    • APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED Consortium. Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
    • An autoimmune disease.
    • An autoimmune disease. APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED Consortium. Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy. Nat Genet 1997;17:399-403.
    • (1997) Nat Genet , vol.17 , pp. 399-403
  • 8
    • 16944367194 scopus 로고    scopus 로고
    • Positional cloning of the APECED gene
    • Nagamine K, et al. Positional cloning of the APECED gene. Nat Genet 1997;17:393-398.
    • (1997) Nat Genet , vol.17 , pp. 393-398
    • Nagamine, K.1
  • 9
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson MS, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002;298:1395-1401.
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 10
    • 84913594338 scopus 로고    scopus 로고
    • Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
    • Sansom SN, et al. Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. Genome Res 2014;24:1918-1931.
    • (2014) Genome Res , vol.24 , pp. 1918-1931
    • Sansom, S.N.1
  • 11
    • 84939622896 scopus 로고    scopus 로고
    • Aire controls gene expression in the thymic epithelium with ordered stochasticity
    • Meredith M, Zemmour D, Mathis D, Benoist C. Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat Immunol 2015;16:942-949.
    • (2015) Nat Immunol , vol.16 , pp. 942-949
    • Meredith, M.1    Zemmour, D.2    Mathis, D.3    Benoist, C.4
  • 12
    • 34248598295 scopus 로고    scopus 로고
    • + regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    • + regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol 2007;8:351-358.
    • (2007) Nat Immunol , vol.8 , pp. 351-358
    • Aschenbrenner, K.1
  • 13
    • 84928581675 scopus 로고    scopus 로고
    • Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
    • Yang S, Fujikado N, Kolodin D, Benoist C, Mathis D. Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science 2015;348:589-594.
    • (2015) Science , vol.348 , pp. 589-594
    • Yang, S.1    Fujikado, N.2    Kolodin, D.3    Benoist, C.4    Mathis, D.5
  • 14
    • 56749161528 scopus 로고    scopus 로고
    • Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
    • Peterson P, Org T, Rebane A. Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat Rev Immunol 2008;8:948-957.
    • (2008) Nat Rev Immunol , vol.8 , pp. 948-957
    • Peterson, P.1    Org, T.2    Rebane, A.3
  • 16
    • 84953837556 scopus 로고    scopus 로고
    • AIRE: from promiscuous molecular partnerships to promiscuous gene expression
    • [Epub ahead of print].
    • Abramson J, Goldfarb Y. AIRE: from promiscuous molecular partnerships to promiscuous gene expression. Eur J Immunol 2015. doi:10.1002/eji.201545792. [Epub ahead of print].
    • (2015) Eur J Immunol
    • Abramson, J.1    Goldfarb, Y.2
  • 17
    • 77349099732 scopus 로고    scopus 로고
    • Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect
    • Cheng MH, et al. Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect. N Engl J Med 2010;362:764-766.
    • (2010) N Engl J Med , vol.362 , pp. 764-766
    • Cheng, M.H.1
  • 18
    • 84907481828 scopus 로고    scopus 로고
    • Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors
    • Wolff AS, et al. Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors. J Immunol 2014;193:3880-3890.
    • (2014) J Immunol , vol.193 , pp. 3880-3890
    • Wolff, A.S.1
  • 19
    • 84946781804 scopus 로고    scopus 로고
    • Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency
    • Walter JE, et al. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest 2015;125:4135-4148.
    • (2015) J Clin Invest , vol.125 , pp. 4135-4148
    • Walter, J.E.1
  • 20
    • 20044376279 scopus 로고    scopus 로고
    • AIRE deficiency in thymus of 2 patients with Omenn syndrome
    • Cavadini P, et al. AIRE deficiency in thymus of 2 patients with Omenn syndrome. J Clin Invest 2005;115:728-732.
    • (2005) J Clin Invest , vol.115 , pp. 728-732
    • Cavadini, P.1
  • 21
    • 84891339888 scopus 로고    scopus 로고
    • The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein
    • Perniola R, Musco G. The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein. Biochim Biophys Acta 2014;1842:326-337.
