메뉴 건너뛰기




Volumn 186, Issue 7, 2011, Pages 4508-4517

Promoter hypomethylation results in increased expression of protein phosphatase 2A in T Cells from patients with systemic lupus erythematosus

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA METHYLTRANSFERASE 1; GENOMIC DNA; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 2A;

EID: 79955048011     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000340     Document Type: Article
Times cited : (67)

References (65)
  • 1
    • 4344625903 scopus 로고    scopus 로고
    • Antinuclear autoantibodies in systemic lupus erythematosus
    • DOI 10.1097/01.bor.0000135452.62800.8f
    • Sawalha, A. H., and J. B. Harley. 2004. Antinuclear autoantibodies in systemic lupus erythematosus. Curr. Opin. Rheumatol. 16: 534-540. (Pubitemid 39128320)
    • (2004) Current Opinion in Rheumatology , vol.16 , Issue.5 , pp. 534-540
    • Sawalha, A.H.1    Harley, J.B.2
  • 2
    • 33749537076 scopus 로고    scopus 로고
    • Unraveling the genetics of systemic lupus erythematosus
    • DOI 10.1007/s00281-006-0040-5
    • Harley, J. B., J. A. Kelly, and K. M. Kaufman. 2006. Unraveling the genetics of systemic lupus erythematosus. Springer Semin. Immunopathol. 28: 119-130. (Pubitemid 44526313)
    • (2006) Springer Seminars in Immunopathology , vol.28 , Issue.2 , pp. 119-130
    • Harley, J.B.1    Kelly, J.A.2    Kaufman, K.M.3
  • 3
    • 0028031370 scopus 로고
    • Twin studies in rheumatic diseases
    • Järvinen, P., and K. Aho. 1994. Twin studies in rheumatic diseases. Semin. Arthritis Rheum. 24: 19-28.
    • (1994) Semin. Arthritis Rheum , vol.24 , pp. 19-28
    • Järvinen, P.1    Aho, K.2
  • 6
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia, E., J. Golbus, J. Maybaum, J. Strahler, S. Hanash, and B. Richardson. 1988. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J. Immunol. 140: 2197-2200. (Pubitemid 18098475)
    • (1988) Journal of Immunology , vol.140 , Issue.7 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 7
    • 0037333972 scopus 로고    scopus 로고
    • Hydralazine may induce autoimmunity by inhibiting extracellular signal - Regulated kinase pathway signaling
    • DOI 10.1002/art.10833
    • Deng, C., Q. Lu, Z. Zhang, T. Rao, J. Attwood, R. Yung, and B. Richardson. 2003. Hydralazine may induce autoimmunity by inhibiting extracellular signalregulated kinase pathway signaling. Arthritis Rheum. 48: 746-756. (Pubitemid 36302012)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.3 , pp. 746-756
    • Deng, C.1    Lu, Q.2    Zhang, Z.3    Rao, T.4    Attwood, J.5    Yung, R.6    Richardsons, B.7
  • 8
    • 70349487008 scopus 로고    scopus 로고
    • Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylation
    • Wang, G. S., M. Zhang, X. P. Li, H. Zhang, W. Chen, M. Kan, and Y. M. Wang. 2009. Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylation. Lupus 18: 1037-1044.
    • (2009) Lupus , vol.18 , pp. 1037-1044
    • Wang, G.S.1    Zhang, M.2    Li, X.P.3    Zhang, H.4    Chen, W.5    Kan, M.6    Wang, Y.M.7
  • 9
    • 0032729725 scopus 로고    scopus 로고
    • Environmentally induced autoimmune diseases: Potential mechanisms
    • Rao, T., and B. Richardson. 1999. Environmentally induced autoimmune diseases: Potential mechanisms. Environ. Health Perspect. 107(Suppl 5): 737-742. (Pubitemid 29527778)
    • (1999) Environmental Health Perspectives , vol.107 , Issue.SUPPL. 5 , pp. 737-742
    • Rao, T.1    Richardson, B.2
  • 10
    • 0033564902 scopus 로고    scopus 로고
    • DNA methylation
    • Singal, R., and G. D. Ginder. 1999. DNA methylation. Blood 93: 4059-4070. (Pubitemid 29279247)
    • (1999) Blood , vol.93 , Issue.12 , pp. 4059-4070
    • Singal, R.1    Ginder, G.D.2
  • 11
    • 0030710153 scopus 로고    scopus 로고
    • How does DNA methylation repress transcription?
