메뉴 건너뛰기




Volumn 15, Issue 7, 2016, Pages 684-689

The key culprit in the pathogenesis of systemic lupus erythematosus: Aberrant DNA methylation

Author keywords

DNA methylation; Epigenetics; SLE; T cells

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; BIOLOGICAL MARKER;

EID: 84962553077     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2016.03.002     Document Type: Review
Times cited : (61)

References (112)
  • 2
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos G.C. Systemic lupus erythematosus. N Engl J Med 2011, 365:2110-2121.
    • (2011) N Engl J Med , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 3
    • 33744822178 scopus 로고    scopus 로고
    • Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden
    • Danchenko N., Satia J.A., Anthony M.S. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus 2006, 15:308-318.
    • (2006) Lupus , vol.15 , pp. 308-318
    • Danchenko, N.1    Satia, J.A.2    Anthony, M.S.3
  • 5
    • 0031112357 scopus 로고    scopus 로고
    • Autoreactive T cell clones from patients with systemic lupus erythematosus support polyclonal autoantibody production
    • Takeno M., Nagafuchi H., Kaneko S., Wakisaka S., Oneda K., Takeba Y., et al. Autoreactive T cell clones from patients with systemic lupus erythematosus support polyclonal autoantibody production. J Immunol 1997, 158:3529-3538.
    • (1997) J Immunol , vol.158 , pp. 3529-3538
    • Takeno, M.1    Nagafuchi, H.2    Kaneko, S.3    Wakisaka, S.4    Oneda, K.5    Takeba, Y.6
  • 6
    • 0032006227 scopus 로고    scopus 로고
    • Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens
    • Santulli-Marotto S., Retter M.W., Gee R., Mamula M.J., Clarke S.H. Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens. Immunity 1998, 8:209-219.
    • (1998) Immunity , vol.8 , pp. 209-219
    • Santulli-Marotto, S.1    Retter, M.W.2    Gee, R.3    Mamula, M.J.4    Clarke, S.H.5
  • 7
    • 0013886630 scopus 로고
    • Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus
    • Tan E.M., Kunkel H.G. Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol 1966, 96:464-471.
    • (1966) J Immunol , vol.96 , pp. 464-471
    • Tan, E.M.1    Kunkel, H.G.2
  • 8
    • 84895896764 scopus 로고    scopus 로고
    • Diagnostic criteria for systemic lupus erythematosus: a critical review
    • (48-49:10-3)
    • Yu C., Gershwin M.E., Chang C. Diagnostic criteria for systemic lupus erythematosus: a critical review. J Autoimmun 2014, (48-49:10-3).
    • (2014) J Autoimmun
    • Yu, C.1    Gershwin, M.E.2    Chang, C.3
  • 11
    • 81155151965 scopus 로고    scopus 로고
    • Cutaneous lupus erythematosus: update of therapeutic options part II
    • Kuhn A., Ruland V., Bonsmann G. Cutaneous lupus erythematosus: update of therapeutic options part II. J Am Acad Dermatol 2011, 65:e195-e213.
    • (2011) J Am Acad Dermatol , vol.65 , pp. e195-e213
    • Kuhn, A.1    Ruland, V.2    Bonsmann, G.3
  • 12
    • 84870340050 scopus 로고    scopus 로고
    • Joint and tendon involvement in systemic lupus erythematosus: an ultrasound study of hands and wrists in 108 patients
    • Gabba A., Piga M., Vacca A., Porru G., Garau P., Cauli A., et al. Joint and tendon involvement in systemic lupus erythematosus: an ultrasound study of hands and wrists in 108 patients. Rheumatology (Oxford) 2012, 51:2278-2285.
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 2278-2285
    • Gabba, A.1    Piga, M.2    Vacca, A.3    Porru, G.4    Garau, P.5    Cauli, A.6
  • 14
    • 80051973863 scopus 로고    scopus 로고
    • Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents
    • Jeffries M.A., Sawalha A.H. Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents. Int J Clin Rheumatol 2011, 6:423-439.
    • (2011) Int J Clin Rheumatol , vol.6 , pp. 423-439
    • Jeffries, M.A.1    Sawalha, A.H.2
  • 15
    • 54549093861 scopus 로고    scopus 로고
    • The genetics of SLE: an update in the light of genome-wide association studies
    • Rhodes B., Vyse T.J. The genetics of SLE: an update in the light of genome-wide association studies. Rheumatology (Oxford) 2008, 47:1603-1611.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 1603-1611
    • Rhodes, B.1    Vyse, T.J.2
  • 16
    • 0027257146 scopus 로고
    • Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice
    • Quddus J., Johnson K.J., Gavalchin J., Amento E.P., Chrisp C.E., Yung R.L., et al. Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice. J Clin Invest 1993, 92:38-53.
    • (1993) J Clin Invest , vol.92 , pp. 38-53
    • Quddus, J.1    Johnson, K.J.2    Gavalchin, J.3    Amento, E.P.4    Chrisp, C.E.5    Yung, R.L.6
  • 19
    • 34547792388 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer: the DNA hypermethylome
    • (Spec No 1:R50-9)
    • Esteller M. Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet 2007, 16. (Spec No 1:R50-9).
