메뉴 건너뛰기




Volumn 15, Issue 3, 2014, Pages 258-265

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; AUTOANTIGENS; CENTRAL TOLERANCE; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN BINDING; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84894431935     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2820     Document Type: Article
Times cited : (77)

References (47)
  • 1
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2, 1032-1039 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 2
    • 23844558032 scopus 로고    scopus 로고
    • The cellular mechanism of Aire control of T cell tolerance
    • Anderson, M.S. et al. The cellular mechanism of Aire control of T cell tolerance. Immunity 23, 227-239 (2005).
    • (2005) Immunity , vol.23 , pp. 227-239
    • Anderson, M.S.1
  • 4
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395-1401 (2002).
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 5
    • 0346599403 scopus 로고    scopus 로고
    • An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
    • Consortium F-GA. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17, 399-403 (1997).
    • (1997) Nat. Genet. , vol.17 , pp. 399-403
    • F-Ga, C.1
  • 6
    • 16944367194 scopus 로고    scopus 로고
    • Positional cloning of the APECED gene
    • Nagamine, K. et al. Positional cloning of the APECED gene. Nat. Genet. 17, 393-398 (1997).
    • (1997) Nat. Genet. , vol.17 , pp. 393-398
    • Nagamine, K.1
  • 8
    • 0038824426 scopus 로고    scopus 로고
    • The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein
    • Pitkänen, J. et al. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J. Biol. Chem. 275, 16802-16809 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 16802-16809
    • Pitkänen, J.1
  • 9
    • 37549060329 scopus 로고    scopus 로고
    • AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells
    • Oven, I. et al. AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol. Cell. Biol. 27, 8815-8823 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 8815-8823
    • Oven, I.1
  • 10
    • 84855995571 scopus 로고    scopus 로고
    • Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
    • Giraud, M. et al. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc. Natl. Acad. Sci. USA 109, 535-540 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 535-540
    • Giraud, M.1
  • 11
    • 73149115486 scopus 로고    scopus 로고
    • Aire's partners in the molecular control of immunological tolerance
    • Abramson, J., Giraud, M., Benoist, C. & Mathis, D. Aire's partners in the molecular control of immunological tolerance. Cell 140, 123-135 (2010).
    • (2010) Cell , vol.140 , pp. 123-135
    • Abramson, J.1    Giraud, M.2    Benoist, C.3    Mathis, D.4
  • 12
    • 38049026826 scopus 로고    scopus 로고
    • DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity
    • Liiv, I. et al. DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. Biochim. Biophys. Acta 1783, 74-83 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 74-83
    • Liiv, I.1
  • 13
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    • Mahaney, B., Meek, K. & Lees-Miller, S.P. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem. J. 417, 639-650 (2009).
    • (2009) Biochem. J. , vol.417 , pp. 639-650
    • Mahaney, B.1    Meek, K.2    Lees-Miller, S.P.3
  • 14
    • 56749174388 scopus 로고    scopus 로고
    • Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity
    • Koh, A.S. et al. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc. Natl. Acad. Sci. USA 105, 15878-15883 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 15878-15883
    • Koh, A.S.1
  • 15
    • 45849137524 scopus 로고    scopus 로고
    • The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
    • Org, T. et al. The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep. 9, 370-376 (2008).
    • (2008) EMBO Rep. , vol.9 , pp. 370-376
    • Org, T.1
  • 16
    • 77955602966 scopus 로고    scopus 로고
    • Global relevance of Aire binding to hypomethylated lysine-4 of histone
    • Koh, A.S., Kingston, R.E., Benoist, C. & Mathis, D. Global relevance of Aire binding to hypomethylated lysine-4 of histone. Proc. Natl. Acad. Sci. USA 107, 13016-13021 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 13016-13021
    • Koh, A.S.1    Kingston, R.E.2    Benoist, C.3    Mathis, D.4
  • 18
    • 5144231380 scopus 로고    scopus 로고
    • Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage
    • Sillanpää, N. et al. Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage. Mol. Immunol. 41, 1185-1198 (2004).
