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Volumn 45, Issue 12, 2015, Pages 3246-3256

A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice

Author keywords

Autoimmune regulator; Enhancer; NF B; Receptor activator of nuclear factor B; Thymic medulla

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR7; CONSERVED NONCODING SEQUENCE 1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SECONDARY LYMPHOID TISSUE CHEMOKINE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; TNFRSF11A PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

EID: 84952639529     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545928     Document Type: Article
Times cited : (47)

References (50)
  • 1
    • 84901487911 scopus 로고    scopus 로고
    • Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
    • Klein, L., Kyewski, B., Allen, P. M. and Hogquist, K. A., Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat. Rev. Immunol. 2014. 14: 377-391.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 377-391
    • Klein, L.1    Kyewski, B.2    Allen, P.M.3    Hogquist, K.A.4
  • 2
    • 36448949476 scopus 로고    scopus 로고
    • Generating intrathymic microenvironments to establish T-cell tolerance
    • Anderson, G., Lane, P. J. and Jenkinson, E. J., Generating intrathymic microenvironments to establish T-cell tolerance. Nat. Rev. Immunol. 2007. 7: 954-963.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 954-963
    • Anderson, G.1    Lane, P.J.2    Jenkinson, E.J.3
  • 3
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski, J., Schulte, A., Kyewski, B. and Klein, L., Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2001. 2: 1032-1039.
    • (2001) Nat. Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 4
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • Kyewski, B. and Klein, L., A central role for central tolerance. Annu. Rev. Immunol. 2006. 24: 571-606.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 7
    • 56749161528 scopus 로고    scopus 로고
    • Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
    • Peterson, P., Org, T. and Rebane, A., Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat. Rev. Immunol. 2008. 8: 948-957.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 948-957
    • Peterson, P.1    Org, T.2    Rebane, A.3
  • 8
    • 84872494068 scopus 로고    scopus 로고
    • Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    • Danso-Abeam, D., Staats, K. A., Franckaert, D., Van Den Bosch, L., Liston, A., Gray, D. H. and Dooley, J., Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism. Eur. J. Immunol. 2013. 43: 75-84.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 75-84
    • Danso-Abeam, D.1    Staats, K.A.2    Franckaert, D.3    Van Den Bosch, L.4    Liston, A.5    Gray, D.H.6    Dooley, J.7
  • 10
    • 1542269618 scopus 로고    scopus 로고
    • Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity
    • Peterson, P., Pitkanen, J., Sillanpaa, N. and Krohn, K., Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity. Clin. Exp. Immunol. 2004. 135: 348-357.
    • (2004) Clin. Exp. Immunol. , vol.135 , pp. 348-357
    • Peterson, P.1    Pitkanen, J.2    Sillanpaa, N.3    Krohn, K.4
  • 11
    • 0346599403 scopus 로고    scopus 로고
    • Finnish-German-Consortium, an autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
    • Finnish-German-Consortium, an autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 1997. 17: 399-403.
    • (1997) Nat. Genet. , vol.17 , pp. 399-403
  • 12
    • 84895532029 scopus 로고    scopus 로고
    • Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients
    • 1-10.
    • Kisand, K., Peterson, P. and Laan, M., Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients. Front. Immunol. 2014. 5: 51: 1-10.
