메뉴 건너뛰기




Volumn 212, Issue 12, 2015, Pages 1993-2002

Identification of a novel cis-regulatory element essential for immune tolerance

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; BETA GALACTOSIDASE; CYTOKERATIN 10; GREEN FLUORESCENT PROTEIN; GUIDE RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INVOLUCRIN; MESSENGER RNA; DNA; PROTEIN BINDING; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

EID: 84961281515     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20151069     Document Type: Article
Times cited : (44)

References (31)
  • 2
    • 51349111243 scopus 로고    scopus 로고
    • The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
    • Akiyama, T., Y. Shimo, H. Yanai, J. Qin, D. Ohshima, Y. Maruyama, Y. Asaumi, J. Kitazawa, H. Takayanagi, J.M. Penninger, et al. 2008. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 29:423-437. http://dx.doi.org/10.1016/j.immuni.2008.06.015
    • (2008) Immunity. , vol.29 , pp. 423-437
    • Akiyama, T.1    Shimo, Y.2    Yanai, H.3    Qin, J.4    Ohshima, D.5    Maruyama, Y.6    Asaumi, Y.7    Kitazawa, J.8    Takayanagi, H.9    Penninger, J.M.10
  • 5
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski, J., A. Schulte, B. Kyewski, and L. Klein. 2001. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2:1032-1039. http://dx.doi.org/10.1038/ni723
    • (2001) Nat. Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 7
    • 3242891068 scopus 로고    scopus 로고
    • VIS TA: computational tools for comparative genomics
    • Web Server
    • Frazer, K.A., L. Pachter, A. Poliakov, E.M. Rubin, and I. Dubchak. 2004. VIS TA: computational tools for comparative genomics. Nucleic Acids Res. 32(Web Server):W273-9. http://dx.doi.org/10.1093/nar/gkh458
    • (2004) Nucleic Acids Res. , vol.32 , pp. W273-W279
    • Frazer, K.A.1    Pachter, L.2    Poliakov, A.3    Rubin, E.M.4    Dubchak, I.5
  • 8
    • 84880570576 scopus 로고    scopus 로고
    • High-frequency off-target mutagenesis induced by CRI SPR-Cas nucleases in human cells
    • Fu, Y., J.A. Foden, C. Khayter, M.L. Maeder, D. Reyon, J.K. Joung, and J.D. Sander. 2013. High-frequency off-target mutagenesis induced by CRI SPR-Cas nucleases in human cells. Nat. Biotechnol. 31:822-826. http://dx.doi.org/10.1038/nbt.2623
    • (2013) Nat. Biotechnol. , vol.31 , pp. 822-826
    • Fu, Y.1    Foden, J.A.2    Khayter, C.3    Maeder, M.L.4    Reyon, D.5    Joung, J.K.6    Sander, J.D.7
  • 10
    • 84884332897 scopus 로고    scopus 로고
    • Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4+ T cells
    • Gardner, J.M., T.C. Metzger, E.J. McMahon, B.B. Au-Yeung, A.K. Krawisz, W. Lu, J.D. Price, K.P. Johannes, A.T. Satpathy, K.M. Murphy, et al.. 2013. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4+ T cells. Immunity. 39:560-572. http://dx.doi.org/10.1016/j.immuni.2013.08.005
    • (2013) Immunity. , vol.39 , pp. 560-572
    • Gardner, J.M.1    Metzger, T.C.2    McMahon, E.J.3    Au-Yeung, B.B.4    Krawisz, A.K.5    Lu, W.6    Price, J.D.7    Johannes, K.P.8    Satpathy, A.T.9    Murphy, K.M.10
  • 11
    • 0033939699 scopus 로고    scopus 로고
    • RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse
    • Heino, M., P. Peterson, N. Sillanp, S. Guérin, L. Wu, G. Anderson, H.S. Scott, S.E. Antonarakis, J. Kudoh, N. Shimizu, et al. 2000. RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse. Eur. J. Immunol. 30:1884-1893. http://dx.doi.org/10.1002/1521-4141(200007)30:7<1884::AID-IMMU1884>3.0.CO;2-P
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1884-1893
    • Heino, M.1    Peterson, P.2    Sillanp, N.3    Guérin, S.4    Wu, L.5    Anderson, G.6    Scott, H.S.7    Antonarakis, S.E.8    Kudoh, J.9    Shimizu, N.10
