-
1
-
-
7144223296
-
Gene action in the X-chromosome of the mouse (Mus musculus L.)
-
Lyon M.F. Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190 (1961) 372-373
-
(1961)
Nature
, vol.190
, pp. 372-373
-
-
Lyon, M.F.1
-
2
-
-
85045484695
-
A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis
-
Barr M.L., and Bertram E.G. A morphological distinction between neurones of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis. Nature 163 (1949) 676
-
(1949)
Nature
, vol.163
, pp. 676
-
-
Barr, M.L.1
Bertram, E.G.2
-
3
-
-
0000255857
-
Asynchronous duplication of human chromosomes and the origin of sex chromatin
-
Morishima A., Grumbach M.M., and Taylor J.H. Asynchronous duplication of human chromosomes and the origin of sex chromatin. Proc Natl Acad Sci U S A 48 (1962) 756-763
-
(1962)
Proc Natl Acad Sci U S A
, vol.48
, pp. 756-763
-
-
Morishima, A.1
Grumbach, M.M.2
Taylor, J.H.3
-
4
-
-
0030589678
-
X-Inactivation and histone H4 acetylation in embryonic stem cells
-
Keohane A.M., O'Neill L.P., Belyaev N.D., Lavender J.S., and Turner B.M. X-Inactivation and histone H4 acetylation in embryonic stem cells. Dev Biol 180 (1996) 618-630
-
(1996)
Dev Biol
, vol.180
, pp. 618-630
-
-
Keohane, A.M.1
O'Neill, L.P.2
Belyaev, N.D.3
Lavender, J.S.4
Turner, B.M.5
-
5
-
-
0035861875
-
Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation
-
Heard E., Rougeulle C., Arnaud D., Avner P., Allis C.D., and Spector D.L. Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell 107 (2001) 727-738
-
(2001)
Cell
, vol.107
, pp. 727-738
-
-
Heard, E.1
Rougeulle, C.2
Arnaud, D.3
Avner, P.4
Allis, C.D.5
Spector, D.L.6
-
6
-
-
0344530944
-
Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells
-
Chaumeil J., Okamoto I., Guggiari M., and Heard E. Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells. Cytogenet Genome Res 99 (2002) 75-84
-
(2002)
Cytogenet Genome Res
, vol.99
, pp. 75-84
-
-
Chaumeil, J.1
Okamoto, I.2
Guggiari, M.3
Heard, E.4
-
7
-
-
19344375746
-
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation
-
Kohlmaier A., Savarese F., Lachner M., Martens J., Jenuwein T., and Wutz A. A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol 2 (2004) E171
-
(2004)
PLoS Biol
, vol.2
-
-
Kohlmaier, A.1
Savarese, F.2
Lachner, M.3
Martens, J.4
Jenuwein, T.5
Wutz, A.6
-
8
-
-
0036338205
-
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
-
Peters A.H., Mermoud J.E., O'Carroll D., Pagani M., Schweizer D., Brockdorff N., and Jenuwein T. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet 30 (2002) 77-80
-
(2002)
Nat Genet
, vol.30
, pp. 77-80
-
-
Peters, A.H.1
Mermoud, J.E.2
O'Carroll, D.3
Pagani, M.4
Schweizer, D.5
Brockdorff, N.6
Jenuwein, T.7
-
9
-
-
62549103324
-
Specific patterns of histone marks accompany X chromosome inactivation in a marsupial
-
This study analysed, by immunofluorescence, the pattern of histone modifications during metaphase across the inactive and active X chromosome in the tammar wallaby. All active histone modifications were found to be excluded from the marsupial inactive X, and thus represents a common feature in all mammals. However, unlike placental mammals, inactive histone modifications were not enriched on the inactive X at metaphase in marsupials, which suggests that the mechanisms involved in inactivation are likely different between the two types of mammals.
-
Koina E., Chaumeil J., Greaves I.K., Tremethick D.J., and Marshall Graves J.A. Specific patterns of histone marks accompany X chromosome inactivation in a marsupial. Chromosome Res 17 (2009) 115-126. This study analysed, by immunofluorescence, the pattern of histone modifications during metaphase across the inactive and active X chromosome in the tammar wallaby. All active histone modifications were found to be excluded from the marsupial inactive X, and thus represents a common feature in all mammals. However, unlike placental mammals, inactive histone modifications were not enriched on the inactive X at metaphase in marsupials, which suggests that the mechanisms involved in inactivation are likely different between the two types of mammals.
