Serotonergic pathways in depression

Neurobiology of Depression

Volumn , Issue , 2011, Pages 143-170

  Altieri, Stefanie C ^a,b   Singh, Yogesh S ^b,c   Sibille, Etienne ^d,e   Andrews, Anne M ^b,c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84962732608     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (273)

1. Agren, H. 1980a. Symptom patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid: II. Suicide. Psychiatry Res 3:225-36
2. Agren, H. 1980b. Symptom patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid: I. General patterns. Psychiatry Res 3:211-23
3. Amin, A. H., Crawford, T. B., and Gaddum, J. H. 1954. The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog. J Physiol (Lond) 126:596-618
4. Andrews, A. M. 2009. Does chronic antidepressant treatment increase extracellular serotonin? Front Neurosci 3:246-7
5. Ansorge, M. S., Zhou, M., Lira, A., Hen, R., and Gingrich, J. A. 2004. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306:879-81
6. Ansorge, M. S., Morelli, E., and Gingrich, J. A. 2008. Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice. J Neurosci 28:199-207
7. Arango, V., Underwood, M. D., and Mann, J. J. 1992. Alterations in monoamine receptors in the brain of suicide victims. J Clin Psychopharmacol 12:8S-12S
8. Arango, V., Underwood, M. D., Boldrini, M., et al. 2001. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 25:892-903
9. Asberg, M., Thorén, P., Träskman, L., Bertilsson, L., and Ringberger, V. 1976a. "Serotonin depression"-a biochemical subgroup within the affective disorders? Science 191:478-80
10. Asberg, M., Träskman, L., and Thorén, P. 1976b. 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33:1193-7
11. Ashcroft, G. W., and Sharman, D. F. 1960. 5-Hydroxyindoles in human cerebrospinal fluids. Nature 186: 1050-1
12. Axelrod, J., Whitby, L. G., and Hertting, G. 1961. Effect of psychotropic drugs on the uptake of H3-norepinephrine by tissues. Science 133:383-4
13. Banki, C. M., and Arató, M. 1983. Amine metabolites and neuroendocrine responses related to depression and suicide. J Affect Disord 5:223-32
14. Bengel, D., Murphy, D. L., Andrews, A. M., et al. 1998. Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol 53:649-55
15. Berger, M., Gray, J. A., and Roth, B. L. 2009. The expanded biology of serotonin. Annu Rev Med 60:355-66
16. Beskow, J., Gottfries, C. G., Roos, B. E., and Winblad, B. 1976. Determination of monoamine and monoamine metabolites in the human brain: Post mortem studies in a group of suicides and in a control group. Acta Psychiatr Scand 53:7-20
17. Bicalho, M. A., Pimenta, G. J., Neves, F. S., et al. 2006. Genotyping of the G1463A (Arg441His) TPH2 polymorphism in a geriatric population of patients with major depression. Mol Psychiatry 11:799-800
18. Biggio, G., Fadda, F., Fanni, P., Tagliamonte, A., and Gessa, G. L. 1974. Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sci 14:1321-9
19. Birkmayer, W., and Riederer, P. 1975. Biochemical post-mortem findings in depressed patients. J Neural Transm 37:95-109
20. Biver, F., Wikler, D., Lotstra, F., Damhaut, P., Goldman, S., and Mendlewicz, J. 1997. Serotonin 5-HT2 receptor imaging in major depression: Focal changes in orbito-insular cortex. Br J Psychiatry 171:444-8
21. Blakely, R. D. 2001. Physiological genomics of antidepressant targets: Keeping the periphery in mind. J Neurosci 21:8319-23
22. Blakely, R. D., Defelice, L. J., and Galli, A. 2005. Biogenic amine neurotransmitter transporters: Just when you thought you knew them. Physiology (Bethesda) 20:225-31
23. Blier, P., De Montigny, C., and Azzaro, A. J. 1986. Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors: Electrophysiological studies in the rat central nervous system. J Pharmacol Exp Ther 237:987-94
24. Bligh-Glover, W., Kolli, T. N., Shapiro-Kulnane, L., et al. 2000. The serotonin transporter in the midbrain of suicide victims with major depression. Biol Psychiatry 47:1015-24
25. Boldrini, M., Underwood, M. D., Mann, J. J., and Arango, V. 2008. Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. J Psychiatr Res 42:433-42
26. Booij, L., Van der Does, A. J. W., and Riedel, W. J. 2003. Monoamine depletion in psychiatric and healthy populations: Review. Mol Psychiatry 8:951-73
27. Borsini, F. 1995. Role of the serotonergic system in the forced swimming test. Neurosci Biobehav Rev 19:377-95
28. Bourne, H. R., Bunney, W. E., Colburn, R. W., et al. 1968. Noradrenaline, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrains of suicidal patients. Lancet 292:805-8
29. Briley, M. S., Langer, S. Z., Raisman, R., Sechter, D., and Zarifian, E. 1980. Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 209:303-5
30. Brunoni, A. R., Lopes, M., and Fregni, F. 2008. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: Implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 11:1169-80
31. Burmeister, M. 1999. Basic concepts in the study of diseases with complex genetics. Biol Psychiatry 45: 522-32
32. Cannon, D. M., Ichise, M., Fromm, S. J., et al. 2006. Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. Biol Psychiatry 60:207-17
33. Carpenter, L. L., Anderson, G. M., Pelton, G. H., et al. 1998. Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology 19:26-35
34. Cases, O., Seif, I., Grimsby, J., et al. 1995. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268:1763-6
35. Cases, O., Lebrand, C., Giros, B., et al. 1998. Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. J Neurosci 18:6914-27
36. Casper, R. C., Fleisher, B. E., Lee-Ancajas, et al. 2003. Follow-up of children of depressed mothers exposed or not exposed to antidepressant drugs during pregnancy. J Pediatr 142:402-8