    • (2007) Hum Mol Genet , vol.16
    • Esteller, M.1
  • 20
    • 44949233068 scopus 로고    scopus 로고
    • Proteins that bind methylated DNA and human cancer: reading the wrong words
    • Lopez-Serra L., Esteller M. Proteins that bind methylated DNA and human cancer: reading the wrong words. Br J Cancer 2008, 98:1881-1885.
    • (2008) Br J Cancer , vol.98 , pp. 1881-1885
    • Lopez-Serra, L.1    Esteller, M.2
  • 22
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi A., Park I.H., Wen B., Murakami P., Aryee M.J., Irizarry R., et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 2009, 41:1350-1353.
    • (2009) Nat Genet , vol.41 , pp. 1350-1353
    • Doi, A.1    Park, I.H.2    Wen, B.3    Murakami, P.4    Aryee, M.J.5    Irizarry, R.6
  • 23
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002, 16:6-21.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 24
    • 79959990071 scopus 로고    scopus 로고
    • Regulation of mammalian DNA methyltransferases: a route to new mechanisms
    • Denis H., Ndlovu M.N., Fuks F. Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBO Rep 2011, 12:647-656.
    • (2011) EMBO Rep , vol.12 , pp. 647-656
    • Denis, H.1    Ndlovu, M.N.2    Fuks, F.3
  • 25
    • 0014243302 scopus 로고
    • Induction by isoniazid and hydrallazine of antinuclear factors in mice
    • Cannat A., Seligmann M. Induction by isoniazid and hydrallazine of antinuclear factors in mice. Clin Exp Immunol 1968, 3:99-105.
    • (1968) Clin Exp Immunol , vol.3 , pp. 99-105
    • Cannat, A.1    Seligmann, M.2
  • 27
    • 51749091994 scopus 로고    scopus 로고
    • DNA methylation in T cells from idiopathic lupus and drug-induced lupus patients
    • Zhou Y., Lu Q. DNA methylation in T cells from idiopathic lupus and drug-induced lupus patients. Autoimmun Rev 2008, 7:376-383.
    • (2008) Autoimmun Rev , vol.7 , pp. 376-383
    • Zhou, Y.1    Lu, Q.2
  • 29
    • 84908483075 scopus 로고    scopus 로고
    • DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype
    • Zhao M., Liu S., Luo S., Wu H., Tang M., Cheng W., et al. DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype. J Autoimmun 2014, 54:127-136.
    • (2014) J Autoimmun , vol.54 , pp. 127-136
    • Zhao, M.1    Liu, S.2    Luo, S.3    Wu, H.4    Tang, M.5    Cheng, W.6
  • 30
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson B., Scheinbart L., Strahler J., Gross L., Hanash S., Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1990, 33:1665-1673.
    • (1990) Arthritis Rheum , vol.33 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 31
    • 0027144105 scopus 로고
    • Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis
    • Takeuchi T., Amano K., Sekine H., Koide J., Abe T. Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. J Clin Invest 1993, 92:3008-3016.
    • (1993) J Clin Invest , vol.92 , pp. 3008-3016
    • Takeuchi, T.1    Amano, K.2    Sekine, H.3    Koide, J.4    Abe, T.5
  • 32
    • 84878361920 scopus 로고    scopus 로고
    • Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients
    • Coit P., Jeffries M., Altorok N., Dozmorov M.G., Koelsch K.A., Wren J.D., et al. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients. J Autoimmun 2013, 43:78-84.
    • (2013) J Autoimmun , vol.43 , pp. 78-84
    • Coit, P.1    Jeffries, M.2    Altorok, N.3    Dozmorov, M.G.4    Koelsch, K.A.5    Wren, J.D.6
  • 33
    • 84949186042 scopus 로고    scopus 로고
    • DNA methylation patterns in naive CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus
    • Renauer P., Coit P., Jeffries M.A., Merrill J.T., McCune W.J., Maksimowicz-McKinnon K., et al. DNA methylation patterns in naive CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus. Lupus Sci Med 2015, 2.
    • (2015) Lupus Sci Med , vol.2
    • Renauer, P.1    Coit, P.2    Jeffries, M.A.3    Merrill, J.T.4    McCune, W.J.5    Maksimowicz-McKinnon, K.6
  • 34
  • 35
    • 77954948735 scopus 로고    scopus 로고
    • Effector T cell plasticity: flexibility in the face of changing circumstances
    • Murphy K.M., Stockinger B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol 2010, 11:674-680.
    • (2010) Nat Immunol , vol.11 , pp. 674-680
    • Murphy, K.M.1    Stockinger, B.2
  • 36
    • 74049099080 scopus 로고    scopus 로고
    • Autoimmunity: increasing suspects in the CD4+ T cell lineup
    • Palmer M.T., Weaver C.T. Autoimmunity: increasing suspects in the CD4+ T cell lineup. Nat Immunol 2010, 11:36-40.
    • (2010) Nat Immunol , vol.11 , pp. 36-40
    • Palmer, M.T.1    Weaver, C.T.2
  • 37
    • 33746930141 scopus 로고    scopus 로고
    • Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis
    • Chan R.W., Lai F.M., Li E.K., Tam L.S., Chow K.M., Li P.K., et al. Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. Rheumatology (Oxford) 2006, 45:951-957.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 951-957
    • Chan, R.W.1    Lai, F.M.2    Li, E.K.3    Tam, L.S.4    Chow, K.M.5    Li, P.K.6
  • 38
    • 66049151440 scopus 로고    scopus 로고
    • Th17 and natural treg cell population dynamics in systemic lupus erythematosus
    • Yang J., Chu Y., Yang X., Gao D., Zhu L., Yang X., et al. Th17 and natural treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum 2009, 60:1472-1483.
