PET imaging of serotonin 1A receptor binding in depression

Biological Psychiatry

Volumn 46, Issue 10, 1999, Pages 1375-1387

  Drevets, Wayne C ^a   Frank, Ellen ^a   Price, Julie C ^a   Kupfer, David J ^a   Holt, Daniel ^a   Greer, Phil J ^a   Huang, Yiyun ^a   Gautier, Clara ^a   Mathis, Chester ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bipolar disorder; Hippocampus; Major depressive disorder; PET; Raphe; Serotonin

Indexed keywords

SEROTONIN 1A RECEPTOR;

AMYGDALOID NUCLEUS; ARTICLE; BIPOLAR DEPRESSION; CONTROLLED STUDY; DEPRESSION; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; MESENCEPHALON; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAPHE NUCLEUS; RECEPTOR BINDING;

ADULT; BINDING, COMPETITIVE; BIPOLAR DISORDER; BRAIN; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; HYDROCORTISONE; MAGNETIC RESONANCE IMAGING; MALE; RECEPTORS, SEROTONIN; RECURRENCE; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0032731312     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00189-4     Document Type: Article

References (97)

1. Altshuler L.L., Casanova M.F., Goldberg T.E., Kleinman J.E. The hippocampus and parahippocampus in schizophrenic, suicide, and control brains. Arch Gen Psychiatry. 47:1990;1029-1034.
2. Altshuler L.L., Bartzokis G., Grieder T., Curran J., Mintz J. Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia An MRI study demonstrating specificity . Arch Gen Psychiatry. 55:1998;663-664.
3. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. 1994;American Psychiatric Press, Washington, DC.
4. Andrade R., Nicoll R.A. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J Physiol. 394:1987;99-124.
5. Arana G.W., Baldessarini R.J., Ornsteen M. The dexamethasone suppression test for diagnosis and prognosis in psychiatry. Arch Gen Psychiatry. 42:1985;1193-1204.
6. Arango V., Underwood M., Gubbi A., Mann J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res. 688:1995;121-133.
7. Arranz B., Eriksson A., Mellerup E., Plenge P., Marcusson J. Brain 5-HT1A, 5-HT1D and 5-HT2 receptors in suicide victims. Biol Psychiatry. 35:1994;457-463.
8. Axelson D., Doraiswamy P.M., McDonald W.M., et al. Hypercortisolemia and amygdala-hippocampal changes in depression. Psychiatry Res. 47:1993;167-173.
9. Azmitia E.C., Gannon P.J., Kheck N.M., Whitaker-Azmitia P.M. Cellular localization of the 5HT1A receptor in primate brain neurons and glial cells. Neuropsychopharmacology. 14:1996;35-46.
10. Azmitia E.C., Whitaker-Azmitia P.M. Awakening the sleeping giant Anatomy and plasticity of the brain serotonergic system . J Clin Psychiatry. 52:(suppl 12):1991;4-16.
11. Bagdv G., Calogero A., Aulakh C., et al. Long-term cortisol treatment impairs behavioral and neuroendocrine responses to 5-HT1 agonists in the rat. Neuroendocrinology. 50:1989;241-247.
12. Baumann BG, Bogerts B (1998): Postmortem studies of bipolar disorder. Presented at the Stanley Foundation European Bipolar Symposium, Royal Society, London, September 24, 1998.
13. Benes F.M., Kwok E.W., Vincent S.L., Todtenkopf M.S. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry. 44:1998;88-97.
14. Bowen D.M., Najlerahim A., Procter A.W., Francis P.T., Murphy E. Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life. Proc Natl Acad Sci U S A. 86:1989;9504-9508.
15. 3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia . Neurochem Int. 30:1997;565-574.
16. Brix G., Zaers J., Adam L.-E., et al. Performance evaluation of a whole-body PET scanner using the NEMA protocol. J Nuc Med. 38:1997;1614-1623.
17. Bronen R.A., Cheung G. Relationship of hippocampus and amygdala to coronal MRI landmarks. Magn Reson Imaging. 9:1991;449-457.
18. 3H]8-OH-DPAT binding and serotonin content in rat cerebral cortex after acute fluoxetine, desipramine, or pargyline. J Psychiatry Neurosci. 21:1996;114-122.
19. Cervo L., Grignaschi G., Samanin R. 8-Hydroxy-2-(di-n-propylamino)tetralin, a selective serotonin 1A receptor agonist reduces the immobility of rats in the forced swimming test by acting on the nucleus raphe dorsalis. Eur J Pharmacol. 158:1988;53-59.