-
(2009)
Chromosome Res
, vol.17
, pp. 115-126
-
-
Koina, E.1
Chaumeil, J.2
Greaves, I.K.3
Tremethick, D.J.4
Marshall Graves, J.A.5
-
10
-
-
33745125901
-
The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene
-
Duret L., Chureau C., Samain S., Weissenbach J., and Avner P. The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene. Science 312 (2006) 1653-1655
-
(2006)
Science
, vol.312
, pp. 1653-1655
-
-
Duret, L.1
Chureau, C.2
Samain, S.3
Weissenbach, J.4
Avner, P.5
-
11
-
-
9244227937
-
Resolution and evolution of the duck-billed platypus karyotype with an X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution
-
Rens W., Grutzner F., O'Brien P.C., Fairclough H., Graves J.A., and Ferguson-Smith M.A. Resolution and evolution of the duck-billed platypus karyotype with an X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution. Proc Natl Acad Sci U S A 101 (2004) 16257-16261
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 16257-16261
-
-
Rens, W.1
Grutzner, F.2
O'Brien, P.C.3
Fairclough, H.4
Graves, J.A.5
Ferguson-Smith, M.A.6
-
12
-
-
11144346999
-
In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes
-
Grutzner F., Rens W., Tsend-Ayush E., El-Mogharbel N., O'Brien P.C., Jones R.C., Ferguson-Smith M.A., and Marshall Graves J.A. In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes. Nature 432 (2004) 913-917
-
(2004)
Nature
, vol.432
, pp. 913-917
-
-
Grutzner, F.1
Rens, W.2
Tsend-Ayush, E.3
El-Mogharbel, N.4
O'Brien, P.C.5
Jones, R.C.6
Ferguson-Smith, M.A.7
Marshall Graves, J.A.8
-
13
-
-
48249115194
-
The status of dosage compensation in the multiple X chromosomes of the platypus
-
This study examined the degree of dosage compensation in monotremes which have 5 pairs of sex chromosomes. Using a combination of quantitative RT-PCR and RNA-FISH for specific genes on the sex chromosomes, the authors found that although there is some evidence for dosage compensation, it was variable between genes.
-
Deakin J.E., Hore T.A., Koina E., and Marshall Graves J.A. The status of dosage compensation in the multiple X chromosomes of the platypus. PLoS Genet 4 (2008) e1000140. This study examined the degree of dosage compensation in monotremes which have 5 pairs of sex chromosomes. Using a combination of quantitative RT-PCR and RNA-FISH for specific genes on the sex chromosomes, the authors found that although there is some evidence for dosage compensation, it was variable between genes.
-
(2008)
PLoS Genet
, vol.4
-
-
Deakin, J.E.1
Hore, T.A.2
Koina, E.3
Marshall Graves, J.A.4
-
14
-
-
10644221120
-
Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome
-
Chadwick B.P., and Willard H.F. Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome. Proc Natl Acad Sci U S A 101 (2004) 17450-17455
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17450-17455
-
-
Chadwick, B.P.1
Willard, H.F.2
-
15
-
-
33747871839
-
Chromosome-wide, allele-specific analysis of the histone code on the human X chromosome
-
Valley C.M., Pertz L.M., Balakumaran B.S., and Willard H.F. Chromosome-wide, allele-specific analysis of the histone code on the human X chromosome. Hum Mol Genet 15 (2006) 2335-2347
-
(2006)
Hum Mol Genet
, vol.15
, pp. 2335-2347
-
-
Valley, C.M.1
Pertz, L.M.2
Balakumaran, B.S.3
Willard, H.F.4
-
16
-
-
33746521889
-
Genomic and epigenomic approaches to the study of X chromosome inactivation
-
Valley C.M., and Willard H.F. Genomic and epigenomic approaches to the study of X chromosome inactivation. Curr Opin Genet Dev 16 (2006) 240-245
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 240-245
-
-
Valley, C.M.1
Willard, H.F.2
-
17
-
-
33947169216
-
Variation in Xi chromatin organization and correlation of the H3K27me3 chromatin territories to transcribed sequences by microarray analysis
-
Chadwick B.P. Variation in Xi chromatin organization and correlation of the H3K27me3 chromatin territories to transcribed sequences by microarray analysis. Chromosoma 116 (2007) 147-157
-
(2007)
Chromosoma
, vol.116
, pp. 147-157
-
-
Chadwick, B.P.1
-
18
-
-
33744783407
-
Histone modification patterns associated with the human X chromosome
-
Brinkman A.B., Roelofsen T., Pennings S.W., Martens J.H., Jenuwein T., and Stunnenberg H.G. Histone modification patterns associated with the human X chromosome. EMBO Rep 7 (2006) 628-634
-
(2006)
EMBO Rep
, vol.7
, pp. 628-634
-
-
Brinkman, A.B.1
Roelofsen, T.2
Pennings, S.W.3
Martens, J.H.4
Jenuwein, T.5
Stunnenberg, H.G.6
-
19
-
-
58149460416
-
Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome
-
By ChIP-chip this study analysed the enrichment and distribution of mH2A1 on the inactive X and found ∼1.5 fold enrichment over autosomes that was distributed uniformly across the chromosome suggestive of a role in global chromatin structure.