37. Caspi, A., Sugden, K., Moffitt, T. E., et al. 2003. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301(5631):386-9
38. Caspi, A., Hariri, A. R., Holmes, A., Uher, R., and Moffitt, T. E. 2010. Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167:509-27
39. Cervo, L., Canetta, A., Calcagno, E., et al. 2005. Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression. J Neurosci 25:8165-72
40. Chaput, Y., Blier, P., and de Montigny, C. 1986a. In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. J Neurosci 6:2796-801
41. Chaput, Y., de Montigny, C., and Blier, P. 1986b. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: Electrophysiological studies in the rat brain. Naunyn Schmiedebergs Arch Pharmacol 333:342-8
42. Chaput, Y., de Montigny, C., and Blier, P. 1991. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology 5:219-29
43. Cheetham, S. C., Crompton, M. R., Katona, C. L., and Horton, R. W. 1988. Brain 5-HT2 receptor binding sites in depressed suicide victims. Brain Res 443:272-80
44. Coppen, A., Shaw, D. M., and Farrell, J. P. 1963. Potentiation of the antidepressive effect of a monoamine-oxidase inhibitor by tryptophan. Lancet 281:79-81
45. Côte, F., Thevenot, E., Fligny, C., et al. 2003. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci USA 100:13525-30
46. Côté, F., Fligny, C., Bayard, E., et al. 2007. Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci USA 104:329-34
47. Crow, T. J., Cross, A. J., Cooper, S. J., et al. 1984. Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology 23:1561-9
48. D'haenen, H., De Waele, M., and Leysen, J. E. 1988. Platelet 3H-paroxetine binding in depressed patients. Psychiatry Res 26:11-7
49. D'haenen, H., Bossuyt, A., Mertens, J., Bossuyt-Piron, C., Gijsemans, M., and Kaufman, L. 1992. SPECT imaging of serotonin2 receptors in depression. Psychiatry Res 45:227-37
50. D'Hondt, P., Maes, M., Leysen, J. E., et al. 1996. Seasonal variation in platelet [3H]paroxetine binding in healthy volunteers. Relationship to climatic variables. Neuropsychopharmacology 15:187-98
51. Dahlstrom, A., and Fuxe, K. 1964. Localization of monoamines in the lower brain stem. Experientia 20:398-9
52. Davison, A. N. 1957. The mechanism of the irreversible inhibition of rat-liver monoamine oxidase by iproniazid (Marsilid). Biochem J 67:316-22
53. Delgado, P. L., Charney, D. S., Price, L. H., Aghajanian, G. K., Landis, H., and Heninger, G. R. 1990. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47:411-8
54. Delgado, P. L., Price, L. H., Miller, H. L., et al. 1994. Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Arch Gen Psychiatry 51:865-74
55. Delorme, R., Durand, C. M., Betancur, C., et al. 2006. No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects. Biol Psychiatry 60:202-3
56. Drevets, W. C., Frank, E., Price, J. C., et al. 1999. PET imaging of serotonin 1A receptor binding in depression. Biol Psychiatry 46:1375-87
57. Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., and Pandey, G. N. 2003. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60:804-15
58. Eccleston, D., Ashcroft, G. W., Moir, A. T., Parker-Rhodes, A., Lutz, W., and O'Mahoney, D. P. 1968. A comparison of 5-hydroxyindoles in various regions of dog brain and cerebrospinal fluid. J Neurochem 15:947-57
59. Edman, G., Asberg, M., Levander, S., and Schalling, D. 1986. Skin conductance habituation and cerebrospinal fluid 5-hydroxyindoleacetic acid in suicidal patients. Arch Gen Psychiatry 43:586-92
60. Ellenbogen, M. A., Young, S. N., Dean, P., Palmour, R. M., and Benkelfat, C. 1996. Mood response to acute tryptophan depletion in healthy volunteers: Sex differences and temporal stability. Neuropsychopharmacology 15:465-74
61. Ellis, P. M., McIntosh, C. J., Beeston, R., Salmond, C. E., Cooke, R. R., and Mellsop, G. 1990. Platelet tritiated imipramine binding in psychiatric patients: Relationship to symptoms and severity of depression. Acta Psychiatr Scand 82:275-82
62. Erspamer, V., and Asero, B. 1952. Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine. Nature 169:800-1
63. Erspamer, V., and Asero, B. 1953. Isolation of enteramine from extracts of posterior salivary glands of Octopus vulgaris and of Discoglossus pictus skin. J Biol Chem 200:311-8
64. Evers, E. A. T., Cools, R., Clark, L., et al. 2005. Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning. Neuropsychopharmacology 30:1138-47
65. Fabre, V., Beaufour, C., Evrard, A., et al. 2000. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur J Neurosci 12:2299-310
66. Fava, M., and Kendler, K. S. 2000. Major depressive disorder. Neuron 28:335-41
67. Ferrier, I. N., McKeith, I. G., Cross, A. J., Perry, E. K., Candy, J. M., Perry, R. H. 1986. Postmortem neurochemical studies in depression. Ann N Y Acad Sci 487:128-42
68. Fisar, Z., Kalisová, L., Paclt, I., Anders, M., and Vevera, J. 2008. Platelet serotonin uptake in drug-naïve depressive patients before and after treatment with citalopram. Psychiatry Res 161:185-94
69. Flory, J. D., Manuck, S. B., Ferrell, R. E., Dent, K. M., Peters, D. G., and Muldoon, M. F. 1999. Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism. Mol Psychiatry 4:93-6
70. Freis, E. D. 1954. Mental depression in hypertensive patients treated for long periods with large doses of reserpine. N Engl J Med 251:1006-8
71. Fusar-Poli, P., Allen, P., McGuire, P., Placentino, A., Cortesi, M., and Perez, J. 2006. Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: A systematic review of the literature. Psychopharmacology (Berl) 188:131-43