20. Chalmers D.T., Kwak S.P., Mansour A., Akil H., Watson S.J. Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression. J Neurosci. 13:1993;914-923.
21. Chaput Y., deMontigny C., Blier P. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology. 5:1991;219-229.
22. Charney D.S., Delgado P.L., Southwick S.M., Krystal J.H., Price L.H., Heninger G.R. Current hypothesis of the mechanism of antidepressant treatments implications for the treatment of refractory depression . Amsterdam J.D. Refractory Depression. 1991;23-40 Raven Press, New York.
23. Cheetham S., Crompton M., Katona C., Horton R. Brain 5-HT1 binding sites in depressed suicides. Psychopharmacology. 102:1990;544-548.
24. Colino A., Halliwell J.V. Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin. Nature. 328:1987;73-77.
25. Detke M., Wieland S., Lucki I. Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists. Psychopharmacology. 119:1995;47-54.
26. Dillon K., Gross-Isseroff R., Israeli M., Biegon A. Autoradiographic analysis of serotonin 5-HT1A receptor binding in the human brain postmortem Effects of age and alcohol . Brain Res. 554:1991;56-64.
27. Drevets WC, Gadde KM, Krishnan KRR (1999): Neuroimaging studies of mood disorders. Charney D, Nestler E, Bunney BS, editors. The Neurobiological Foundation of Mental Illness. New York: Oxford University Press.
28. Drevets W.C., Price J.L., Simpson J.R., Todd R.D., Reich T., Raichle M.E. State- and trait-like neuroimaging abnormalities in depression Effects of antidepressant treatment . Soc Neurosci Abstr. 22:1996;266.
29. Drevets W.C., Price J.L., Simpson J.R., et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 386:1997;824-827.
30. Drevets W.C., Price J.L., Simpson J.R., et al. Amygdala hypermetabolism in unipolar and bipolar depression correlation with plasma cortisol. Soc Neurosci Abstr. 23:1997;1407.
31. Drevets W.C., Spitznagel E., Raichle M. Functional anatomical differences between major depressive subtypes. J Cereb Blood Flow Metab. 15:1995;S93.
32. Drevets W.C., Todd R.D. Depression, mania and related disorders. Guze S.B. Adult Psychiatry. 1997;99-142 Mosby Press, St. Louis.
33. Drevets W.C., Videen T.O., Price J.L., Preskorn S.H., Carmichael S.T., Raichle M.E. A functional anatomical study of unipolar depression. J Neurosci. 12:1992;3628-3641.
34. Fletcher A., Bill D., Cliffe I., Forster E., Reilly Y. A pharmacological profile of WAY-100635, a potent and highly effective 5-HT1A receptor antagonist. Br J Pharmacol. 112:1993;91P.
35. Forster E.A., Cliffe I.A., Bill D.J., et al. A pharmacological profile of the selective silent 5HT1A receptor antagonist, WAY-100635. Eur J Pharmacol. 281:1995;81-88.
36. Frazer A., Hensler J.G. 5-HT1A receptors and 5-HT1A-mediated responses Effect on treatments that modify serotonergic neurotransmission . Whitaker-Azmitia P.M., Peroutka S.J. The Neuropharmacology of Serotonin. 1990;460-475 The New York Academy of Sciences, New York.
37. Grubb R.L., Raichle M.E., Higgins C.S., Eichling J.O. Measurement of regional cerebral blood volume by emission tomography. Ann Neurol. 4:1978;322-328.
38. 11C]WAY-100635 for PET. Neuroimage. 8:1998;426-440.
39. Haddjeri N., Blier P., de Montigny C. Long-term antidepressant treatments result in tonic activation of forebrain 5-HT1A receptors. J Neurosci. 18:1998;10150-10156.
40. 11C]WAY-100635. Brain Res. 745:1997;96-108.
41. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 23:1960;56-62.
42. Hauser P., Altshuler L.L., Berrettini W., Dauphinais I.D., Gelernter J., Post R.M. Temporal lobe measurement in primary affective disorder by magnetic resonance imaging. J Neuropsychiatry. 1:1989;128-134.
43. Hensler J., Kovachich G., Frazer A. A quantitative autoradiographic study of serotonin1A receptor regulation. Neuropsychopharmacology. 4:1991;131-144.
44. Joyce J., Shane A., Lexow N., Winokur A., Casanova M., Kleinman J. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology. 8:1993;315-336.
45. Kassir S.A., Underwood M.D., Bakalian M.J., Mann J.J., Arango V. 5HT1A binding in dorsal and median raphe nuclei of suicide victims. Soc Neurosci Abstr. 24:1998;1274.