    • DOI 10.1016/S0168-9525(97)01268-7
    • Kass, S. U., D. Pruss, and A. P. Wolffe. 1997. How does DNA methylation repress transcription? Trends Genet. 13: 444-449. (Pubitemid 27479903)
    • (1997) Trends in Genetics , vol.13 , Issue.11 , pp. 444-449
    • Kass, S.U.1    Pruss, D.2    Wolffe, A.P.3
  • 12
    • 0031468447 scopus 로고    scopus 로고
    • Genomic imprinting in mammals
    • DOI 10.1146/annurev.genet.31.1.493
    • Bartolomei, M. S., and S. M. Tilghman. 1997. Genomic imprinting in mammals. Annu. Rev. Genet. 31: 493-525. (Pubitemid 28023717)
    • (1997) Annual Review of Genetics , vol.31 , pp. 493-525
    • Bartolomei, M.S.1    Tilghman, S.M.2
  • 13
    • 0029742296 scopus 로고    scopus 로고
    • Genomic imprinting: Significance in development and diseases and the molecular mechanisms
    • Nakao, M., and H. Sasaki. 1996. Genomic imprinting: Significance in development and diseases and the molecular mechanisms. J. Biochem. 120: 467-473. (Pubitemid 26331630)
    • (1996) Journal of Biochemistry , vol.120 , Issue.3 , pp. 467-473
    • Nakao, M.1    Sasaki, H.2
  • 14
    • 0036560022 scopus 로고    scopus 로고
    • Review: Abnormal T cell signal transduction in systemic lupus erythematosus
    • DOI 10.1002/art.10192
    • Kammer, G. M., A. Perl, B. C. Richardson, and G. C. Tsokos. 2002. Abnormal T cell signal transduction in systemic lupus erythematosus. Arthritis Rheum. 46: 1139-1154. (Pubitemid 34525819)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.5 , pp. 1139-1154
    • Kammer, G.M.1    Perl, A.2    Richardson, B.C.3    Tsokos, G.C.4
  • 16
    • 0036095885 scopus 로고    scopus 로고
    • Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus
    • DOI 10.1002/art.10234
    • Lu, Q., M. Kaplan, D. Ray, D. Ray, S. Zacharek, D. Gutsch, and B. Richardson. 2002. Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis Rheum. 46: 1282-1291. (Pubitemid 34525836)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.5 , pp. 1282-1291
    • Lu, Q.1    Kaplan, M.2    Ray, D.3    Ray, D.4    Zacharek, S.5    Gutsch, D.6    Richardson, B.7
  • 17
    • 18644376210 scopus 로고    scopus 로고
    • Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs
    • Lu, Q., A. Wu, and B. C. Richardson. 2005. Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs. J. Immunol. 174: 6212-6219. (Pubitemid 40663812)
    • (2005) Journal of Immunology , vol.174 , Issue.10 , pp. 6212-6219
    • Lu, Q.1    Wu, A.2    Richardson, B.C.3
  • 18
    • 38449116161 scopus 로고    scopus 로고
    • Demethylation of CD40LG on the inactive X in T cells from women with lupus
    • Lu, Q., A. Wu, L. Tesmer, D. Ray, N. Yousif, and B. Richardson. 2007. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J. Immunol. 179: 6352-6358.
    • (2007) J. Immunol , vol.179 , pp. 6352-6358
    • Lu, Q.1    Wu, A.2    Tesmer, L.3    Ray, D.4    Yousif, N.5    Richardson, B.6
  • 19
    • 42649132074 scopus 로고    scopus 로고
    • Epigenetics and autoimmunity overview
    • Richardson, B. C. 2008. Epigenetics and autoimmunity. Overview. Autoimmunity 41: 243-244.