-
Mietton F., Sengupta A.K., Molla A., Picchi G., Barral S., Heliot L., Grange T., Wutz A., and Dimitrov S. Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome. Mol Cell Biol 29 (2009) 150-156. By ChIP-chip this study analysed the enrichment and distribution of mH2A1 on the inactive X and found ∼1.5 fold enrichment over autosomes that was distributed uniformly across the chromosome suggestive of a role in global chromatin structure.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 150-156
-
-
Mietton, F.1
Sengupta, A.K.2
Molla, A.3
Picchi, G.4
Barral, S.5
Heliot, L.6
Grange, T.7
Wutz, A.8
Dimitrov, S.9
-
20
-
-
23044514626
-
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
-
Weber M., Davies J.J., Wittig D., Oakeley E.J., Haase M., Lam W.L., and Schubeler D. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 37 (2005) 853-862
-
(2005)
Nat Genet
, vol.37
, pp. 853-862
-
-
Weber, M.1
Davies, J.J.2
Wittig, D.3
Oakeley, E.J.4
Haase, M.5
Lam, W.L.6
Schubeler, D.7
-
21
-
-
33847304609
-
Gene body-specific methylation on the active X chromosome
-
Hellman A., and Chess A. Gene body-specific methylation on the active X chromosome. Science 315 (2007) 1141-1143
-
(2007)
Science
, vol.315
, pp. 1141-1143
-
-
Hellman, A.1
Chess, A.2
-
22
-
-
0031467130
-
X-chromosome inactivation in mammals
-
Heard E., Clerc P., and Avner P. X-chromosome inactivation in mammals. Annu Rev Genet 31 (1997) 571-610
-
(1997)
Annu Rev Genet
, vol.31
, pp. 571-610
-
-
Heard, E.1
Clerc, P.2
Avner, P.3
-
23
-
-
33748629119
-
Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis
-
Zhang X., Yazaki J., Sundaresan A., Cokus S., Chan S.W., Chen H., Henderson I.R., Shinn P., Pellegrini M., Jacobsen S.E., et al. Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. Cell 126 (2006) 1189-1201
-
(2006)
Cell
, vol.126
, pp. 1189-1201
-
-
Zhang, X.1
Yazaki, J.2
Sundaresan, A.3
Cokus, S.4
Chan, S.W.5
Chen, H.6
Henderson, I.R.7
Shinn, P.8
Pellegrini, M.9
Jacobsen, S.E.10
-
24
-
-
0030034051
-
XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure
-
Clemson C.M., McNeil J.A., Willard H.F., and Lawrence J.B. XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J Cell Biol 132 (1996) 259-275
-
(1996)
J Cell Biol
, vol.132
, pp. 259-275
-
-
Clemson, C.M.1
McNeil, J.A.2
Willard, H.F.3
Lawrence, J.B.4
-
25
-
-
33746076412
-
A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced
-
Chaumeil J., Le Baccon P., Wutz A., and Heard E. A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes Dev 20 (2006) 2223-2237
-
(2006)
Genes Dev
, vol.20
, pp. 2223-2237
-
-
Chaumeil, J.1
Le Baccon, P.2
Wutz, A.3
Heard, E.4
-
26
-
-
33646743365
-
The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences
-
Clemson C.M., Hall L.L., Byron M., McNeil J., and Lawrence J.B. The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences. Proc Natl Acad Sci U S A 103 (2006) 7688-7693
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 7688-7693
-
-
Clemson, C.M.1
Hall, L.L.2
Byron, M.3
McNeil, J.4
Lawrence, J.B.5
-
27
-
-
36749083424
-
Chromosome territory reorganization in a human disease with altered DNA methylation
-
Matarazzo M.R., Boyle S., D'Esposito M., and Bickmore W.A. Chromosome territory reorganization in a human disease with altered DNA methylation. Proc Natl Acad Sci U S A 104 (2007) 16546-16551
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 16546-16551
-
-
Matarazzo, M.R.1
Boyle, S.2
D'Esposito, M.3
Bickmore, W.A.4
-
28
-
-
43149100549
-
The facultative heterochromatin of the inactive X chromosome has a distinctive condensed ultrastructure
-
Using light and electron microscopy combined with immunostaining, this study describes the ultrastructure of the H3K27me3-associated, DAPI-dense portion of the Xi. This region of the Xi territory was shown to be made up of tightly packed fibers with significant amounts of intervening spaces and a mean density of chromatin compaction higher than euchromatin but less than constitutive heterochromatin.
