Decreased DNA methyltransferase levels contribute to abnormal gene expression in "senescent" CD4+CD28- T cells

Clinical Immunology

Volumn 132, Issue 2, 2009, Pages 257-265

  Liu, Ying ^a   Chen, Yingxuan ^a   Richardson, Bruce ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

Aging; DNA methylation; Rheumatoid arthritis; Senescence; T cell

Indexed keywords

CD70 ANTIGEN; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; PERFORIN; SMALL INTERFERING RNA;

ADULT; AGED; ARTICLE; CD4 CD28 T LYMPHOCYTE; CELL AGING; CLINICAL ARTICLE; CONTROLLED STUDY; DEMETHYLATION; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD28; ANTIGENS, CD70; ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CELL AGING; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; PERFORIN; PROMOTER REGIONS, GENETIC; RECEPTORS, KIR2DL4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; YOUNG ADULT;

EID: 67649967556     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2009.03.529     Document Type: Article

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