The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

Nature Immunology

Volumn 16, Issue 7, 2015, Pages 737-745

  Chuprin, Anna ^a   Avin, Ayelet ^a   Goldfarb, Yael ^a   Herzig, Yonatan ^a   Levi, Ben ^a   Jacob, Adi ^a   Sela, Asaf ^a   Katz, Shir ^a   Grossman, Moran ^a   Guyon, Clotilde ^b   Rathaus, Moran ^c   Cohen, Haim Y ^c   Sagi, Irit ^a   Giraud, Matthieu ^b   McBurney, Michael W ^d   Husebye, Eystein S ^e   Abramson, Jakub ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b INSTITUT COCHIN   (France)

^c BAR ILAN UNIVERSITY   (Israel)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOIMMUNE REGULATOR PROTEIN; COLLAGENASE 3; GELATINASE B; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; SIRTUIN 1; TISSUE ANTIGEN; TISSUE RESTRICTED ANTIGEN; UNCLASSIFIED DRUG; ANTIGEN; IL2RG PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR GAMMA; PROTEIN BINDING; SIRT1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; CELL LYSATE; COMPARATIVE STUDY; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVE SITE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOLOGICAL TOLERANCE; IMMUNOPRECIPITATION; KIDNEY CAPSULE; LYMPHOCYTIC INFILTRATION; MASS SPECTROMETRY; MEDULLARY THYMIC EPITHELIAL CELL; MICROARRAY ANALYSIS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RNA SEQUENCE; STABLE EXPRESSION; THYMOCYTE; ACETYLATION; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CYTOLOGY; DEFICIENCY; DNA MICROARRAY; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; NONOBESE DIABETIC MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; THYMUS; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ACETYLATION; ANIMALS; ANTIGENS; CENTRAL TOLERANCE; EPITHELIAL CELLS; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SPECIFICITY; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIRTUIN 1; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSCRIPTOME;

EID: 84931432951     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3194     Document Type: Article

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