    • (2009) Arthritis Rheum , vol.60 , pp. 1472-1483
    • Yang, J.1    Chu, Y.2    Yang, X.3    Gao, D.4    Zhu, L.5    Yang, X.6
  • 39
    • 84871272970 scopus 로고    scopus 로고
    • Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus
    • Feng X., Wang D., Chen J., Lu L., Hua B., Li X., et al. Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus. PLoS One 2012, 7.
    • (2012) PLoS One , vol.7
    • Feng, X.1    Wang, D.2    Chen, J.3    Lu, L.4    Hua, B.5    Li, X.6
  • 40
    • 84925762443 scopus 로고    scopus 로고
    • Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity
    • Choi J.Y., Hsi-enHo J., Pasoto S.G., Bunin V., Kim S., Carrasco S., et al. Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity. Arthritis Rheum 2015.
    • (2015) Arthritis Rheum
    • Choi, J.Y.1    Hsi-enHo, J.2    Pasoto, S.G.3    Bunin, V.4    Kim, S.5    Carrasco, S.6
  • 41
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia E., Golbus J., Maybaum J., Strahler J., Hanash S., Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988, 140:2197-2200.
    • (1988) J Immunol , vol.140 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 42
    • 0021237183 scopus 로고
    • The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymoma
    • Ballas Z.K. The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymoma. J Immunol 1984, 133:7-9.
    • (1984) J Immunol , vol.133 , pp. 7-9
    • Ballas, Z.K.1
  • 43
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal S., Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 1998, 9:765-775.
    • (1998) Immunity , vol.9 , pp. 765-775
    • Agarwal, S.1    Rao, A.2
  • 44
    • 0032575727 scopus 로고    scopus 로고
    • Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells
    • Bix M., Locksley R.M. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Science 1998, 281:1352-1354.
    • (1998) Science , vol.281 , pp. 1352-1354
    • Bix, M.1    Locksley, R.M.2
  • 45
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
    • Lal G., Zhang N., van der Touw W., Ding Y., Ju W., Bottinger E.P., et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol 2009, 182:259-273.
    • (2009) J Immunol , vol.182 , pp. 259-273
    • Lal, G.1    Zhang, N.2    van der Touw, W.3    Ding, Y.4    Ju, W.5    Bottinger, E.P.6
  • 46
    • 84959088532 scopus 로고    scopus 로고
    • Genome-wide analysis identifies Bcl6-controlled regulatory networks during T Follicular helper cell differentiation
    • Liu X., Lu H., Chen T., Nallaparaju K.C., Yan X., Tanaka S., et al. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T Follicular helper cell differentiation. Cell Rep 2016.
    • (2016) Cell Rep
    • Liu, X.1    Lu, H.2    Chen, T.3    Nallaparaju, K.C.4    Yan, X.5    Tanaka, S.6
  • 47
    • 84865654244 scopus 로고    scopus 로고
    • Protein kinase cdelta oxidation contributes to ERK inactivation in lupus T cells
    • Gorelik G.J., Yarlagadda S., Patel D.R., Richardson B.C. Protein kinase cdelta oxidation contributes to ERK inactivation in lupus T cells. Arthritis Rheum 2012, 64:2964-2974.
    • (2012) Arthritis Rheum , vol.64 , pp. 2964-2974
    • Gorelik, G.J.1    Yarlagadda, S.2    Patel, D.R.3    Richardson, B.C.4
  • 48
    • 33749555820 scopus 로고    scopus 로고
    • Measurement and significance of 3-nitrotyrosine in systemic lupus erythematosus
    • Khan F., Siddiqui A.A., Ali R. Measurement and significance of 3-nitrotyrosine in systemic lupus erythematosus. Scand J Immunol 2006, 64:507-514.
    • (2006) Scand J Immunol , vol.64 , pp. 507-514
    • Khan, F.1    Siddiqui, A.A.2    Ali, R.3
  • 49
    • 33750942095 scopus 로고    scopus 로고
    • The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus
    • Oates J.C., Gilkeson G.S. The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus. Clin Immunol 2006, 121:243-250.
    • (2006) Clin Immunol , vol.121 , pp. 243-250
    • Oates, J.C.1    Gilkeson, G.S.2
  • 50
    • 0036330337 scopus 로고    scopus 로고
    • Proceedings of the trans-HHS workshop: diet, DNA methylation processes and health
    • Ross S.A., Poirier L. Proceedings of the trans-HHS workshop: diet, DNA methylation processes and health. J Nutr 2002, 132:2329S-2332S.
    • (2002) J Nutr , vol.132 , pp. 2329S-2332S
    • Ross, S.A.1    Poirier, L.2
  • 51
    • 84899512224 scopus 로고    scopus 로고
    • Environmental exposures, epigenetic changes and the risk of lupus
    • Somers E.C., Richardson B.C. Environmental exposures, epigenetic changes and the risk of lupus. Lupus 2014, 23:568-576.