    • (2014) Front. Immunol. , vol.5 , pp. 51
    • Kisand, K.1    Peterson, P.2    Laan, M.3
  • 13
    • 33746423947 scopus 로고    scopus 로고
    • Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1
    • Meager, A., Visvalingam, K., Peterson, P., Moll, K., Murumagi, A., Krohn, K., Eskelin, P. et al., Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med. 2006. 3: e289: 1152-1164.
    • (2006) PLoS Med. , vol.3 , pp. 1152-1164
    • Meager, A.1    Visvalingam, K.2    Peterson, P.3    Moll, K.4    Murumagi, A.5    Krohn, K.6    Eskelin, P.7
  • 14
    • 84872711825 scopus 로고    scopus 로고
    • Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens
    • 1-16.
    • Wang, X., Laan, M., Bichele, R., Kisand, K., Scott, H. S. and Peterson, P., Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front. Immunol. 2012. 3: 19: 1-16.
    • (2012) Front. Immunol. , vol.3 , pp. 19
    • Wang, X.1    Laan, M.2    Bichele, R.3    Kisand, K.4    Scott, H.S.5    Peterson, P.6
  • 15
    • 77952302980 scopus 로고    scopus 로고
    • Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
    • Nishikawa, Y., Hirota, F., Yano, M., Kitajima, H., Miyazaki, J., Kawamoto, H., Mouri, Y. et al., Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J. Exp. Med. 2010. 207: 963-971.
    • (2010) J. Exp. Med. , vol.207 , pp. 963-971
    • Nishikawa, Y.1    Hirota, F.2    Yano, M.3    Kitajima, H.4    Miyazaki, J.5    Kawamoto, H.6    Mouri, Y.7
  • 17
    • 34250336454 scopus 로고    scopus 로고
    • RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
    • Rossi, S. W., Kim, M. Y., Leibbrandt, A., Parnell, S. M., Jenkinson, W. E., Glanville, S. H., McConnell, F. M. et al., RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J. Exp. Med. 2007. 204: 1267-1272.
    • (2007) J. Exp. Med. , vol.204 , pp. 1267-1272
    • Rossi, S.W.1    Kim, M.Y.2    Leibbrandt, A.3    Parnell, S.M.4    Jenkinson, W.E.5    Glanville, S.H.6    McConnell, F.M.7
  • 18
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray, D., Abramson, J., Benoist, C. and Mathis, D., Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J. Exp. Med. 2007. 204: 2521-2528.
    • (2007) J. Exp. Med. , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 23
    • 84937631527 scopus 로고    scopus 로고
    • Thymic B cells are licensed to present self antigens for central T cell tolerance induction
    • Yamano, T., Nedjic, J., Hinterberger, M., Steinert, M., Koser, S., Pinto, S., Gerdes, N. et al., Thymic B cells are licensed to present self antigens for central T cell tolerance induction. Immunity 2015. 42: 1048-1061.
    • (2015) Immunity , vol.42 , pp. 1048-1061
    • Yamano, T.1    Nedjic, J.2    Hinterberger, M.3    Steinert, M.4    Koser, S.5    Pinto, S.6    Gerdes, N.7
  • 24
    • 51349092893 scopus 로고    scopus 로고
    • The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
    • Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M. et al., The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 2008. 29: 438-450.
    • (2008) Immunity , vol.29 , pp. 438-450
    • Hikosaka, Y.1    Nitta, T.2    Ohigashi, I.3    Yano, K.4    Ishimaru, N.5    Hayashi, Y.6    Matsumoto, M.7
  • 25
    • 84874962972 scopus 로고    scopus 로고
    • Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors
    • Baik, S., Jenkinson, E. J., Lane, P. J., Anderson, G. and Jenkinson, W. E., Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors. Eur. J. Immunol. 2013. 43: 589-594.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 589-594
    • Baik, S.1    Jenkinson, E.J.2    Lane, P.J.3    Anderson, G.4    Jenkinson, W.E.5
  • 26
    • 51349111243 scopus 로고    scopus 로고
    • The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
    • Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y. et al., The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 2008. 29: 423-437.
    • (2008) Immunity , vol.29 , pp. 423-437
    • Akiyama, T.1    Shimo, Y.2    Yanai, H.3    Qin, J.4    Ohshima, D.5    Maruyama, Y.6    Asaumi, Y.7
  • 27
    • 51349101423 scopus 로고    scopus 로고
    • Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity
    • Irla, M., Hugues, S., Gill, J., Nitta, T., Hikosaka, Y., Williams, I. R., Hubert, F. X. et al., Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 2008. 29: 451-463.
    • (2008) Immunity , vol.29 , pp. 451-463
    • Irla, M.1    Hugues, S.2    Gill, J.3    Nitta, T.4    Hikosaka, Y.5    Williams, I.R.6    Hubert, F.X.7
  • 28
    • 84858795036 scopus 로고    scopus 로고
    • Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium
    • Roberts, N. A., White, A. J., Jenkinson, W. E., Turchinovich, G., Nakamura, K., Withers, D. R., McConnell, F. M. et al., Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium. Immunity 2012. 36: 427-437.
    • (2012) Immunity , vol.36 , pp. 427-437
    • Roberts, N.A.1    White, A.J.2    Jenkinson, W.E.3    Turchinovich, G.4    Nakamura, K.5    Withers, D.R.6    McConnell, F.M.7
  • 29
    • 84872172303 scopus 로고    scopus 로고
    • TNF receptor family signaling in the development and functions of medullary thymic epithelial cells
    • 1-9.
    • Akiyama, T., Shinzawa, M. and Akiyama, N., TNF receptor family signaling in the development and functions of medullary thymic epithelial cells. Front. Immunol. 2012. 3: 278: 1-9.
    • (2012) Front. Immunol. , vol.3 , pp. 278
    • Akiyama, T.1    Shinzawa, M.2    Akiyama, N.3
  • 30
    • 17544385823 scopus 로고    scopus 로고
    • Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter
    • Murumägi, A., Vähämurto, P. and Peterson, P., Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. J. Biol. Chem. 2003. 278: 19784-19790.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19784-19790
    • Murumägi, A.1    Vähämurto, P.2    Peterson, P.3
  • 32
    • 81955167444 scopus 로고    scopus 로고
    • DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues
    • Kont, V., Murumagi, A., Tykocinski, L. O., Kinkel, S. A., Webster, K. E., Kisand, K., Tserel, L. et al., DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues. Mol. Immunol. 2011. 49: 518-526.
    • (2011) Mol. Immunol. , vol.49 , pp. 518-526
    • Kont, V.1    Murumagi, A.2    Tykocinski, L.O.3    Kinkel, S.A.4    Webster, K.E.5    Kisand, K.6    Tserel, L.7
  • 37
    • 34548285420 scopus 로고    scopus 로고
    • Modulation of Aire regulates the expression of tissue-restricted antigens
    • Kont, V., Laan, M., Kisand, K., Merits, A., Scott, H. S. and Peterson, P., Modulation of Aire regulates the expression of tissue-restricted antigens. Mol. Immunol. 2008. 45: 25-33.
    • (2008) Mol. Immunol. , vol.45 , pp. 25-33
    • Kont, V.1    Laan, M.2    Kisand, K.3    Merits, A.4    Scott, H.S.5    Peterson, P.6
  • 38
    • 76249101988 scopus 로고    scopus 로고
    • Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
    • Laan, M., Kisand, K., Kont, V., Moll, K., Tserel, L., Scott, H. S. and Peterson, P., Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J. Immunol. 2009. 183: 7682-7691.
    • (2009) J. Immunol. , vol.183 , pp. 7682-7691
    • Laan, M.1    Kisand, K.2    Kont, V.3    Moll, K.4    Tserel, L.5    Scott, H.S.6    Peterson, P.7
  • 39
    • 79951715831 scopus 로고    scopus 로고
    • Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
    • Lei, Y., Ripen, A. M., Ishimaru, N., Ohigashi, I., Nagasawa, T., Jeker, L. T., Bosl, M. R. et al., Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J. Exp. Med. 2011. 208: 383-394.