    • (2008) Autoimmunity , vol.41 , pp. 243-244
    • Richardson, B.C.1
  • 20
    • 1542724431 scopus 로고    scopus 로고
    • + Lupus T Cells
    • Kaplan, M. J., Q. Lu, A. Wu, J. Attwood, and B. Richardson. 2004. Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells. J. Immunol. 172: 3652-3661. (Pubitemid 38337948)
    • (2004) Journal of Immunology , vol.172 , Issue.6 , pp. 3652-3661
    • Kaplan, M.J.1    Lu, Q.2    Wu, A.3    Attwood, J.4    Richardson, B.5
  • 21
    • 40149105740 scopus 로고    scopus 로고
    • DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma
    • Kwon, N. H., J. S. Kim, J. Y. Lee, M. J. Oh, and D. C. Choi. 2008. DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma. J. Clin. Immunol. 28: 139-146.
    • (2008) J. Clin. Immunol , vol.28 , pp. 139-146
    • Kwon, N.H.1    Kim, J.S.2    Lee, J.Y.3    Oh, M.J.4    Choi, D.C.5
  • 22
    • 49449106856 scopus 로고    scopus 로고
    • Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis
    • Nile, C. J., R. C. Read, M. Akil, G. W. Duff, and A. G. Wilson. 2008. Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum. 58: 2686-2693.
    • (2008) Arthritis Rheum , vol.58 , pp. 2686-2693
    • Nile, C.J.1    Read, R.C.2    Akil, M.3    Duff, G.W.4    Wilson, A.G.5
  • 23
    • 37848999684 scopus 로고    scopus 로고
    • Hypomethylation of interleukin-4 and -6 promoters in T cells from systemic lupus erythematosus patients
    • Mi, X. B., and F. Q. Zeng. 2008. Hypomethylation of interleukin-4 and -6 promoters in T cells from systemic lupus erythematosus patients. Acta Pharmacol. Sin. 29: 105-112.
    • (2008) Acta Pharmacol. Sin , vol.29 , pp. 105-112
    • Mi, X.B.1    Zeng, F.Q.2
  • 24
    • 53149087481 scopus 로고    scopus 로고
    • CpG methylation of the IFNG gene as a mechanism to induce immunosuppression [correction of immunosupression] in tumor-infiltrating lymphocytes
    • Janson, P. C., P. Marits, M. Thörn, R. Ohlsson, and O. Winqvist. 2008. CpG methylation of the IFNG gene as a mechanism to induce immunosuppression [correction of immunosupression] in tumor-infiltrating lymphocytes. J. Immunol. 181: 2878-2886.
    • (2008) J. Immunol , vol.181 , pp. 2878-2886
    • Janson, P.C.1    Marits, P.2    Thörn, M.3    Ohlsson, R.4    Winqvist, O.5
  • 25
    • 44849087740 scopus 로고    scopus 로고
    • Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients
    • DOI 10.1038/gene.2008.29, PII GENE200829
    • Sawalha, A. H., M. Jeffries, R. Webb, Q. Lu, G. Gorelik, D. Ray, J. Osban, N. Knowlton, K. Johnson, and B. Richardson. 2008. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 9: 368-378. (Pubitemid 351791493)
    • (2008) Genes and Immunity , vol.9 , Issue.4 , pp. 368-378
    • Sawalha, A.H.1    Jeffries, M.2    Webb, R.3    Lu, Q.4    Gorelik, G.5    Ray, D.6    Osban, J.7    Knowlton, N.8    Johnson, K.9    Richardson, B.10
  • 26
    • 58149475865 scopus 로고    scopus 로고
    • Aberrant T cell ERK pathway signaling and chromatin structure in lupus
    • Gorelik, G., and B. Richardson. 2009. Aberrant T cell ERK pathway signaling and chromatin structure in lupus. Autoimmun. Rev. 8: 196-198.