  • 12
    • 51349092893 scopus 로고    scopus 로고
    • The cytokine RAN KL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
    • Hikosaka, Y., T. Nitta, I. Ohigashi, K. Yano, N. Ishimaru, Y. Hayashi, M. Matsumoto, K. Matsuo, J.M. Penninger, H. Takayanagi, et al. 2008. The cytokine RAN KL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity. 29:438-450. http://dx.doi.org/10.1016/j.immuni.2008.06.018
    • (2008) Immunity. , vol.29 , pp. 438-450
    • Hikosaka, Y.1    Nitta, T.2    Ohigashi, I.3    Yano, K.4    Ishimaru, N.5    Hayashi, Y.6    Matsumoto, M.7    Matsuo, K.8    Penninger, J.M.9    Takayanagi, H.10
  • 13
    • 65449133931 scopus 로고    scopus 로고
    • Airedeficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype
    • Hubert, F.-X., S.A. Kinkel, P.E. Crewther, P.Z.F. Cannon, K.E. Webster, M. Link, R. Uibo, M.K. O'Bryan, A. Meager, S.P. Forehan, et al. 2009. Airedeficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. J. Immunol. 182:3902-3918. http://dx.doi.org/10.4049/jimmunol.0802124
    • (2009) J. Immunol. , vol.182 , pp. 3902-3918
    • Hubert, F.-X.1    Kinkel, S.A.2    Crewther, P.E.3    Cannon, P.Z.F.4    Webster, K.E.5    Link, M.6    Uibo, R.7    O'Bryan, M.K.8    Meager, A.9    Forehan, S.P.10
  • 14
    • 84899767409 scopus 로고    scopus 로고
    • Enhancement of an antitumor immune response by transient blockade of central T cell tolerance
    • Khan, I.S., M.L. Mouchess, M.-L. Zhu, B. Conley, K.J. Fasano, Y. Hou, L. Fong, M.A. Su, and M.S. Anderson. 2014. Enhancement of an antitumor immune response by transient blockade of central T cell tolerance. J. Exp. Med. 211:761-768. http://dx.doi.org/10.1084/jem.20131889
    • (2014) J. Exp. Med. , vol.211 , pp. 761-768
    • Khan, I.S.1    Mouchess, M.L.2    Zhu, M.-L.3    Conley, B.4    Fasano, K.J.5    Hou, Y.6    Fong, L.7    Su, M.A.8    Anderson, M.S.9
  • 15
    • 3242888285 scopus 로고    scopus 로고
    • rVIS TA 2.0: evolutionary analysis of transcription factor binding sites
    • Loots, G.G., and I. Ovcharenko. 2004. rVIS TA 2.0: evolutionary analysis of transcription factor binding sites. Nucleic Acids Res. 32:W217-W21. http://dx.doi.org/10.1093/nar/gkh383
    • (2004) Nucleic Acids Res. , vol.32 , pp. W217-W221
    • Loots, G.G.1    Ovcharenko, I.2
  • 18
    • 77957946016 scopus 로고    scopus 로고
    • Genomics of long-range regulatory elements
    • Noonan, J.P., and A.S. McCallion. 2010. Genomics of long-range regulatory elements. Annu. Rev. Genomics Hum. Genet. 11:1-23. http://dx.doi.org/10.1146/annurev-genom-082509-141651
    • (2010) Annu. Rev. Genomics Hum. Genet. , vol.11 , pp. 1-23
    • Noonan, J.P.1    McCallion, A.S.2
  • 19
    • 62749130573 scopus 로고    scopus 로고
    • Diagnosis and management of polyendocrinopathy syndromes
    • x
    • Owen, C.J., and T.D. Cheetham. 2009. Diagnosis and management of polyendocrinopathy syndromes. Endocrinol. Metab. Clin. North Am. 38:419-436: x. http://dx.doi.org/10.1016/j.ecl.2009.01.007
    • (2009) Endocrinol. Metab. Clin. North Am. , vol.38 , pp. 419-436
    • Owen, C.J.1    Cheetham, T.D.2
  • 20
    • 84883798955 scopus 로고    scopus 로고
    • Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity
    • Pinto, S., C. Michel, H. Schmidt-Glenewinkel, N. Harder, K. Rohr, S. Wild, B. Brors, and B. Kyewski. 2013. Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity. Proc. Natl. Acad. Sci. USA. 110:E3497-E3505. http://dx.doi.org/10.1073/pnas.1308311110
    • (2013) Proc. Natl. Acad. Sci. USA. , vol.110 , pp. E3497-E3505
    • Pinto, S.1    Michel, C.2    Schmidt-Glenewinkel, H.3    Harder, N.4    Rohr, K.5    Wild, S.6    Brors, B.7    Kyewski, B.8