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 326-337
    • Perniola, R.1    Musco, G.2
  • 22
    • 38349110211 scopus 로고    scopus 로고
    • AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity
    • Ferguson BJ, et al. AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity. J Biol Chem 2008;283:1723-1731.
    • (2008) J Biol Chem , vol.283 , pp. 1723-1731
    • Ferguson, B.J.1
  • 23
    • 84922105556 scopus 로고    scopus 로고
    • The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-kappaB signaling
    • Kao WP, Yang CY, Su TW, Wang YT, Lo YC, Lin SC. The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-kappaB signaling. Apoptosis 2015;20:174-195.
    • (2015) Apoptosis , vol.20 , pp. 174-195
    • Kao, W.P.1    Yang, C.Y.2    Su, T.W.3    Wang, Y.T.4    Lo, Y.C.5    Lin, S.C.6
  • 24
    • 0038824426 scopus 로고    scopus 로고
    • The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein
    • Pitkanen J, et al. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J Biol Chem 2000;275:16802-16809.
    • (2000) J Biol Chem , vol.275 , pp. 16802-16809
    • Pitkanen, J.1
  • 25
    • 0035798665 scopus 로고    scopus 로고
    • The autoimmune regulator (AIRE) is a DNA-binding protein
    • Kumar PG, et al. The autoimmune regulator (AIRE) is a DNA-binding protein. J Biol Chem 2001;276:41357-41364.
    • (2001) J Biol Chem , vol.276 , pp. 41357-41364
    • Kumar, P.G.1
  • 26
    • 84894431935 scopus 로고    scopus 로고
    • The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance
    • Waterfield M, et al. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol 2014;15:258-265.
    • (2014) Nat Immunol , vol.15 , pp. 258-265
    • Waterfield, M.1
  • 27
    • 0034749749 scopus 로고    scopus 로고
    • A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis
    • Cetani F, et al. A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis. J Clin Endocrinol Metab 2001;86:4747-4752.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4747-4752
    • Cetani, F.1
  • 28
    • 43049128502 scopus 로고    scopus 로고
    • Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
    • Su MA, et al. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest 2008;118:1712-1726.
    • (2008) J Clin Invest , vol.118 , pp. 1712-1726
    • Su, M.A.1
  • 30
    • 0038309923 scopus 로고    scopus 로고
    • Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions
    • Surdo PL, Bottomley MJ, Sattler M, Scheffzek K. Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions. Mol Endocrinol 2003;17:1283-1295.
    • (2003) Mol Endocrinol , vol.17 , pp. 1283-1295
    • Surdo, P.L.1    Bottomley, M.J.2    Sattler, M.3    Scheffzek, K.4
  • 31
    • 56749174388 scopus 로고    scopus 로고
    • Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity
    • Koh AS, et al. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci USA 2008;105:15878-15883.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15878-15883
    • Koh, A.S.1
  • 32
    • 45849137524 scopus 로고    scopus 로고
    • The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
    • Org T, et al. The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep 2008;9:370-376.
    • (2008) EMBO Rep , vol.9 , pp. 370-376
    • Org, T.1
  • 33
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group
    • Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329:977-986.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 34
    • 84873107959 scopus 로고    scopus 로고
    • Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance
    • Yang S, Bansal K, Lopes J, Benoist C, Mathis D. Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proc Natl Acad Sci USA 2013;110:1833-1838.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 1833-1838
    • Yang, S.1    Bansal, K.2    Lopes, J.3    Benoist, C.4    Mathis, D.5
  • 35
    • 0033590981 scopus 로고    scopus 로고
    • Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla
    • Heino M, et al. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem Biophys Res Commun 1999;257:821-825.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 821-825
    • Heino, M.1
  • 36
    • 0035147378 scopus 로고    scopus 로고
    • Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)
    • Halonen M, Pelto-Huikko M, Eskelin P, Peltonen L, Ulmanen I, Kolmer M. Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED). J Histochem Cytochem 2001;49:197-208.