    • (2009) Autoimmun. Rev , vol.8 , pp. 196-198
    • Gorelik, G.1    Richardson, B.2
  • 27
    • 0035096761 scopus 로고    scopus 로고
    • Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients
    • Deng, C., M. J. Kaplan, J. Yang, D. Ray, Z. Zhang, W. J. McCune, S. M. Hanash, and B. C. Richardson. 2001. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum. 44: 397-407.
    • (2001) Arthritis Rheum , vol.44 , pp. 397-407
    • Deng, C.1    Kaplan, M.J.2    Yang, J.3    Ray, D.4    Zhang, Z.5    McCune, W.J.6    Hanash, S.M.7    Richardson, B.C.8
  • 28
    • 44849104309 scopus 로고    scopus 로고
    • + T cells from patients with systemic lupus erythematosus
    • DOI 10.1111/j.1365-2567.2007.02771.x
    • Balada, E., J. Ordi-Ros, S. Serrano-Acedo, L. Martinez-Lostao, M. Rosa-Leyva, and M. Vilardell-Tarrés. 2008. Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus. Immunology 124: 339-347. (Pubitemid 351793466)
    • (2008) Immunology , vol.124 , Issue.3 , pp. 339-347
    • Balada, E.1    Ordi-Ros, J.2    Serrano-Acedo, S.3    Martinez-Lostao, L.4    Rosa-Leyva, M.5    Vilardell-Tarres, M.6
  • 29
    • 27644546349 scopus 로고    scopus 로고
    • Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus
    • DOI 10.1172/JCI24895
    • Katsiari, C. G., V. C. Kyttaris, Y. T. Juang, and G. C. Tsokos. 2005. Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus. J. Clin. Invest. 115: 3193-3204. (Pubitemid 41567584)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.11 , pp. 3193-3204
    • Katsiari, C.G.1    Kyttaris, V.C.2    Juang, Y.-T.3    Tsokos, G.C.4
  • 31
    • 0035252894 scopus 로고    scopus 로고
    • Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
    • DOI 10.1042/0264-6021:3530417
    • Janssens, V., and J. Goris. 2001. Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353: 417-439. (Pubitemid 32158309)
    • (2001) Biochemical Journal , vol.353 , Issue.3 , pp. 417-439
    • Janssens, V.1    Goris, J.2
  • 32
    • 0035754324 scopus 로고    scopus 로고
    • Protein phosphatase 2A: Variety of forms and diversity of functions
    • Lechward, K., O. S. Awotunde, W. Swiatek, and G. Muszynska. 2001. Protein phosphatase 2A: variety of forms and diversity of functions. Acta Biochim. Pol. 48: 921-933. (Pubitemid 33602348)
    • (2001) Acta Biochimica Polonica , vol.48 , Issue.4 , pp. 921-933
    • Lechward, K.1    Awotunde, O.S.2    Swiatek, W.3    Muszynska, G.4
  • 33
    • 0027221605 scopus 로고
    • Nuclear protein phosphatase 2A dephosphorylates protein kinase A- phosphorylated CREB and regulates CREB transcriptional stimulation
    • Wadzinski, B. E., W. H. Wheat, S. Jaspers, L. F. Peruski, Jr., R. L. Lickteig, G. L. Johnson, and D. J. Klemm. 1993. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol. Cell. Biol. 13: 2822-2834. (Pubitemid 23133954)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.5 , pp. 2822-2834
    • Wadzinski, B.E.1    Wheat, W.H.2    Jaspers, S.3    Peruski Jr., L.F.4    Lickteig, R.L.5    Johnson, G.L.6    Klemm, D.J.7
  • 34
    • 63149134464 scopus 로고    scopus 로고
    • Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity
    • Sunahori, K., Y. T. Juang, and G. C. Tsokos. 2009. Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. J. Immunol. 182: 1500-1508.
