Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

Genome Research

Volumn 24, Issue 12, 2014, Pages 1918-1931

  Sansom, Stephen N ^a   Shikama Dorn, Noriko ^b   Zhanybekova, Saule ^b   Nusspaumer, Gretel ^b   Macaulay, Iain C ^c   Deadman, Mary E ^a   Heger, Andreas ^a   Ponting, Chris P ^a,c   Holländer, Georg A ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCOMB GROUP PROTEIN; TRANSCRIPTOME; AUTOANTIGEN; AUTOIMMUNE REGULATOR PROTEIN; CHROMATIN; HISTONE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE REGULATOR GENE; AUTOIMMUNITY; CELL TYPE; CONTROLLED STUDY; EPIGENETICS; EPITHELIUM CELL; GENE EXPRESSION; GENE FREQUENCY; GENE SILENCING; GENE TARGETING; GENOMICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATOR GENE; THYMIC EPITHELIAL CELL; THYMOCYTE; TISSUE SPECIFICITY; ACETYLATION; ANIMAL; ANTIBODY SPECIFICITY; BIOLOGY; CHROMATIN; CLUSTER ANALYSIS; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LOCUS; GENE ORDER; GENE VECTOR; GENETICS; IMMUNOLOGY; METABOLISM; PROCEDURES; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; THYMUS; TRANSGENIC MOUSE;

ACETYLATION; ANIMALS; AUTOANTIGENS; CHROMATIN; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; EPITHELIAL CELLS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ORDER; GENE SILENCING; GENE TARGETING; GENETIC LOCI; GENETIC VECTORS; GENOMICS; HISTONES; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; POLYCOMB-GROUP PROTEINS; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84913594338     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.171645.113     Document Type: Article

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