    • (2001) J Histochem Cytochem , vol.49 , pp. 197-208
    • Halonen, M.1    Pelto-Huikko, M.2    Eskelin, P.3    Peltonen, L.4    Ulmanen, I.5    Kolmer, M.6
  • 37
    • 49449093723 scopus 로고    scopus 로고
    • Deletional tolerance mediated by extrathymic Aire-expressing cells
    • Gardner JM, et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 2008;321:843-847.
    • (2008) Science , vol.321 , pp. 843-847
    • Gardner, J.M.1
  • 38
    • 84937631527 scopus 로고    scopus 로고
    • Thymic B cells are licensed to present self antigens for central T cell tolerance induction
    • Yamano T, et al. Thymic B cells are licensed to present self antigens for central T cell tolerance induction. Immunity 2015;42:1048-1061.
    • (2015) Immunity , vol.42 , pp. 1048-1061
    • Yamano, T.1
  • 39
    • 77952302980 scopus 로고    scopus 로고
    • Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
    • Nishikawa Y, et al. Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med 2010;207:963-971.
    • (2010) J Exp Med , vol.207 , pp. 963-971
    • Nishikawa, Y.1
  • 40
    • 40749106576 scopus 로고    scopus 로고
    • Expression of Aire and the early wave of apoptosis in spermatogenesis
    • Schaller CE, et al. Expression of Aire and the early wave of apoptosis in spermatogenesis. J Immunol 2008;180:1338-1343.
    • (2008) J Immunol , vol.180 , pp. 1338-1343
    • Schaller, C.E.1
  • 41
    • 0033939699 scopus 로고    scopus 로고
    • RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse
    • Heino M, et al. RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse. Eur J Immunol 2000;30:1884-1893.
    • (2000) Eur J Immunol , vol.30 , pp. 1884-1893
    • Heino, M.1
  • 43
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray D, Abramson J, Benoist C, Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 2007;204:2521-2528.
    • (2007) J Exp Med , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 44
    • 56749184864 scopus 로고    scopus 로고
    • Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated
    • Villasenor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci USA 2008;105:15854-15859.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15854-15859
    • Villasenor, J.1    Besse, W.2    Benoist, C.3    Mathis, D.4
  • 45
    • 84939600854 scopus 로고    scopus 로고
    • Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells
    • Brennecke P, et al. Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells. Nat Immunol 2015;16:933-941.
    • (2015) Nat Immunol , vol.16 , pp. 933-941
    • Brennecke, P.1
  • 46
    • 33750585066 scopus 로고    scopus 로고
    • NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway
    • Zhu M, et al. NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J Clin Invest 2006;116:2964-2971.
    • (2006) J Clin Invest , vol.116 , pp. 2964-2971
    • Zhu, M.1
  • 47
    • 0242624626 scopus 로고    scopus 로고
    • Lymphotoxin pathway directs thymic Aire expression
    • Chin RK, et al. Lymphotoxin pathway directs thymic Aire expression. Nat Immunol 2003;4:1121-1127.
    • (2003) Nat Immunol , vol.4 , pp. 1121-1127
    • Chin, R.K.1
  • 48
    • 84952639529 scopus 로고    scopus 로고
    • A highly conserved NF-kappaB-responsive enhancer is critical for thymic expression of Aire in mice
    • Haljasorg U, et al. A highly conserved NF-kappaB-responsive enhancer is critical for thymic expression of Aire in mice. Eur J Immunol 2015;45:3246-3256.
    • (2015) Eur J Immunol , vol.45 , pp. 3246-3256
    • Haljasorg, U.1
  • 49
    • 84961281515 scopus 로고    scopus 로고
    • Identification of a novel cis-regulatory element essential for immune tolerance
    • LaFlam TN, et al. Identification of a novel cis-regulatory element essential for immune tolerance. J Exp Med 2015;212:1993-2002.
    • (2015) J Exp Med , vol.212 , pp. 1993-2002
    • LaFlam, T.N.1
  • 50
    • 84946600428 scopus 로고    scopus 로고
    • Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus
    • Yanagihara T, et al. Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus. Nat Commun 2015;6:8820.
