A possible role of HMGB1 in DNA demethylation in CD4+ T cells from patients with systemic lupus erythematosus

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Li, Yaping ^a   Huang, Chenghui ^b   Zhao, Ming ^a   Liang, Gongping ^a   Xiao, Rong ^a   Yung, Susan ^c   Chan, Tak Mao ^c   Lu, Qianjin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CD70 ANTIGEN; CYCLOPHOSPHAMIDE; GADD45A PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MESSENGER RNA; PREDNISONE; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; GADD45A PROTEIN, HUMAN; NUCLEAR PROTEIN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DISEASE ACTIVITY; DISEASE EXACERBATION; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; WESTERN BLOTTING; ADOLESCENT; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE PROTEINS; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; HMGB1 PROTEIN; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; NUCLEAR PROTEINS; RNA, MESSENGER; YOUNG ADULT;

EID: 84885332506     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/206298     Document Type: Article

References (16)

1. Strickland F., Richardson B., Epigenetics in human autoimmunity. Epigenetics in autoimmunity-DNA methylation in systemic lupus erythematosus and beyond. Autoimmunity 2008 41 4 278 286 2-s2.0-42649095663 10.1080/ 08916930802024616 (Pubitemid 351593858)
2. Lu Q., Ray D., Gutsch D., Richardson B., Effect of DNA methylation and chromatin structure on ITGAL expression. Blood 2002 99 12 4503 4508 2-s2.0-0037097819 10.1182/blood.V99.12.4503 (Pubitemid 34627220)
3. Lu Q., Wu A., Richardson B. C., Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs. Journal of Immunology 2005 174 10 6212 6219 2-s2.0-18644376210 (Pubitemid 40663812)
4. Lu Q., Kaplan M., Ray D., Ray D., Zacharek S., Gutsch D., Richardson B., Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis and Rheumatism 2002 46 5 1282 1291 2-s2.0-0036095885 10.1002/art.10234 (Pubitemid 34525836)
5. Li Y., Zhao M., Yin H., Gao F., Wu X., Luo Y., Zhao S., Zhang X., Su Y., Hu N., Long H., Richardson B., Lu Q., Overexpression of the growth arrest and DNA damage-induced 45 α gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells. Arthritis and Rheumatism 2010 62 5 1438 1447 2-s2.0-77951745847 10.1002/art.27363
6. Barreto G., Schäfer A., Marhold J., Stach D., Swaminathan S. K., Handa V., Döderlein G., Maltry N., Wu W., Lyko F., Niehrs C., Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 2007 445 7128 671 675 2-s2.0-33846933274 10.1038/nature05515 (Pubitemid 46232889)
7. Rai K., Huggins I. J., James S. R., Karpf A. R., Jones D. A., Cairns B. R., DNA Demethylation in Zebrafish involves the coupling of a deaminase, a glycosylase, and Gadd45. Cell 2008 135 7 1201 1212 2-s2.0-57649196594 10.1016/j.cell.2008.11.042
8. Tan E. M., Cohen A. S., Fries J. F., The 1982 revised criteria for the classification of systemic lupus erythrematosus. Arthritis and Rheumatism 1982 25 11 1271 1277 2-s2.0-0020436689 (Pubitemid 13221242)
9. Bombardier C., Gladman D. D., Urowitz M. B., Caron D., Chi Hsing Chang C. H. C., Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis and Rheumatism 1992 35 6 630 640 2-s2.0-0026777352 10.1002/art.1780350606
10. Li J., Xie H., Wen T., Liu H., Zhu W., Chen X., Expression of high mobility group box chromosomal protein 1 and its modulating effects on downstream cytokines in systemic lupus erythematosus. Journal of Rheumatology 2010 37 4 766 775 2-s2.0-77950681441 10.3899/jrheum.090663
11. Jiang W., Pisetsky D. S., Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus. Annals of the Rheumatic Diseases 2008 67 5 727 728 2-s2.0-42449084910 10.1136/ard.2007.074484 (Pubitemid 351571946)
12. Urbonaviciute V., Fürnrohr B. G., Weber C., Haslbeck M., Wilhelm S., Herrmann M., Voll R. E., Factors masking HMGB1 in human serum and plasma. Journal of Leukocyte Biology 2007 81 1 67 74 2-s2.0-33845880868 10.1189/jlb.0306196 (Pubitemid 46021254)
13. Dintilhac A., Bernués J., HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. Journal of Biological Chemistry 2002 277 9 7021 7028 2-s2.0-0036510607 10.1074/jbc. M108417200 (Pubitemid 34953089)
14. Messmer D., Yang H., Telusma G., Knoll F., Li J., Messmer B., Tracey K. J., Chiorazzi N., High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization. Journal of Immunology 2004 173 1 307 313 2-s2.0-2942700201 (Pubitemid 38797355)
15. Popovic K., Ek M., Espinosa A., Padyukov L., Harris H. E., Wahren-Herlenius M., Nyberg F., Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus. Arthritis and Rheumatism 2005 52 11 3639 3645 2-s2.0-27744461020 10.1002/art.21398 (Pubitemid 41612235)
16. Pisetsky D. S., HMGB1: a dangerous player in lupus pathogenesis. Journal of Rheumatology 2010 37 4 689 691 2-s2.0-77950669506 10.3899/jrheum.091459