  • 21
    • 84887010498 scopus 로고    scopus 로고
    • Genome engineering using the CRI SPR-Cas9 system
    • Ran, F.A., P.D. Hsu, J. Wright, V. Agarwala, D.A. Scott, and F. Zhang. 2013. Genome engineering using the CRI SPR-Cas9 system. Nat. Protoc. 8:2281-2308. http://dx.doi.org/10.1038/nprot.2013.143
    • (2013) Nat. Protoc. , vol.8 , pp. 2281-2308
    • Ran, F.A.1    Hsu, P.D.2    Wright, J.3    Agarwala, V.4    Scott, D.A.5    Zhang, F.6
  • 22
    • 0032827115 scopus 로고    scopus 로고
    • Variegated expression of the endogenous immunoglobulin heavy-chain gene in the absence of the intronic locus control region
    • Ronai, D., M. Berru, and M.J. Shulman. 1999. Variegated expression of the endogenous immunoglobulin heavy-chain gene in the absence of the intronic locus control region. Mol. Cell. Biol. 19:7031-7040.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7031-7040
    • Ronai, D.1    Berru, M.2    Shulman, M.J.3
  • 25
    • 72949093686 scopus 로고    scopus 로고
    • Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance
    • Shum, A.K., J. DeVoss, C.L. Tan, Y. Hou, K. Johannes, C.S. O'Gorman, K.D. Jones, E.B. Sochett, L. Fong, and M.S Anderson. 2009. Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med. 1:9ra20. http://dx.doi.org/10.1126/scitranslmed.3000284.
    • (2009) Sci Transl Med. , vol.1 , pp. 9ra20
    • Shum, A.K.1    DeVoss, J.2    Tan, C.L.3    Hou, Y.4    Johannes, K.5    O'Gorman, C.S.6    Jones, K.D.7    Sochett, E.B.8    Fong, L.9    Anderson, M.S.10
  • 27
    • 84861212351 scopus 로고    scopus 로고
    • Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection
    • Taniguchi, R.T., J.J. DeVoss, J.J. Moon, J. Sidney, A. Sette, M.K. Jenkins, and M.S. Anderson. 2012. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc. Natl. Acad. Sci. USA. 109:7847-7852. http://dx.doi.org/10.1073/pnas.1120607109
    • (2012) Proc. Natl. Acad. Sci. USA. , vol.109 , pp. 7847-7852
    • Taniguchi, R.T.1    DeVoss, J.J.2    Moon, J.J.3    Sidney, J.4    Sette, A.5    Jenkins, M.K.6    Anderson, M.S.7
  • 29
    • 84872711825 scopus 로고    scopus 로고
    • Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens
    • Wang, X., M. Laan, R. Bichele, K. Kisand, H.S. Scott, and P. Peterson. 2012. Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front. Immunol. 3:19. http://dx.doi.org/10.3389/fimmu.2012.00019
    • (2012) Front. Immunol. , vol.3 , pp. 19
    • Wang, X.1    Laan, M.2    Bichele, R.3    Kisand, K.4    Scott, H.S.5    Peterson, P.6
  • 30
    • 78049496246 scopus 로고    scopus 로고
    • Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells
    • White, A.J., K. Nakamura, W.E. Jenkinson, M. Saini, C. Sinclair, B. Seddon, P. Narendran, K. Pfeffer, T. Nitta, Y. Takahama, et al. 2010. Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells. J. Immunol. 185:4769-4776. http://dx.doi.org/10.4049/jimmunol.1002151
    • (2010) J. Immunol. , vol.185 , pp. 4769-4776
    • White, A.J.1    Nakamura, K.2    Jenkinson, W.E.3    Saini, M.4    Sinclair, C.5    Seddon, B.6    Narendran, P.7    Pfeffer, K.8    Nitta, T.9    Takahama, Y.10
  • 31
    • 33750585066 scopus 로고    scopus 로고
    • NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway
    • Zhu, M., R.K. Chin, P.A. Christiansen, J.C. Lo, X. Liu, C. Ware, U. Siebenlist, and Y.-X. Fu. 2006. NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J. Clin. Invest. 116:2964-2971. http://dx.doi.org/10.1172/JCI28326
    • (2006) J. Clin. Invest. , vol.116 , pp. 2964-2971
    • Zhu, M.1    Chin, R.K.2    Christiansen, P.A.3    Lo, J.C.4    Liu, X.5    Ware, C.6    Siebenlist, U.7    Fu, Y.-X.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.