    • (2015) Nat Commun , vol.6 , pp. 8820
    • Yanagihara, T.1
  • 51
    • 70450192681 scopus 로고    scopus 로고
    • AIRE activated tissue specific genes have histone modifications associated with inactive chromatin
    • Org T, et al. AIRE activated tissue specific genes have histone modifications associated with inactive chromatin. Hum Mol Genet 2009;18:4699-4710.
    • (2009) Hum Mol Genet , vol.18 , pp. 4699-4710
    • Org, T.1
  • 52
    • 84855995571 scopus 로고    scopus 로고
    • Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
    • Giraud M, et al. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc Natl Acad Sci USA 2012;109:535-540.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 535-540
    • Giraud, M.1
  • 53
    • 84923780299 scopus 로고    scopus 로고
    • Getting up to speed with transcription elongation by RNA polymerase II
    • Jonkers I, Lis JT. Getting up to speed with transcription elongation by RNA polymerase II. Nat Rev Mol Cell Biol 2015;16:167-177.
    • (2015) Nat Rev Mol Cell Biol , vol.16 , pp. 167-177
    • Jonkers, I.1    Lis, J.T.2
  • 54
    • 37549060329 scopus 로고    scopus 로고
    • AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells
    • Oven I, Brdickova N, Kohoutek J, Vaupotic T, Narat M, Peterlin BM. AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol Cell Biol 2007;27:8815-8823.
    • (2007) Mol Cell Biol , vol.27 , pp. 8815-8823
    • Oven, I.1    Brdickova, N.2    Kohoutek, J.3    Vaupotic, T.4    Narat, M.5    Peterlin, B.M.6
  • 55
    • 84893370802 scopus 로고    scopus 로고
    • An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription
    • Giraud M, et al. An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription. Proc Natl Acad Sci USA 2014;111:1491-1496.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 1491-1496
    • Giraud, M.1
  • 56
    • 84938921551 scopus 로고    scopus 로고
    • Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells
    • Yoshida H, et al. Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells. Proc Natl Acad Sci USA 2015;112:E4448-E4457.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. E4448-E4457
    • Yoshida, H.1
  • 57
    • 23744514308 scopus 로고    scopus 로고
    • The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
    • Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell 2005;19:523-534.
    • (2005) Mol Cell , vol.19 , pp. 523-534
    • Jang, M.K.1    Mochizuki, K.2    Zhou, M.3    Jeong, H.S.4    Brady, J.N.5    Ozato, K.6
  • 58
    • 84925556593 scopus 로고    scopus 로고
    • BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones
    • Kanno T, et al. BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones. Nat Struct Mol Biol 2014;21:1047-1057.
    • (2014) Nat Struct Mol Biol , vol.21 , pp. 1047-1057
    • Kanno, T.1
  • 59
    • 84961574727 scopus 로고    scopus 로고
    • A genetically encoded FRET probe to detect intranucleosomal histone H3K9 or H3K14 acetylation using BRD4, a BET family member
    • [Epub ahead of print].
    • Nakaoka S, Sasaki K, Ito A, Nakao Y, Yoshida M. A genetically encoded FRET probe to detect intranucleosomal histone H3K9 or H3K14 acetylation using BRD4, a BET family member. ACS Chem Biol 2015. doi:10.1021/cb501046t. [Epub ahead of print].
    • (2015) ACS Chem Biol
    • Nakaoka, S.1    Sasaki, K.2    Ito, A.3    Nakao, Y.4    Yoshida, M.5
  • 60
    • 73149115486 scopus 로고    scopus 로고
    • Aire's partners in the molecular control of immunological tolerance
    • Abramson J, Giraud M, Benoist C, Mathis D. Aire's partners in the molecular control of immunological tolerance. Cell 2010;140:123-135.
    • (2010) Cell , vol.140 , pp. 123-135
    • Abramson, J.1    Giraud, M.2    Benoist, C.3    Mathis, D.4
  • 61
    • 38049026826 scopus 로고    scopus 로고
    • DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity
    • Liiv I, et al. DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. Biochim Biophys Acta 2008;1783:74-83.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 74-83
    • Liiv, I.1
  • 62
    • 84871186320 scopus 로고    scopus 로고
    • AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome
    • Gaetani M, et al. AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome. Nucleic Acids Res 2012;40:11756-11768.
