Serotonin transport kinetics correlated between human platelets and brain synaptosomes

Psychopharmacology

Volumn 180, Issue 3, 2005, Pages 391-398

  Rausch, Jeffrey L ^a,b   Johnson, Maria E ^b   Li, Junqing ^a   Hutcheson, Julian ^a,b   Carr, Benjamin M ^b   Corley, Katina M ^b   Gowans, Amanda B ^b   Smith, Joseph ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

5 HT; 5 HTT; Depression; Epilepsy; Human brain; Platelet; pO2; Serotonin transport (SERT); Uptake

Indexed keywords

SEROTONIN;

ADULT; ARTICLE; BRAIN SYNAPTOSOME; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EPILEPSY; FEMALE; GENDER; HUMAN; HUMAN TISSUE; LINEAR REGRESSION ANALYSIS; MALE; NEUROPATHOLOGY; NEUROSURGERY; OXYGEN TENSION; PRIORITY JOURNAL; SEROTONIN UPTAKE; SEX DIFFERENCE; TEMPORAL CORTEX; THROMBOCYTE; TRANSPORT KINETICS; VELOCITY;

ADULT; ANALYSIS OF VARIANCE; BIOLOGICAL TRANSPORT; BLOOD PLATELETS; BRAIN; FEMALE; HUMANS; KINETICS; MALE; MIDDLE AGED; OXYGEN; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SYNAPTOSOMES;

EID: 21344469121     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-2178-6     Document Type: Article

References (87)

