The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA. A candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 20812-20820

  Detich, Nancy ^a   Hamm, Stefan ^b   Just, George ^a   Knox, J David ^a   Szyf, Moshe ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; ORGANIC COMPOUNDS; TUMORS;

HYPERMETHYLATION;

BIOCHEMISTRY;

DNA; DNA BINDING PROTEIN; DNA DEMETHYLASE; GREEN FLUORESCENT PROTEIN; METHYL GROUP; METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CYTOMEGALOVIRUS; DEMETHYLATION; DNA DEMETHYLATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOUTHERN BLOTTING; WESTERN BLOTTING;

CELLS, CULTURED; DNA METHYLATION; DNA MODIFICATION METHYLASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HUMANS; HYDROXAMIC ACIDS; INDICATORS AND REAGENTS; KIDNEY; LUMINESCENT PROTEINS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; TRANSFECTION;

ANIMALIA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS;

EID: 0038080948     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211813200     Document Type: Article

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