    • (2014) Lupus , vol.23 , pp. 568-576
    • Somers, E.C.1    Richardson, B.C.2
  • 52
    • 84879873763 scopus 로고    scopus 로고
    • Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus
    • Strickland F.M., Hewagama A., Wu A., Sawalha A.H., Delaney C., Hoeltzel M.F., et al. Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus. Arthritis Rheum 2013, 65:1872-1881.
    • (2013) Arthritis Rheum , vol.65 , pp. 1872-1881
    • Strickland, F.M.1    Hewagama, A.2    Wu, A.3    Sawalha, A.H.4    Delaney, C.5    Hoeltzel, M.F.6
  • 53
    • 79957615493 scopus 로고    scopus 로고
    • Hypomethylation of the HTR1A promoter region and high expression of HTR1A in the peripheral blood lymphocytes of patients with systemic lupus erythematosus
    • Xu J., Zhang G., Cheng Y., Chen B., Dong Y., Li L., et al. Hypomethylation of the HTR1A promoter region and high expression of HTR1A in the peripheral blood lymphocytes of patients with systemic lupus erythematosus. Lupus 2011, 20:678-689.
    • (2011) Lupus , vol.20 , pp. 678-689
    • Xu, J.1    Zhang, G.2    Cheng, Y.3    Chen, B.4    Dong, Y.5    Li, L.6
  • 54
    • 0036095885 scopus 로고    scopus 로고
    • Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus
    • Lu Q., Kaplan M., Ray D., Ray D., Zacharek S., Gutsch D., et al. Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis Rheum 2002, 46:1282-1291.
    • (2002) Arthritis Rheum , vol.46 , pp. 1282-1291
    • Lu, Q.1    Kaplan, M.2    Ray, D.3    Ray, D.4    Zacharek, S.5    Gutsch, D.6
  • 55
    • 77953288009 scopus 로고    scopus 로고
    • Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells
    • Zhao M., Sun Y., Gao F., Wu X., Tang J., Yin H., et al. Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells. J Autoimmun 2010, 35:58-69.
    • (2010) J Autoimmun , vol.35 , pp. 58-69
    • Zhao, M.1    Sun, Y.2    Gao, F.3    Wu, X.4    Tang, J.5    Yin, H.6
  • 56
    • 78650626621 scopus 로고    scopus 로고
    • RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1
    • Zhao M., Wu X., Zhang Q., Luo S., Liang G., Su Y., et al. RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1. Arthritis Res Ther 2010, 12:R227.
    • (2010) Arthritis Res Ther , vol.12 , pp. R227
    • Zhao, M.1    Wu, X.2    Zhang, Q.3    Luo, S.4    Liang, G.5    Su, Y.6
  • 57
    • 34548398164 scopus 로고    scopus 로고
    • Primer: epigenetics of autoimmunity
    • Richardson B. Primer: epigenetics of autoimmunity. Nat Clin Pract Rheumatol 2007, 3:521-527.
    • (2007) Nat Clin Pract Rheumatol , vol.3 , pp. 521-527
    • Richardson, B.1
  • 58
    • 79955693133 scopus 로고    scopus 로고
    • Epigenetics and autoimmunity, with special emphasis on methylation
    • Renaudineau Y., Youinou P. Epigenetics and autoimmunity, with special emphasis on methylation. Keio J Med 2011, 60:10-16.
    • (2011) Keio J Med , vol.60 , pp. 10-16
    • Renaudineau, Y.1    Youinou, P.2
  • 59
    • 0037287976 scopus 로고    scopus 로고
    • Preferential expression of B7.2 (CD86), but not B7.1 (CD80), on B cells induced by CD40/CD40L interaction is essential for anti-DNA autoantibody production in patients with systemic lupus erythematosus
    • Nagafuchi H., Shimoyama Y., Kashiwakura J., Takeno M., Sakane T., Suzuki N. Preferential expression of B7.2 (CD86), but not B7.1 (CD80), on B cells induced by CD40/CD40L interaction is essential for anti-DNA autoantibody production in patients with systemic lupus erythematosus. Clin Exp Rheumatol 2003, 21:71-77.
    • (2003) Clin Exp Rheumatol , vol.21 , pp. 71-77
    • Nagafuchi, H.1    Shimoyama, Y.2    Kashiwakura, J.3    Takeno, M.4    Sakane, T.5    Suzuki, N.6
  • 60
    • 77951745847 scopus 로고    scopus 로고
    • Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells
    • Li Y., Zhao M., Yin H., Gao F., Wu X., Luo Y., et al. Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells. Arthritis Rheum 2010, 62:1438-1447.
    • (2010) Arthritis Rheum , vol.62 , pp. 1438-1447
    • Li, Y.1    Zhao, M.2    Yin, H.3    Gao, F.4    Wu, X.5    Luo, Y.6
  • 61
    • 84885332506 scopus 로고    scopus 로고
    • A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus
    • Li Y., Huang C., Zhao M., Liang G., Xiao R., Yung S., et al. A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus. Clin Dev Immunol 2013, 2013:206298.
    • (2013) Clin Dev Immunol , vol.2013 , pp. 206298
    • Li, Y.1    Huang, C.2    Zhao, M.3    Liang, G.4    Xiao, R.5    Yung, S.6
  • 62
    • 84956615593 scopus 로고    scopus 로고
    • IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus
    • Zhao M., Zhou Y., Zhu B., Wan M., Jiang T., Tan Q., et al. IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus. Ann Rheum Dis 2016.