46. 11C]raclopride studies. J Cereb Blood Flow Metab. 16:1996;42-52.
47. 3H]WAY 100635 in the mouse. Eur J Pharmacol. 271:1994;505-514.
48. Lesch K. The ipsapirone/5-HT1A receptor challenge in anxiety disorders and depression. Stahl S., Hesselink J.K., Gastpar M., Traber J. Serotonin 1A Receptors in Depression and Anxiety. 1992;135-162 Raven Press, Ltd, New York.
49. Lesch K., Disselkamp-Tietze J., Schmidtke A. 5-HT1A receptor function in depression Effect of chronic amitriptyline treatment . J Neural Transm. 80:1990;157-161.
50. Lesch K., Mayer S., Disselkamp-Tietze J., et al. 5-HT1A receptor responsivity in unipolar depression. Evaluation of ipsapirone-induced ACTH and cortisol secretion in patients and controls. Biol Psychiatry. 28:1990;620-628.
51. Lesch K., Schulte H., Osterheider M., Miller T. Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obsessive-compulsive disorder. Psychopharmacology. 105:1991;415-420.
52. Lewis D.A., Kathol R.G., Sherman B.M., Winokur G., Schlesser M.A. Differentiation of depressive subtypes by insulin insensitivity in the recovered phase. Arch Gen Psychiatry. 40:1984;167-170.
53. Lewis D.A., McChesney C. Tritiated imipramine binding distinguishes among subtypes of depression. Arch Gen Psychiatry. 42:1985;485-488.
54. Links J.M., Zubieta J.K., Meltzer C.C., Stumpf M.J., Frost J.J. Influence of spatially heterogenous background activity on "hot object" quantitation in brain emission computed tomography. J Comput Assist Tomogr. 20:1996;680-687.
55. 1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus Implications for the neurobiology of depression . Biol Psychiatry. 43:1998;547-573.
56. Lowther S., DePaermentier F., Cheetham S.C., Crompton M.R., Katona C.L.E., Horton R.W. 5HT1A Receptor binding sites in postmortem brain samples from depressed suicides and controls. J Affect Disord. 42:1997;199-207.
57. Maes M., Meltzer H.Y. The serotonin hypothesis of major depression. Bloom F.E., Kupfer D.J. Psychopharmacology The Fourth Generation of Progress . 1995;933-944 Raven Press, New York.
58. 123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography. Biol Psychiatry. 44:1998;1090-1098.
59. Matsubara S., Arora R., Meltzer H. Serotonergic measures in suicide brain 5-HT1A binding sites in frontal cortex of suicide victims . J Neural Transm. 85:1991;181-194.
60. Mazziotta J.C., Phelps M.E., Plummer D., Kuhl D.E. Quantitation in positron emission computed tomography 5. Physical-anatomical effects . J Comput Assist Tomogr. 5:1981;734-743.
61. 11C-carboxylation of an immobilized Grignard reagent. J Label Compds Radiopharm. 38:1996;941-953.
62. McEwen B.S. Stressful experience, brain, and emotions developmental, genetic, and hormonal influences . Gazzaniga M.S. The Cognitive Neurosciences. 1995;MIT Press, Cambridge, Massachusetts. chapter 74.
63. McKittrick C.R., Blanchard D.C., McEwen B.S., Sakai R.R. Serotonin receptor binding in a colony model of chronic social stress. Biol Psychiatry. 37:1995;383-393.
64. Meijer O.C., de Kloet E.R. Corticosterone suppresses the expression of 5-HT1A receptor mRNA in rat dentate gyrus. Eur J Pharmacol. 266:1994;255-261.
65. Meijer O.C., Van Oosten R.V., de Kloet E.R. Elevated basal trough levels of corticosterone suppress hippocampal 5-HT1A receptor expression in adrenally intact rats Implication for the pathogenesis of depression . Neuroscience. 80:1997;419-426.
66. Mendelson S.D., McEwen B.S. Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats. Neuroendocrinology. 54:1991;454-461.
67. Mendelson S.D., McEwen B.S. Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat. Neuroendocrinology. 55:1992;444-450.
68. Moldin S.O., Reich T., Rice J.P. Current perspectives on the genetics of unipolar depression. Behav Genet. 21:1991;211-242.
69. Nemeroff C.B., Widerlov E., Bisette G., et al. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science. 226:1984;1342-1344.
70. Öngür D., Drevets W.C., Price J.L. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Nat Acad Sci U S A. 95:1998;13290-13295.
