Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography

Archives of General Psychiatry

Volumn 64, Issue 2, 2007, Pages 201-208

  Oquendo, Maria A ^a,b   Hastings, Ramin S ^b   Huang, Yung Yu ^a,b   Simpson, Norman ^a,b   Ogden, R Todd ^a,b,d   Hu, Xian Zhang ^c   Goldman, David ^c   Arango, Victoria ^a,b   Van Heertum, Ronald L ^a,b   Mann, J John ^a,b   Parsey, Ramin V ^a,b  

^a College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE C 11; MCNEIL 5652; RADIOPHARMACEUTICAL AGENT; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BIPOLAR DISORDER; BRAIN REGION; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DNA POLYMORPHISM; FEMALE; GENOTYPE; HIPPOCAMPUS; HUMAN; IN VIVO STUDY; ISOTOPE LABELING; MALE; MESENCEPHALON; NEUROTRANSMISSION; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; PUTAMEN; RADIOASSAY; SEROTONINERGIC SYSTEM; SEROTONINERGIC TRANSMISSION; THALAMUS; UNIVERSITY HOSPITAL;

ADOLESCENT; ADULT; AGED; BIPOLAR DISORDER; BRAIN; CARBON RADIOISOTOPES; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER; FEMALE; GENOTYPE; HUMANS; ISOQUINOLINES; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TISSUE DISTRIBUTION;

EID: 33846857304     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.64.2.201     Document Type: Article

References (60)