-
Rego A., Sinclair P.B., Tao W., Kireev I., and Belmont A.S. The facultative heterochromatin of the inactive X chromosome has a distinctive condensed ultrastructure. J Cell Sci 121 (2008) 1119-1127. Using light and electron microscopy combined with immunostaining, this study describes the ultrastructure of the H3K27me3-associated, DAPI-dense portion of the Xi. This region of the Xi territory was shown to be made up of tightly packed fibers with significant amounts of intervening spaces and a mean density of chromatin compaction higher than euchromatin but less than constitutive heterochromatin.
-
(2008)
J Cell Sci
, vol.121
, pp. 1119-1127
-
-
Rego, A.1
Sinclair, P.B.2
Tao, W.3
Kireev, I.4
Belmont, A.S.5
-
29
-
-
0042767995
-
The dynamics of chromosome organization and gene regulation
-
Spector D.L. The dynamics of chromosome organization and gene regulation. Annu Rev Biochem 72 (2003) 573-608
-
(2003)
Annu Rev Biochem
, vol.72
, pp. 573-608
-
-
Spector, D.L.1
-
30
-
-
34249006523
-
Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing
-
This study describes the perinucleolar localization of the inactive X chromosome during S phase and proposes a link with maintenance of the inactive state.
-
Zhang L.F., Huynh K.D., and Lee J.T. Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing. Cell 129 (2007) 693-706. This study describes the perinucleolar localization of the inactive X chromosome during S phase and proposes a link with maintenance of the inactive state.
-
(2007)
Cell
, vol.129
, pp. 693-706
-
-
Zhang, L.F.1
Huynh, K.D.2
Lee, J.T.3
-
31
-
-
0032805149
-
Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation
-
Csankovszki G., Panning B., Bates B., Pehrson J.R., and Jaenisch R. Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nat Genet 22 (1999) 323-324
-
(1999)
Nat Genet
, vol.22
, pp. 323-324
-
-
Csankovszki, G.1
Panning, B.2
Bates, B.3
Pehrson, J.R.4
Jaenisch, R.5
-
32
-
-
0942268864
-
Epigenetic dynamics of imprinted X inactivation during early mouse development
-
Okamoto I., Otte A.P., Allis C.D., Reinberg D., and Heard E. Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303 (2004) 644-649
-
(2004)
Science
, vol.303
, pp. 644-649
-
-
Okamoto, I.1
Otte, A.P.2
Allis, C.D.3
Reinberg, D.4
Heard, E.5
-
33
-
-
0034934749
-
Imprinted X inactivation maintained by a mouse Polycomb group gene
-
Wang J., Mager J., Chen Y., Schneider E., Cross J.C., Nagy A., and Magnuson T. Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat Genet 28 (2001) 371-375
-
(2001)
Nat Genet
, vol.28
, pp. 371-375
-
-
Wang, J.1
Mager, J.2
Chen, Y.3
Schneider, E.4
Cross, J.C.5
Nagy, A.6
Magnuson, T.7
-
34
-
-
0242668706
-
Role of histone H3 lysine 27 methylation in X inactivation
-
Plath K., Fang J., Mlynarczyk-Evans S.K., Cao R., Worringer K.A., Wang H., de la Cruz C.C., Otte A.P., Panning B., and Zhang Y. Role of histone H3 lysine 27 methylation in X inactivation. Science 300 (2003) 131-135
-
(2003)
Science
, vol.300
, pp. 131-135
-
-
Plath, K.1
Fang, J.2
Mlynarczyk-Evans, S.K.3
Cao, R.4
Worringer, K.A.5
Wang, H.6
de la Cruz, C.C.7
Otte, A.P.8
Panning, B.9
Zhang, Y.10
-
35
-
-
33746407708
-
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
-
Schoeftner S., Sengupta A.K., Kubicek S., Mechtler K., Spahn L., Koseki H., Jenuwein T., and Wutz A. Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J 25 (2006) 3110-3122
-
(2006)
EMBO J
, vol.25
, pp. 3110-3122
-
-
Schoeftner, S.1
Sengupta, A.K.2
Kubicek, S.3
Mechtler, K.4
Spahn, L.5
Koseki, H.6
Jenuwein, T.7
Wutz, A.8
-
36
-
-
0033637110
-
A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
-
Wutz A., and Jaenisch R. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell 5 (2000) 695-705
-
(2000)
Mol Cell
, vol.5
, pp. 695-705
-
-
Wutz, A.1
Jaenisch, R.2
-
37
-
-
65249115919
-
Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice
