Attempted Suicide characteristics and cerebrospinal fluid amine metabolites in depressed inpatients

Neuropsychopharmacology

Volumn 15, Issue 6, 1996, Pages 576-586

  Mann, J John ^a,d   Malone, Kevin M ^a   Sweeney, John A ^b   Brown, Richard P ^a   Linnoila, Markku ^c   Stanley, Barbara ^a   Stanley, Michael ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^d NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

CSF amine metabolites; Depression; Serotonin; Suicide

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; SEROTONIN;

ADULT; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SUICIDE ATTEMPT;

EID: 0030560860     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(96)00102-9     Document Type: Article

References (77)

1. Ågren H (1980a): Symptom patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid. I. General patterns. Psychiatry Res 3:211-223
2. Ågren H (1980b): Symptom patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid. II. Suicide. Psychiatry Res 3:225-236
3. Ågren H, Niklasson F (1986): Suicidal potential in depression: Focus on CSF monoamine and purine metabolites. Psychopharmacol Bull 22(3):656-660
4. American Psychiatric Association Task Force (1987): Diagnostic and Statistical Manual of Mental Disorders (DMS-III-R). Washington, DC: APA Press
5. 2 and β-adrenergic receptor binding sites in the brain of suicide victims. Arch Gen Psychiatry 47:1038-1047
6. Arango V, Mann JJ (1992): Relevance of serotonergic post-mortem studies to suicidal behavior. Int Rev Psychiatry 4:131-140
7. 2 receptors in suicide victims. Biol Psychiatry 35:457-463
8. Åsberg M, Thorén P, Träskman L, Bertilsson L, Ringberger V (1976a): "Serotonin depression" - A biochemical subgroup within the affective disorders? Science 191:478-480
9. Åsberg M, Träskman L, Thorén P (1976b): 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33:1193-1197
10. Åsberg M, Träskman L (1981): Studies of CSF-5-HIAA in depression and suicidal behavior. Adv Exp Med Biol 133:739-752
11. Banki CM, Arató M (1983): Amine metabolites and neuroendocrine responses related to depression and suicide. J Affect Disord 5:223-232
12. Beck A, Schuyler D, Herman J (1974a): Development of suicidal intent scales. In Beck A, Resnick K, Letierri D (eds), The Prediction of Suicide. Bowie, MD, Charles Press
13. Beck RW, Morris JB, Beck AT (1974b): Cross-validation of the suicidal intent scale. Psychol Rep 34:445-446
14. Beck AT, Beck R, Kovacs M (1975): Classification of suicidal behaviors. I. Quantifying intent and medical lethality. Am J Psychiatry 132(3) :285-287
15. Beck AT, Lester D (1976): Components of suicidal intent in completed and attempted suicides. J Psychol 92:35-38
16. Beck AT, Steer RA (1989): Clinical predictors of eventual suicide: A 5-to 10-year prospective study of suicide attempters. J Affect Disord 17:203-209
17. Beskow J, Gottfries CG, Roos BE, Winblad B. (1976): Determination of monoamine and monoamine metabolites in the human brain: Post mortem studies in a group of suicides and in a control group. Acta Psychiatr Scand 53:7-20
18. Bourne HR, Bunney WEJ, Colburn RW, Davis JM, Shaw DM, Coppen AJ (1968): Noradrenaline, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrains of suicidal patients. Lancet ii:805-808
19. Brown GL, Ebert MH, Goyer PF, Jimersom DC, Klein WJ, Bunney WEJ, Goodwin FK (1982): Aggression, suicide and serotonin: Relationships to CSF amine metabolites. Am J Psychiatry 139:741-746
20. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF (1979): Aggression in human correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1:131-139
21. Cochran E, Robins E, Grote S (1976): Regional serotonin levels in brain: A comparison of depressive suicides and alcoholic suicides with controls. Biol Psychiatry 11:283-294
22. Cooper SJ, Kelly CB, King DJ (1992): 5-Hydroxyindoleacetic acid in cerebrospinal fluid and prediction of suicidal behaviour in schizophrenia. Lancet 340:940-941
23. Edman G, Åsberg M, Levander S, Schalling D (1986): Skin conductance habituation and cerebrospinal fluid 5-hydroxyindoleacetic acid in suicidal patients. Arch Gen Psychiatry 43:586-592
24. Gardner DL, Lucas PB, Cowdry RW (1990): CSF metabolites in borderline personality disorder compared with normal controls. Biol Psychiatry 28:247-254
25. Hamilton M (1960): A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62
26. Higley JD, Thompson WW, Champoux M, Goldman D, Hasert MF, Kraemer GW, Scanlan JM, Suomi SJ, Linnoila M (1993): Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in Rhesus monkeys (Macaca mulatta). Arch Gen Psychiatry 50:615-623
