A molecular signature of depression in the amygdala

American Journal of Psychiatry

Volumn 166, Issue 9, 2009, Pages 1011-1024

  Sibille, Etienne ^a   Wang, Yingjie ^b   Joeyen Waldorf, Jennifer ^b   Gaiteri, Chris ^b   Surget, Alexandre ^b   Oh, Sunghee ^b   Belzung, Catherine ^b   Tseng, George C ^b   Lewis, David A ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 CHLORO 4 METHOXY 5 METHYLPHENYL) N [2 CYCLOPROPYL 1 (3 FLUORO 4 METHYLPHENYL)ETHYL] 5 METHYL N (2 PROPYNYL) 2 THIAZOLAMINE; FLUOXETINE;

ADULT; AGED; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENE EXPRESSION; GENE INTERACTION; HUMAN; MAJOR DEPRESSION; MALE; MOUSE; NERVE CELL; NONHUMAN; OLIGODENDROGLIA; PATHOGENESIS; PHENOTYPE; PHYLOGENY; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT; WESTERN BLOTTING;

ADULT; AGED; AMYGDALA; ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; CHRONIC DISEASE; DEPRESSIVE DISORDER, MAJOR; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GYRUS CINGULI; HUMANS; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; MODELS, GENETIC; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SPECIES SPECIFICITY; STRESS, PSYCHOLOGICAL;

EID: 69949100833     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2009.08121760     Document Type: Article

References (48)