    • (2016) Ann Rheum Dis
    • Zhao, M.1    Zhou, Y.2    Zhu, B.3    Wan, M.4    Jiang, T.5    Tan, Q.6
  • 63
    • 67649967556 scopus 로고    scopus 로고
    • Decreased DNA methyltransferase levels contribute to abnormal gene expression in "senescent" CD4(+)CD28(-) T cells
    • Liu Y., Chen Y., Richardson B. Decreased DNA methyltransferase levels contribute to abnormal gene expression in "senescent" CD4(+)CD28(-) T cells. Clin Immunol 2009, 132:257-265.
    • (2009) Clin Immunol , vol.132 , pp. 257-265
    • Liu, Y.1    Chen, Y.2    Richardson, B.3
  • 64
    • 77954548251 scopus 로고    scopus 로고
    • Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus
    • Zhao M., Tang J., Gao F., Wu X., Liang Y., Yin H., et al. Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus. J Biomed Biotechnol 2010, 2010:931018.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 931018
    • Zhao, M.1    Tang, J.2    Gao, F.3    Wu, X.4    Liang, Y.5    Yin, H.6
  • 65
    • 77953624215 scopus 로고    scopus 로고
    • MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
    • Pan W., Zhu S., Yuan M., Cui H., Wang L., Luo X., et al. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 2010, 184:6773-6781.
    • (2010) J Immunol , vol.184 , pp. 6773-6781
    • Pan, W.1    Zhu, S.2    Yuan, M.3    Cui, H.4    Wang, L.5    Luo, X.6
  • 66
    • 84878260646 scopus 로고    scopus 로고
    • TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
    • Pastor W.A., Aravind L., Rao A. TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol 2013, 14:341-356.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 341-356
    • Pastor, W.A.1    Aravind, L.2    Rao, A.3
  • 67
    • 0037333972 scopus 로고    scopus 로고
    • Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling
    • Deng C., Lu Q., Zhang Z., Rao T., Attwood J., Yung R., et al. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum 2003, 48:746-756.
    • (2003) Arthritis Rheum , vol.48 , pp. 746-756
    • Deng, C.1    Lu, Q.2    Zhang, Z.3    Rao, T.4    Attwood, J.5    Yung, R.6
  • 68
    • 38449104652 scopus 로고    scopus 로고
    • Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
    • Gorelik G., Fang J.Y., Wu A., Sawalha A.H., Richardson B. Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus. J Immunol 2007, 179:5553-5563.
    • (2007) J Immunol , vol.179 , pp. 5553-5563
    • Gorelik, G.1    Fang, J.Y.2    Wu, A.3    Sawalha, A.H.4    Richardson, B.5
  • 69
    • 84928616162 scopus 로고    scopus 로고
    • T cell PKCdelta kinase inactivation induces lupus-like autoimmunity in mice
    • Gorelik G., Sawalha A.H., Patel D., Johnson K., Richardson B. T cell PKCdelta kinase inactivation induces lupus-like autoimmunity in mice. Clin Immunol 2015, 158:193-203.
    • (2015) Clin Immunol , vol.158 , pp. 193-203
    • Gorelik, G.1    Sawalha, A.H.2    Patel, D.3    Johnson, K.4    Richardson, B.5
  • 70
    • 0037171731 scopus 로고    scopus 로고
    • Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta
    • Miyamoto A., Nakayama K., Imaki H., Hirose S., Jiang Y., Abe M., et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 2002, 416:865-869.
    • (2002) Nature , vol.416 , pp. 865-869
    • Miyamoto, A.1    Nakayama, K.2    Imaki, H.3    Hirose, S.4    Jiang, Y.5    Abe, M.6
  • 71
  • 72
    • 44849087740 scopus 로고    scopus 로고
    • Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
    • Sawalha A.H., Jeffries M., Webb R., Lu Q., Gorelik G., Ray D., et al. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun 2008, 9:368-378.
    • (2008) Genes Immun , vol.9 , pp. 368-378
    • Sawalha, A.H.1    Jeffries, M.2    Webb, R.3    Lu, Q.4    Gorelik, G.5    Ray, D.6
  • 74
    • 84931071592 scopus 로고    scopus 로고
    • DNA methylation and hydroxymethylation in stem cells
    • Cheng Y., Xie N., Jin P., Wang T. DNA methylation and hydroxymethylation in stem cells. Cell Biochem Funct 2015, 33:161-173.
    • (2015) Cell Biochem Funct , vol.33 , pp. 161-173
    • Cheng, Y.1    Xie, N.2    Jin, P.3    Wang, T.4
  • 75
    • 84876580885 scopus 로고    scopus 로고
    • Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method
    • Tan L., Xiong L., Xu W., Wu F., Huang N., Xu Y., et al. Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method. Nucleic Acids Res 2013, 41.
    • (2013) Nucleic Acids Res , vol.41
    • Tan, L.1    Xiong, L.2    Xu, W.3    Wu, F.4    Huang, N.5    Xu, Y.6
  • 76
    • 84928184771 scopus 로고    scopus 로고
    • The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells
    • Ichiyama K., Chen T., Wang X., Yan X., Kim B.S., Tanaka S., et al. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells. Immunity 2015, 42:613-626.