    • (2009) J. Immunol , vol.182 , pp. 1500-1508
    • Sunahori, K.1    Juang, Y.T.2    Tsokos, G.C.3
  • 35
    • 0020436689 scopus 로고
    • The 1982 revised criteria for the classification of systemic lupus erythrematosus
    • DOI 10.1002/art.1780251101
    • Tan, E. M., A. S. Cohen, J. F. Fries, A. T. Masi, D. J. McShane, N. F. Rothfield, J. G. Schaller, N. Talal, and R. J. Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25: 1271-1277. (Pubitemid 13221242)
    • (1982) Arthritis and Rheumatism , vol.25 , Issue.11 , pp. 1271-1277
    • Tan, E.M.1    Cohen, A.S.2    Fries, J.F.3
  • 36
    • 0026777352 scopus 로고    scopus 로고
    • The Committee on Prognosis Studies in SLE 1992. Derivation of the SLEDAI. A disease activity index for lupus patients
    • Bombardier, C., D. D. Gladman, M. B. Urowitz, D. Caron, C. H. Chang; The Committee on Prognosis Studies in SLE. 1992. Derivation of the SLEDAI. A disease activity index for lupus patients. Arthritis Rheum. 35: 630-640.
    • Arthritis Rheum , vol.35 , pp. 630-640
    • Bombardier, C.1    Gladman, D.D.2    Urowitz, M.B.3    Caron, D.4    Chang, C.H.5
  • 37
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller, M. 2008. Epigenetics in cancer. N. Engl. J. Med. 358: 1148-1159.
    • (2008) N. Engl. J. Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 39
    • 42649137264 scopus 로고    scopus 로고
    • Epigenetics and T-cell immunity
    • DOI 10.1080/08916930802024145, PII 792385982
    • Sawalha, A. H. 2008. Epigenetics and T-cell immunity. Autoimmunity 41: 245-252. (Pubitemid 351593855)
    • (2008) Autoimmunity , vol.41 , Issue.4 , pp. 245-252
    • Sawalha, A.H.1
  • 40
    • 58849092225 scopus 로고    scopus 로고
    • Epigenetic control of Thelper- cell differentiation
    • Wilson, C. B., E. Rowell, and M. Sekimata. 2009. Epigenetic control of Thelper- cell differentiation. Nat. Rev. Immunol. 9: 91-105.
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 91-105
    • Wilson, C.B.1    Rowell, E.2    Sekimata, M.3
  • 42
    • 58149215075 scopus 로고    scopus 로고
    • Epigenetic regulation and the pathogenesis of systemic lupus erythematosus
    • Pan, Y., and A. H. Sawalha. 2009. Epigenetic regulation and the pathogenesis of systemic lupus erythematosus. Transl. Res. 153: 4-10.
    • (2009) Transl. Res , vol.153 , pp. 4-10
    • Pan, Y.1    Sawalha, A.H.2
  • 43
    • 2942755745 scopus 로고    scopus 로고
    • Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus
    • Januchowski, R., J. Prokop, and P. P. Jagodzinski. 2004. Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus. J. Appl. Genet. 45: 237-248. (Pubitemid 38834576)
    • (2004) Journal of Applied Genetics , vol.45 , Issue.2 , pp. 237-248
    • Januchowski, R.1    Prokop, J.2    Jagodzinski, P.P.3
  • 46
    • 9744251005 scopus 로고    scopus 로고
    • Biochemistry and biology of mammalian DNA methyltransferases
    • DOI 10.1007/s00018-004-4201-1
    • Hermann, A., H. Gowher, and A. Jeltsch. 2004. Biochemistry and biology of mammalian DNA methyltransferases. Cell. Mol. Life Sci. 61: 2571-2587. (Pubitemid 39586518)
    • (2004) Cellular and Molecular Life Sciences , vol.61 , Issue.19-20 , pp. 2571-2587
    • Hermann, A.1    Gowher, H.2    Jeltsch, A.3
  • 47
    • 38449104652 scopus 로고    scopus 로고
    • Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
    • Gorelik, G., J. Y. Fang, A. Wu, A. H. Sawalha, and B. Richardson. 2007. Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus. J. Immunol. 179: 5553-5563.
    • (2007) J. Immunol , vol.179 , pp. 5553-5563
    • Gorelik, G.1    Fang, J.Y.2    Wu, A.3    Sawalha, A.H.4    Richardson, B.5
  • 48
    • 77953624215 scopus 로고    scopus 로고
    • MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
    • Pan, W., S. Zhu, M. Yuan, H. Cui, L. Wang, X. Luo, J. Li, H. Zhou, Y. Tang, and N. Shen. 2010. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J. Immunol. 184: 6773-6781.
