Tryptophan depletion selectively reduces CSF 5-HT metabolites in healthy young men: Results from single lumbar puncture sampling technique

International Journal of Neuropsychopharmacology

Volumn 3, Issue 4, 2000, Pages 277-283

  Moreno, Francisco A ^a   McGavin, Cameron ^a   Phillip Malan Jr , T ^a   Gelenberg, Alan J ^a   Heninger, George R ^b   Mathé, Aleksander A ^c   Delgado, Pedro L ^d  

^a UNIVERSITY OF ARIZONA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ST GÖRAN S HOSPITAL   (Sweden)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebrospinal fluid (CSF); Monoamine metabolites; Tryptophan depletion

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; HOMOVANILLIC ACID; SEROTONIN; TRYPTOPHAN;

ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; LUMBAR PUNCTURE; MALE; MENTAL DISEASE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SAFETY; SAMPLING; SEROTONIN BRAIN LEVEL; SEROTONINERGIC SYSTEM; TECHNIQUE;

EID: 0034531542     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145700002133     Document Type: Article

References (40)

1. Reduction of serotonin function in rat brain by tryptophan depletion: Effects in control and fluvoxamine-treated rats
2. Mood-lowering effect of tryptophan depletion: Enhanced susceptibility in young men at genetic risk for major affective disorders
3. Rapid depletion of serum tryptophan, brain tryptophan, serotonin, and 5-hydroxyindoleacetic acid by a tryptophanfree diet
4. Clinical measurement of central dopamine and 5-hydroxytryptamine metabolism: Reliability and interpretation of cerebrospinal fluid acid monoamine metabolite measures
5. Tryptophan depletion during continuous CSF sampling in healthy human subjects
6. Enhanced stress responsivity of Tourette syndrome patients undergoing lumbar puncture
7. Serotonin function and the mechanism of antidepressant action: Reversal of antidepressant induced remission by rapid depletion of plasma tryptophan
8. Serotonin and the neurobiology of depression: Effects of tryptophan depletion in drug-free depressed patients
9. Mood response to acute tryptophan depletion in healthy volunteers: Sex differences and temporal stability
10. Effects of the diet on brain neurotransmitters
11. Simultaneous quantification of homovanillic acid and 5-hydroxy-indoleacetic acid in cerebrospinal fluid by mass fragmentography
12. Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid
13. Monoamine metabolites in lumbar CSF: The question of their origin in relation to clinical studies
14. The simultaneous determination of free homovanillic acid (3-methoxy-4-hydroxyphenyl) glycol, and vanilmandelic acid in human plasma by high-performance liquid chromatography coupled with dual-electrode coulometric electrochemical detection
15. Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: A reexamination of the α-methyl-1-tryptophan method
16. The assessment of anxiety states by rating
17. Assessment of diurnal variation of cerebrospinal fluid Tryptophan and 5-hydroxyindoleacetic acid in healthy human females
18. Analytical methodology for assays of serum tryptophan metabolites in control subjects and newly abstinent alcoholics: Preliminary investigation by liquid chromatography with amperometric detection
19. Reliability and validity of the symptoms of major depressive illness
20. Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain
21. Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats
22. Cycloheximide blocks the fall of plasma and tissue tryptophan levels after tryptophan-free amino acid mixtures
23. Tryptophan depletion and depressive vulnerability
24. Circadian variation in 5-hydroxyindoleacetic acid levels in human cerebrospinal fluid
25. Differences between males and females in rates of serotonin synthesis in human brain
26. The amino acid requirements of man
27. The inventory for depressive symptomatology (IDS): Preliminary findings
28. 11C)-α-methyl-1-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations
29. Relapse of depression after rapid tryptophan depletion
30. Correlations between aminergic metabolites simultaneously obtained from human CSF and brain
31. Cerebrospinal fluid monoamine metabolite levels in male arsonist
32. 5-Hydroxyindoleacetic acid in spinal fluid: Relative contribution from brain and spinal cord
33. Acute tryptophan depletion in bulimia: Effects on large neutral amino acids
34. Effects of acute tryptophan depletion on plasma and cerobrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers
35. Carbon dioxide induced anxiety
36. Biochemical aspects of tryptophan depletion in primates
37. Tryptophan depletion causes a rapid lowering of mood in normal males