    • (2015) Immunity , vol.42 , pp. 613-626
    • Ichiyama, K.1    Chen, T.2    Wang, X.3    Yan, X.4    Kim, B.S.5    Tanaka, S.6
  • 77
    • 0036278549 scopus 로고    scopus 로고
    • DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines
    • Danbara M., Kameyama K., Higashihara M., Takagaki Y. DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. Mol Immunol 2002, 38:1161-1166.
    • (2002) Mol Immunol , vol.38 , pp. 1161-1166
    • Danbara, M.1    Kameyama, K.2    Higashihara, M.3    Takagaki, Y.4
  • 78
    • 0033377786 scopus 로고    scopus 로고
    • DNA methylation and chromatin structure regulate PU.1 expression
    • Amaravadi L., Klemsz M.J. DNA methylation and chromatin structure regulate PU.1 expression. DNA Cell Biol 1999, 18:875-884.
    • (1999) DNA Cell Biol , vol.18 , pp. 875-884
    • Amaravadi, L.1    Klemsz, M.J.2
  • 79
    • 52649146908 scopus 로고    scopus 로고
    • Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus
    • Walter K., Bonifer C., Tagoh H. Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus. Blood 2008, 112:1673-1682.
    • (2008) Blood , vol.112 , pp. 1673-1682
    • Walter, K.1    Bonifer, C.2    Tagoh, H.3
  • 80
    • 66949176660 scopus 로고    scopus 로고
    • IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation
    • Garaud S., Le Dantec C., Jousse-Joulin S., Hanrotel-Saliou C., Saraux A., Mageed R.A., et al. IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation. J Immunol 2009, 182:5623-5632.
    • (2009) J Immunol , vol.182 , pp. 5623-5632
    • Garaud, S.1    Le Dantec, C.2    Jousse-Joulin, S.3    Hanrotel-Saliou, C.4    Saraux, A.5    Mageed, R.A.6
  • 81
    • 84898483114 scopus 로고    scopus 로고
    • DNA methylation modulates HRES1/p28 expression in B cells from patients with lupus
    • Fali T., Le Dantec C., Thabet Y., Jousse S., Hanrotel C., Youinou P., et al. DNA methylation modulates HRES1/p28 expression in B cells from patients with lupus. Autoimmunity 2014, 47:265-271.
    • (2014) Autoimmunity , vol.47 , pp. 265-271
    • Fali, T.1    Le Dantec, C.2    Thabet, Y.3    Jousse, S.4    Hanrotel, C.5    Youinou, P.6
  • 82
    • 34247630966 scopus 로고    scopus 로고
    • Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus
    • Mazari L., Ouarzane M., Zouali M. Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus. Proc Natl Acad Sci U S A 2007, 104:6317-6322.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6317-6322
    • Mazari, L.1    Ouarzane, M.2    Zouali, M.3
  • 84
    • 52649138951 scopus 로고    scopus 로고
    • Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus
    • Giambra V., Volpi S., Emelyanov A.V., Pflugh D., Bothwell A.L., Norio P., et al. Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus. Mol Cell Biol 2008, 28:6123-6133.
    • (2008) Mol Cell Biol , vol.28 , pp. 6123-6133
    • Giambra, V.1    Volpi, S.2    Emelyanov, A.V.3    Pflugh, D.4    Bothwell, A.L.5    Norio, P.6
  • 85
    • 77954083521 scopus 로고    scopus 로고
    • Epigenetic perspectives in systemic lupus erythematosus: pathogenesis, biomarkers, and therapeutic potentials
    • Zhao S., Long H., Lu Q. Epigenetic perspectives in systemic lupus erythematosus: pathogenesis, biomarkers, and therapeutic potentials. Clin Rev Allergy Immunol 2010, 39:3-9.
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 3-9
    • Zhao, S.1    Long, H.2    Lu, Q.3
  • 86
    • 66049083160 scopus 로고    scopus 로고
    • X inactivation and the complexities of silencing a sex chromosome
    • Chow J., Heard E. X inactivation and the complexities of silencing a sex chromosome. Curr Opin Cell Biol 2009, 21:359-366.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 359-366
    • Chow, J.1    Heard, E.2
  • 87
    • 84906069844 scopus 로고    scopus 로고
    • The role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: dendritic cells as potential targets
    • Biermann M.H., Veissi S., Maueroder C., Chaurio R., Berens C., Herrmann M., et al. The role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: dendritic cells as potential targets. Expert Rev Clin Immunol 2014, 10:1151-1164.
    • (2014) Expert Rev Clin Immunol , vol.10 , pp. 1151-1164
    • Biermann, M.H.1    Veissi, S.2    Maueroder, C.3    Chaurio, R.4    Berens, C.5    Herrmann, M.6
  • 88
    • 77649334441 scopus 로고    scopus 로고
    • Dendritic cell function in lupus: independent contributors or victims of aberrant immune regulation
    • Kis-Toth K., Tsokos G.C. Dendritic cell function in lupus: independent contributors or victims of aberrant immune regulation. Autoimmunity 2010, 43:121-130.
