The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: Alternative biallelic variation in rhesus monkeys

Journal of Neural Transmission

Volumn 104, Issue 11-12, 1997, Pages 1259-1266

  Lesch, K P ^a   Meyer, J ^a   Glatz, K ^a   Flugge G ^b   Hinney, A ^c   Hebebrand, J ^c   Klauck, S M ^d   Poustka, A ^d   Poustka, F ^e   Bengel, D ^a   Mossner R ^a   Riederer, P ^a   Heils, A ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b GERMAN PRIMATE CENTER   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e GOETHE UNIVERSITY   (Germany)

Author keywords

Allelic variation; Evolution; Macaca mulatta; Primates; Serotonin transporter gene linked polymorphic region

Indexed keywords

SEROTONIN TRANSPORTER;

ALLELE; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; EVOLUTION; GENE FREQUENCY; GENE LOCUS; GENE SEQUENCE; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOME; GENOTYPE; HUMAN; MAMMAL; MENTAL DISEASE; MONKEY; NEUROPATHOLOGY; NONHUMAN; PERSONALITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RHESUS MONKEY; RISK; SOCIALIZATION; SOUTHERN BLOTTING; SPECIES DIFFERENCE;

ALLELES; ANIMALS; CARRIER PROTEINS; CEBIDAE; CERCOPITHECIDAE; EVOLUTION; FEMALE; GALAGO; GORILLA GORILLA; HUMANS; MACACA MULATTA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PAN TROGLODYTES; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC; TUPAIA;

EID: 6844252264     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01294726     Document Type: Article

References (11)

1. Baumeister RF, Tice DM (1990) Anxiety and social exclusion. J Soc Clin Psychol 9: 165-195
2. Bengel D, Heils A, Petri S, Teufel A, Seemann M, Riederer P, Murphy DL, Lesch KP (1997) Gene structure and 5′-flanking regulatory region of the murine serotonin transporter. Mol Brain Res 44: 286-293
3. Collier DA, Stöber G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, P VH, Bengel D, Müller CR, Roberts GW, Smeraldi E, Kirov G, Sham P, Lesch KP (1996) Susceptibility to bipolar affective disorder and unipolar depression is influenced by allelic variation of functional serotonin transporter expression. Mol Psychiatry 1: 453-460
4. Cook EH, Courchesne R, Lord C, Cox NJ, Van S, Lincoln A, Haas R, Courchesne E, Leventhal BL (1997) Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 2: 247-250
5. Heils A, Teufel A, Petri S, Stöber C, Riederer P, Bengel B, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 6: 2621-2624
6. Klauck SM, Poustka F, Benner A, Lesch KP, Poustka A (1997) Serotonin transporter (5-HTT) gene variants associated with autism? Hum Mol Gen 6 (in press)
7. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531
8. Li T, Holmes C, Sham PC, Vallada H, Birkett J, Kirov G, Lesch KP, Powell J, Lovestone S, Collier D (1997) Allelic functional variation of serotonin transporter expression is a susceptibility factor for late-onset Alzheimer's disease. Neuroreport 8: 683-686
9. Matsushita S, Muramatsu T, Kimura M, Shirakawa O, Mita T, Nakai T, Higuchi S (1997) Serotonin transporter gene regulatory region polymorphism and panic disorder. Mol Psychiatry 2: 390-391
10. Mountain JL, Lin AA, Bowcock AM, Cavalli-Sforza LL (1992) Evolution of modern humans: evidence from nuclear DNA polymorphisms. Phil Trans R Soc Lond Biol 337: 159-165
11. Sander T, Harms H, Dufeu P, Kuhn S, Hoehe M, Lesch KP, Schmidt LG (1997) Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psychiatry (in press)