    • (2011) J. Exp. Med. , vol.208 , pp. 383-394
    • Lei, Y.1    Ripen, A.M.2    Ishimaru, N.3    Ohigashi, I.4    Nagasawa, T.5    Jeker, L.T.6    Bosl, M.R.7
  • 40
    • 78650376503 scopus 로고    scopus 로고
    • Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla
    • Matsumoto, M., Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla. Eur. J. Immunol. 2011. 41: 12-17.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 12-17
    • Matsumoto, M.1
  • 41
    • 58149316251 scopus 로고    scopus 로고
    • Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
    • Yano, M., Kuroda, N., Han, H., Meguro-Horike, M., Nishikawa, Y., Kiyonari, H., Maemura, K. et al., Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J. Exp. Med. 2008. 205: 2827-2838.
    • (2008) J. Exp. Med. , vol.205 , pp. 2827-2838
    • Yano, M.1    Kuroda, N.2    Han, H.3    Meguro-Horike, M.4    Nishikawa, Y.5    Kiyonari, H.6    Maemura, K.7
  • 42
    • 84928581675 scopus 로고    scopus 로고
    • Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
    • Yang, S., Fujikado, N., Kolodin, D., Benoist, C. and Mathis, D., Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science 2015. 348: 589-594.
    • (2015) Science , vol.348 , pp. 589-594
    • Yang, S.1    Fujikado, N.2    Kolodin, D.3    Benoist, C.4    Mathis, D.5
  • 44
    • 84938287359 scopus 로고    scopus 로고
    • A unified architecture of transcriptional regulatory elements
    • Andersson, R., Sandelin, A. and Danko, C. G., A unified architecture of transcriptional regulatory elements. Trends Genet. 2015. 8: 426-433.
    • (2015) Trends Genet. , vol.8 , pp. 426-433
    • Andersson, R.1    Sandelin, A.2    Danko, C.G.3
  • 45
    • 65449133931 scopus 로고    scopus 로고
    • Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype
    • Hubert, F. X., Kinkel, S. A., Crewther, P. E., Cannon, P. Z., Webster, K. E., Link, M., Uibo, R. et al., Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. J. Immunol. 2009. 182: 3902-3918.
    • (2009) J. Immunol. , vol.182 , pp. 3902-3918
    • Hubert, F.X.1    Kinkel, S.A.2    Crewther, P.E.3    Cannon, P.Z.4    Webster, K.E.5    Link, M.6    Uibo, R.7
  • 46
    • 25144432460 scopus 로고    scopus 로고
    • Modifier loci condition autoimmunity provoked by Aire deficiency
    • Jiang, W., Anderson, M. S., Bronson, R., Mathis, D. and Benoist, C., Modifier loci condition autoimmunity provoked by Aire deficiency. J. Exp. Med. 2005. 202: 805-815.
    • (2005) J. Exp. Med. , vol.202 , pp. 805-815
    • Jiang, W.1    Anderson, M.S.2    Bronson, R.3    Mathis, D.4    Benoist, C.5
  • 47
    • 0037446538 scopus 로고    scopus 로고
    • Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene
    • Boekhoudt, G. H., Guo, Z., Beresford, G. W. and Boss, J. M., Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene. J. Immunol. 2003. 170: 4139-4147.
    • (2003) J. Immunol. , vol.170 , pp. 4139-4147
    • Boekhoudt, G.H.1    Guo, Z.2    Beresford, G.W.3    Boss, J.M.4
  • 48
    • 17544385823 scopus 로고    scopus 로고
    • Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter
    • Murumagi, A., Vahamurto, P. and Peterson, P., Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. J. Biol. Chem. 2003. 278: 19784-19790.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19784-19790
    • Murumagi, A.1    Vahamurto, P.2    Peterson, P.3
  • 49
    • 34147171123 scopus 로고    scopus 로고
    • Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells
    • Dahl, J. A. and Collas, P., Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells. Stem Cells 2007. 25: 1037-1046.
    • (2007) Stem Cells , vol.25 , pp. 1037-1046
    • Dahl, J.A.1    Collas, P.2


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