Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: A review

Fundamental and Clinical Pharmacology

Volumn 23, Issue 1, 2009, Pages 23-42

  Gardier, Alain M ^a   Guiard, Bruno P ^a   Guilloux, Jean Philippe ^a   Repérant, Christelle ^a   Coudoré, François ^a   David, Denis J ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Animal models; Antidepressant drugs; Behavioral studies; Brain derived neurotrophic factor; Depression; Hippocampus; Intracerebral microdialysis; Knockout mice; Neurogenesis; Norepinephrine; Serotonin

Indexed keywords

1 (4 AMINO 5 CHLORO 2 METHOXYPHENYL) 3 (1 BUTYL 4 PIPERIDINYL) 1 PROPANONE; ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CITALOPRAM; DESIPRAMINE; DIAZEPAM; FLUOXETINE; IMIPRAMINE; PAROXETINE; PINDOLOL; PROTEIN TYROSINE KINASE; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DEPRESSION; DRUG ACTIVITY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; GENE MUTATION; GENETIC ENGINEERING; HUMAN; KNOCKOUT MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROCHEMISTRY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TARGETING; PSYCHOPHARMACOLOGY; SINGLE DRUG DOSE;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MICE, KNOCKOUT; RECEPTORS, G-PROTEIN-COUPLED; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 61349098820     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2008.00640.x     Document Type: Article

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