Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 5, 2013, Pages 1833-1838

  Yang, Siyoung ^a   Bansal, Kushagra ^a   Lopes, Jared ^a,b   Benoist, Christophe ^a   Mathis, Diane ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Alkermes   (United States)

Author keywords

Negative selection; Protein protein interactions; Thymus transcription factor

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; HOMEODOMAIN 2; HOMEODOMAIN PROTEIN; MESSENGER RNA PRECURSOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; IMMUNOLOGICAL TOLERANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; THYMUS; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; HEK293 CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNOBLOTTING; MALE; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN BINDING; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84873107959     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222023110     Document Type: Article

References (34)

1. Hogquist KA, Baldwin TA, Jameson SC (2005) Central tolerance: Learning self-control in the thymus. Nat Rev Immunol 5(10):772-782. (Pubitemid 41400851)
2. Peterson P, Org T, Rebane A (2008) Transcriptional regulation by AIRE: Molecular mechanisms of central tolerance. Nat Rev Immunol 8(12):948-957.
3. Mathis D, Benoist C (2009) Aire. Annu Rev Immunol 27:287-312.
4. Derbinski J, Schulte A, Kyewski B, Klein L (2001) Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2(11):1032-1039. (Pubitemid 33069498)
5. Gervois N, et al. (1992) Structure of the TCR-Ag-MHC complex. T lymphocytes: Structure, Functions, Choices, eds Celada F, Pernis B (Plenum, New York), pp 17-23.
6. Gronski MA, et al. (2004) TCR affinity and negative regulation limit autoimmunity. Nat Med 10(11):1234-1239. (Pubitemid 39540441)
7. Krimpenfort P, Ossendorp F, Borst J, Melief C, Berns A (1989) T cell depletion in transgenic mice carrying a mutant gene for TCR-beta. Nature 341(6244):742-746. (Pubitemid 19260888)
8. Lang P, et al. (2001) TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. Science 291(5508):1537-1540. (Pubitemid 32179218)
9. Oven I, et al. (2007) AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol Cell Biol 27(24):8815-8823.
10. Giraud M, et al. (2012) Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc Natl Acad Sci USA 109(2):535-540.
11. Halonen M, et al. (2004) APECED-causing mutations in AIRE reveal the functional domains of the protein. Hum Mutat 23(3):245-257. (Pubitemid 38337889)
12. Abramson J, Giraud M, Benoist C, Mathis D (2010) Aire's partners in the molecular control of immunological tolerance. Cell 140(1):123-135.
13. Gaetani M, et al. (2012) AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome. Nucleic Acids Res 40(22):11756-11768.
14. Sanchez R, Zhou MM (2011) The PHD finger: A versatile epigenome reader. Trends Biochem Sci 36(7):364-372.
15. Org T, et al. (2008) The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep 9(4):370-376.
16. Koh AS, et al. (2008) Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci USA 105(41):15878-15883.
17. Chignola F, et al. (2009) The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res 37(9):2951-2961.
18. Ge Q, Bai A, Jones B, Eisen HN, Chen J (2004) Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors. Proc Natl Acad Sci USA 101(9):3041-3046. (Pubitemid 38327731)
19. Koh AS, Kingston RE, Benoist C, Mathis D (2010) Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci USA 107(29):13016-13021.
20. Zumer K, Low AK, Jiang H, Saksela K, Peterlin BM (2012) Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes. Mol Cell Biol 32(8):1354-1362.
21. Uchida J, et al. (2004) The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med 199(12):1659-1669. (Pubitemid 38821999)
22. Bottomley MJ, et al. (2005) NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasisectodermal dystrophy (APECED) disease. J Biol Chem 280(12):11505-11512. (Pubitemid 40418461)
23. Björses P, et al. (2000) Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein. Am J Hum Genet 66(2):378-392. (Pubitemid 30468815)
24. Pitkänen J, et al. (2000) The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J Biol Chem 275(22):16802-16809. (Pubitemid 30398914)
25. Meloni A, Incani F, Corda D, Cao A, Rosatelli MC (2008) Role of PHD fingers and COOH-terminal 30 amino acids in AIRE transactivation activity. Mol Immunol 45(3):805-809. (Pubitemid 47498571)
26. Witherden D, et al. (2000) Tetracycline-controllable selection of CD4(+) T cells: Halflife and survival signals in the absence of major histocompatibility complex class II molecules. J Exp Med 191 (2):355-364. (Pubitemid 30060924)
27. Guerau-de-Arellano M, Martinic M, Benoist C, Mathis D (2009) Neonatal tolerance revisited: A perinatal window for Aire control of autoimmunity. J Exp Med 206(6):1245-1252.
28. Anderson MS, et al. (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298(5597):1395-1401. (Pubitemid 35346134)
29. Chakravarty S, Zeng L, Zhou MM (2009) Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator. Structure 17(5):670-679.
30. Saltis M, et al. (2008) Evolutionary conserved and divergent regions of the autoimmune regulator (Aire) gene: A comparative analysis. Immunogenetics 60(2):105-114.
31. Gray DHD, Abramson J, Benoist C, Mathis D (2007) Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204(11):2521-2528. (Pubitemid 350044777)
32. Fu W, et al. (2012) A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol 13(10):972-980.
33. Irizarry RA, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4(2):249-264.
34. Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C (2005) Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 202(6):805-815. (Pubitemid 41345969)