No Human Tryptophan Hydroxylase-2 Gene R441H Mutation in a Large Cohort of Psychiatric Patients and Control Subjects

Biological Psychiatry

Volumn 60, Issue 2, 2006, Pages 202-203

  Delorme, Richard ^a,b   Durand, Christelle M ^a   Betancur, Catalina ^b   Wagner, Michael ^c   Ruhrmann, Stephan ^d   Grabe, Hans Juergen ^e   Nygren, Gudrun ^f   Gillberg, Christopher ^f   Leboyer, Marion ^a,b   Bourgeron, Thomas ^a   Courtet, Philippe ^g,h   Jollant, Fabrice ^g,h   Buresi, Catherine ⁱ   Aubry, Jean Michel ⁱ   Baud, Patrick ⁱ   Bondolfi, Guido ⁱ   Bertschy, Gilles ⁱ   Perroud, Nader ⁱ   Malafosse, Alain ^h,i  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY OF GREIFSWALD   (Germany)

^f UNIVERSITY OF GOTHENBURG   (Sweden)

^g MONTPELLIER UNIVERSITY HOSPITAL   (France)

^h INSERM   (France)

ⁱ GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

autism spectrum disorder; bipolar disorder; Human tryptophan hydroxylase 2 gene; major depressive disorder; obsessive compulsive disorder; unipolar major depression

Indexed keywords

TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG;

AFRICA SOUTH OF THE SAHARA; ARTICLE; AUTISM; CHINA; CHROMOSOME; COHORT ANALYSIS; CONTROLLED STUDY; ERROR; ETHNIC GROUP; EXPLORATORY RESEARCH; FEMALE; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; INDIA; MALE; MENTAL PATIENT; MOOD DISORDER; NORTH AFRICA; OBSESSIVE COMPULSIVE DISORDER; POPULATION; PRIORITY JOURNAL; PUBLICATION; SWEDEN;

ADULT; ALLELES; CHROMOSOMES; COHORT STUDIES; FEMALE; GENE FREQUENCY; HUMANS; MALE; MENTAL DISORDERS; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; TRYPTOPHAN HYDROXYLASE;

EID: 33745698333     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.12.014     Document Type: Article

References (4)

1. Coon H., Dunn D., Lainhart J., Miller J., Hamil C., Battaglia A., et al. Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). Am J Med Genet B Neuropsychiatr Genet 135 (2005) 42-46
2. Patel P.D., Pontrello C., and Burke S. Robust and tissue specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol Psychiatry 55 (2004) 428-433
3. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76
4. Zhang X., Gainetdinov R.R., Beaulieu J.M., Sotnikova T.D., Burch L.H., Williams R.B., et al. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45 (2005) 11-16