1. Arango V, Underwood MD, Gubbi AV, Mann JJ (1995) Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res 688:121-133
2. Arato M, Tekes K, Tothfalusi L, Magyar K, Palkovits M, Demeter E, Falus A (1987) Serotonergic split brain and suicide. Psychiatry Res 21:355-356
3. 3H-imipramine binding in the frontal cortex of suicides. Psychiatry Res 30:125-135
4. Arora RC, Tong C, Jackman HL, Stoff D, Meltzer HY (1983) Serotonin uptake and imipramine binding in blood platelets and brain of Fawn-hooded and Sprague Dawley rats. Life Sci 33:437-442
5. Austin MC, Whitehead RE, Edgar CL, Janosky JE, Lewis DA (2002) Localized decrease in serotonin transporter-immunoreactive axons in the prefrontal cortex of depressed subjects committing suicide. Neuroscience 114:807-815
6. Bianchi M, Moser C, Lazzarini C, Vecchiato E, Crespi F (2002) Forced swimming test and fluoxetine treatment: in vivo evidence that peripheral 5-HT in rat platelet-rich plasma mirrors cerebral extracellular 5-HT levels, whilst 5-HT in isolated platelets mirrors neuronal 5-HT changes. Exp Brain Res 143:191-197
7. Block ER, Fisher AB (1977) Depression of serotonin clearance by rat lungs during oxygen exposure. J Appl Physiol 42:33-38
8. 2 tension. J Appl Physiol 50:1212-1219
9. Butler J, Tannian M, Leonard BE (1988) The chronic effects of desipramine and sertraline on platelet and synaptosomal 5HT uptake in olfactory bulbectomised rats. Prog Neuro-Psychopharmacol Biol Psychiatry 12:585-594
10. Cambell JC, Marangos PJ, Murphy DL (1993) Neuron specific enolase (NSE) in human blood platelets: implications for the neuronal model. In: Angrist B, Burrows GD, Lader M, Lingjaerde O, Sedvall G, Wheatley D (eds) Advances in the biosciences. Pergamon Press, New York, pp 203-211
11. Cho R, Kapur S, Du L, Hrdina P (1999) Relationship between central and peripheral serotonin 5-HT2A receptors: a positron emission tomography study in healthy individuals. Neurosci Lett 261:139-142
12. Chou DT, Cuzzone H, Hirsh KR (1983) Assessment of blood platelets as a model for CNS response: comparative effects of caffeine on 5-HT uptake and release mechanisms in rat platelets and rat brain serotonin neurons. Life Sci 33(12):1149-1156
13. Cleland WW (1967) The statistical analysis of enzyme kinetic data. Adv Enzymol 29:1-32
14. Coppen A, Swade C, Wood K (1978) Platelet 5-hydroxytryptamine accumulation in depressive illness. Clin Chim Acta 87:165-168
15. 3H-imipramine binding in normal and depressed subjects. Biol Psychiatry 21:283-292
16. Ellis PM, Salmond C (1994) Is platelet imipramine binding reduced in depression? A meta-analysis. Biol Psychiatry 36:292-299
17. Fisher AB, Block ER, Pietra G (1980) Environmental influences on uptake of serotonin and other amines. Environ Health Perspect 35:191-198
18. Franke L, Schewe HJ, Muller B, Campman V, Kitzrow W, Uebelhack R, Berghofer A, Muller-Oerlinghausen B (2000) Serotonergic platelet variables in unmedicated patients suffering from major depression and healthy subjects: relationship between 5HT content and 5HT uptake. Life Sci 67:301-305
19. Godinez MH, Godinez RI (1996) Inspired oxygen concentration alters the phospholipids and protein content in the bronchoalveolar lavage-accessible space. Crit Care Med 24:862-869
20. Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL (1999) Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88:83-87
21. Gross-Isseroff R, Israeli M, Biegon A (1989) Autoradiographic analysis of tritiated imipramine binding in the human brain postmortem: effects of suicide. Arch Gen Psychiatry 46:237-241
22. Halbreich U, Vital-Herne J, Goldstein S, Zander K (1984) Sex differences in biological factors putatively related to depression. J Affect Disord 7:223-233
23. Healy D, O'Halloran A, Camey PA, Leonard BE (1986) Platelet 5-HT uptake in delusional and nondelusional depressions. J Affect Disord 10:233-239
24. Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D, Linnoila M, Weinberger DR (2000) A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 47:643-649
25. Hrdina PD, Demeter E, Vu TB, Sotonyi P, Palkovits M (1993) 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain Res 614:37-44
26. Hrdina PD, Bakish D, Chudzik J, Ravindran A, Lapierre YD (1995) Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. J Psychiatry Neurosci 20:11-19
27. Jones PP, Davy KP, Seals DR (1999) Influence of gender on the sympathetic neural adjustments to alterations in systemic oxygen levels in humans. Clin Physiol 19:153-160
28. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE (1993) Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 8:315-336
29. Kaplan RD, Mann JJ (1982) Altered platelet serotonin uptake kinetics in schizophrenia and depression. Life Sci 31:583-588