    • (2010) J. Immunol. , Issue.184 , pp. 6773-6781
    • Pan, W.1    Zhu, S.2    Yuan, M.3    Cui, H.4    Wang, L.5    Luo, X.6    Li, J.7    Zhou, H.8    Tang, Y.9    Shen, N.10
  • 49
    • 15244341292 scopus 로고    scopus 로고
    • Association analyses of DNA methyltransferase-1 (DNMT1) polymorphisms with systemic lupus erythematosus
    • DOI 10.1007/s10038-004-0192-x
    • Park, B. L., L. H. Kim, H. D. Shin, Y. W. Park, W. S. Uhm, and S. C. Bae. 2004. Association analyses of DNA methyltransferase-1 (DNMT1) polymorphisms with systemic lupus erythematosus. J. Hum. Genet. 49: 642-646. (Pubitemid 40385254)
    • (2004) Journal of Human Genetics , vol.49 , Issue.11 , pp. 642-646
    • Park, B.L.1    Kim, L.H.2    Shin, H.D.3    Park, Y.W.4    Uhm, W.S.5    Bae, S.-C.6
  • 50
    • 77953288009 scopus 로고    scopus 로고
    • Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells
    • Zhao, M., Y. Sun, F. Gao, X. Wu, J. Tang, H. Yin, Y. Luo, B. Richardson, and Q. Lu. 2010. Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells. J. Autoimmun. 35: 58-69.
    • (2010) J. Autoimmun. , Issue.35 , pp. 58-69
    • Zhao, M.1    Sun, Y.2    Gao, F.3    Wu, X.4    Tang, J.5    Yin, H.6    Luo, Y.7    Richardson, B.8    Lu, Q.9
  • 51
    • 34547220582 scopus 로고    scopus 로고
    • MTR 2756 a > G polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population
    • DOI 10.1177/0961203307077988
    • Burzynski, M., S. Duriagin, M. Mostowska, M. Wudarski, H. Chwalinska- Sadowska, and P. P. Jagodzinski. 2007. MTR 2756 A > G polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population. Lupus 16: 450-454. (Pubitemid 47122221)
    • (2007) Lupus , vol.16 , Issue.6 , pp. 450-454
    • Burzynski, M.1    Duriagin, S.2    Mostowska, M.3    Wudarski, M.4    Chwalinska-Sadowska, H.5    Jagodzinski, P.P.6
  • 52
    • 65249129825 scopus 로고    scopus 로고
    • Recent advances in MeCP2 structure and function
    • Hite, K. C., V. H. Adams, and J. C. Hansen. 2009. Recent advances in MeCP2 structure and function. Biochem. Cell Biol. 87: 219-227.
    • (2009) Biochem. Cell Biol , vol.87 , pp. 219-227
    • Hite, K.C.1    Adams, V.H.2    Hansen, J.C.3
  • 53
    • 42549126341 scopus 로고    scopus 로고
    • Epigenetic regulation of vascular endothelial gene expression
    • DOI 10.1161/CIRCRESAHA.107.171025, PII 0000301220080425000006
    • Matouk, C. C., and P. A. Marsden. 2008. Epigenetic regulation of vascular endothelial gene expression. Circ. Res. 102: 873-887. (Pubitemid 351591544)
    • (2008) Circulation Research , vol.102 , Issue.8 , pp. 873-887
    • Matouk, C.C.1    Marsden, P.A.2
  • 55
    • 67651152585 scopus 로고    scopus 로고
    • T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus
    • Zhou, Y., J. Yuan, Y. Pan, Y. Fei, X. Qiu, N. Hu, Y. Luo, W. Lei, Y. Li, H. Long, et al.. 2009. T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus. Clin. Immunol. 132: 362-370.
