DNA methylation in T cells from idiopathic lupus and drug-induced lupus patients

Autoimmunity Reviews

Volumn 7, Issue 5, 2008, Pages 376-383

  Zhou, Ying ^a   Lu, Qianjin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

DNA methylation; Epigenetics; Lupus; T cells

Indexed keywords

AUTOANTIBODY; AZACITIDINE; CD70 ANTIGEN; CYTOKINE; HYDRALAZINE; PERFORIN; PROCAINAMIDE;

ANTIBODY PRODUCTION; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL INTERACTION; CYTOKINE RELEASE; CYTOTOXICITY; DNA METHYLATION; EPIGENETICS; GENE ACTIVATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; IDIOPATHIC DISEASE; LUPUS LIKE SYNDROME; LYMPHOCYTE FUNCTION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FAMILY; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; X CHROMOSOME; X CHROMOSOME INACTIVATION;

AUTOANTIBODIES; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; DNA METHYLATION; HUMANS; HYDRALAZINE; LUPUS ERYTHEMATOSUS, SYSTEMIC; PROCAINAMIDE; T-LYMPHOCYTE SUBSETS;

EID: 51749091994     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2008.03.003     Document Type: Review

References (40)

1. Richardson B.C., Strahler J.R., Pivirotto T.S., Quddus J., Bayliss G.E., Gross L.A., et al. Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus. Arthritis Rheum 35 (1992) 647-662
2. Kaplan M.J., Lu Q., Wu A., Attwood J., and Richardson B. Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells. J Immunol 172 (2004) 3652-3661
3. Oelke K., Lu Q., Richardson D., Wu A., Deng C., Hanash S., and Richardson B. Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum 50 (2004) 1850-1860
4. Lu Q., Wu A., Tesmer L., Ray D., Yousif N., and Richardson B. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J Immunol 179 (2007) 6352-6358
5. Holliday R. Epigenetics: a historical overview. Epigenetics 1 (2006) 76-80
6. Weber M., and Schübeler D. Genomic patterns of DNA methylation: targets and function of an epigenetic mark. Curr Opin Cell Biol 19 (2007) 273-280
7. Rodenhiser D., and Mann M. Epigenetics and human disease: translating basic biology into clinical applications. CMAJ 174 (2006) 341-348
8. Klose R.J., and Bird A.P. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31 (2006) 89-97
9. Kass S.U., Pruss D., and Wolffe A.P. How does DNA methylation repress transcription?. Trends Genet 13 (1997) 444-449
10. Wilson A.S., Power B.E., and Molloy P.L. DNA hypomethylation and human diseases. Biochim Biophys Acta 1775 (2007) 138-162
11. Richardson B. Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells. Hum Immunol 17 (1986) 456-470
12. Richardson B., Scheinbart L., Strahler J., Gross L., Hanash S., and Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 33 (1990) 1665-1673
13. Corvetta A., Della Bitta R., Luchetti M.M., and Pomponio G. 5-Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmune rheumatic diseases. J Chromatogr 566 (1991) 481-491
14. Cornachia E., Golbus J., Maybaum J., Strahler J., Hanash S., and Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 140 (1988) 2197-2200
15. Richardson B., Powers D., Hooper F., Yung R.L., and O'Rourke K. Lymphocyte function-associated antigen 1 overexpression and T cell autoreactivity. Arthritis Rheum 37 (1994) 1363-1372
16. Yung R., Chang S., Hemati N., Johnson K., and Richardson B. Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo. Arthritis Rheum 40 (1997) 1436-1443
17. Quddus J., Johnson K.J., Gavalchin J., Amento E.P., Chrisp C.E., Yung R.L., et al. Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice. J Clin Invest 92 (1993) 38-53
18. Yung R.L., Quddus J., Chrisp C.E., Johnson K.J., and Richardson B.C. Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J Immunol 154 (1995) 3025-3035
19. Richardson B. DNA methylation and autoimmune disease. Clin Immunol 109 (2003) 72-79
20. Hogg N., Laschinger M., Giles K., and McDowall A. T-cell integrins-more than just sticking points. J Cell Sci 116 (2003) 4695-4705
21. Yung R., Powers D., Johnson K., Amento E., Carr D., Laing T., et al. Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. J Clin Invest 97 (1996) 2866-2871
22. Lu Q., Kaplan M., Ray D., Ray D., Zacharek S., Gutsch D., et al. Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis Rheum 46 (2002) 1282-1291
23. van den Broek M.F., and Hengartner H. The role of perforin in infections and tumour surveillance. Exp Physiol 85 (2000) 681-685
24. Kobata T., Jacquot S., Kozlowski S., Agematsu K., Schlossman S.F., and Morimoto C. CD27-CD70 interactions regulate B-cell activation by T cells. Proc Natl Acad Sci USA 92 (1995) 11249-11253
25. Sawalha A.H., and Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol 37 (2007) 1407-1413
26. Lu Q., Wu A., and Richardson B.C. Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs. J Immunol 174 (2005) 6212-6219
27. Heard E., and Disteche C.M. Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev 20 (2006) 1848-1867
28. Ross M.T., Grafham D.V., Coffey A.J., et al. The DNA sequence of the human X chromosome. Nature 434 (2005) 325-327
29. Deng C., Kaplan M.J., Yang J., Ray D., Zhang Z., McCune W.J., et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum 44 (2001) 397-407
30. Balada E., Ordi-Ros J., Vilardell-Tarrés M., and Vilardell-Tarres M. DNA methylation and systemic lupus erythematosus. Ann N Y Acad Sci 1108 (2007) 127-136
31. Januchowski R., Wudarski M., Chwalińska-Sadowska H., and Jagodzinski P.P. Prevalence of ZAP-70, LAT, SLP-76, and DNA methyltransferase 1 expression in CD4(+) T cells of patients with systemic lupus erythematosus. Clin Rheumatol 27 (2008) 21-27
32. Yang J., Deng C., Hemati N., Hanash S.M., and Richardson B.C. Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity. J Immunol 159 (1997) 1303-1309
33. Scheinbart L.S., Johnson M.A., Gross L.A., Edelstein S.R., and Richardson B.C. Procainamide inhibits DNA methyltransferase in a human T cell line. J Rheumatol 18 (1991) 530-534
34. Deng C., Lu Q., Zhang Z., Rao T., Attwood J., Yung R., et al. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum 48 (2003) 746-756
35. Klinman D.M., Mushinski J.F., Honda M., Ishigatsubo Y., Mountz J.D., Raveche E.S., et al. Oncogene expression in autoimmune and normal peripheral blood mononuclear cells. J Exp Med 163 (1986) 1292-1307
36. Balada E., Ordi-Ros J., Serrano-Acedo S., Martinez-Lostao L., and Vilardell-Tarrés M. Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients. J Leukoc Biol 81 (2007) 1609-1616
37. Richardson B.C., Liebling M.R., and Hudson J.L. CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation. Clin Immunol Immunopathol 55 (1990) 368-381
38. Kaplan M.J., Ray D., Mo R.R., Yung R.L., and Richardson B.C. TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages. J Immunol 164 (2000) 2897-2904
39. Lu Q., Wu A., Ray D., Deng C., Attwood J., Hanash S., et al. DNA methylation and chromatin structure regulate T cell perforin gene expression. J Immunol 170 (2003) 5124-5132
40. Yung R., Kaplan M., Ray D., Schneider K., Mo R.R., Johnson K., et al. Autoreactive murine Th1 and Th2 cells kill syngeneic macrophages and induce autoantibodies. Lupus 10 (2001) 539-546