    • (2012) Nucleic Acids Res , vol.40 , pp. 11756-11768
    • Gaetani, M.1
  • 63
    • 84861325370 scopus 로고    scopus 로고
    • Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes
    • Zumer K, Low AK, Jiang H, Saksela K, Peterlin BM. Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes. Mol Cell Biol 2012;32:1354-1362.
    • (2012) Mol Cell Biol , vol.32 , pp. 1354-1362
    • Zumer, K.1    Low, A.K.2    Jiang, H.3    Saksela, K.4    Peterlin, B.M.5
  • 64
    • 84942619984 scopus 로고    scopus 로고
    • PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity
    • Mathieu AL, et al. PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. J Allergy Clin Immunol 2015;135(1578-1588):e1575.
    • (2015) J Allergy Clin Immunol , vol.135 , Issue.1578-1588 , pp. e1575
    • Mathieu, A.L.1
  • 65
    • 4043130957 scopus 로고    scopus 로고
    • Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner
    • Akiyoshi H, et al. Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. J Biol Chem 2004;279:33984-33991.
    • (2004) J Biol Chem , vol.279 , pp. 33984-33991
    • Akiyoshi, H.1
  • 66
    • 20744433548 scopus 로고    scopus 로고
    • Cooperative activation of transcription by autoimmune regulator AIRE and CBP
    • Pitkanen J, et al. Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochem Biophys Res Commun 2005;333:944-953.
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 944-953
    • Pitkanen, J.1
  • 67
    • 84931432951 scopus 로고    scopus 로고
    • The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance
    • Chuprin A, et al. The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance. Nat Immunol 2015;16:737-745.
    • (2015) Nat Immunol , vol.16 , pp. 737-745
    • Chuprin, A.1
  • 68
    • 51649112590 scopus 로고    scopus 로고
    • sirt1-null mice develop an autoimmune-like condition
    • Sequeira J, et al. sirt1-null mice develop an autoimmune-like condition. Exp Cell Res 2008;314:3069-3074.
    • (2008) Exp Cell Res , vol.314 , pp. 3069-3074
    • Sequeira, J.1
  • 69
    • 84855421642 scopus 로고    scopus 로고
    • Sirtuin 1 in immune regulation and autoimmunity
    • Kong S, McBurney MW, Fang D. Sirtuin 1 in immune regulation and autoimmunity. Immunol Cell Biol 2012;90:6-13.
    • (2012) Immunol Cell Biol , vol.90 , pp. 6-13
    • Kong, S.1    McBurney, M.W.2    Fang, D.3
  • 70
    • 84875332275 scopus 로고    scopus 로고
    • Identification of a SIRT1 mutation in a family with type 1 diabetes
    • Biason-Lauber A, et al. Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metab 2013;17:448-455.
    • (2013) Cell Metab , vol.17 , pp. 448-455
    • Biason-Lauber, A.1
  • 71
    • 13544262691 scopus 로고    scopus 로고
    • Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
    • Kuroda N, et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol 2005;174:1862-1870.
    • (2005) J Immunol , vol.174 , pp. 1862-1870
    • Kuroda, N.1
  • 73
    • 33846203837 scopus 로고    scopus 로고
    • A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    • Kekalainen E, et al. A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Immunol 2007;178:1208-1215.
    • (2007) J Immunol , vol.178 , pp. 1208-1215
    • Kekalainen, E.1
  • 74
    • 77958150859 scopus 로고    scopus 로고
    • Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population
    • Laakso SM, et al. Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population. J Autoimmun 2010;35:351-357.