    • (2010) Autoimmunity , vol.43 , pp. 121-130
    • Kis-Toth, K.1    Tsokos, G.C.2
  • 89
    • 84866533031 scopus 로고    scopus 로고
    • Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus
    • Chan V.S., Nie Y.J., Shen N., Yan S., Mok M.Y., Lau C.S. Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus. Autoimmun Rev 2012, 11:890-897.
    • (2012) Autoimmun Rev , vol.11 , pp. 890-897
    • Chan, V.S.1    Nie, Y.J.2    Shen, N.3    Yan, S.4    Mok, M.Y.5    Lau, C.S.6
  • 90
    • 0037103187 scopus 로고    scopus 로고
    • American College of Rheumatology Ad Hoc Committee on Immunologic Testing G Evidence-based guidelines for the use of immunologic tests: antinuclear antibody testing
    • Solomon D.H., Kavanaugh A.J., Schur P.H., American College of Rheumatology Ad Hoc Committee on Immunologic Testing G Evidence-based guidelines for the use of immunologic tests: antinuclear antibody testing. Arthritis Rheum 2002, 47:434-444.
    • (2002) Arthritis Rheum , vol.47 , pp. 434-444
    • Solomon, D.H.1    Kavanaugh, A.J.2    Schur, P.H.3
  • 91
    • 84870243580 scopus 로고    scopus 로고
    • Are anti-nucleosome antibodies a better diagnostic marker than anti-dsDNA antibodies for systemic lupus erythematosus? A systematic review and a study of metanalysis
    • Bizzaro N., Villalta D., Giavarina D., Tozzoli R. Are anti-nucleosome antibodies a better diagnostic marker than anti-dsDNA antibodies for systemic lupus erythematosus? A systematic review and a study of metanalysis. Autoimmun Rev 2012, 12:97-106.
    • (2012) Autoimmun Rev , vol.12 , pp. 97-106
    • Bizzaro, N.1    Villalta, D.2    Giavarina, D.3    Tozzoli, R.4
  • 92
    • 0041761208 scopus 로고    scopus 로고
    • The anti-Sm immune response in autoimmunity and cell biology
    • Zieve G.W., Khusial P.R. The anti-Sm immune response in autoimmunity and cell biology. Autoimmun Rev 2003, 2:235-240.
    • (2003) Autoimmun Rev , vol.2 , pp. 235-240
    • Zieve, G.W.1    Khusial, P.R.2
  • 93
    • 84962310123 scopus 로고    scopus 로고
    • An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese
    • Wang Y., Yu Y., Ye R., Zhang D., Li Q., An D., et al. An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese. Oncotarget 2016, 7:2754-2764.
    • (2016) Oncotarget , vol.7 , pp. 2754-2764
    • Wang, Y.1    Yu, Y.2    Ye, R.3    Zhang, D.4    Li, Q.5    An, D.6
  • 94
    • 84860516671 scopus 로고    scopus 로고
    • Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk
    • Brennan K., Garcia-Closas M., Orr N., Fletcher O., Jones M., Ashworth A., et al. Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk. Cancer Res 2012, 72:2304-2313.
    • (2012) Cancer Res , vol.72 , pp. 2304-2313
    • Brennan, K.1    Garcia-Closas, M.2    Orr, N.3    Fletcher, O.4    Jones, M.5    Ashworth, A.6
  • 95
    • 84938212403 scopus 로고    scopus 로고
    • DNA methylation level of OPCML and SFRP1: a potential diagnostic biomarker of cholangiocarcinoma
    • Amornpisutt R., Proungvitaya S., Jearanaikoon P., Limpaiboon T. DNA methylation level of OPCML and SFRP1: a potential diagnostic biomarker of cholangiocarcinoma. Tumour Biol 2015, 36:4973-4978.
    • (2015) Tumour Biol , vol.36 , pp. 4973-4978
    • Amornpisutt, R.1    Proungvitaya, S.2    Jearanaikoon, P.3    Limpaiboon, T.4
  • 96
    • 66449125866 scopus 로고    scopus 로고
    • LINE-1 methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors
    • Aparicio A., North B., Barske L., Wang X., Bollati V., Weisenberger D., et al. LINE-1 methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors. Epigenetics 2009, 4:176-184.
    • (2009) Epigenetics , vol.4 , pp. 176-184
    • Aparicio, A.1    North, B.2    Barske, L.3    Wang, X.4    Bollati, V.5    Weisenberger, D.6
  • 97
    • 77954089823 scopus 로고    scopus 로고
    • Epigenetic therapeutics in autoimmune disease
    • Szyf M. Epigenetic therapeutics in autoimmune disease. Clin Rev Allergy Immunol 2010, 39:62-77.
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 62-77
    • Szyf, M.1
  • 98
    • 3843113658 scopus 로고    scopus 로고
    • Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo
    • Campbell P.M., Bovenzi V., Szyf M. Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo. Carcinogenesis 2004, 25:499-507.
    • (2004) Carcinogenesis , vol.25 , pp. 499-507
    • Campbell, P.M.1    Bovenzi, V.2    Szyf, M.3
  • 99
    • 0038080948 scopus 로고    scopus 로고
    • The methyl donor S-adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-adenosylmethionine
    • Detich N., Hamm S., Just G., Knox J.D., Szyf M. The methyl donor S-adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-adenosylmethionine. J Biol Chem 2003, 278:20812-20820.
