Signaling circuitries controlling stem cell fate: To be or not to be

Current Opinion in Cell Biology

Volumn 23, Issue 6, 2011, Pages 716-723

  Iglesias Bartolome, Ramiro ^a   Gutkind, J Silvio ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DNA METHYLTRANSFERASE; G PROTEIN COUPLED RECEPTOR; HISTONE METHYLTRANSFERASE; MAMMALIAN TARGET OF RAPAMYCIN; NOTCH RECEPTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; YES ASSOCIATED PROTEIN;

CANCER GROWTH; CELL ACTIVATION; CELL AGING; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL FATE; CELL GROWTH; CELL LOSS; CELL PROTECTION; CELL REGENERATION; CELL RENEWAL; EPITHELIUM CELL; GENETIC EPIGENESIS; GENETIC REGULATION; HOMEOSTASIS; HUMAN; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TISSUE REGENERATION; TISSUE SPECIFICITY;

ADULT; ADULT STEM CELLS; ANIMALS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; HOMEOSTASIS; HUMANS; MICE; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 82555167017     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2011.08.002     Document Type: Review

References (52)

1. Scadden D.T. The stem-cell niche as an entity of action. Nature 2006, 441:1075-1079.
2. Barker N., Bartfeld S., Clevers H. Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell 2010, 7:656-670.
3. Blanpain C., Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol 2009, 10:207-217.
4. Klaus A., Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008, 8:387-398.
5. Nusse R. Wnt signaling and stem cell control. Cell Res 2008, 18:523-527.
6. Reya T., Clevers H. Wnt signalling in stem cells and cancer. Nature 2005, 434:843-850.
7. Moon R.T., Kohn A.D., De Ferrari G.V., Kaykas A. WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet 2004, 5:691-701.
8. Alonso L., Fuchs E. Stem cells in the skin: waste not, Wnt not. Genes Dev 2003, 17:1189-1200.
9. Zhu A.J., Watt F.M. beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 1999, 126:2285-2298.
10. Gat U., DasGupta R., Degenstein L., Fuchs E. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 1998, 95:605-614.
11. Zechner D., Fujita Y., Hulsken J., Muller T., Walther I., Taketo M.M., Crenshaw E.B., Birchmeier W. Birchmeier C: beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol 2003, 258:406-418.
12. Kirstetter P., Anderson K., Porse B.T., Jacobsen S.E.W., Nerlov C. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 2006, 7:1048-1056.
13. Scheller M., Huelsken J., Rosenbauer F., Taketo M.M., Birchmeier W., Tenen D.G., Leutz A. Hematopoietic stem cell and multilineage defects generated by constitutive [beta]-catenin activation. Nat Immunol 2006, 7:1037-1047.
14. Castilho R.M., Squarize C.H., Chodosh L.A., Williams B.O., Gutkind J.S. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009, 5:279-289.
15. Zoncu R., Efeyan A., Sabatini D.M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011, 12:21-35.
16. Pierce K.L., Premont R.T., Lefkowitz R.J. Seven-transmembrane receptors. Nat Rev Mol Cell Biol 2002, 3:639-650.
17. Dorsam R.T., Gutkind J.S. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007, 7:79-94.
18. Knox S.M., Lombaert I.M.A., Reed X., Vitale-Cross L., Gutkind J.S., Hoffman M.P. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science 2010, 329:1645-1647.
19. Jaks V., Barker N., Kasper M., van Es J.H., Snippert H.J., Clevers H., Toftgard R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet 2008, 40:1291-1299.
20. Barker N., Huch M., Kujala P., van de Wetering M., Snippert H.J., van Es J.H., Sato T., Stange D.E., Begthel H., van den Born M., et al. Lgr5+ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 2010, 6:25-36.
21. Barker N., Clevers H. Tracking down the stem cells of the intestine: strategies to identify adult stem cells. Gastroenterology 2007, 133:1755-1760.
22. de Lau W., Barker N., Low T.Y., Koo B.K., Li V.S., Teunissen H., Kujala P., Haegebarth A., Peters P.J., van de Wetering M., et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 2011.
23. Carmon K.S., Gong X., Lin Q., Thomas A., Liu Q. R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling. Proc Natl Acad Sci USA 2011.
24. Snippert H.J., Haegebarth A., Kasper M., Jaks V., Van Es J.H., Barker N., Van De Wetering M., Van Den Born M., Begthel H., Vries R.G., et al. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 2010, 327:1385-1389.