72. Gardier, A. M. et al. 2009. Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: A review. Fundam Clin Pharmacol 23(1):23-42
73. Garriock, H. A., and Hamilton, S. P. 2009. Genetic studies of drug response and side effects in the STAR*D study, part 1. J Clin Psychiatry 70:1186-7
74. Gaspar, P., Cases, O., and Maroteaux, L. 2003. The developmental role of serotonin: News from mouse molecular genetics. Nat Rev Neurosci 4:1002-12
75. Gentsch, C., Lichtsteiner, M., Gastpar, M., Gastpar, G., and Feer, H. 1985. 3H-Imipramine binding sites in platelets of hospitalized psychiatric patients. Psychiatry Res 14:177-87
76. Ghanbari, R., El Mansari, M., and Blier, P. 2010. Sustained administration of trazodone enhances serotonergic neurotransmission: In vivo electrophysiological study in the rat brain. J Pharmacol Exp Ther 335:197-206
77. Gordon, J., and Barnes, N. M. 2003. Lymphocytes transport serotonin and dopamine: Agony or ecstasy? Trends Immunol 24:438-43
78. Gottfries, C. G., von Knorring, L., and Perris, C. 1976. Neurophysiological measures related to levels of 5-hydroxyindoleacetic acid, homovanillic acid and tryptophan in cerebrospinal fluid of psychiatric patients. Neuropsychobiology 2:1-8
79. Grimes, M. A., Cameron, J. L., and Fernstrom, J. D. 2000. Cerebrospinal fluid concentrations of tryptophan and 5-hydroxyindoleacetic acid in Macaca mulatta: Diurnal variations and response to chronic changes in dietary protein intake. Neurochem Res 25:413-22
80. Grimsby, J., Toth, M., Chen, K., et al. 1997. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet 17:206-10
81. Gross, C., Zhuang, X., Stark, K., et al. 2002. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416:396-400
82. Gupta, J. C., Ghosh, S., Dutta, A. T., and Kahali, B. S. 1947. A note on the hypnotic principle of Rauwolfia serpentina. J Am Pharm Assoc Am Pharm Assoc 36:416
83. Gurevich, I., Englander, M. T., Adlersberg, M., Siegal, N. B., and Schmauss, C. 2002. Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission. J Neurosci 22: 10529-32
84. Gutknecht, L., Kriegebaum, C., Waider, J., Schmitt, A., and Lesch, K.-P. 2009. Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: Convergent data from Tph2 knockout mice. Eur Neuropsychopharmacol 19:266-82
85. Hannon, J., and Hoyer, D. 2008. Molecular biology of 5-HT receptors. Behav Brain Res 195:198-213
86. Hariri, A. R., Mattay, V. S., Tessitore, A., et al. 2002. Serotonin transporter genetic variation and the response of the human amygdala. Science 297:400-3
87. Heils, A., Teufel, A., Petri, S., et al. 1996. Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-4
88. Heinz, A., Jones, D. W., Mazzanti, C., et al. 2000. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 47:643-9
89. Heisler, L. K., Chu, H. M., Brennan, et al. 1998. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc Natl Acad Sci USA 95:15049-54
90. Hendrick, V., Smith, L. M., Suri, R., Hwang, S., Haynes, D., and Altshuler, L. 2003a. Birth outcomes after prenatal exposure to antidepressant medication. Am J Obstet Gynecol 188:812-5
91. Hendrick, V., Stowe, Z. N., Altshuler, L. L., Hwang, S., Lee, E., and Haynes, D. 2003b. Placental passage of antidepressant medications. Am J Psychiatry 160:993-6
92. Hendricks, T., Francis, N., Fyodorov, D., and Deneris, E. S. 1999. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. J Neurosci 19:10348-56
93. Hensler, J. G. 2002. Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology 26:565-73
94. Hensler, J. G. 2006. Serotonin. In Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 7th edn, ed. Siegel, G. J., Albers, R. W., Brady, S. T., and Price, D. L., 227-48. Burlington: Elsevier Academic Press
95. Hirvonen, J., Karlsson, H., Kajander, J., et al. 2008. Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: An in-vivo imaging study using PET and [carbonyl-11C]WAY-100635. Int J Neuropsychopharmacol 11:465-76
96. Hjorth, S., Bengtsson, H. J., Kullberg, A., Carlzon, D., Peilot, H., and Auerbach, S. B. 2000. Serotonin autoreceptor function and antidepressant drug action. J Psychopharmacol (Oxford) 14:177-85
97. Holmes, A., Yang, R. J., and Crawley, J. N. 2002a. Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice. J Mol Neurosci 18:151-65
98. Holmes, A., Yang, R. J., Murphy, D. L., and Crawley, J. N. 2002b. Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology 27: 914-23
99. Holmes, A., Lit, Q., Murphy, D. L., Gold, E., and Crawley, J. N. 2003. Abnormal anxiety-related behavior in serotonin transporter null mutant mice: The influence of genetic background. Genes Brain Behav 2:365-80
100. Holzbauer, M., and Vogt, M. 1956. Depression by reserpine of the noradrenaline concentration in the hypothalamus of the cat. J Neurochem 1:8-11
101. Hood, S. D., Bell, C. J., and Nutt, D. J. 2005. Acute tryptophan depletion. Part I: Rationale and methodology. Austral N Z J Psychiatry 39:558-64
102. Hornung, J. P. 2003. The human raphe nuclei and the serotonergic system. J Chem Neuroanat 26:331-43
103. Hostetter, A., Ritchie, J. C., and Stowe, Z. N. 2000. Amniotic fluid and umbilical cord blood concentrations of antidepressants in three women. Biol Psychiatry 48:1032-4
104. Hou, C., Jia, F., Liu, Y., and Li, L. 2006. CSF serotonin, 5-hydroxyindolacetic acid and neuropeptide Y levels in severe major depressive disorder. Brain Res 1095:154-8
105. Hoyer, D., Hannon, J. P., and Martin, G. R. 2002. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71:533-54
106. Hrdina, P. D., Demeter, E., Vu, T. B., Sótónyi, P., and Palkovits, M. 1993. 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: Increase in 5-HT2 sites in cortex and amygdala. Brain Res 614:37-44