1. Murray CJL. Rethinking DALYs. In: Murray CJL, Lopez AD, eds. The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability From Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020. Boston, Mass: Harvard School of Public Health; 1996:1-98.
2. Haldane M, Frangou S. New insights help define the pathophysiology of bipolar affective disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:943-960.
3. Strakowski SM, DelBello MP, Adler CM. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry. 2005;10:105-116.
4. Gijsman HJ, Geddes JR, Rendell JM, Nolen WA, Goodwin GM. Antidepressants for bipolar depression. Am J Psychiatry. 2004;161:1537-1547.
5. Oquendo MA, Mann JJ. Serotonergic dysfunction in mood disorders. In: Soares J, Gershon S, eds. Basic Mechanisms and Therapeutic Implications of Bipolar Disorder. New York, NY: Marcel Dekker Inc; 2000:121-142.
6. Meltzer HY, Arora RC, Baber R, Tricou B-J. Serotonin uptake in blood platelets of psychiatric patients. Arch Gen Psychiatry. 1981;38:1322-1326.
7. Born GVR, Grignani G, Martin K. Long-term effect of lithium on the uptake of 5-hydroxytryptamine by human platelets. Br J Clin Pharmacol. 1980;9:321-325.
8. Scott M, Reading HW, Loudon JB. Studies on human blood platelets in affective disorders. Psychopharmacol (Berl). 1979;60:131-135.
9. Marazziti D, Lenzi A, Galli L, San Martino S, Cassano GB. Decreased platelet serotonin uptake in bipolar I patients. Int Clin Psychopharmacol. 1991;6:25-30.
10. Stahl SM, Woo DJ, Mefford WN, Berger PA, Ciaranello RD. Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders. Am J Psychiatry. 1983;140:26-30.
11. 123I]-2β-carbomethoxy-3β-(4-iodophenyl) tropane and single photon emission computer tomography. Biol Psychiatry. 1998;44:1090-1098.
12. Newberg AB, Plossl K, Mozley PD, Stubbs JB, Wintering N, Udeshi M, Alavi A, Kauppinen T, Kung HF. Biodistribution and imaging with (123)I-ADAM: a serotonin transporter imaging agent. J Nucl Med. 2004;45:834-841.
13. Parsey RV, Hastings RS, Oquendo MA, Huang YY, Simpson N, Arcement J, Huang Y, Ogden RT, Van Heertum RL, Arango V, Mann JJ. Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatry. 2006;163:48-57.
14. Meyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, Potter WZ, Ginovart N, Spencer EP, Cheok A, Houle S. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am J Psychiatry. 2004;161:826-835.
15. Ichimiya T, Suhara T, Sudo Y, Okubo Y, Nakayama K, Nankai M, Inoue M, Yasuno F, Takano A, Maeda J, Shibuya H. Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652. Biol Psychiatry. 2002;51:715-722.
16. Reivich M, Amsterdam JD, Brunswick DJ, Shiue C-Y. PET brain imaging with [11C](+)McN5652 shows increased serotonin transporter availability in major depression. J Affect Disord. 2004;82:321-327.
17. Parsey RV, Mann JJ. Applications of positron emission tomography in psychiatry. Semin Nucl Med. 2003;33:129-135.
18. Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527-1531.
19. Cho HJ, Meira-Lima I, Cordeiro O, Michelon L, Sham P, Vallada H, Collier DA. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder. Mol Psychiatry. 2005;10:771-781.
20. Lasky-Su JA, Faraone SV, Glatt SJ, Tsuang MT. Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet B Neuropsychiatr Genet. 2005;133:110-115.
21. Hu X, Oroszi G, Chun J, Smith TL, Goldman D, Schuckit MA. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res. 2005;29:8-16.
22. Mayberg HS. Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci. 1997;9:471-481.
23. Drevets WC, Ongür D, Price JL. Neuroimaging abnormalities in the subgenual prefrontal cortex. Mol Psychiatry. 1998;3:220-226.
24. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994.
25. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders. Washington, DC: American Psychiatric Press; 1997.
26. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960; 23:56-62.
27. Parsey RV, Oquendo MA, Ogden RT, Olvet DM, Simpson N, Huang YY, Van Heertum RL, Arango V, Mann JJ. Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol Psychiatry. 2006;59:106-113.
28. Frankle WG, Huang Y, Hwang DR, Talbot PS, Slifstein M, Van Heertum R, Abi-Dargham A, Laruelle M. Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. J Nucl Med. 2004;45:682-694.
29. Jenkinson M, Smith S. A global optimisation method for robust affine registration of brain images. Med Image Anal. 2001;5:143-156.
30. Duvernoy HM. The Human Brain: Surface, Three-dimensional Sectional Anatomy and MRI. Vienna, Austria: Springer-Verlag Wien; 1991.
31. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging. New York, NY: Thieme Medical Publishers Inc; 1988.
32. Kates WR, Abrams MT, Kaufmann WE, Breiter SN, Reiss AL. Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Res. 1997;75:31-48.