30. Komulainen H (1983) Enhancement of 5-hydroxytryptamine uptake in rabbit hypothalamic synaptosomes but not in blood platelets by zinc and lead ex vivo. Acta Pharm Toxicol (Copenh) 53:166-174
31. Lahr PD, Mais DE, Bosin TR (1983) Reparative changes following oxygen-induced lung injury: effect on serotonin disposition and metabolism. Toxicol Appl Pharmacol 70:188-194
32. Lampugnani MG, Buczko W, Ceci A, Mennini A, de Gaetano G (1986) Normal serotonin uptake by blood platelets and brain synaptosomes but selective impairment of platelet serotonin storage in mice with Chediack-Higashi syndrome. Life Sci 38:2193-2198
33. Laruelle M, Abi-Dargham A, Casanova MF, Toti R, Weinberger DR, Kleinman JE (1993) Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study. Arch Gen Psychiatry 810-818
34. 3H] paroxetine, in antidepressant-free depressed suicides. Brain Res 526(1):17-22
35. Lemmer B, Jarosch U, Breddin K (1977) Influence of the time interval after venepuncture and the storage temperature on the uptake of 14C-serotonin by human blood platelets. Life Sci 21:1665-1673
36. Lesch KP, Wolozin BL, Murphy DL, Reiderer P (1993) Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem 60:2319-2322
37. Lingjaerde O (1984) Blood platelets as a model system for studying the biochemistry of depression. In: Usdin E, Asberg M, Bertilsson L, Sjoqvist F (eds) Biological and pharmacological research in depression: advances in biochemical psychopharmacology. Raven Press, New York, pp 99-111
38. Little KY, McLauglin DP, Ranc J, Gilmore J, Lopez JF, Watson SJ, Carroll FI, Butts JD (1997) Serotonin transporter binding sites and mRNA levels in depressed persons committing suicide. Biol Psychiatry 41:1156-1164
39. Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, McFinton PR, DelProposto ZS, Hill E, Cassin BJ, Watson SJ, Cook EH (1998) Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 155:207-213
40. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275
41. Mais DE, Bosin TR (1984) Hyperoxia alters platelet disposition of serotonin. Toxicol Lett 22:255-259
42. Mais DE, Lahr PD, Bosin TR (1984) Hyperoxia and paraquat alter the kinetics of platelet serotonin uptake. Toxicol Appl Pharmacol 76:1-8
43. Maitre L, Moser P, Baumann PA, Waldmeier PC (1980) Amine uptake inhibitors: criteria of selectivity. Acta Psychiatr Scand 280 (suppl):97-110
44. 123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane and single photon emission computed tomography. Biol Psychiatry 44:1090-1098
45. Malmgren R, Asberg M, Olsson P, Tornling G, Unge G (1981) Defective serotonin transport mechanism in platelets from endogenously depressed patients. Life Sci 29:2649-2658
46. Mann JJ, Huang YY, Underwood MD, Kassir SA, Oppenheim S, Kelly TM, Dwork AJ, Arango V (2000) A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 57:729-734 (see Fig. 5)
47. 3H]-paroxetine binding to human platelets. J Affect Disord 50:11-15
48. Marazziti D, Baroni S, Rossi A, Masala I, Giannaccini G, Gori V, Lucacchini A, Cassano GB (2001) Pharmacological characterization of the serotonin transporter in young and elderly subjects. Neuropsychobiology 44:78-83
49. Martin DC, Watkins CA, Adams RJ, Nason LA (1988a) Anesthetic effects on 5-hydroxytryptamine uptake by rat brain synaptosomes. Brain Res 455:360-365
50. Martin DC, Watkins CA, Adams RJ, Nason LA (1988b) Anesthetic effects on 5-hydroxytryptamine uptake by rat brain synaptosomes. Brain Res 455:360-365
51. McQueen JK, Wilson H, Fink G (1997) Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain Res Mol Brain Res 45:13-23
52. McQueen JK, Wilson H, Sumner BE, Fink G (1999) Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids. Brain Res Mol Brain Res 63:241-247
53. Meltzer HY, Arora RC (1988) Genetic control of serotonin uptake in blood platelets: a twin study. Psychiatry Res 24:263-269
54. Meltzer HY, Arora RC, Baber R, Tricou BJ (1981) Serotonin uptake in blood platelets of psychiatric patients. Arch Gen Psychiatry 38:1322-1326
55. Meyerson LR, Wennogle LP, Abel MS, Coupet J, Lippa AS, Rauh CE, Beer B (1982) Human brain receptor alterations in suicide victims. Pharmacol Biochem Behav 17:159-163
56. 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. Psychiatry Res 38:97-104
57. Naesh O, Hindberg I, Bruun AB (2001) Decreased reuptake of serotonin in human platelets after surgery. Clin Physiol 21(1):39-43
58. Neuger J, El Khoury A, Kjellman BF, Wahlund B, Aberg-Wistedt A, Stain-Malmgren R (1999) Platelet serotonin functions in untreated major depression. Psychiatry Res 85:189-198
59. Nobile M, Begni B, Giorda R, Frigerio A, Marino C, Molteni M, Ferrarese C, Battaglia M (1999) Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry 38:1396-1402