107. Hu, X., Oroszi, G., Chun, J., Smith, T. L., Goldman, D., and Schuckit, M. A. 2005. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res 29:8-16
108. Hu, X.-Z., Lipsky, R. H., Zhu, G., et al. 2006. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78:815-26
109. Hu, X. Z., Rush, A. J., Charney, D., et al. 2007. Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. Arch Gen Psychiatry 64:783-92
110. Iceta, R., Aramayona, J. J., Mesonero, J. E., and Alcalde, A. I. 2008. Regulation of the human serotonin transporter mediated by long-term action of serotonin in Caco-2 cells. Acta Physiol (Oxf) 193:57-65
111. Ichise, M., Vines, D. C., Gura, T., et al. 2006. Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer-and mother-reared rhesus monkeys. J Neurosci 26:4638-43
112. Jayanthi, L. D., and Ramamoorthy, S. 2005. Regulation of monoamine transporters: Influence of psychostimulants and therapeutic antidepressants. AAPS J 7:E728-38
113. Jefferson, J. W. 1975. A review of the cardiovascular effects and toxicity of tricyclic antidepressants. Psychosom Med 37:160-79
114. Jensen, P., Farago, A. F., Awatramani, R. B., Scott, M. M., Deneris, E. S., and Dymecki, S. M. 2008. Redefining the serotonergic system by genetic lineage. Nat Neurosci 11:417-9
115. Joeyen-Waldorf, J., Edgar, N., and Sibille, E. 2009. The roles of sex and serotonin transporter levels in age-and stress-related emotionality in mice. Brain Res 1286:84-93
116. Jones, J. S., Stanley, B., Mann, J. J., et al. 1990. CSF 5-HIAA and HVA concentrations in elderly depressed patients who attempted suicide. Am J Psychiatry 147:1225-7
117. Kalueff, A. V., Gallagher, P. S., and Murphy, D. L. 2006. Are serotonin transporter knockout mice 'depressed'?: Hypoactivity but no anhedonia. Neuroreport 17:1347-51
118. Kanner, B. I., and Schuldiner, S. 1987. Mechanism of transport and storage of neurotransmitters. CRC Crit Rev Biochem 22:1-38
119. Kanof, P. D., Coccaro, E. F., Johns, C. A., Siever, L. J., and Davis, K. L. 1987. Platelet [3H]imipramine binding in psychiatric disorders. Biol Psychiatry 22:278-86
120. Kennedy, J. S., Gwirtsman, H. E., Schmidt, D. E., et al. 2002. Serial cerebrospinal fluid tryptophan and 5-hydroxy indoleacetic acid concentrations in healthy human subjects. Life Sci 71:1703-15
121. Kim, D.-K., Tolliver, T. J., Huang, S.-J., et al. 2005. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology 49:798-810
122. Klaassen, T., Riedel, W. J., van Someren, A., Deutz, N. E., Honig, A., and van Praag, H. M. 1999. Mood effects of 24-hour tryptophan depletion in healthy first-degree relatives of patients with affective disorders. Biol Psychiatry 46:489-97
123. Kline, N. S. 1954. Use of Rauwolfia serpentina Benth. in neuropsychiatric conditions. Ann N Y Acad Sci 59:107-32
124. Kostowski, W., and Krzascik, P. 2003. Neonatal 5-hydroxytryptamine depletion induces depressive-like behavior in adult rats. Pol J Pharmacol 55:957-63
125. Kraft, J. B., Peters, E. J., Slager, S. L., et al. 2007. Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Biol Psychiatry 61:734-42
126. Kreiss, D. S., and Lucki, I. 1995. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. J Pharmacol Exp Ther 274:866-76
127. Kuhn, R. 1958. The treatment of depressive states with G 22355 (imipramine hydrochloride). Am J Psychiatry 115:459-64
128. Laje, G., Perlis, R. H., Rush, A. J., and McMahon, F. J. 2009. Pharmacogenetics studies in STAR*D: Strengths, limitations, and results. Psychiatr Serv 60:1446-57
129. Langer, S. Z., and Schoemaker, H. 1988. Effects of antidepressants on monoamine transporters. Prog Neuropsychopharmacol Biol Psychiatry 12:193-216
130. Lawrence, K. M., De Paermentier, F., Cheetham, S. C., Crompton, M. R., Katona, C. L., and Horton, R. W. 1989. Brain 5-HT uptake sites, labelled with [3H]-paroxetine, in post-mortem samples from depressed suicide victims. Br J Pharmacol 98 (Suppl):812P
131. Lawrence, K. M., Falkowski, J., Jacobson, R. R., and Horton, R. W. 1993. Platelet 5-HT uptake sites in depression: Three concurrent measures using [3H]imipramine and [3H]paroxetine. Psychopharmacology (Berl) 110:235-9
132. Leake, A., Fairbairn, A. F., McKeith, I. G., and Ferrier, I. N. 1991. Studies on the serotonin uptake binding site in major depressive disorder and control post-mortem brain: Neurochemical and clinical correlates. Psychiatry Res 39:155-65
133. Lebrand, C., Cases, O., Adelbrecht, C., et al. 1996. Transient uptake and storage of serotonin in developing thalamic neurons. Neuron 17:823-35
134. Lebrand, C., Cases, O., Wehrlé, R., Blakely, R. D., Edwards, R. H., and Gaspar, P. 1998a. Transient developmental expression of monoamine transporters in the rodent forebrain. J Comp Neurol 401:506-24
135. Lebrand, C., Cases, O., Wehrlé, R., Blakely, R. D., Edwards, R. H., and Gaspar, P. 1998b. Transient developmental expression of monoamine transporters in the rodent forebrain. J Comp Neurol 401:506-24
136. Lesch, K. P., Bengel, D., Heils, A., et al. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-31
137. Lesch, K. P., Meyer, J., Glatz, K., et al. 1997. The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: Alternative biallelic variation in rhesus monkeys. Rapid communication. J Neural Transm 104:1259-66
138. Leuchter, A. F., Cook, I. A., Hunter, A. M., and Korb, A. S. 2009. A new paradigm for the prediction of antidepressant treatment response. Dialogues Clin Neurosci 11:435-46
139. Leuchter, A. F., Cook, I. A., Hamilton, S. P., et al. 2010. Biomarkers to predict antidepressant response. Curr Psychiatry Rep 12:553-62