-
Patrat C., Okamoto I., Diabangouaya P., Vialon V., Le Baccon P., Chow J., and Heard E. Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice. Proc Natl Acad Sci U S A 13 (2009) 5198-5203
-
(2009)
Proc Natl Acad Sci U S A
, vol.13
, pp. 5198-5203
-
-
Patrat, C.1
Okamoto, I.2
Diabangouaya, P.3
Vialon, V.4
Le Baccon, P.5
Chow, J.6
Heard, E.7
-
38
-
-
38749117957
-
Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes
-
Lin H., Gupta V., Vermilyea M.D., Falciani F., Lee J.T., O'Neill L.P., and Turner B.M. Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes. PLoS Biol 5 (2007) e326
-
(2007)
PLoS Biol
, vol.5
-
-
Lin, H.1
Gupta, V.2
Vermilyea, M.D.3
Falciani, F.4
Lee, J.T.5
O'Neill, L.P.6
Turner, B.M.7
-
39
-
-
0347357614
-
Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos
-
Huynh K.D., and Lee J.T. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 426 (2003) 857-862
-
(2003)
Nature
, vol.426
, pp. 857-862
-
-
Huynh, K.D.1
Lee, J.T.2
-
40
-
-
42649100978
-
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation
-
This study identified a novel player in the X inactivation process, Smchd1, an Smc-like protein. Mutations in female mice affect both random and imprinted inactivation and result in relatively late lethality and defects in promoter methylation, suggestive of a role in the maintenance stages of inactivation. Smc-like proteins have been implicated in dosage compensation in C. elegans and the identification of a similar type of protein in mammalian X inactivation provides a potential link between the two mechanisms.
-
Blewitt M.E., Gendrel A.V., Pang Z., Sparrow D.B., Whitelaw N., Craig J.M., Apedaile A., Hilton D.J., Dunwoodie S.L., Brockdorff N., et al. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet 40 (2008) 663-669. This study identified a novel player in the X inactivation process, Smchd1, an Smc-like protein. Mutations in female mice affect both random and imprinted inactivation and result in relatively late lethality and defects in promoter methylation, suggestive of a role in the maintenance stages of inactivation. Smc-like proteins have been implicated in dosage compensation in C. elegans and the identification of a similar type of protein in mammalian X inactivation provides a potential link between the two mechanisms.
-
(2008)
Nat Genet
, vol.40
, pp. 663-669
-
-
Blewitt, M.E.1
Gendrel, A.V.2
Pang, Z.3
Sparrow, D.B.4
Whitelaw, N.5
Craig, J.M.6
Apedaile, A.7
Hilton, D.J.8
Dunwoodie, S.L.9
Brockdorff, N.10
-
41
-
-
0028104856
-
DPY-27: a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome
-
Chuang P.T., Albertson D.G., and Meyer B.J. DPY-27: a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome. Cell 79 (1994) 459-474
-
(1994)
Cell
, vol.79
, pp. 459-474
-
-
Chuang, P.T.1
Albertson, D.G.2
Meyer, B.J.3
-
42
-
-
15244353967
-
X-inactivation profile reveals extensive variability in X-linked gene expression in females
-
Carrel L., and Willard H.F. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434 (2005) 400-404
-
(2005)
Nature
, vol.434
, pp. 400-404
-
-
Carrel, L.1
Willard, H.F.2
-
43
-
-
0031820331
-
X-chromosome inactivation: a repeat hypothesis
-
Lyon M.F. X-chromosome inactivation: a repeat hypothesis. Cytogenet Cell Genet 80 (1998) 133-137
-
(1998)
Cytogenet Cell Genet
, vol.80
, pp. 133-137
-
-
Lyon, M.F.1
-
44
-
-
0034612238
-
Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis
-
Bailey J.A., Carrel L., Chakravarti A., and Eichler E.E. Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis. Proc Natl Acad Sci U S A 97 (2000) 6634-6639
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6634-6639
-
-
Bailey, J.A.1
Carrel, L.2
Chakravarti, A.3
Eichler, E.E.4
-
45
-
-
33749407724
-
Genomic environment predicts expression patterns on the human inactive X chromosome
-