    • (2004) Mol. Immunol. , vol.41 , pp. 1185-1198
    • Sillanpaa, N.1
  • 19
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • Derbinski, J. et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202, 33-45 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 33-45
    • Derbinski, J.1
  • 20
    • 38649131259 scopus 로고    scopus 로고
    • Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
    • Derbinski, J., Pinto, S., Rosch, S., Hexel, K. & Kyewski, B. Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc. Natl. Acad. Sci. USA 105, 657-662 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 657-662
    • Derbinski, J.1    Pinto, S.2    Rosch, S.3    Hexel, K.4    Kyewski, B.5
  • 21
    • 56749184864 scopus 로고    scopus 로고
    • Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated
    • Villaseñor, J., Besse, W., Benoist, C. & Mathis, D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc. Natl. Acad. Sci. USA 105, 15854-15859 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 15854-15859
    • Villaseñor, J.1    Besse, W.2    Benoist, C.3    Mathis, D.4
  • 22
    • 56749105120 scopus 로고    scopus 로고
    • The variable immunological self: Genetic variation and nongenetic noise in Aire-regulated transcription
    • Venanzi, E.S., Melamed, R., Mathis, D. & Benoist, C. The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription. Proc. Natl. Acad. Sci. USA 105, 15860-15865 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 15860-15865
    • Venanzi, E.S.1    Melamed, R.2    Mathis, D.3    Benoist, C.4
  • 23
    • 0033860185 scopus 로고    scopus 로고
    • Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator
    • Bloch, D.B. et al. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol. Cell. Biol. 20, 6138-6146 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 6138-6146
    • Bloch, D.B.1
  • 24
    • 0032560477 scopus 로고    scopus 로고
    • Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
    • Seeler, J.S., Marchio, A., Sitterlin, D., Transy, C. & Dejean, A. Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proc. Natl. Acad. Sci. USA 95, 7316-7321 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7316-7321
    • Seeler, J.S.1    Marchio, A.2    Sitterlin, D.3    Transy, C.4    Dejean, A.5
  • 25
    • 0032722209 scopus 로고    scopus 로고
    • Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites
    • Christensen, J., Cotmore, S.F. & Tattersall, P. Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites. Mol. Cell. Biol. 19, 7741-7750 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7741-7750
    • Christensen, J.1    Cotmore, S.F.2    Tattersall, P.3
  • 26
    • 0029986957 scopus 로고    scopus 로고
    • A novel protein that binds an essential region in a Deformed response element
    • Gross, C.T. & McGinnis, W. DEAF-1, a novel protein that binds an essential region in a Deformed response element. EMBO J. 15, 1961-1970 (1996).
    • (1996) EMBO J. , vol.15 , pp. 1961-1970
    • Gross, C.T.1    Deaf, M.W.2
  • 27
    • 0034957535 scopus 로고    scopus 로고
    • The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation
    • Bottomley, M.J. et al. The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation. Nat. Struct. Biol. 8, 626-633 (2001).
    • (2001) Nat. Struct. Biol. , vol.8 , pp. 626-633
    • Bottomley, M.J.1
  • 28
    • 0032127876 scopus 로고    scopus 로고
    • The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor
    • Gibson, T.J., Ramu, C., Gemünd, C. & Aasland, R. The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor. Trends Biochem. Sci. 23, 242-244 (1998).
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 242-244
    • Gibson, T.J.1    Ramu, C.2    Gemünd, C.3    Aasland, R.4
  • 29
    • 0034749749 scopus 로고    scopus 로고
    • A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis
    • Cetani, F. et al. A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis. J. Clin. Endocrinol. Metab. 86, 4747-4752 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 4747-4752
    • Cetani, F.1
  • 30
    • 0037385288 scopus 로고    scopus 로고
    • MCAF mediates MBD1-dependent transcriptional repression
    • Fujita, N. et al. MCAF mediates MBD1-dependent transcriptional repression. Mol. Cell. Biol. 23, 2834-2843 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2834-2843
    • Fujita, N.1
  • 31
    • 17144392514 scopus 로고    scopus 로고
    • Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins
    • Ichimura, T. et al. Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. J. Biol. Chem. 280, 13928-13935 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 13928-13935
    • Ichimura, T.1
  • 32
    • 0141992115 scopus 로고    scopus 로고
    • MAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression
    • Wang, H. et al. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12, 475-487 (2003).
    • (2003) Mol. Cell , vol.12 , pp. 475-487
    • Wang, H.1
  • 33
    • 49449093723 scopus 로고    scopus 로고
    • Deletional tolerance mediated by extrathymic Aire-expressing cells
    • Gardner, J.M. et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 321, 843-847 (2008).