33. Killiany RJ, Moss MB, Nicholson T, Jolesz F, Sandor T. An interactive procedure for extracting features of the brain from magnetic resonance images: the lobes. Hum Brain Mapp. 1997;5:355-363.
34. Lemieux L, Hammers A, Mackinnon T, Liu RS. Automatic segmentation of the brain and intracranial cerebrospinal fluid in T1-weighted volume MRI scans of the head, and its application to serial cerebral and intracranial volumetry. Magn Reson Med. 2003;49:872-884.
35. 11C]McN 5652. J Nucl Med. 2000;41:1465-1477.
36. 11C]NNC 756. Synapse. 1999;32:93-109.
37. Gandelman MS, Baldwin RM, Zoghbi SS, Zea-Ponce Y, Innis RB. Evaluation of ultrafiltration for the free-fraction determination of single photon emission computed tomography (SPECT) radiotracers: β-CIT, IBF, and iomazenil. J Pharm Sci. 1994;83:1014-1019.
38. Logan J, Wolf AP, Shiue C-Y, Fowler JS. Kinetic modeling of receptor-ligand binding applied to positron emission tomographic studies with neuroleptic tracers. J Neurochem. 1987;48:73-83.
39. Slifstein M, Laruelle M. Effects of statistical noise on graphic analysis of PET neuroreceptor studies. J Nucl Med. 2000;41:2083-2088.
40. Ogden RT. Estimation of kinetic parameters in graphical analysis of PET imaging data. Stat Med. 2003;22:3557-3568.
41. Parsey RV, Ogden RT, Mann JJ. Determination of volume of distribution using likelihood estimation in graphical analysis: elimination of estimation bias. J Cereb Blood Flow Metab. 2003;23:1471-1478.
42. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol. 1984;15:217-227.
43. Parsey RV, Arango V, Olvet DM, Oquendo MA, Van Heertum RL, Mann JJ. Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography. J Cereb Blood Flow Metab. 2005;25:785-793.
44. Ramamoorthy S, Blakely RD. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science. 1999;258:763-766.
45. Adell A, Celada P, Abellan MT, Artigas F. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. Brain Res Brain Res Rev. 2002;39:154-180.
46. Mann JJ, Huang Y, Underwood MD, Kassir SA, Oppenheim S, Kelly TM, Dwork AJ, Arango V. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry. 2000;57:729-738.
47. Soucy J-P, Lafaille F, Lemoine P, Mrini A, Descarries L. Validation of the transporter ligand cyanoimipramine as a marker of serotonin innervation density in brain. J Nucl Med. 1994;35:1822-1830.
48. Baumann B, Bielau H, Krell D, Agelink MW, Diekmann S, Wurthmann C, Trubner K, Bernstein HG, Danos P, Bogerts B. Circumscribed numerical deficit of dorsal raphe neurons in mood disorders. Psychol Med. 2002;32:93-103.
49. Underwood MD, Khaibulina AA, Ellis SP, Moran A, Rice PM, Mann JJ, Arango V. Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims. Biol Psychiatry. 1999;46:473-483.
50. Boldrini M, Underwood MD, Mann JJ, Arango V. More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. Brain Res. 2005;1041:19-28.
51. Bach-Mizrachi H, Underwood MD, Kassir SA, Bakalian MJ, Sibille E, Tamir H, Mann JJ, Arango V. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology. 2006;31:814-824.
52. Bleuler E. Dementia Praecox or the Group of Schizophrenias. New York, NY: International Universities Press; 1950.
53. Simpson SG, Folstein SE, Meyers DA, DePaulo JR. Assessment of lineality in bipolar I linkage studies. Am J Psychiatry. 1992;149:1660-1665.
54. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception, II: implications for major psychiatric disorders. Biol Psychiatry. 2003;54:515-528.
55. Leibenluft E, Charney DS, Pine DS. Researching the pathophysiology of pediatric bipolar disorder. Biol Psychiatry. 2003;53:1009-1020.
56. Tolmunen T, Joensuu M, Saarinen PI, Mussalo H, Ahola P, Vanninen R, Kuikka J, Tiihonen J, Lehtonen J. Elevated midbrain serotonin transporter availability in mixed mania: a case report. BMC Psychiatry. 2004;4:27.
57. Simpson HB, Lombardo I, Slifstein M, Huang HY, Hwang DR, Abi-Dargham A, Liebowitz MR, Laruelle M. Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652. Biol Psychiatry. 2003;54:1414-1421.
58. Meyer JH, Houle S, Sagrati S, Carella A, Hussey DF, Ginovart N, Goulding V, Kennedy J, Wilson AA. Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes. Arch Gen Psychiatry. 2004;61:1271-1279.
59. Cannon D, Ichise M, Fromm S, Nugetn AL, Rollis D, Gandhi SK, Drevets WC. Serotonin transporter binding in unmedicated bipolar disorder subjects using [carbon 11] DASB and positron emission tomography. Paper presented at: American College of Neuropsychopharmacology Annual Meeting; December 6, 2005; Kona, Hi.
60. Parsey RV, Kent JM, Oquendo MA, Richards MC, Pratap M, Cooper TB, Arango V, Mann JJ. Acute occupancy of brain serotonin transporter by sertraline as measured by [(11)C] DASB and positron emission tomography. Biol Psychiatry. 2006;59:821-828.