27. Hildebrand J, Bourgeois F, Buyse M, Przedborski S, Goldman S (1990): Reproducibility of monoamine metabolite measurements in human cerebrospinal fluid. Acta Neurol Scand 81:427-430
28. Jones JS, Stanley B, Mann JJ, Frances AJ, Guido JR, Träskman-Bendz L, Winchel R, Brown RP, Stanley M (1990): CSF 5-HIAA and HVA concentrations in elderly depressed patients who attempted suicide. Am J Psychiatry 147:1225-1227
29. Korpi ER, Kleinman J, Goodman SI, Phillips I, DeLisi LE, Linnoila M, Wyatt RJ (1986): Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. Comparison in chronic schizophrenic patients with suicide as cause of death. Arch Gen Psychiatry 43:594-600
30. Koslow SH, Maas JW, Bowden CL, David JM, Hanin I, Javaid J (1983): CSF and urinary biogenic amines and metabolism in depression and mania. A controlled univariate analysis. Arch Gen Psychiatry 40:999-1010
31. Lemus CZ, Lieberman JA, Johns CA, Pollack S, Bookstein P, Cooper TB (1990): CSF 5-hydroxyindoleacetic acid levels and suicide attempts in schizophrenia. Biol Psychiatry 27:926-929
32. Lennard-Jones JE, Asher R (1959): Why do they do it? A study of pseudocide. Lancet i:1138-1140
33. Lidberg L, Tuck JR, Åsberg M, Scalia Tomba GP, Bertilsson L (1985): Homicide, suicide and CSF 5-HIAA. Acta Psychiatr Scand 71:230-236
34. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimond R, Goodwin FK (1983): Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from non-impulsive violent behavior. Life Sci 33:2609-2614
35. Lloyd KG, Farley IJ, Deck JHN, Hornykiewicz O (1974): Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Adv Biochem Psychopharmacol 11:387-397
36. Lopez-Ibor JJ, Saiz-Ruiz R, Perez de los Cobos JC (1985): Biological correlations of suicide and aggressivity in major depressions (with melancholia): 5-hydroxyindoleacetic acid and cortisol in cerebral spinal fluid, dexamethasone suppression test and therapeutic response to 5-hydroxytryptophan, Neuropsychobiology 14:67-74
37. Malone KM, Corbitt EM, Li S-H, Mann JJ (1995): Prolactin response to fenfluramine and suicide attempt lethality in major depression. Br J Psychiatry 168:324-329
38. Mann JJ, Arango V (1992): Integration of neurobiology and psychopathology in a unified model of suicidal behavior. J Clin Psychopharmacol 12(2):2S-7S
39. Mann JJ, Arango V, Marzuk PM, Theccanat S, Reis DJ (1989): Evidence for the 5-HT hypothesis of suicide: A review of post-mortem studies. Br J Psychiatry 155(Suppl 8):7-14
40. Mann JJ, McBride PA, Brown RP, Linnoila M, Leon AC, DeMeo MD, Mieczkowski TA, Myers JE, Stanley M (1992): Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry 49(6):442-446
41. Mann JJ, Underwood MD, Arango V (1996): Postmortem studies of suicide victims. In Watson SJ (ed), Biology of Schizophrenia and Affective Disease, ed 1. Washington, DC, American Psychiatric Press, pp. 197-220
42. Marzuk PM, Leon AC, Tardiff K, Morgan EB, Stajic M, Mann JJ (1992): The effect of access to lethal methods of injury on suicide rates. Arch Gen Psychiatry 49:451-458
43. Menachem BE, Persson L, Schechter PJ, Haegele KD, Huebert N, Hardenberg J (1989): Cerebrospinal fluid parameters in healthy volunteers during serial lumbar punctures. J Neurochem 52:632-635
44. Mieczkowski TA, Sweeney JA, Haas GL, Mann JJ, Brown RP, Junker B (1993): Factor composition of the suicide intent scale. Suicide Life Threat Behav 23:37-45
45. Moses SG, Robins E (1975): Regional distribution of norepinephrine and dopamine in brains of depressive suicides and alcoholic suicides. Psychopharmacol Commun 1: 327-337
46. Ninan PT, van Kammen DP, Scheinin M, Linnoila M, Bunney WEJ, Goodwin FK (1984): CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenic patients. Am J Psychiatry 141:566-569
47. Nordin C (1988): Relationships between clinical symptoms and monoamine metabolite concentrations in biochemically defined subgroups of depressed patients. Acta Psychiatr Scand 78:720-729
48. 2 receptor occupancy in relation to clozapine serum concentration: A PET study of schizophrenic patients. Am J Psychiatry 152: 1444-1449
49. Nordström P, Samuelsson M, Asberg M, Träskman-Bendz L, Aberg-Wistedt A, Nordin C, Bertilsson L (1994): CSF 5-HIAA predicts suicide risk after attempted suicide. Suicide Life Threat Behav 24:1-9
50. Oxenstierna G, Edman G, Iselius L, Oreland L, Ross SB, Sedvall G (1986): Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals. A genetic study. J Psychiatr Res 20:19-29