    • (2010) J Autoimmun , vol.35 , pp. 351-357
    • Laakso, S.M.1
  • 75
    • 79151482847 scopus 로고    scopus 로고
    • The susceptibility of Aire(-/-) mice to experimental myasthenia gravis involves alterations in regulatory T cells
    • Aricha R, Feferman T, Scott HS, Souroujon MC, Berrih-Aknin S, Fuchs S. The susceptibility of Aire(-/-) mice to experimental myasthenia gravis involves alterations in regulatory T cells. J Autoimmun 2011;36:16-24.
    • (2011) J Autoimmun , vol.36 , pp. 16-24
    • Aricha, R.1    Feferman, T.2    Scott, H.S.3    Souroujon, M.C.4    Berrih-Aknin, S.5    Fuchs, S.6
  • 76
    • 79951715831 scopus 로고    scopus 로고
    • Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
    • Lei Y, et al. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med 2011;208:383-394.
    • (2011) J Exp Med , vol.208 , pp. 383-394
    • Lei, Y.1
  • 77
    • 84874745221 scopus 로고    scopus 로고
    • Aire-dependent thymic development of tumor-associated regulatory T cells
    • Malchow S, et al. Aire-dependent thymic development of tumor-associated regulatory T cells. Science 2013;339:1219-1224.
    • (2013) Science , vol.339 , pp. 1219-1224
    • Malchow, S.1
  • 78
    • 84907982768 scopus 로고    scopus 로고
    • Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus
    • Perry JS, et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity 2014;41:414-426.
    • (2014) Immunity , vol.41 , pp. 414-426
    • Perry, J.S.1
  • 79
    • 0025295238 scopus 로고
    • Clinical variation of autoimmune polyendocrinopathy-candidiasis- ectodermal dystrophy (APECED) in a series of 68 patients
    • Ahonen P, Myllarniemi S, Sipila I, Perheentupa J. Clinical variation of autoimmune polyendocrinopathy-candidiasis- ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med 1990;322:1829-1836.
    • (1990) N Engl J Med , vol.322 , pp. 1829-1836
    • Ahonen, P.1    Myllarniemi, S.2    Sipila, I.3    Perheentupa, J.4
  • 80
    • 0000283137 scopus 로고
    • Chronic tetany and chronic mycelial stomatitis in a child ages 4 and a half years
    • Thorpe ES, Handley HE. Chronic tetany and chronic mycelial stomatitis in a child ages 4 and a half years. Am J Dis Child 1929;38:328-338.
    • (1929) Am J Dis Child , vol.38 , pp. 328-338
    • Thorpe, E.S.1    Handley, H.E.2
  • 81
    • 0019811879 scopus 로고
    • Two types of autoimmune Addison's disease associated with different polyglandular autoimmune (PGA) syndromes
    • Neufeld M, Maclaren NK, Blizzard RM. Two types of autoimmune Addison's disease associated with different polyglandular autoimmune (PGA) syndromes. Medicine (Baltimore) 1981;60:355-362.
    • (1981) Medicine (Baltimore) , vol.60 , pp. 355-362
    • Neufeld, M.1    Maclaren, N.K.2    Blizzard, R.M.3
  • 82
    • 10744233772 scopus 로고    scopus 로고
    • Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I
    • Soderbergh A, et al. Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 2004;89:557-562.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 557-562
    • Soderbergh, A.1
  • 83
    • 77952310454 scopus 로고    scopus 로고
    • Autoimmune polyglandular syndrome type 1 in Russian patients: clinical variants and autoimmune regulator mutations
    • Orlova EM, et al. Autoimmune polyglandular syndrome type 1 in Russian patients: clinical variants and autoimmune regulator mutations. Horm Res Paed 2010;73:449-457.
    • (2010) Horm Res Paed , vol.73 , pp. 449-457
    • Orlova, E.M.1
  • 84
    • 85047684725 scopus 로고    scopus 로고
    • Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction
    • Betterle C, Dal Pra C, Mantero F, Zanchetta R. Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev 2002;23:327-364.
    • (2002) Endocr Rev , vol.23 , pp. 327-364
    • Betterle, C.1    Dal Pra, C.2    Mantero, F.3    Zanchetta, R.4
  • 85
    • 40449109084 scopus 로고    scopus 로고
    • Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen
    • Alimohammadi M, et al. Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med 2008;358:1018-1028.