140. Levitt, P., and Rakic, P. 1982. The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey. Brain Res 256:35-57
141. Li, Q., Wichems, C., Heils, A., Van De Kar, L. D., Lesch, K. P., Murphy, D. L. 1999. Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice. J Pharmacol Exp Ther 291:999-1007
142. Lieben, C. K. J., Steinbusch, H. W. M., and Blokland, A. 2006. 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat. Behav Brain Res 168:197-207
143. Lipsky, R. H., Hu, X. Z., and Goldman, D. 2009. Additional functional variation at the SLC6A4 gene. Am J Med Genet B Neuropsychiatr Genet 150B:153
144. Little, K. Y., McLauglin, D. P., Ranc, J., et al. 1997. Serotonin transporter binding sites and mRNA levels in depressed persons committing suicide. Biol Psychiatry 41:1156-64
145. Little, K. Y., McLaughlin, D. P., Zhang, L., et al. 1998. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 155:207-13
146. Lloyd, K. G., Farley, I. J., Deck, J. H., and Hornykiewicz, O. 1974. Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Adv Biochem Psychopharmacol 11:387-97
147. Lopez, J. F., Chalmers, D. T., Little, K. Y., and Watson, S. J. 1998. A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression. Biol Psychiatry 43:547-73
148. Lopez-Ibor, J. J., Saiz-Ruiz, J., and Pérez de los Cobos, J. C. 1985. Biological correlations of suicide and aggressivity in major depressions (with melancholia): 5-Hydroxyindoleacetic acid and cortisol in cerebral spinal fluid, dexamethasone suppression test and therapeutic response to 5-hydroxytryptophan. Neuropsychobiology 14:67-74
149. Lorens, S. A., Guldberg, H. C., Hole, K., Köhler, C., and Srebro, B. 1976. Activity, avoidance learning and regional 5-hydroxytryptamine following intra-brain stem 5,7-dihydroxytryptamine and electrolytic midbrain raphe lesions in the rat. Brain Res 108:97-113
150. Lowther, S., De Paermentier, F., Cheetham, S. C., Crompton, M. R., Katona, C. L., and Horton, R. W. 1997. 5-HT1A receptor binding sites in post-mortem brain samples from depressed suicides and controls. J Affect Disord 42:199-207
151. Luellen, B. A., Gilman, T. L., and Andrews, A. M. 2010. Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake. In Experimental Models in Serotonin Transporter Research, ed. Kalueff, A. V., and LaPorte, J. L., 1-42. Cambridge: Cambridge University Press
152. Malison, R. T., Price, L. H., Berman, R., et al. 1998. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biol Psychiatry 44:1090-8
153. Mann, J. J., Malone, K. M., Psych, M. R., et al. 1996. Attempted suicide characteristics and cerebrospinal fluid amine metabolites in depressed inpatients. Neuropsychopharmacology 15:576-86
154. Mann, J. J., Huang, Y. Y., Underwood, M. D., et al. 2000. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 57:729-38
155. Mathews, T. A., Fedele, D. E., Coppelli, F. M., Avila, A. M., Murphy, D. L., and Andrews, A. M. 2004. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods 140:169-81
156. McKeith, I. G., Marshall, E. F., Ferrier, I. N., et al. 1987. 5-HT receptor binding in post-mortem brain from patients with affective disorder. J Affect Disord 13:67-74
157. McKinnon, M. C., Yucel, K., Nazarov, A., and MacQueen, G. M. 2009. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 34:41-54
158. Meltzer, C. C., Price, J. C., Mathis, C. A., et al. 1999. PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders. Am J Psychiatry 156:1871-8
159. Meltzer, C. C., Price, J. C., Mathis, C. A., et al. 2004. Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology 29:2258-65
160. Merens, W., Booij, L., Haffmans, P. J., and van der Does, A. 2008. The effects of experimentally lowered serotonin function on emotional information processing and memory in remitted depressed patients. J Psychopharmacol (Oxford) 22:653-62
161. Messa, C., Colombo, C., Moresco, R. M., et al. 2003. 5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study. Psychopharmacology (Berl) 167:72-8
162. Meyer, J. H., Kapur, S., Houle, S., et al. 1999. Prefrontal cortex 5-HT2 receptors in depression: An [18F]setoperone PET imaging study. Am J Psychiatry 156:1029-34
163. Miller, J. M., Brennan, K. G., Ogden, T. R., et al. 2009a. Elevated serotonin 1A binding in remitted major depressive disorder: Evidence for a trait biological abnormality. Neuropsychopharmacology 34:2275-84
164. Miller, J. M., Kinnally, E. L., Ogden, R. T., Oquendo, M. A., Mann, J. J., and Parsey, R. V. 2009b. Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder. Synapse 63:565-73
165. Mirmiran, M., van de Poll, N. E., Corner, M. A., van Oyen, H. G., and Bour, H. L. 1981. Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: Effects upon adult sleep and behavior in the rat. Brain Res 204:129-46
166. Montanez, S., Owens, W. A., Gould, G. G., Murphy, D. L., and Daws, L. C. 2003. Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. J Neurochem 86:210-9
167. Moreno, F. A., McGavin, C., Malan, T. P., et al. 2000. Tryptophan depletion selectively reduces CSF 5-HT metabolites in healthy young men: Results from single lumbar puncture sampling technique. Int J Neuropsychopharmacol 3:277-83
168. Moreno, F. A., McGahuey, C. A., Freeman, M. P., and Delgado, P. L. 2006. Sex differences in depressive response during monoamine depletions in remitted depressive subjects. J Clin Psychiatry 67:1618-23
169. Mrazek, D. A., Rush, A. J., Biernacka, J. M., et al. 2009. SLC6A4 variation and citalopram response. Am J Med Genet B Neuropsychiatr Genet 150B:341-51