71. Osman S., Lundkvist C., Pike V., et al. Radioactive metabolites of the 5-HT1A receptor radioligand. [O-methyl-11C]WAY-100635, in rat, monkey and humans plus evaluation of the brain uptake of the metabolite. [O-methyl-11C]WAY-100634 in monkey. J Label Compds Radiopharm. 37:1995;283.
72. 11C]WAY-100635 - explanation of high signal contrast in PET and an aid to biomathematical modelling. Nucl Med Biol. 25:1998;215-223.
73. Pazos A., Probst A., Palacios J. Serotonin receptors in the human brain-III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience. 21:1987;97-122.
74. Pearlson G.D., Barta P.E., Powers R.E., et al. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry. 41:1997;1-14.
75. Pike V., McCarron J., Lammertsma A., et al. Exquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11C]WAY-100635. Eur J Pharmacol. 301:1996;R5-R7.
76. Pranzatelli M.R. Dissociation of the plasticity of 5HT1A sites and 5HT transporter sites. Neurochem Res. 19:1994;311-315.
77. Rajkowska G., Miguel-Hidalgo J.J., Wei J., et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry. 45:1999;1085-1098.
78. Rice J., Reich T., Andreasen N., et al. The familial transmission of bipolar illness. Arch Gen Psychiatry. 44:1987;441-447.
79. 11C]WAY100635. Neuroimage. 5:1997;A41.
80. Sheline Y.I., Wang P.W., Gado M.H., Csernansky J.G., Vannier M.W. Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci U S A. 93:1996;3908-3913.
81. Sprouse J.S., Aghajanian G.K. Responses of hippocampal pyramidal cells to putative serotonin 5- HT1A and 5-HT1B agonists A comparative study with dorsal raphe neurons . Neuropharmacology. 27:1988;707-715.
82. Spurlock G., Buckland P., O'Donovan M., McGuffin P. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology. 33:1994;433-440.
83. Stockmeier C.A., Dilley G.E., Shapiro L.A., Overholser J.C., Thompson P.A., Meltzer H.Y. Serotonin receptors in suicide victims with major depression. Neuropsychopharmacology. 16:(2):1997;162-173.
84. Stockmeier C.A., Shapiro L.A., Dilley G.E., et al. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression - postmortem evidence for decreased serotonin activity. J Neurosci. 18:1998;7394-7401.
85. Swayze S.M., Andreasen N.C., Alliger R.J., et al. Subcortical and temporal lobe structures in affective disorder and schizophrenia A magnetic resonance imaging study . Biol Psychiatry. 31:1992;221-240.
86. Townsend D.W., Isoardi R.A., Bendriem B. Volume imaging tomographs. Bendriem B., Townsend D.W. The Theory and Practice of 3D PET. 1998;133-167 Kluwer Academic Publishers, Boston.
87. Underwood M.D., Johnson V.L., Bakalian M.J., et al. Morphometry of dorsal raphe nucleus serotonergic neurons in alcoholics. Soc Neurosci Abstr. 24:1998;1273.
88. Verge D., Davel G., Marcinkiewicz M., et al. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control and 5,7 dihydroxytryptamine treated rats. J Neurosci. 6:1986;3474-3482.
89. Wallach J. Interpretation of Diagnostic Tests. 1978;18 Little Brown, Boston.
90. Wang R.Y., Aghajanian G.K. Enhanced sensitivity of amygdaloid neurons to serotonin and norepinephrine after chronic antidepressant treatment. Commun Psychopharmacol. 4:1980;83-90.
91. Welner S., deMontigny C., Desroches J., Desjardins P., Suranyl-Cadotte B. Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse. 4:1989;347-352.
92. Wienhard K. Applications of 3D PET. Bendriem B., Townsend D.W. The Theory and Practice of 3D PET. 1998;133-167 Kluwer Academic Publishers, Boston.
93. Winokur G. The development and validity of familial subtypes in primary unipolar depression. Pharmacopsychiatry. 15:1982;142-146.
94. Wiseman M., Nichols T., Dachille M., Mintun M. Working toward an automatic and accurate method for PET-MR alignment. J Nucl Med. 37:1996;224P.
95. Woods R.P., Mazziotta J.C., Cherry S.R. MRI-PET registration with automated algorithm. J Comput Assist Tomogr. 17:1993;536-546.
96. Young E.A., Haskett R.F., Grunhaus L., et al. Increased evening activation of the hypothalamic-pituitary-adrenal axis in depressed patients. Arch Gen Psychiatry. 50:1993;395-403.
97. Zhono P., Ciaranello R. Transcriptional regulation of hippocampal 5-HT1A receptors by glucocorticoid hormones. Neuroscience. 20:1994;1161.