    • (2008) N Engl J Med , vol.358 , pp. 1018-1028
    • Alimohammadi, M.1
  • 86
    • 84885461634 scopus 로고    scopus 로고
    • BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease
    • 206ra139
    • Shum AK, et al. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Trans Med 2013;5:206ra139.
    • (2013) Sci Trans Med , vol.5
    • Shum, A.K.1
  • 87
    • 33747662305 scopus 로고    scopus 로고
    • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    • Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab 2006;91:2843-2850.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2843-2850
    • Perheentupa, J.1
  • 88
    • 54049151288 scopus 로고    scopus 로고
    • Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency
    • Bensing S, et al. Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency. Clin Endocrinol (Oxf) 2008;69:697-704.
    • (2008) Clin Endocrinol (Oxf) , vol.69 , pp. 697-704
    • Bensing, S.1
  • 89
    • 0242536432 scopus 로고    scopus 로고
    • Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy protein
    • Bjorses P, et al. Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy protein. Am J Hum Genet 2000;66:378-392.
    • (2000) Am J Hum Genet , vol.66 , pp. 378-392
    • Bjorses, P.1
  • 90
    • 33748299062 scopus 로고    scopus 로고
    • Molecular background of polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome in a Polish population: novel AIRE mutations and an estimate of disease prevalence
    • Stolarski B, et al. Molecular background of polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome in a Polish population: novel AIRE mutations and an estimate of disease prevalence. Clin Genet 2006;70:348-354.
    • (2006) Clin Genet , vol.70 , pp. 348-354
    • Stolarski, B.1
  • 91
    • 33846990524 scopus 로고    scopus 로고
    • Autoimmune polyendocrine syndrome type 1 in Norway: phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene
    • Wolff AS, et al. Autoimmune polyendocrine syndrome type 1 in Norway: phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene. J Clin Endocrinol Metab 2007;92:595-603.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 595-603
    • Wolff, A.S.1
  • 92
    • 0032470812 scopus 로고    scopus 로고
    • A common and recurrent 13-bp deletion in the autoimmune regulator gene in British kindreds with autoimmune polyendocrinopathy type 1
    • Pearce SH, et al. A common and recurrent 13-bp deletion in the autoimmune regulator gene in British kindreds with autoimmune polyendocrinopathy type 1. Am J Hum Genet 1998;63:1675-1684.
    • (1998) Am J Hum Genet , vol.63 , pp. 1675-1684
    • Pearce, S.H.1
  • 93
    • 84868328888 scopus 로고    scopus 로고
    • Clinical phenotypes of autoimmune polyendocrinopathycandidiasis-ectodermal dystrophy seen in the Northern Ireland paediatric population over the last 30 years
    • Millar S, Carson D. Clinical phenotypes of autoimmune polyendocrinopathycandidiasis-ectodermal dystrophy seen in the Northern Ireland paediatric population over the last 30 years. Ulster Med J 2012;81:118-122.
    • (2012) Ulster Med J , vol.81 , pp. 118-122
    • Millar, S.1    Carson, D.2
  • 94
    • 0029836686 scopus 로고    scopus 로고
    • Genetic homogeneity of autoimmune polyglandular disease type I
    • Bjorses P, et al. Genetic homogeneity of autoimmune polyglandular disease type I. Am J Hum Genet 1996;59:879-886.
    • (1996) Am J Hum Genet , vol.59 , pp. 879-886
    • Bjorses, P.1
  • 95
    • 0031753977 scopus 로고    scopus 로고
    • A common mutation in Sardinian autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy patients
    • Rosatelli MC, et al. A common mutation in Sardinian autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy patients. Hum Genet 1998;103:428-434.
    • (1998) Hum Genet , vol.103 , pp. 428-434
    • Rosatelli, M.C.1
  • 96
    • 18444378139 scopus 로고    scopus 로고
    • AIRE mutations and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy phenotype
    • Halonen M, et al. AIRE mutations and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy phenotype. J Clin Endocrinol Metab 2002;87:2568-2574.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2568-2574
    • Halonen, M.1
  • 97
    • 0026481974 scopus 로고
    • Polyglandular autoimmune syndrome type I among Iranian Jews
    • Zlotogora J, Shapiro MS. Polyglandular autoimmune syndrome type I among Iranian Jews. J Med Genet 1992;29:824-826.