170. Murphy, D. L., and Lesch, K.-P. 2008. Targeting the murine serotonin transporter: Insights into human neurobiology. Nat Rev Neurosci 9:85-96
171. Murphy, D. L., Lerner, A., Rudnick, G., Lesch, K.-P. 2004. Serotonin transporter: Gene, genetic disorders, and pharmacogenetics. Mol Interv 4:109-23
172. Murphy, D. L., Fox, M. A., Timpano, K. R., et al. 2008. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology 55:932-60
173. Murphy, F. C., Smith, K. A., Cowen, P. J., Robbins, T. W., and Sahakian, B. J. 2002. The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Psychopharmacology (Berl) 163:42-53
174. Murthy, N. V., Selvaraj, S., Cowen, P. J., et al. 2010. Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain. NeuroImage 52:50-4
175. Naylor, L., Dean, B., Pereira, A., Mackinnon, A., Kouzmenko, A., and Copolov, D. 1998. No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter in human hippocampus. Mol Med 4:671-4
176. Neill, D., Vogel, G., Hagler, M., Kors, D., and Hennessey, A. 1990. Diminished sexual activity in a new animal model of endogenous depression. Neurosci Biobehav Rev 14:73-6
177. Nemeroff, C. B., Knight, D. L., Franks, J., Craighead, W. E., and Krishnan, K. R. 1994. Further studies on platelet serotonin transporter binding in depression. Am J Psychiatry 151:1623-5
178. Neumeister, A., Praschak-Rieder, N., Hesselmann, B., et al. 1997. Rapid tryptophan depletion in drug-free depressed patients with seasonal affective disorder. Am J Psychiatry 154:1153-5
179. Newman, M. E., Shalom, G., Ran, A., Gur, E., and Van de Kar, L. D. 2004. Chronic fluoxetine-induced desensitization of 5-HT1A and 5-HT1B autoreceptors: Regional differences and effects of WAY-100635. Eur J Pharmacol 486:25-30
180. Nishizawa, S., Benkelfat, C., Young, S. N., et al. 1997. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 94:5308-13
181. Nordström, P., Samuelsson, M., Asberg, M., et al. 1994. CSF 5-HIAA predicts suicide risk after attempted suicide. Suicide Life Threat Behav 24:1-9
182. Oquendo, M. A., Hastings, R. S., Huang, Y.-Y., et al. 2007. Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry 64:201-8
183. Oreland, L., Wiberg, A., Asberg, M., et al. 1981. Platelet MAO activity and monoamine metabolites in cerebrospinal fluid in depressed and suicidal patients and in healthy controls. Psychiatry Res 4:21-9
184. Owen, F., Cross, A. J., Crow, T. J., et al. 1983. Brain 5-HT-2 receptors and suicide. Lancet 2:1256
185. Paasonen, M. K., and Vogt, M. 1956. The effect of drugs on the amounts of substance P and 5-hydroxytryptamine in mammalian brain. J Physiol (Lond) 131:617-26
186. Papeschi, R., and McClure, D. J. 1971. Homovanillic and 5-hydroxyindoleacetic acid in cerebrospinal fluid of depressed patients. Arch Gen Psychiatry 25:354-8
187. Pare, C. M., Yeung, D. P., Price, K., and Stacey, R. S. 1969. 5-Hydroxytryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coal-gas poisoning. Lancet 294:133-5
188. Parks, C. L., Robinson, P. S., Sibille, E., Shenk, T., and Toth, M. 1998. Increased anxiety of mice lacking the serotonin 1A receptor. Proc Natl Acad Sci USA 95:10734-9
189. Parsey, R. V., Hastings, R. S., Oquendo, M. A., et al. 2006a. Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatry 163:52-8
190. Parsey, R. V., Hastings, R. S., Oquendo, M. A., et al. 2006b. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry 163:48-51
191. Parsey, R. V., Oquendo, M. A., Ogden, R. T., et al. 2006c. Altered serotonin 1A binding in major depression: A [carbonyl-C-11]WAY100635 positron emission tomography study. Biol Psychiatry 59:106-13
192. Paul, S. M., Rehavi, M., Skolnick, P., Ballenger, J. C., and Goodwin, F. K. 1981. Depressed patients have decreased binding of tritiated imipramine to platelet serotonin "transporter". Arch Gen Psychiatry 38:1315-7
193. Peabody, C. A., Faull, K. F., King, R. J., Whiteford, H. A., Barchas, J. D., and Berger, P. A. 1987. CSF amine metabolites and depression. Psychiatry Res 21:1-7
194. Pejchal, T., Foley, M. A., Kosofsky, B. E., and Waeber, C. 2002. Chronic fluoxetine treatment selectively uncouples raphe 5-HT(1A) receptors as measured by [(35)S]-GTP gamma S autoradiography. Br J Pharmacol 135:1115-22
195. Perez, X. A., and Andrews, A. M. 2005. Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice. Anal Chem 77:818-26
196. Perez, X. A., Bianco, L. E., and Andrews, A. M. 2006. Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: Comparison with chronoamperometry in SERT knockout mice. J Neurosci Methods 154:245-55
197. Perry, E. K., Marshall, E. F., Blessed, G., Tomlinson, B. E., and Perry, R. H. 1983. Decreased imipramine binding in the brains of patients with depressive illness. Br J Psychiatry 142:188-92
198. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., et al. 2005. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nat Neurosci 8:828-34
199. Philibert, R. A., Sandhu, H., Hollenbeck, N., Gunter, T., Adams, W., and Madan, A. 2008. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet 147B:543-9
200. Pineyro, G., and Blier, P. 1999. Autoregulation of serotonin neurons: Role in antidepressant drug action. Pharmacol Rev 51:533-91
201. Pollin, W., Cardon, P. V., and Kety, S. S. 1961. Effects of amino acid feedings in schizophrenic patients treated with iproniazid. Science 133:104-5
202. Popa, D., Léna, C., Alexandre, C., and Adrien, J. 2008. Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: Evidence from sleep, stress, and behavior. J Neurosci 28:3546-54
203. Popa, D., Cerdan, J., Repérant, C., et al. 2010. A longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain. Eur J Pharmacol 628:83-90
