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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6773-6776

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs

(13) Yang, Shyh Ming a Tang, Yuting a Zhang, Rui a Lu, Huajun a Kuo, Gee Hong a Gaul, Michael D a Li, Yaxin a Ho, George a Conway, James G a Liang, Yin a Lenhard, James M a Demarest, Keith T a Murray, William V a

a JANSSEN RESEARCH AND DEVELOPMENT (Belgium)

Author keywords

Desaturation index; Obesity; SCD1 inhibitors; Stearoyl CoA desaturase

Indexed keywords

4 BICYCLIC HETEROARYL PIPERIDINE DERIVATIVE; ACYL COENZYME A DESATURASE 1; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DRUG VEHICLE; OXYGENASE INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; EVENING DOSAGE; HUMAN; HUMAN CELL; MAXIMUM PLASMA CONCENTRATION; MORNING DOSAGE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; WEIGHT GAIN;

MUS;

DESATURATION INDEX; OBESITY; SCD1 INHIBITORS; STEAROYL-COA DESATURASE;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; DIET; ENZYME ACTIVATION; ENZYME INHIBITORS; MICE; MICE, INBRED C57BL; OBESITY; PIPERIDINES; PROTEIN BINDING; RATS; STEAROYL-COA DESATURASE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84888860040 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.09.096 Document Type: Article

Times cited : (6)

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