    • (1992) J Med Genet , vol.29 , pp. 824-826
    • Zlotogora, J.1    Shapiro, M.S.2
  • 98
    • 0037084784 scopus 로고    scopus 로고
    • Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
    • Ramsey C, et al. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 2002;11:397-409.
    • (2002) Hum Mol Genet , vol.11 , pp. 397-409
    • Ramsey, C.1
  • 99
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski J, Schulte A, Kyewski B, Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2001;2:1032-1039.
    • (2001) Nat Immunol , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 100
    • 25144432460 scopus 로고    scopus 로고
    • Modifier loci condition autoimmunity provoked by Aire deficiency
    • Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 2005;202:805-815.
    • (2005) J Exp Med , vol.202 , pp. 805-815
    • Jiang, W.1    Anderson, M.S.2    Bronson, R.3    Mathis, D.4    Benoist, C.5
  • 101
    • 33746423947 scopus 로고    scopus 로고
    • Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1
    • Meager A, et al. Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med 2006;3:e289.
    • (2006) PLoS Med , vol.3 , pp. e289
    • Meager, A.1
  • 102
    • 33749524196 scopus 로고    scopus 로고
    • Aire deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients
    • Pontynen N, et al. Aire deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients. J Autoimmun 2006;27:96-104.
    • (2006) J Autoimmun , vol.27 , pp. 96-104
    • Pontynen, N.1
  • 103
    • 84931466170 scopus 로고    scopus 로고
    • Transglutaminase 4 as a prostate autoantigen in male subfertility
    • 292ra101
    • Landegren N, et al. Transglutaminase 4 as a prostate autoantigen in male subfertility. Sci Trans Med 2015;7:292ra101.
    • (2015) Sci Trans Med , vol.7
    • Landegren, N.1
  • 104
    • 33947694597 scopus 로고    scopus 로고
    • Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1)
    • Strobel P, et al. Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1). J Pathol 2007;211:563-571.
    • (2007) J Pathol , vol.211 , pp. 563-571
    • Strobel, P.1
  • 105
    • 0031556856 scopus 로고    scopus 로고
    • Spontaneous neutralising antibodies to interferon-alpha and interleukin-12 in thymoma-associated autoimmune disease
    • Meager A, Vincent A, Newsom-Davis J, Willcox N. Spontaneous neutralising antibodies to interferon-alpha and interleukin-12 in thymoma-associated autoimmune disease. Lancet 1997;350:1596-1597.
    • (1997) Lancet , vol.350 , pp. 1596-1597
    • Meager, A.1    Vincent, A.2    Newsom-Davis, J.3    Willcox, N.4
  • 106
    • 70349440053 scopus 로고    scopus 로고
    • The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
    • Zhang J, et al. The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest 2009;119:3048-3058.
    • (2009) J Clin Invest , vol.119 , pp. 3048-3058
    • Zhang, J.1
  • 107
    • 84906344581 scopus 로고    scopus 로고
    • + T-regulatory cells
    • + T-regulatory cells. Mucosal Immunol 2014;7:1209-1220.
    • (2014) Mucosal Immunol , vol.7 , pp. 1209-1220
    • Akimova, T.1
  • 108
    • 79952274915 scopus 로고    scopus 로고
    • + T-regulatory cell function and prolongs allograft survival
    • + T-regulatory cell function and prolongs allograft survival. Mol Cell Biol 2011;31:1022-1029.
    • (2011) Mol Cell Biol , vol.31 , pp. 1022-1029
    • Beier, U.H.1
  • 110
    • 84899767409 scopus 로고    scopus 로고
    • Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance
    • Khan IS, et al. Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J Exp Med 2014;211:761-768.
    • (2014) J Exp Med , vol.211 , pp. 761-768
    • Khan, I.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.