204. Ramage, A. G., and Villalon, C. M. 2008. 5-Hydroxytryptamine and cardiovascular regulation. Trends Pharmacol Sci 29:472-81
205. Ramboz, S., Oosting, R., Amara, D. A., et al. 1998. Serotonin receptor 1A knockout: An animal model of anxiety-related disorder. Proc Natl Acad Sci USA 95:14476-81
206. Rapport, M. M., Green, A. A., and Page, I. H. 1948. Crystalline serotonin. Science 108:329-30
207. Rausch, J. L., Johnson, M. E., Li, J., et al. 2005. Serotonin transport kinetics correlated between human platelets and brain synaptosomes. Psychopharmacology (Berl) 180:391-8
208. Remick, R. A., Froese, C., and Keller, F. D. 1989. Common side effects associated with monoamine oxidase inhibitors. Prog Neuropsychopharmacol Biol Psychiatry 13:497-504
209. Richardson-Jones, J. W., Craige, C. P., Guiard, B. P., et al. 2010. 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron 65:40-52
210. Robinson, O. J., and Sahakian, B. J. 2009. Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion. Psychopharmacology (Berl) 205:227-35
211. Roiser, J. P., Blackwell, A. D., Cools, R., et al. 2006. Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion. Neuropsychopharmacology 31:2264-72
212. Rose, W. C., Haines, W. J., and Warner, D. T. 1954. The amino acid requirements of man. V. The role of lysine, arginine, and tryptophan. J Biol Chem 206:421-30
213. Rossi, D. V., Valdez, M., Gould, G. G., and Hensler, J. G. 2006. Chronic administration of venlafaxine fails to attenuate 5-HT1A receptor function at the level of receptor-G protein interaction. Int J Neuropsychopharmacol 9:393-406
214. Rossi, D. V., Burke, T. F., McCasland, M., and Hensler, J. G. 2008. Serotonin-1A receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline. J Neurochem 105:1091-9
215. Roubein, I. F., and Embree, L. J. 1979. Post mortem stability of catecholamines in discrete regions of rat brain. Res Commun Chem Pathol Pharmacol 23:143-53
216. Roy-Byrne, P., Post, R. M., Rubinow, D. R., Linnoila, M., Savard, R., and Davis, D. 1983. CSF 5HIAA and personal and family history of suicide in affectively ill patients: A negative study. Psychiatry Res 10:263-74
217. Rudnick, G. 2006. Structure/function relationships in serotonin transporter: New insights from the structure of a bacterial transporter. Handb Exp Pharmacol 175:59-73
218. Ruhé, H. G., Mason, N. S., and Schene, A. H. 2007. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: A meta-analysis of monoamine depletion studies. Mol Psychiatry 12:331-59
219. Rush, A. J. 2007. Limitations in efficacy of antidepressant monotherapy. J Clin Psychiatry 68 Suppl 10:8-10
220. Sakowski, S. A., Geddes, T. J., and Kuhn, D. M. 2006. Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. J Neurochem 96:758-65
221. Samuelsson, M., Jokinen, J., Nordström, A.-L., and Nordström, P. 2006. CSF 5-HIAA, suicide intent and hopelessness in the prediction of early suicide in male high-risk suicide attempters. Acta Psychiatr Scand 113:44-7
222. Sanders-Bush, E., Fentress, H., and Hazelwood, L. 2003. Serotonin 5-HT2 receptors: Molecular and genomic diversity. Mol Interv 3:319-30
223. Sanz, E. J., De-las-Cuevas, C., Kiuru, A., Bate, A., and Edwards, R. 2005. Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: A database analysis. Lancet 365: 482-7
224. Saunders, J. C., Radinger, N., Rochlin, D., and Kline, N. S. 1959. Treatment of depressed and regressed patients with iproniazid and reserpine. Dis Nerv Syst 20:31-9
225. Savelieva, K. V., Zhao, S., Pogorelov, V. M., et al. 2008. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS ONE 3:e3301
226. Secunda, S. K., Cross, C. K., Koslow, S., et al. 1986. Biochemistry and suicidal behavior in depressed patients. Biol Psychiatry 21:756-67
227. Sen, G., and Bose, K. 1931. Rauwolfia serpentina, a new Indian drug for insanity and high blood pressure. Ind Med World 2:194-201
228. Sen, S., Duman, R., and Sanacora, G. 2008. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: Meta-analyses and implications. Biol Psychiatry 64:527-32
229. Shaw, D. M., Camps, F. E., and Eccleston, E. G. 1967. 5-Hydroxytryptamine in the hind-brain of depressive suicides. Br J Psychiatry 113:1407-11
230. Sheline, Y. I., Mintun, M. A., Barch, D. M., Wilkins, C., Snyder, A. Z., and Moerlein, S. M. 2004. Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomography. Neuropsychopharmacology 29:2235-41
231. Sibille, E., and Lewis, D. A. 2006. SERT-ainly involved in depression, but when? Am J Psychiatry 163:8-11
232. Sibille, E., Wang, Y., Joeyen-Waldorf, J., et al. 2009. A molecular signature of depression in the amygdala. Am J Psychiatry 166:1011-24
233. Siddiqui, A., Clark, J. S., and Gilmore, D. P. 1990. Post-mortem changes of neurotransmitter concentrations in the rat brain regions. Acta Physiol Hung 75:179-85
234. Singh, Y. S., Sawarynski, L. E., Michael, H. M., et al. 2010. Boron-doped diamond microelectrodes reveal reduced serotonin uptake rates in lymphocytes from adult rhesus monkeys carrying the short allele of the 5-HTTLPR. ACS Chem Neurosci 1:49-64
235. Sinyor, M., Schaffer, A., and Levitt, A. 2010. The sequenced treatment alternatives to relieve depression (STAR*D) trial: A review. Can J Psychiatry 55:126-35
236. Spiller, R. 2008. Serotonin and GI clinical disorders. Neuropharmacology 55:1072-80
237. Stanley, M., and Mann, J. J. 1983. Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1:214-6
238. Stanley, M., Traskman-Bendz, L., and Dorovini-Zis, K. 1985. Correlations between aminergic metabolites simultaneously obtained from human CSF and brain. Life Sci 37:1279-86