51. Palaniappan V, Ramachandran V, Somasundaram O (1983): Suicidal ideation and biogenic amines in depression. Indian J Psychiatry 25(4):286-292
52. Pallis DJ, Sainsbury P (1976): The value of assessing intent in attempted suicide. Psychol Med 6:487-492
53. Pare CMB, Yeung DPH, Price K, Stacey RS (1969): 5-Hydroxytryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coal-gas poisoning. Lancet ii:133-135
54. Paul SM, Rehavi M, Skolnick P, Goodwin FK (1984): High affinity binding of antidepressants to a biogenic amine transport site in human brain and platelet; studies in depression. In Post RM, Bellinger CJ (eds), Neurobiology of Mood Disorders. Baltimore, MD, Williams and Wilkins, pp. 846-853
55. Pickar D, Roy A, Breier A, Doran A, Wolkowitz O, Colison J, Ågren H (1986): Suicide and aggression in schizophrenia. Neurobiologic correlates. Ann NY Acad Sci 487: 189-196
56. Roy A, Ninan PT, Mazonson A, Pickar D, van Kammen DP, Linnoila M, Paul SM (1985): CSF monoamine metabolites in chronic schizophrenic patients who attempt suicide. Psychol Med 15:335-340
57. Roy A, Ågren H, Pickar D, Linnoila M, Doran A, Cutler N, Paul SM (1986): Reduced CSF concentrations of homovanillic acid and homovanillic acid to 5-hydroxyindoleacetic acid ratios in depressed patients: Relationship to suicidal behavior and dexamethasone nonsuppression. Am J Psychiatry 143:1539-1545
58. Roy A, De Jong J, Linnoila M (1989): Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. A 5-year follow-up study. Arch Gen Psychiatry 46:609-612
59. Roy-Byrne P, Post RM, Rubinow DR, Linnoila M, Savard R, Davis D (1983): CSF 5HIAA and personal and family history of suicide in affectively ill patients: A negative study. Psychiatry Res 10:263-274
60. Scheinin M, Chang W-H, Kirk KL, Linnoila M (1983): Simultaneous determination of 3-methoxy-4-hydroxphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. Anal Biochem 131:246-253
61. Secunda SK, Cross CK, Koslow S, Katz MM, Kocsis J, Maas JW, Landis H (1986a): Biochemistry and suicidal behavior in depressed patients. Biol Psychiatry 21:756-767
62. Shaw DM, Camps FE, Eccleston EG (1967): 5-Hydroxytryptamine in the hind-brain of depressive suicides. Br J Psychiatry 113:1407-1411
63. Spitzer RL, Williams JBW, Gibbon M, First MB (1989): Instruction Manual for the Structured Clinical Interview for DSM-III-R (SCID, 5/1/89 Revision). New York, Biometrics Research Department, New York State Psychiatric Institute
64. Spitzer RL, Endicott J (1978): Schedule for Affective Disorders and Schizophrenia (SADS), ed 3. New York: New York State Psychiatric Institute
65. Stanley M, Mann JJ (1983): Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet I:214-216
66. Stanley M, Virgilio J, Gershon S (1982): Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science 216:1337-1339
67. Stanley M, Träskman-Bendz L, Dorovini-Zis K (1985): Correlations between aminergic metabolites simultaneously obtained from human CSF and brain. Life Sci 37:1279-1286
68. Stengel E (1973): Suicide and Attempted Suicide. Harmondsworth, Middlesex, U.K.: C. Nichools & Company Ltd
69. Träskman L, Åsberg M, Bertilsson L, Sjöstrand L (1981): Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psychiatry 38:631-636
70. Träskman-Bendz L, Åsberg M, Schalling D (1986): Serotonergic function and suicidal behavior in personality disorders. Ann NY Acad Sci 487:168-174
71. van Praag HM (1982): Depression, suicide and the metabolism of serotonin in the brain. J Affect Disord 4:275-290
72. van Praag HM (1983): CSF 5-HIAA and suicide in non-depressed schizophrenics. Lancet ii:977-978
73. Vestergaard P, Sorensen T, Hoppe E, Rafaelsen OJ, Yates CM, Nicolaou N (1978): Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders. Acta Psychiatr Scand 58:88-96
74. Virkkunen M, Nuutila A, Goodwin FK, Linnoila M (1987): Cerebrospinal fluid monoamine metabolites levels in male arsonists. Arch Gen Psychiatry 44:241-247
75. Virkkunen M, De Jong J, Bartko J, Goodwin FK, Linnoila M (1989a): Relationship of psychobiological variables to recidivism in violent offenders and impulsive fire setters. A follow-up study. Arch Gen Psychiatry 46:600-603
76. Virkkunen M, De Jong J, Bartko J, Linnoila M (1989b): Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Arch Gen Psychiatry 46:604-606
77. Westenberg HG, Verhoeven WM (1988): CSF monoamine metabolites in patients and controls: Support for a bimodal distribution in major affective disorders. Acta Psychiatr Scand 78:541-549