Sustained administration of trazodone enhances serotonergic neurotransmission: In vivo electrophysiological study in the rat brain

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 1, 2010, Pages 197-206

  Ghanbari, Ramez ^a   El Mansari, Mostafa ^a   Blier, Pierre ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; AUTORECEPTOR; POSTSYNAPTIC RECEPTOR; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; TRAZODONE; ANTIDEPRESSANT AGENT; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; HIPPOCAMPUS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; ANIMAL; BRAIN; BRAIN LEVEL; DENDRITE; DOSE RESPONSE; DRUG EFFECTS; ELECTROPHYSIOLOGY; ELECTROSPRAY MASS SPECTROMETRY; EXTRACELLULAR SPACE; IONTOPHORESIS; MALE; METABOLISM; PHYSIOLOGY; PYRAMIDAL NERVE CELL; RAPHE NUCLEUS; SPRAGUE DAWLEY RAT; SYNAPTIC TRANSMISSION;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BRAIN; BRAIN CHEMISTRY; DENDRITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EXTRACELLULAR SPACE; HIPPOCAMPUS; IONTOPHORESIS; MALE; PYRAMIDAL CELLS; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SYNAPTIC TRANSMISSION; TRAZODONE;

EID: 77957235566     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.169417     Document Type: Article

References (40)