Carrel L., Park C., Tyekucheva S., Dunn J., Chiaromonte F., and Makova K.D. Genomic environment predicts expression patterns on the human inactive X chromosome. PLoS Genet 2 (2006) e151
-
(2006)
PLoS Genet
, vol.2
-
-
Carrel, L.1
Park, C.2
Tyekucheva, S.3
Dunn, J.4
Chiaromonte, F.5
Makova, K.D.6
-
46
-
-
11244258156
-
Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development
-
Filippova G.N., Cheng M.K., Moore J.M., Truong J.P., Hu Y.J., Nguyen D.K., Tsuchiya K.D., and Disteche C.M. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev Cell 8 (2005) 31-42
-
(2005)
Dev Cell
, vol.8
, pp. 31-42
-
-
Filippova, G.N.1
Cheng, M.K.2
Moore, J.M.3
Truong, J.P.4
Hu, Y.J.5
Nguyen, D.K.6
Tsuchiya, K.D.7
Disteche, C.M.8
-
47
-
-
55949099351
-
Escape from X chromosome inactivation is an intrinsic property of the Jarid1c locus
-
Using a transgenic approach, this study showed that the ability to escape inactivation is an intrinsic property of the Jarid1c locus. Jarid1c-containing BACs were introduced into mouse ES cells and in four different X chromosome integration sites, the transgenic locus retained its ability to escape inactivation. Based on the region of overlap between two different BACs, the authors delimit a 112 kb region that may confer its escape capacity.
-
Li N., and Carrel L. Escape from X chromosome inactivation is an intrinsic property of the Jarid1c locus. Proc Natl Acad Sci U S A 105 (2008) 17055-17060. Using a transgenic approach, this study showed that the ability to escape inactivation is an intrinsic property of the Jarid1c locus. Jarid1c-containing BACs were introduced into mouse ES cells and in four different X chromosome integration sites, the transgenic locus retained its ability to escape inactivation. Based on the region of overlap between two different BACs, the authors delimit a 112 kb region that may confer its escape capacity.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17055-17060
-
-
Li, N.1
Carrel, L.2
-
48
-
-
38949090440
-
Large-scale population study of human cell lines indicates that dosage compensation is virtually complete
-
Johnston C.M., Lovell F.L., Leongamornlert D.A., Stranger B.E., Dermitzakis E.T., and Ross M.T. Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. PLoS Genet 4 (2008) e9
-
(2008)
PLoS Genet
, vol.4
-
-
Johnston, C.M.1
Lovell, F.L.2
Leongamornlert, D.A.3
Stranger, B.E.4
Dermitzakis, E.T.5
Ross, M.T.6
-
49
-
-
33646473832
-
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues
-
Garrick D., Sharpe J.A., Arkell R., Dobbie L., Smith A.J., Wood W.G., Higgs D.R., and Gibbons R.J. Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet 2 (2006) e58
-
(2006)
PLoS Genet
, vol.2
-
-
Garrick, D.1
Sharpe, J.A.2
Arkell, R.3
Dobbie, L.4
Smith, A.J.5
Wood, W.G.6
Higgs, D.R.7
Gibbons, R.J.8
-
50
-
-
62549150310
-
ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells
-
Baumann C., and De La Fuente R. ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells. Chromosoma 118 (2009) 209-222
-
(2009)
Chromosoma
, vol.118
, pp. 209-222
-
-
Baumann, C.1
De La Fuente, R.2
-
51
-
-
60749133597
-
A new model for random X chromosome inactivation
-
Starmer J., and Magnuson T. A new model for random X chromosome inactivation. Development 136 (2009) 1-10
-
(2009)
Development
, vol.136
, pp. 1-10
-
-
Starmer, J.1
Magnuson, T.2
-
52
-
-
0036479009
-
Chromosomal silencing and localization are mediated by different domains of Xist RNA
-
Wutz A., Rasmussen T.P., and Jaenisch R. Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet 30 (2002) 167-174
-
(2002)
Nat Genet
, vol.30
, pp. 167-174
-
-
Wutz, A.1
Rasmussen, T.P.2
Jaenisch, R.3
-
53
-
-
17744388101
-
Characterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence
-
Nesterova T.B., Slobodyanyuk S.Y., Elisaphenko E.A., Shevchenko A.I., Johnston C., Pavlova M.E., Rogozin I.B., Kolesnikov N.N., Brockdorff N., and Zakian S.M. Characterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence. Genome Res 11 (2001) 833-849