    • (2009) Clin. Immunol , vol.132 , pp. 362-370
    • Zhou, Y.1    Yuan, J.2    Pan, Y.3    Fei, Y.4    Qiu, X.5    Hu, N.6    Luo, Y.7    Lei, W.8    Li, Y.9    Long, H.10
  • 56
    • 0348149025 scopus 로고    scopus 로고
    • Possible role of DNA hypomethylation in the induction of SLE: Relationship of the transcription of human endogenous retroviruses
    • Ogasawara, H., M. Okada, H. Kaneko, T. Hishikawa, I. Sekigawa, and H. Hashimoto. 2003. Possible role of DNA hypomethylation in the induction of SLE: Relationship to the transcription of human endogenous retroviruses. Clin. Exp. Rheumatol. 21: 733-738. (Pubitemid 38008756)
    • (2003) Clinical and Experimental Rheumatology , vol.21 , Issue.6 , pp. 733-738
    • Ogasawara, H.1    Okada, M.2    Kaneko, H.3    Hishikawa, T.4    Sekigawa, I.5    Hashimoto, H.6
  • 59
    • 51549087191 scopus 로고    scopus 로고
    • PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells
    • Juang, Y. T., Y. Wang, G. Jiang, H. B. Peng, S. Ergin, M. Finnell, A. Magilavy, V. C. Kyttaris, and G. C. Tsokos. 2008. PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells. J. Immunol. 181: 3658-3664.
    • (2008) J. Immunol. , Issue.181 , pp. 3658-3664
    • Juang, Y.T.1    Wang, Y.2    Jiang, G.3    Peng, H.B.4    Ergin, S.5    Finnell, M.6    Magilavy, A.7    Kyttaris, V.C.8    Tsokos, G.C.9
  • 60
    • 0026023150 scopus 로고
    • Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes
    • Khew-Goodall, Y., R. E. Mayer, F. Maurer, S. R. Stone, and B. A. Hemmings. 1991. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. Biochemistry 30: 89-97.
    • (1991) Biochemistry , vol.30 , pp. 89-97
    • Khew-Goodall, Y.1    Mayer, R.E.2    Maurer, F.3    Stone, S.R.4    Hemmings, B.A.5
  • 62
    • 0032563209 scopus 로고    scopus 로고
    • Autoregulation of protein phosphatase type 2A expression
    • DOI 10.1074/jbc.273.30.19019
    • Baharians, Z., and A. H. Schönthal. 1998. Autoregulation of protein phosphatase type 2A expression. J. Biol. Chem. 273: 19019-19024. (Pubitemid 28366293)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.30 , pp. 19019-19024
    • Baharians, Z.1    Schonthal, A.H.2
  • 63
    • 33646476174 scopus 로고    scopus 로고
    • Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice
    • Schild, A., L. M. Ittner, and J. Götz. 2006. Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochem. Biophys. Res. Commun. 343: 1171-1178.
    • (2006) Biochem. Biophys. Res. Commun , vol.343 , pp. 1171-1178
    • Schild, A.1    Ittner, L.M.2    Götz, J.3
  • 64
    • 0038185273 scopus 로고    scopus 로고
    • Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness
    • DOI 10.1016/S1097-2765(03)00134-5
    • Conkright, M. D., E. Guzmaán, L. Flechner, A. I. Su, J. B. Hogenesch, and M. Montminy. 2003. Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol. Cell 11: 1101-1108. (Pubitemid 36566330)
    • (2003) Molecular Cell , vol.11 , Issue.4 , pp. 1101-1108
    • Conkright, M.D.1    Guzman, E.2    Flechner, L.3    Su, A.I.4    Hogenesch, J.B.5    Montminy, M.6
  • 65
    • 67650178047 scopus 로고    scopus 로고
    • Alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2AJNK- Sp1-signaling axis
    • Huang, P. H., D. Wang, H. C. Chuang, S. Wei, S. K. Kulp, and C. S. Chen. 2009. alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2AJNK- Sp1-signaling axis. Carcinogenesis 30: 1125-1131.
    • (2009) Carcinogenesis , vol.30 , pp. 1125-1131
    • Huang, P.H.1    Wang, D.2    Chuang, H.C.3    Wei, S.4    Kulp, S.K.5    Chen, C.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.