1. Aghajanian GK (1978) Feedback regulation of central monoaminergic neurons: evidence from single cell recording studies. Essays Neurochem Neuropharmacol 3:1-32.
2. Al-Yassiri MM, Ankier SI, and Bridges PK (1981) Trazodone-a new antidepressant. Life Sci 28:2449-2458.
3. Besson A, Haddjeri N, Blier P, and de Montigny C (2000) Effects of the coadministration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain. Eur Neuropsychopharmacol 10:177-188.
4. Blier P and de Montigny C (1990) Differential effect of gepirone on presynaptic and postsynaptic serotonin receptors: single-cell recording studies. J Clin Psychopharmacol 10: 13S-20S.
5. Chaput Y and de Montigny C (1988) Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system. J Pharmacol Exp Ther 246: 359-370.
6. Chaput Y, Blier P, and de Montigny C (1986) In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. J Neurosci 6:2796-2801.
7. Chung YC, Li Z, Dai J, Meltzer HY, and Ichikawa J (2004) Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism. Brain Res 1023:54-63.
8. Cunningham LA, Borison RL, Carman JS, Chouinard G, Crowder JE, Diamond BI, Fischer DE, and Hearst E (1994) A comparison of venlafaxine, trazodone, and placebo in major depression. J Clin Psychopharmacol 14:99-106.
9. Curet O and de Montigny C (1988) Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. I. Receptors mediating the effect of microiontophoretically applied norepinephrine. Brain Res 475:35-46.
10. Cusack B, Nelson A, and Richelson E (1994) Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl) 114:559-565.
11. de Montigny C, Wang RY, Reader TA, and Aghajanian GK (1980) Monoaminergic denervation of the rat hippocampus: microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin. Brain Res 200: 363-376.
12. DeVane CL, Boulton DW, Miller LF, and Miller RL (1999) Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats. Int J Neuropsychopharmacol 2:17-23.
13. Di Matteo V, Di Giovanni G, Di Mascio M, and Esposito E (1999) SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system. Neuropharmacology 38:1195-1205.
14. Dong J, de Montigny C, and Blier P (1998) Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe. J Pharmacol Exp Ther 286:1239-1247.
15. Dong J, de Montigny C, and Blier P (1999) Assessment of the serotonin reuptake blocking property of YM992: electrophysiological studies in the rat hippocampus and dorsal raphe. Synapse 34:277-289.
16. Dremencov E, El Mansari M, and Blier P (2007) Noradrenergic augmentation of escitalopram response by risperidone: electrophysiologic studies in the rat brain. Biol Psychiatry 61:671-678.
17. Garrone B, De Santi S, D'Amico D, di Matteo A, Olivieri L, Magnani M, Comandini A, and Guglielmotti A (2009) Trazodone increases extracellular serotonin levels in the frontal cortex of rats. Eur Neuropsychopharmacol 19:S447.
18. Gartside SE, Umbers V, Hajós M, and Sharp T (1995) Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br J Pharmacol 115:1064-1070.
19. Gobert A and Millan MJ (1999) Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats. Neuropharmacology 38:315-317.
20. Gross G, Hante K, and Göthert M (1987) Effect of antidepressant and neuroleptic drugs on the electrically evoked release of serotonin from rat cerebral cortex. Psychopharmacology (Berl) 91:175-181.
21. Haddjeri N, Blier P, and de Montigny C (1998) Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. J Neurosci 18:10150-10156.
22. Haddjeri N, Lavoie N, and Blier P (2004) Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus. Neuropsychopharmacology 29:1800-1806.
23. 1A receptor function in brain following agonist or antidepressant administration. Life Sci 72:1665-1682.
24. Hughes ZA, Starr KR, Langmead CJ, Hill M, Bartoszyk GD, Hagan JJ, Middlemiss DN, and Dawson LA (2005) Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. Eur J Pharmacol 510:49-57.
25. Kandel ER and Spencer WA (1961) Electrophysiology of hippocampal neurons. II. After-potentials and repetitive firing. J. Neurophysiology 24:243-259.
26. Khawaja X, Evans N, Reilly Y, Ennis C, and Minchin MC (1995) Characterisation of the binding of [3H]WAY-100635, a novel 5-hydroxytryptamine1A receptor antagonist, to rat brain. J Neurochem 64:2716-2726.
27. Meyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, Potter WZ, Ginovart N, Spencer EP, Cheok A, and Houle S (2004) Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am J Psychiatry 161:826-835.
28. Millan MJ (2006) Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110:135-370.
29. Odagaki Y, Toyoshima R, and Yamauchi T (2005) Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPγS binding. J Psychopharmacol 19:235-241.
30. Owens MJ, Morgan WN, Plott SJ, and Nemeroff CB (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-1322.
31. Paxinos G, Watson C (1998) The Rat Brain in Stereotaxic Coordinates, 4th ed, Academic Press, New York.
32. Pazzagli M, Giovannini MG, and Pepeu G (1999) Trazodone increases extracellular serotonin levels in the frontal cortex of rats. Eur J Pharmacol 383:249-257.
33. Piñeyro G and Blier P (1999) Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev 51:533-591.
34. Piñeyro G, Blier P, Dennis T, and de Montigny C (1994) Desensitization of the neuronal 5-HT carrier following its long-term blockade. J Neurosci 14:3036-3047.
35. Ranck JB (1975) Behavioral correlates and firing repertoires of neurons in the dorsal hippocampal formation and septum of unrestrained rats, in The Hippocampus (Isaacson LR, ed) pp 207-244, Plenum Press, New York.
36. Romero L, Bel N, Casanovas JM, and Artigas F (1996) Two actions are better than one: avoiding self-inhibition of serotonergic neurones enhances the effects of serotonin uptake inhibitors. Int Clin Psychopharmacol 11 (Suppl):1-8.
37. Schmidt CJ and Fadayel GM (1995) The selective 5-HT2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat. Eur J Pharmacol 273:273-279.
38. Scuvée-Moreau J and Dresse A (1982) Effect of trazodone on the firing rate of central monoaminergic neurons. Comparison with various antidepressants. Arch Int Pharmacodyn Ther 260:299-301.
39. Sheehan DV, Croft HA, Gossen ER, Levitt RJ, Brullé C, Bouchard S, and Rozova A (2009) Extended-release trazodone in major depressive disorder: a randomized, double-blind, placebo-controlled study. Psychiatry (Edgmont) 6:20-33.
40. Tatsumi M, Groshan K, Blakely RD, and Richelson E (1997) Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-258.