-
(2001)
Genome Res
, vol.11
, pp. 833-849
-
-
Nesterova, T.B.1
Slobodyanyuk, S.Y.2
Elisaphenko, E.A.3
Shevchenko, A.I.4
Johnston, C.5
Pavlova, M.E.6
Rogozin, I.B.7
Kolesnikov, N.N.8
Brockdorff, N.9
Zakian, S.M.10
-
54
-
-
60749087716
-
A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse
-
Hoki Y., Kimura N., Kanbayashi M., Amakawa Y., Ohhata T., Sasaki H., and Sado T. A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse. Development 136 (2009) 139-146
-
(2009)
Development
, vol.136
, pp. 139-146
-
-
Hoki, Y.1
Kimura, N.2
Kanbayashi, M.3
Amakawa, Y.4
Ohhata, T.5
Sasaki, H.6
Sado, T.7
-
55
-
-
55349109963
-
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
-
This study reports the discovery of an independent short transcript, RepA, from the Xist A-repeat region.
-
Zhao J., Sun B.K., Erwin J.A., Song J.J., and Lee J.T. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science 322 (2008) 750-756. This study reports the discovery of an independent short transcript, RepA, from the Xist A-repeat region.
-
(2008)
Science
, vol.322
, pp. 750-756
-
-
Zhao, J.1
Sun, B.K.2
Erwin, J.A.3
Song, J.J.4
Lee, J.T.5
-
56
-
-
33646942973
-
The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation
-
Kalantry S., and Magnuson T. The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation. PLoS Genet 2 (2006) e66
-
(2006)
PLoS Genet
, vol.2
-
-
Kalantry, S.1
Magnuson, T.2
-
57
-
-
64549153094
-
SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells
-
This study has identified a factor SATB1 that is essential for the initiation of Xist-mediated silencing. Its expression correlates with Xist's silencing window early in ES cell differentiation and is able to confer Xist-mediated gene silencing outside this context when aberrantly expressed in both tumor cells as well as in fibroblasts when introduced as a transgene.
-
Agrelo R., Souabni A., Novatchkova M., Haslinger C., Leeb M., Komnenovic V., Kishimoto H., Gresh L., Kohwi-Shigematsu T., Kenner L., et al. SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells. Dev Cell 16 (2009) 507-516. This study has identified a factor SATB1 that is essential for the initiation of Xist-mediated silencing. Its expression correlates with Xist's silencing window early in ES cell differentiation and is able to confer Xist-mediated gene silencing outside this context when aberrantly expressed in both tumor cells as well as in fibroblasts when introduced as a transgene.
-
(2009)
Dev Cell
, vol.16
, pp. 507-516
-
-
Agrelo, R.1
Souabni, A.2
Novatchkova, M.3
Haslinger, C.4
Leeb, M.5
Komnenovic, V.6
Kishimoto, H.7
Gresh, L.8
Kohwi-Shigematsu, T.9
Kenner, L.10
-
58
-
-
33750465872
-
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes
-
Cai S., Lee C.C., and Kohwi-Shigematsu T. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet 38 (2006) 1278-1288
-
(2006)
Nat Genet
, vol.38
, pp. 1278-1288
-
-
Cai, S.1
Lee, C.C.2
Kohwi-Shigematsu, T.3
-
59
-
-
34547203213
-
Inducible XIST-dependent X-chromosome inactivation in human somatic cells is reversible
-
Chow J.C., Hall L.L., Baldry S.E., Thorogood N.P., Lawrence J.B., and Brown C.J. Inducible XIST-dependent X-chromosome inactivation in human somatic cells is reversible. Proc Natl Acad Sci U S A 104 (2007) 10104-10109
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 10104-10109
-
-
Chow, J.C.1
Hall, L.L.2
Baldry, S.E.3
Thorogood, N.P.4
Lawrence, J.B.5
Brown, C.J.6
-
60
-
-
0037173064
-
An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells
-
Hall L.L., Byron M., Sakai K., Carrel L., Willard H.F., and Lawrence J.B. An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells. Proc Natl Acad Sci U S A 99 (2002) 8677-8682
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8677-8682
-
-
Hall, L.L.1
Byron, M.2