1. Belmaker RH, Agam G: Major depressive disorder. N Engl J Med 2008; 358:55-68
2. Sibille E, Arango V, Galfalvy HC, Pavlidis P, Erraji-BenChekroun L, Ellis SP, Mann JJ: Gene expression profiling of depression and suicide in human prefrontal cortex. Neuropsychopharmacology 2004; 29:351-361 (Pubitemid 38175153)
3. Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE Jr, Akil H, Watson SJ, Jones EG: Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci USA 2005; 102:15653-15658 (Pubitemid 41528111)
4. Aston C, Jiang L, Sokolov BP: Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry 2005; 10:309-322 (Pubitemid 40432684)
5. Sequeira A, Gwadry FG, Ffrench-Mullen JM, Canetti L, Gingras Y, Casero RA Jr, Rouleau G, Benkelfat C, Turecki G: Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry 2006; 63:35-48 (Pubitemid 43037467)
6. Kang HJ, Adams DH, Simen A, Simen BB, Rajkowska G, Stockmeier CA, Overholser JC, Meltzer HY, Jurjus GJ, Konick LC, Newton SS, Duman RS: Gene expression profiling in postmortem prefrontal cortex of major depressive disorder. J Neurosci 2007; 27:13329-13340 (Pubitemid 350220503)
7. Hasler G, Drevets WC, Manji HK, Charney DS: Discovering endophenotypes for major depression. Neuropsychopharmacology 2004; 29:1765-1781
8. Willner P: Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 2005; 52:90-110
9. Surget A, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G, Belzung C, Sibille E: Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology 2009; 34:1363-1380
10. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR: 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8:828-834 (Pubitemid 43085851)
11. Seminowicz DA, Mayberg HS, McIntosh AR, Goldapple K, Kennedy S, Segal Z, Rafi-Tari S: Limbic-frontal circuitry in major depression: a path modeling metanalysis. Neuroimage 2004; 22:409-418 (Pubitemid 38515850)
12. Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME: Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997; 386:824-827 (Pubitemid 27181254)
13. Botteron KN, Raichle ME, Drevets WC, Heath AC, Todd RD: Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biol Psychiatry 2002; 51:342-344
14. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, Silva JA, Tekell JL, Martin CC, Lancaster JL, Fox PT: Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 1999; 156:675-682 (Pubitemid 29220063)
15. Drevets WC, Bogers W, Raichle ME: Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 2002; 12:527-544 (Pubitemid 35408704)
16. Cotter D, Mackay D, Landau S, Kerwin R, Everall I: Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry 2001; 58:545-553 (Pubitemid 32523734)
17. Ongur D, Drevets WC, Price JL: Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 1998; 95:13290-13295 (Pubitemid 28509564)
18. Bowley MP, Drevets WC, Ongur D, Price JL: Low glial numbers in the amygdala in major depressive disorder. Biol Psychiatry 2002; 52:404-412 (Pubitemid 35266731)
19. Hamidi M, Drevets WC, Price JL: Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes. Biol Psychiatry 2004; 55:563-569 (Pubitemid 38315029)
20. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA: Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry 2001; 50:651-658
21. Siegle GJ, Steinhauer SR, Thase ME, Stenger VA, Carter CS: Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry 2002; 51:693-707
22. Roberson-Nay R, McClure EB, Monk CS, Nelson EE, Guyer AE, Fromm SJ, Charney DS, Leibenluft E, Blair J, Ernst M, Pine DS: Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: an fMRI study. Biol Psychiatry 2006; 60:966-973 (Pubitemid 44584205)
23. Sibille E, Arango V, Joeyen-Waldorf J, Wang Y, Leman S, Surget A, Belzung C, Mann JJ, Lewis DA: Large-scale estimates of cellular origins of mRNAs: enhancing the yield of transcriptome analyses. J Neurosci Methods 2008; 167:198-206 (Pubitemid 350235629)
24. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP: Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 2003; 31:e15
25. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R: Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003; 301:805-809 (Pubitemid 36962615)
26. Bodnoff SR, Suranyi-Cadotte B, Aitken DH, Quirion R, Meaney MJ: The effects of chronic antidepressant treatment in an animal model of anxiety. Psychopharmacology (Berl) 1988; 95:298-302 (Pubitemid 18160702)
27. Mineur YS, Prasol DJ, Belzung C, Crusio WE: Agonistic behavior and unpredictable chronic mild stress in mice. Behav Genet 2003; 33:513-519 (Pubitemid 37243297)
28. Sibille E, Su J, Leman S, Le Guisquet AM, Ibarguen-Vargas Y, Joeyen-Waldorf J, Glorioso C, Tseng GC, Pezzone M, Hen R, Belzung C: Lack of serotonin(1B) receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging, and reduced longevity. Mol Psychiatry 2007; 12:1042-1056 (Pubitemid 350006204)
29. Akaike H: A new look at the statistical model identification. IEEE Transact Automatic Control 1974; 19:716-723
30. Lee HK, Hsu AK, Sajdak J, Qin J, Pavlidis P: Coexpression analysis of human genes across many microarray data sets. Genome Res 2003; 14:1085-1094 (Pubitemid 38811545)
31. Zhang B, Horvath S: A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol 2005; 4(1) (Pubitemid 41192119)
32. Oldham MC, Konopka G, Iwamoto K, Langfelder P, Kato T, Horvath S, Geschwind DH: Functional organization of the transcriptome in human brain. Nat Neurosci 2008; 11:1271-1282
33. Bergmann S, Ihmels J, Barkai N: Similarities and differences in genome-wide expression data of six organisms. PLoS Biol 2004; 2:E9 (Pubitemid 39234589)
34. Sporns O, Chialvo DR, Kaiser M, Hilgetag CC: Organization, development, and function of complex brain networks. Trends Cogn Sci 2004; 8:418-425 (Pubitemid 39179905)
35. Elo LL, Jarvenpaa H, Oresic M, Lahesmaa R, Aittokallio T: Systematic construction of gene coexpression networks with applications to human T helper cell differentiation process. Bioinformatics 2007; 23:2096-2103 (Pubitemid 47394109)
36. Girvan M, Newman ME: Community structure in social and biological networks. Proc Natl Acad Sci USA 2002; 99:7821-7826 (Pubitemid 34650963)
37. Paus T: Primate anterior cingulate cortex: where motor control, drive, and cognition interface. Nat Rev Neurosci 2001; 2:417-424
38. Allman JM, Hakeem A, Erwin JM, Nimchinsky E, Hof P: The anterior cingulate cortex: the evolution of an interface between emotion and cognition. Ann NY Acad Sci 2001; 935:107-117 (Pubitemid 32511395)
39. Allman J, Hakeem A, Watson K: Two phylogenetic specializations in the human brain. Neuroscientist 2002; 8:335-346 (Pubitemid 34824017)
40. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM: Neurobiology of depression. Neuron 2002; 34:13-25
41. Uranova NA, Vostrikov VM, Orlovskaya DD, Rachmanova VI: Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium. Schizophr Res 2004; 67:269-275
42. Rosin C, Bates TE, Skaper SD: Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms. J Neurochem 2004; 90:1173-1185 (Pubitemid 39167350)
43. Banasr M, Valentine GW, Li XY, Gourley SL, Taylor JR, Duman RS: Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat. Biol Psychiatry 2007; 62:496-504 (Pubitemid 47284039)
44. Wennstrom M, Hellsten J, Ekstrand J, Lindgren H, Tingstrom A: Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures. Biol Psychiatry 2006; 59:178-186 (Pubitemid 43117508)
45. Vyas A, Mitra R, Shankaranarayana Rao BS, Chattarji S: Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J Neurosci 2002; 22:6810-6818 (Pubitemid 35386438)
46. Duvarci S, Pare D: Glucocorticoids enhance the excitability of principal basolateral amygdala neurons. J Neurosci 2007; 27:4482-4491 (Pubitemid 46640721)
47. Drevets WC: Prefrontal cortical-amygdalar metabolism in major depression. Ann NY Acad Sci 1999; 877:614-637
48. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR: Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297:400-403 (Pubitemid 34790769)