Inhibition of Aberrant Circulating Tfh Cell Proportions by Corticosteroids in Patients with Systemic Lupus Erythematosus

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Feng, Xuebing ^a   Wang, Dandan ^a   Chen, Jingjing ^a   Lu, Lin ^a   Hua, Bingzhu ^a   Li, Xia ^a   Tsao, Betty P ^b   Sun, Lingyun ^a  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; CD19 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR5; CORTICOSTEROID; DEXAMETHASONE; INTERLEUKIN 21; METHYLPREDNISOLONE; PROGRAMMED DEATH 1 RECEPTOR; SYNDECAN 1;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; DRUG MEGADOSE; DRUG PULSE THERAPY; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE COUNT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMA CELL; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; T FOLLICULAR HELPER CELL; TH17 CELL;

ADOLESCENT; ADRENAL CORTEX HORMONES; ADULT; ANTIGENS, CD19; AUTOANTIBODIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PROGRAMMED CELL DEATH 1 RECEPTOR; RECEPTORS, CXCR5; SYNDECAN-1; T-LYMPHOCYTES, HELPER-INDUCER; YOUNG ADULT;

EID: 84871272970     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051982     Document Type: Article

References (33)

1. Deenick EK, Ma CS, (2011) The regulation and role of T follicular helper cells in immunity. Immunology 134: 361-367.
2. Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, et al. (2010) PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol 11: 535-542.
3. Linterman MA, Beaton L, Yu D, Ramiscal RR, Srivastava M, et al. (2010) IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 207: 353-363.
4. Kerfoot SM, Yaari G, Patel JR, Johnson KL, Gonzalez DG, et al. (2011) Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 34: 947-960.
5. Simpson N, Gatenby PA, Wilson A, Malik S, Fulcher DA, et al. (2010) Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 62: 234-244.
6. Zeller GC, Hirahashi J, Schwarting A, Sharpe AH, Kelley VR, (2006) Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus. J Am Soc Nephrol 17: 122-130.
7. Zhang W, Wu J, Qiao B, Xu W, Xiong S, (2011) Amelioration of lupus nephritis by serum amyloid P component gene therapy with distinct mechanisms varied from different stage of the disease. PLoS One 6: e22659.
8. Lucas JA, Menke J, Rabacal WA, Schoen FJ, Sharpe AH, et al. (2008) Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J Immunol 181: 2513-2521.
9. Herber D, Brown TP, Liang S, Young DA, Collins M, et al. (2007) IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 178: 3822-3830.
10. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, et al. (2008) Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29: 138-149.
11. Feng X, Li R, Huang J, Zhang H, Zhu L, et al. (2010) Olf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus. Arthritis Res Ther 12: R59.
12. Hochberg MC, (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40: 1725.
13. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH, (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35: 630-640.
14. Feng J, Lu L, Hua C, Qin L, Zhao P, et al. (2011) High frequency of CD4+ CXCR5+ TFH cells in patients with immune-active chronic hepatitis B. PLoS One. 6: e21698.
15. Harrison OJ, Foley J, Bolognese BJ, Long E III, Podolin PL, et al. (2008) Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol Lett 121: 13-21.
16. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, et al. (2012) B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood 119: 2819-2828.
17. Cepika AM, Bendelja K, Vergles JM, Malenica B, Kapitanovic S, et al. (2010) Monocyte response to LPS after exposure to corticosteroids and chloroquine with implications for systemic lupus erythematosus. Scand J Immunol 72: 434-443.
18. Dolff S, Abdulahad WH, Westra J, Doornbos-van der Meer B, Limburg PC, et al. (2011) Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus. Arthritis Res Ther 13: R157.
19. Nguyen V, Luzina I, Rus H, Tegla C, Chen C, et al. (2012) IL-21 Promotes Lupus-like Disease in Chronic Graft-versus-Host Disease through Both CD4 T Cell- and B Cell-Intrinsic Mechanisms. J Immunol 189: 1081-1093.
20. Alunno A, Bartoloni E, Bistoni O, Nocentini G, Ronchetti S, et al. (2012) Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New. Clin Dev Immunol 2012: 823085.
21. Shah K, Lee WW, Lee SH, Kim SH, Kang SW, et al. (2010) Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Res Ther 12: R53.
22. Appel H, Maier R, Wu P, Scheer R, Hempfing A, et al. (2011) Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 13: R95.
23. Prado C, de PB, Gomez J, Lopez P, Rodriguez-Carrio J, et al. (2011) Glucocorticoids enhance Th17/Th1 imbalance and signal transducer and activator of transcription 3 expression in systemic lupus erythematosus patients. Rheumatology (Oxford) 50: 1794-1801.
24. Terrier B, Costedoat-Chalumeau N, Garrido M, Geri G, Rosenzwajg M, et al. (2012) Interleukin 21 Correlates with T Cell and B Cell Subset Alterations in Systemic Lupus Erythematosus. J Rheumatol 39: 1819-1828.
25. Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, et al. (2008) A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29: 127-137.
26. Ma CS, Deenick EK, Batten M, Tangye SG, (2012) The origins, function, and regulation of T follicular helper cells. J Exp Med 209: 1241-1253.
27. Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, et al. (2005) A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435: 452-458.
28. Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, et al. (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192: 1545-1552.
29. Patakas A, Platt AM, Butcher JP, Maffia P, McInnes IB, et al. (2011) Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune disease. Immunol Lett 138: 38-46.
30. Rhen T, Cidlowski JA, (2005) Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 353: 1711-1723.
31. King JK, Hahn BH, (2007) Systemic lupus erythematosus: modern strategies for management: a moving target. Best Pract Res Clin Rheumatol 21: 971-987.
32. Fagerli UM, Ullrich K, Stuhmer T, Holien T, Kochert K, et al. (2011) Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells. Oncogene 30: 3198-3206.
33. Maranville JC, Luca F, Richards AL, Wen X, Witonsky DB, et al. (2011) Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes. PLoS Genet 7: e1002162.