Sakai, K.3
Carrel, L.4
Willard, H.F.5
Lawrence, J.B.6
-
61
-
-
33749177531
-
Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation
-
Savarese F., Flahndorfer K., Jaenisch R., Busslinger M., and Wutz A. Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation. Mol Cell Biol 26 (2006) 7167-7177
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7167-7177
-
-
Savarese, F.1
Flahndorfer, K.2
Jaenisch, R.3
Busslinger, M.4
Wutz, A.5
-
62
-
-
24344454298
-
Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome
-
Heard E. Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome. Curr Opin Genet Dev 15 (2005) 482-489
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 482-489
-
-
Heard, E.1
-
63
-
-
34250654571
-
RNA and protein actors in X-chromosome inactivation
-
Masui O., and Heard E. RNA and protein actors in X-chromosome inactivation. Cold Spring Harb Symp Quant Biol 71 (2006) 419-428
-
(2006)
Cold Spring Harb Symp Quant Biol
, vol.71
, pp. 419-428
-
-
Masui, O.1
Heard, E.2
-
64
-
-
7744228427
-
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation
-
de Napoles M., Mermoud J.E., Wakao R., Tang Y.A., Endoh M., Appanah R., Nesterova T.B., Silva J., Otte A.P., Vidal M., et al. Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell 7 (2004) 663-676
-
(2004)
Dev Cell
, vol.7
, pp. 663-676
-
-
de Napoles, M.1
Mermoud, J.E.2
Wakao, R.3
Tang, Y.A.4
Endoh, M.5
Appanah, R.6
Nesterova, T.B.7
Silva, J.8
Otte, A.P.9
Vidal, M.10
-
65
-
-
11144237618
-
Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation
-
Fang J., Chen T., Chadwick B., Li E., and Zhang Y. Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J Biol Chem 279 (2004) 52812-52815
-
(2004)
J Biol Chem
, vol.279
, pp. 52812-52815
-
-
Fang, J.1
Chen, T.2
Chadwick, B.3
Li, E.4
Zhang, Y.5
-
66
-
-
11244313165
-
Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome
-
Plath K., Talbot D., Hamer K.M., Otte A.P., Yang T.P., Jaenisch R., and Panning B. Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. J Cell Biol 167 (2004) 1025-1035
-
(2004)
J Cell Biol
, vol.167
, pp. 1025-1035
-
-
Plath, K.1
Talbot, D.2
Hamer, K.M.3
Otte, A.P.4
Yang, T.P.5
Jaenisch, R.6
Panning, B.7
-
67
-
-
33645231102
-
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin
-
Bernstein E., Duncan E.M., Masui O., Gil J., Heard E., and Allis C.D. Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol 26 (2006) 2560-2569
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2560-2569
-
-
Bernstein, E.1
Duncan, E.M.2
Masui, O.3
Gil, J.4
Heard, E.5
Allis, C.D.6
-
68
-
-
0032507949
-
Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals
-
Costanzi C., and Pehrson J.R. Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. Nature 393 (1998) 599-601
-
(1998)
Nature
, vol.393
, pp. 599-601
-
-
Costanzi, C.1
Pehrson, J.R.2
-
69
-
-
0034081857
-
Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos
-
Costanzi C., Stein P., Worrad D.M., Schultz R.M., and Pehrson J.R. Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos. Development 127 (2000) 2283-2289
-
(2000)
Development
, vol.127
, pp. 2283-2289
-
-
Costanzi, C.1
Stein, P.2
Worrad, D.M.3
Schultz, R.M.4
Pehrson, J.R.5
-
70
-
-
0033611106
-
Histone macroH2A1 2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation
-
Mermoud J.E., Costanzi C., Pehrson J.R., and Brockdorff N. Histone macroH2A1 2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation. J Cell Biol 147 (1999) 1399-1408
-
(1999)
J Cell Biol
, vol.147
, pp. 1399-1408
-
-
Mermoud, J.E.1
Costanzi, C.2
Pehrson, J.R.3
Brockdorff, N.4
-
71
-
-
1642363256
-
De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation
-
Sado T., Okano M., Li E., and Sasaki H. De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation. Development 131 (2004) 975-982
-
(2004)
Development
, vol.131
, pp. 975-982
-
-
Sado, T.1
Okano, M.2
Li, E.3
Sasaki, H.4
|