Genome-wide DNA methylation study suggests epigenetic accessibility andtranscriptional poising of interferon-regulated genes in naïve CD4+ T cellsfrom lupus patients

Journal of Autoimmunity

Volumn 43, Issue , 2013, Pages 78-84

  Coit, Patrick ^a   Jeffries, Matlock ^b   Altorok, Nezam ^a   Dozmorov, Mikhail G ^c   Koelsch, Kristi A ^c   Wren, Jonathan D ^b,c   Merrill, Joan T ^c   McCune, W Joseph ^a   Sawalha, Amr H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

DNA methylation; Lupus; Methylome; Na ve CD4+ T cells; Type I interferon

Indexed keywords

BST2 PROTEIN; IFI44L PROTEIN; IFIT1 PROTEIN; IFIT3 PROTEIN; INTERFERON; MESSENGER RNA; MX1 PROTEIN; STAT1 PROTEIN; TRIM22 PROTEIN; UNCLASSIFIED DRUG; USP18 PROTEIN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; FEMALE; GENE LOCUS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENOME; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE REGULATORY NETWORKS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INTERFERON TYPE I; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; YOUNG ADULT;

EID: 84878361920     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2013.04.003     Document Type: Article

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