    • (2008) Science , vol.321 , pp. 843-847
    • Gardner, J.M.1
  • 34
    • 4344685735 scopus 로고    scopus 로고
    • Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly
    • Sarraf, S.A. & Stancheva, I. Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol. Cell 15, 595-605 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 595-605
    • Sarraf, S.A.1    Stancheva, I.2
  • 35
    • 44449140370 scopus 로고    scopus 로고
    • Methyl-CpG binding proteins: Specialized transcriptional repressors or structural components of chromatin?
    • Clouaire, T. & Stancheva, I. Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin? Cell. Mol. Life Sci. 65, 1509-1522 (2008).
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 1509-1522
    • Clouaire, T.1    Stancheva, I.2
  • 36
    • 43049128502 scopus 로고    scopus 로고
    • Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
    • Su, M.A. et al. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J. Clin. Invest. 118, 1712-1726 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1712-1726
    • Su, M.A.1
  • 37
    • 77955838329 scopus 로고    scopus 로고
    • Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
    • Clouaire, T., de las Heras, J.I., Merusi, C. & Stancheva, I. Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA. Nucleic Acids Res. 38, 4620-4634 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. 4620-4634
    • Clouaire, T.1    De Las Heras, J.I.2    Merusi, C.3    Stancheva, I.4
  • 38
    • 84876278080 scopus 로고    scopus 로고
    • Methylation-dependent and-independent genomic targeting principles of the MBD protein family
    • Baubec, T., Ivánek, R., Lienert, F. & Schübeler, D. Methylation-dependent and-independent genomic targeting principles of the MBD protein family. Cell 153, 480-492 (2013).
    • (2013) Cell , vol.153 , pp. 480-492
    • Baubec, T.1    Ivánek, R.2    Lienert, F.3    Schübeler, D.4
  • 39
    • 24044523177 scopus 로고    scopus 로고
    • DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG
    • Klose, R.J. et al. DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. Mol. Cell 19, 667-678 (2005).
    • (2005) Mol. Cell , vol.19 , pp. 667-678
    • Klose, R.J.1
  • 40
    • 0037636512 scopus 로고    scopus 로고
    • Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
    • Zhao, X. et al. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl. Acad. Sci. USA 100, 6777-6782 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6777-6782
    • Zhao, X.1
  • 41
    • 79954416946 scopus 로고    scopus 로고
    • Readers of histone modifications
    • Yun, M., Wu, J., Workman, J.L. & Li, B. Readers of histone modifications. Cell Res. 21, 564-578 (2011).
    • (2011) Cell Res. , vol.21 , pp. 564-578
    • Yun, M.1    Wu, J.2    Workman, J.L.3    Li, B.4
  • 42
    • 77950882645 scopus 로고    scopus 로고
    • CpG islands recruit a histone H3 lysine 36 demethylase
    • Blackledge, N.P. et al. CpG islands recruit a histone H3 lysine 36 demethylase. Mol. Cell 38, 179-190 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 179-190
    • Blackledge, N.P.1
  • 43
    • 84875129831 scopus 로고    scopus 로고
    • DNA methylation dynamics in health and disease
    • Bergman, Y. & Cedar, H. DNA methylation dynamics in health and disease. Nat. Struct. Mol. Biol. 20, 274-281 (2013).
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 274-281
    • Bergman, Y.1    Cedar, H.2
  • 44
    • 25144432460 scopus 로고    scopus 로고
    • Modifier loci condition autoimmunity provoked by Aire deficiency
    • Jiang, W., Anderson, M.S., Bronson, R., Mathis, D. & Benoist, C. Modifier loci condition autoimmunity provoked by Aire deficiency. J. Exp. Med. 202, 805-815 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 805-815
    • Jiang, W.1    Anderson, M.S.2    Bronson, R.3    Mathis, D.4    Benoist, C.5
  • 45
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad, B.M., Irizarry, R.A., Åstrand, M. & Speed, T.P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19, 185-193 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Åstrand, M.3    Speed, T.P.4
  • 46
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman, R.C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004).
    • (2004) Genome Biol. , vol.5
    • Gentleman, R.C.1
  • 47
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical Bayes methods for assessing differential expression in microarray experiments
    • Article 3
    • Smyth, G.K. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, Article 3 (2004).
    • (2004) Stat. Appl. Genet. Mol. Biol. , vol.3
    • Smyth, G.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.