    • (2003) J Biol Chem , vol.278 , pp. 20812-20820
    • Detich, N.1    Hamm, S.2    Just, G.3    Knox, J.D.4    Szyf, M.5
  • 100
    • 45849122855 scopus 로고    scopus 로고
    • Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis
    • Hosea Blewett H.J. Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis. Crit Rev Food Sci Nutr 2008, 48:458-463.
    • (2008) Crit Rev Food Sci Nutr , vol.48 , pp. 458-463
    • Hosea Blewett, H.J.1
  • 101
    • 84940614381 scopus 로고    scopus 로고
    • Epigenetics in autoimmune diseases: pathogenesis and prospects for therapy
    • Zhang Z., Zhang R. Epigenetics in autoimmune diseases: pathogenesis and prospects for therapy. Autoimmun Rev 2015, 14:854-863.
    • (2015) Autoimmun Rev , vol.14 , pp. 854-863
    • Zhang, Z.1    Zhang, R.2
  • 102
    • 69349092918 scopus 로고    scopus 로고
    • Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression
    • Annilo T., Kepp K., Laan M. Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression. BMC Mol Biol 2009, 10:81.
    • (2009) BMC Mol Biol , vol.10 , pp. 81
    • Annilo, T.1    Kepp, K.2    Laan, M.3
  • 103
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O., Mullally A., Hedvat C., Garcia-Manero G., Patel J., Wadleigh M., et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 2009, 114:144-147.
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3    Garcia-Manero, G.4    Patel, J.5    Wadleigh, M.6
  • 105
    • 79251542357 scopus 로고    scopus 로고
    • Epigenetics in lupus
    • Zouali M. Epigenetics in lupus. Ann N Y Acad Sci 2011, 1217:154-165.
    • (2011) Ann N Y Acad Sci , vol.1217 , pp. 154-165
    • Zouali, M.1
  • 106
    • 70350049103 scopus 로고    scopus 로고
    • Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis
    • Lei W., Luo Y., Lei W., Luo Y., Yan K., Zhao S., et al. Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. Scand J Rheumatol 2009, 38:369-374.
    • (2009) Scand J Rheumatol , vol.38 , pp. 369-374
    • Lei, W.1    Luo, Y.2    Lei, W.3    Luo, Y.4    Yan, K.5    Zhao, S.6
  • 107
    • 70349487008 scopus 로고    scopus 로고
    • Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylation
    • Wang G.S., Zhang M., Li X.P., Zhang H., Chen W., Kan M., et al. Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylation. Lupus 2009, 18:1037-1044.
    • (2009) Lupus , vol.18 , pp. 1037-1044
    • Wang, G.S.1    Zhang, M.2    Li, X.P.3    Zhang, H.4    Chen, W.5    Kan, M.6
  • 108
    • 18644376210 scopus 로고    scopus 로고
    • Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs
    • Lu Q., Wu A., Richardson B.C. Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs. J Immunol 2005, 174:6212-6219.
    • (2005) J Immunol , vol.174 , pp. 6212-6219
    • Lu, Q.1    Wu, A.2    Richardson, B.C.3
  • 109
    • 0029662353 scopus 로고    scopus 로고
    • Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes
    • Singer N.G., Richardson B.C., Powers D., Hooper F., Lialios F., Endres J., et al. Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes. Immunology 1996, 88:537-543.
    • (1996) Immunology , vol.88 , pp. 537-543
    • Singer, N.G.1    Richardson, B.C.2    Powers, D.3    Hooper, F.4    Lialios, F.5    Endres, J.6
  • 110
    • 38449116161 scopus 로고    scopus 로고
    • Demethylation of CD40LG on the inactive X in T cells from women with lupus
    • Lu Q., Wu A., Tesmer L., Ray D., Yousif N., Richardson B. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J Immunol 2007, 179:6352-6358.
    • (2007) J Immunol , vol.179 , pp. 6352-6358
    • Lu, Q.1    Wu, A.2    Tesmer, L.3    Ray, D.4    Yousif, N.5    Richardson, B.6
  • 111
    • 79955048011 scopus 로고    scopus 로고
    • Promoter hypomethylation results in increased expression of protein phosphatase 2 A in T cells from patients with systemic lupus erythematosus
    • Sunahori K., Juang Y.T., Kyttaris V.C., Tsokos G.C. Promoter hypomethylation results in increased expression of protein phosphatase 2 A in T cells from patients with systemic lupus erythematosus. J Immunol 2011, 186:4508-4517.
    • (2011) J Immunol , vol.186 , pp. 4508-4517
    • Sunahori, K.1    Juang, Y.T.2    Kyttaris, V.C.3    Tsokos, G.C.4
  • 112
    • 79956330057 scopus 로고    scopus 로고
    • Hypomethylation of LINE-1 but not alu in lymphocyte subsets of systemic lupus erythematosus patients
    • Nakkuntod J., Avihingsanon Y., Mutirangura A., Hirankarn N. Hypomethylation of LINE-1 but not alu in lymphocyte subsets of systemic lupus erythematosus patients. Clin Chim Acta 2011, 412:1457-1461.
    • (2011) Clin Chim Acta , vol.412 , pp. 1457-1461
    • Nakkuntod, J.1    Avihingsanon, Y.2    Mutirangura, A.3    Hirankarn, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.