No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter in human hippocampus

Molecular Medicine

Volumn 4, Issue 10, 1998, Pages 671-674

  Naylor, Lee ^a,b   Dean, Brian ^a   Pereira, Avril ^a   Mackinnon, Andrew ^a,c   Kouzmenko, Alexander ^a   Copolov, David ^a  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MESSENGER RNA; PAROXETINE; SEROTONIN TRANSPORTER; TRITIUM;

ARTICLE; BINDING AFFINITY; CASE CONTROL STUDY; CEREBELLUM; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENOTYPE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA;

EID: 0031788633     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401928     Document Type: Article

References (18)

1. 3H]Paroxetine binding is altered in the hippocampus but not the frontal cortex or caudate nucleus from subjects with schizophrenia. J. Neurochem. 64: 1197-1202.
2. 3H]paroxetine. J. Neural Transm. 103: 749-757.
3. Kendler KS, Diehl SR. (1993) The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr. Bull. 19: 261-285.
4. Lesch KP, Balling U, Gross J, Strauss K, Murphy DL, Riederer P. (1994) Organisation of the human serotonin transporter gene. J. Neural Transm. 95: 157-162.
5. Heils A, Teufel A, Petri S, Stober G, Bengel D, Lesch KP. (1996) Allelic variation of human serotonin transporter gene expression. J. Neurochem. 6: 561-567.
6. Furlong R, Ho L, Walsh C, et al. (1998) Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am. J. Med. Genet. 81: 58-63.
7. Collier DA, Stober G, Li T, et al. (1996) A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol. Psychiatry 1: 453-460.
8. Lesch KP, Bengal D, Heils A, et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531.
9. Li T, Holmes C, Sham P, et al. (1997) Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neuroreport 8: 683-686.
10. Mendes-de-Oliveira J, Otto P, Vallada H, et al. (1998) Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia. Am. J. Med. Genet. 81: 225-227.
11. Hoehe M, Wendel B, Grunewald I, et al. (1998) Serotonin transporter (5-HTT) gene polymorphism are not associated with susceptibility to mood disorders. Am. J. Med. Genet. 81: 1-3.
12. Stober G, Jatzke S, Heils A, et al. (1998) Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene. Eur. Arch. Psychiatr. Clin. Neurosci. 248: 82-86.
13. Sanders-Bush E. (1988) The Serotonin Receptors. Humana Press, Clifton, NJ.
14. Stahl S, Woo D, Mefford I, Berger P, Ciaranello R. (1983) Hyperserotonemia and platelet serotonin uptake in schizophrenia and affective disorders. Am. J. Psychiatry 140: 26-31.
15. Meltzer HY. (1989) Serotonergic dysfunction in depression. Br. J. Psychiatry Suppl. 8: 25-31.
16. American Psychiatric Association. (1994) Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition (DSM-IV). Washington, DC: American Psychiatric Press.
17. Hill C, Keks N, Roberts S, Opeskin K, Dean B, Copolov DL. (1996) Postmortem brain studies in schizophrenia: the problems of diagnosis. Am. J. Psychiatry 153: 533-537.
18. Sasieni, PD. (1997) From genotype to genes: doubling the sample size. Biometrics 53: 1253-1261.