T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice

Clinical Immunology

Volumn 158, Issue 2, 2015, Pages 193-203

  Gorelik, Gabriela ^a   Sawalha, Amr H ^a   Patel, Dipak ^a   Johnson, Kent ^a   Richardson, Bruce ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

Autoimmunity; Extracellular signal regulated kinase (ERK); Lupus; PKC ; T cells; Transgenic mouse model

Indexed keywords

DNA METHYLTRANSFERASE 1; DOUBLE STRANDED DNA ANTIBODY; DOXYCYCLINE; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C DELTA; ANTIINFECTIVE AGENT; AUTOANTIBODY; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DNA METHYLATION; ENZYME INACTIVATION; GENE; GLOMERULONEPHRITIS; IMMUNE RESPONSE; LUPUS LIKE SYNDROME; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; ANIMAL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; METABOLISM; MUTATION; PHOSPHORYLATION; PROMOTER REGION; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENIC MOUSE;

ANIMALS; ANTI-BACTERIAL AGENTS; AUTOANTIBODIES; AUTOIMMUNITY; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DOXYCYCLINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLOMERULONEPHRITIS; IMMUNOGLOBULIN G; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, TRANSGENIC; MUTATION; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C-DELTA; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTES; TRANS-ACTIVATORS;

EID: 84928616162     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2015.03.017     Document Type: Article

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