60. Ostrowitzki S, Rao ML, Redei J, Andres AH (1993) Concurrence of cortex and platelet serotonin2 receptor binding characteristics in the individual and the putative regulation by serotonin. J Neural Transm Gen Sect 93(1):27-35
61. Owen F, Chambers DR, Cooper SJ, Crow TJ, Johnson JA, Lofthouse R, Poulter M (1986) Serotonergic mechanisms in brains of suicide victims. Brain Res 362:185-188
62. Paul SM, Rehavi M, Skolnick P, Goodwin FK (1984) High affinity binding of antidepressants to a biogenic amine transport site in human brain and platelet; studies in depression. In: Post RM, Bellinger CJ (eds) Neurobiology of mood disorders. Williams and Wilkins, Baltimore, pp 846-853
63. Pearse AGE (1986) The diffuse neuroendocrine system: peptides, amines, placodes and the APUD theory. In: Hokfelt I, Fuxe K, Pernow B (eds) Progress in brain research. Elsevier, Amsterdam, pp 25-31
64. Perry EK, Marshall EF, Blessed G, Tomlinson BE, Perry RH (1983) Decreased imipramine binding in the brains of patients with depressive illness. Br J Psychiatry 142:188-192
65. Pletscher A, Affolter H, Cesura AM, Erne P, Mueller K (1984) Blood platelet as a model for neurons: similarities for the 5-hydroxytryptamine systems. In: Schlossenberger HG, Kochen W, Linzen B, Steinhart H (eds) Progress in tryptophan and serotonin research. Walter de Gruyter, Berlin, pp 231-239
66. 3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers. Psychopharmacology (Berl) 77:332-335
67. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD (1993) Antidepressant-and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci U S A 90:2542-2546
68. Rausch JL, Shah NS, Yates M, and Burch EA (1980) Platelet Serotonin Uptake in Patients with Major Depression. Biol Psychiatry 66
69. Rausch JL, Shah NS, Burch EA, Donald AG (1982) Platelet serotonin uptake in depressed patients: circadian effect. Biol Psychiatry 17:121-123
70. Rausch JL, Janowsky DS, Risch SC, Huey LY (1986) A kinetic analysis and replication of decreased platelet serotonin uptake in depressed patients. Psychiatry Res 19:105-112
71. Rausch JL, Fei Y, Li J, Hobby HM, Shendarkar N, Ganapathy V, Leibach FH (2000) Two SERT gene polymorphisms interact on 5-HT transport and temperament. Eur Psychiatry 15(Suppl 1):56
72. Rausch JL, Hobby HM, Shendarkar N, Johnson ME, Li J (2001) Fluvoxamine treatment of mixed anxiety and depression: evidence for serotonergically mediated anxiolysis. J Clin Psychopharmacol 21(2):139-142
73. 3H]paroxetine binding sites in suicide brains. Psychiatry Res 82:161-170
74. Ross SB, Aperia B, Beck-Friis J, Jansa S, Wetterberg L, Aberg A (1980) Inhibition of 5-hydroxytryptamine uptake in human platelets by antidepressant agents in vivo. Psychopharmacology 67:1-7
75. Roy A, Everett D, Pickar D, Paul SM (1987) Platelet tritiated imipramine binding and serotonin uptake in depressed patients and controls. Relationship to plasma cortisol levels before and after dexamethasone administration. Arch Gen Psychiatry 44:320-327
76. Scott M, Reading HW, Loudon JB (1979) Studies on human blood platelets in affective disorder. Psychopharmacology (Berl) 60:131-135
77. Slotkin TA, Whitmore WL, Dew KL, Kilts CD (1986) Uptake of serotonin into rat platelets and synaptosomes: comparative structure-activity relationships, energetics and evaluation of the effects of acute and chronic nortriptyline administration. Brain Res Bull 17:67-73
78. Slotkin TA, McCook EC, Ritchie JC, Seidler FJ (1996) Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biol Psychiatry 40:576-584
79. Slotkin TA, McCook EC, Ritchie JC, Carroll BJ, Seidler FJ (1997) Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. Biol Psychiatry 41:172-183
80. Smith LT, Hanson DR, Omenn GS (1978) Comparisons of serotonin uptake by blood platelets and brain synaptosomes. Brain Res 146:400-403
81. Stahl SM, Meltzer HY (1978) A kinetic and pharmacologic analysis of 5 hydroxytryptamine transport by human platelets and platelet storage granules: comparison with central serotonergic neurons. J Pharmacol Exp Ther 205:118-132
82. Stahl SM, Woo DJ, Mefford IN, Berger PA, Ciaranello RD (1983) Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders. Am J Psychiatry 140:26-30
83. Stanley M, Virgilio J, Gershon S (1982) Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science 216
84. Tuomisto J, Tukiainen E (1976) Decreased uptake of 5 hydroxytryptamine in blood platelets from depressed patients. Nature 262:596-598
85. Tuomisto J, Tukiainen E, Ahlfors UG (1979) Decreased uptake of 5 hydroxytryptamine in blood platelets from patients with endogenous depression. Psychopharmacology 65:141-147
86. 3H]cyanoimipramine. J Pharmacol Exp Ther 241:196-203
87. Wong DT, Horng JS, Fuller RW (1973) Kinetics of serotonin accumulation into synaptosomes of rat brain-effects of amphetamine and chloroamphetamines. Biochem Pharmacol 22:311-322