239. Stockmeier, C. A., Shapiro, L. A., Dilley, G. E., Kolli, T. N., Friedman, L., and Rajkowska, G. 1998. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J Neurosci 18:7394-401
240. Sullivan, G. M., Oquendo, M. A., Huang, Y.-Y., and Mann, J. J. 2006. Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder. Int J Neuropsychopharmacol 9:547-56
241. Tagliamonte, A., Biggio, G., Vargiu, L., and Gessa, G. L. 1973. Free tryptophan in serum controls brain tryptophan level and serotonin synthesis. Life Sci II 12:277-87
242. Tanis, K. Q., Newton, S. S., and Duman, R. S. 2007. Targeting neurotrophic/growth factor expression and signaling for antidepressant drug development. CNS Neurol Disord Drug Targets 6:151-60
243. Thomas, A. J., Hendriksen, M., Piggott, M., et al. 2006. A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression. Neuropathol Appl Neurobiol 32:296-303
244. Tjurmina, O. A., Armando, I., Saavedra, J. M., Goldstein, D. S., and Murphy, D. L. 2002. Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology 143:4520-6
245. Träskman, L., Asberg, M., Bertilsson, L., and Sjöstrand, L. 1981. Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psychiatry 38:631-6
246. Träskman-Bendz, L., Asberg, M., Bertilsson, L., and Thorén, P. 1984. CSF monoamine metabolites of depressed patients during illness and after recovery. Acta Psychiatr Scand 69:333-42
247. Trowbridge, S., Narboux-Neme, N., and Gaspar, P. 2010. Genetic models of serotonin (5-HT) depletion: What do they tell us about the developmental role of 5-HT? Anat Rec (Hoboken) PMID: 20818612
248. Twarog, B. M., and Page, I. H. 1953. Serotonin content of some mammalian tissues and urine and a method for its determination. Am J Physiol 175:157-61
249. Uebelhack, R., Franke, L., Herold, N., Plotkin, M., Amthauer, H., and Felix, R. 2006. Brain and platelet serotonin transporter in humans-correlation between [123I]-ADAM SPECT and serotonergic measurements in platelets. Neurosci Lett 406:153-8
250. Uher, R., and McGuffin, P. 2008. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Mol Psychiatry 13:131-46
251. Vakil, R. J. 1949. A clinical trial of Rauwolfia serpentina in essential hypertension. Br Heart J 11:350-5
252. van Dyck, C. H., Malison, R. T., Staley, J. K., et al. 2004. Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. Am J Psychiatry 161:525-31
253. Velazquez-Moctezuma, J., and Diaz Ruiz, O. 1992. Neonatal treatment with clomipramine increased immobility in the forced swim test: An attribute of animal models of depression. Pharmacol Biochem Behav 42:737-9
254. Verney, C., Lebrand, C., and Gaspar, P. 2002. Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter. Anat Rec 267:87-93
255. Vialli, M., and Erspamer, V. 1937. Ricerche sul secreto delle cellule enterocromaffini. IX Intorno alla natura chimica della sostanza specifica. Boll Soc Med-Chir Pavia 51:1111-6
256. Vialli, M., and Erspamer, V. 1940. Ricerche di caratterizzazione chimica delle sostanze fenoliche presenti negli estratti acetonici di ghiandole salivari posteriori di Octopus vulgaris. Arch Fisiol 40:293-302
257. Vitalis, T., Cases, O., Callebert, J., et al. 1998. Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: Determination of a sensitive developmental period. J Comp Neurol 393:169-84
258. Vitalis, T., Fouquet, C., Alvarez, C., et al. 2002. Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse. J Comp Neurol 442:331-47
259. Vogel, G., Neill, D., Hagler, M., and Kors, D. 1990. A new animal model of endogenous depression: A summary of present findings. Neurosci Biobehav Rev 14:85-91
260. Walderhaug, E., Magnusson, A., Neumeister, A., et al. 2007. Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biol Psychiatry 62:593-9
261. Walther, D. J., Peter, J.-U., Bashammakh, S., et al. 2003. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299:76
262. Wendland, J. R., Moya, P. R., Kruse, M. R., et al. 2008. A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet 17:717-23
263. White, K. J., Walline, C. C., and Barker, E. L. 2005. Serotonin transporters: Implications for antidepressant drug development. AAPS J 7:E421-33
264. Wilkins, R. W., and Judson, W. E. 1953. The use of Rauwolfia serpentina in hypertensive patients. N Engl J Med 248:48-53
265. Willeit, M., Stastny, J., Pirker, W., et al. 2001. No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism. Biol Psychiatry 50:8-12
266. Yang, G. B., Qiu, C. L., Zhao, H., Liu, Q., and Shao, Y. 2006. Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques. J Neuroimmunol 178:24-9
267. Yang, G. B., Qiu, C. L., Aye, P., Shao, Y., and Lackner, A. A. 2007. Expression of serotonin transporters by peripheral blood mononuclear cells of rhesus monkeys (Macaca mulatta). Cell Immunol 248:69-76
268. Yates, M., Leake, A., Candy, J. M., Fairbairn, A. F., McKeith, I. G., and Ferrier, I. N. 1990. 5HT2 receptor changes in major depression. Biol Psychiatry 27:489-96
269. Zalsman, G., Huang, Y. Y., Oquendo, M. A., et al. 2006. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 163:1588-93
270. Zhang, X., Beaulieu, J.-M., Sotnikova, T. D., Gainetdinov, R. R., and Caron, M. G. 2004. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305:217
271. Zhang, X., Gainetdinov, R. R., Beaulieu, J.-M., et al. 2005. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45:11-6
272. Zhang, X., Nicholls, P. J., Laje, G., et al. 2010. A functional alternative splicing mutation in human tryptophan hydroxylase-2. Mol Psychiatry doi: 10.1038/mp.2010.99
273. Zipursky, R. B., Meyer, J. H., and Verhoeff, N. P. 2007. PET and SPECT imaging in psychiatric disorders. Can J Psychiatry 52:146-57