25. Hsu S.Y., Kudo M., Chen T., Nakabayashi K., Bhalla A., van der Spek P.J., van Duin M., Hsueh A.J. The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol 2000, 14:1257-1271.
26. Dotto G.P. Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer 2009, 9:587-595.
27. Agrawal N., Frederick M.J., Pickering C.R., Bettegowda C., Chang K., Li R.J., Fakhry C., Xie T.-X., Zhang J., Wang J., et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011.
28. Rock Jason R., Gao X., Xue Y., Randell Scott H., Kong Y.-Y., Hogan Brigid L.M. Notch-dependent differentiation of adult airway basal stem cells. Cell Stem Cell 2011, 8:639-648.
29. Williams S.E., Beronja S., Pasolli H.A., Fuchs E. Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature 2011, 470:353-358.
30. Connelly J.T., Gautrot J.E., Trappmann B., Tan D.W.M., Donati G., Huck W.T.S., Watt F.M. Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol 2010, 12:711-718.
31. Ezhkova E., Pasolli H.A., Parker J.S., Stokes N., Su Ih, Hannon G., Tarakhovsky A., Fuchs E. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 2009, 136:1122-1135.
32. Iglesias-Bartolome R., Gutkind J.S. Keeping the epidermal stem cell niche in shape. Cell Stem Cell 2010, 7:143-145.
33. Castilho R.M., Squarize C.H., Leelahavanichkul K., Zheng Y., Bugge T., Gutkind J.S. Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. PLoS ONE 2010, 5:e10503.
34. Chen G., Hou Z., Gulbranson D.R., Thomson J.A. Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell 2010, 7:240-248.
35. Xu Y., Zhu X., Hahm H.S., Wei W., Hao E., Hayek A., Ding S. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci USA 2010, 107:8129-8134.
36. Pan D. The hippo signaling pathway in development and cancer. Dev Cell 2010, 19:491-505.
37. Lian I., Kim J., Okazawa H., Zhao J., Zhao B., Yu J., Chinnaiyan A., Israel M.A., Goldstein L.S., Abujarour R., et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 2010, 24:1106-1118.
38. Zhang H., Pasolli H.A., Fuchs E. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci USA 2011, 108:2270-2275.
39. Schlegelmilch K., Mohseni M., Kirak O., Pruszak J., Rodriguez J.R., Zhou D., Kreger B.T., Vasioukhin V., Avruch J., Brummelkamp T.R., et al. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell 2011, 144:782-795.
40. Silvis M.R., Kreger B.T., Lien W.-H., Klezovitch O., Rudakova G.M., Camargo F.D., Lantz D.M., Seykora J.T., Vasioukhin V. {alpha}-Catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal 2011, 4. ra33.
41. Dupont S., Morsut L., Aragona M., Enzo E., Giulitti S., Cordenonsi M., Zanconato F., Le Digabel J., Forcato M., Bicciato S., et al. Role of YAP/TAZ in mechanotransduction. Nature 2011, 474:179-183.
42. Ezhkova E., Lien W.H., Stokes N., Pasolli H.A., Silva J.M., Fuchs E. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev 2011, 25:485-498.
43. Collado M., Blasco M.A., Serrano M. Cellular senescence in cancer and aging. Cell 2007, 130:223-233.
44. Caramel J., Lacroix M., Le Cam L., Sardet C. E4F1 connects the Bmi1-ARF-p53 pathway to epidermal stem cell-dependent skin homeostasis. Cell Cycle 2011, 10:866-867.
45. Cordisco S., Maurelli R., Bondanza S., Stefanini M., Zambruno G., Guerra L., Dellambra E. Bmi-1 reduction plays a key role in physiological and premature aging of primary human keratinocytes. J Invest Dermatol 2010, 130:1048-1062.
46. Lacroix M., Caramel J., Goguet-Rubio P., Linares L.K., Estrach S., Hatchi E., Rodier G., Lledo G., de Bettignies C., Thépot A., et al. Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis. Proc Natl Acad Sci USA 2010, 107:21076-21081.
47. Yang M.-H., Hsu D.S.-S., Wang H.-W., Wang H.-J., Lan H.-Y., Yang W.-H., Huang C.-H., Kao S.-Y., Tzeng C.-H., Tai S.-K., et al. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol 2010, 12:982-992.
48. Sen G.L., Reuter J.A., Webster D.E., Zhu L., Khavari P.A. DNMT1 maintains progenitor function in self-renewing somatic tissue. Nature 2010, 463:563-567.
49. Sen G.L., Webster D.E., Barragan D.I., Chang H.Y., Khavari P.A. Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev 2008, 22:1865-1870.
50. Denis H., Ndlovu N., Fuks F. Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBO Rep 2011, 12:647-656.
51. Esteve P.O., Chang Y., Samaranayake M., Upadhyay A.K., Horton J.R., Feehery G.R., Cheng X., Pradhan S. A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol 2011, 18:42-48.
52. Xu W., Yang H., Liu Y., Yang Y., Wang P., Kim S.H., Ito S., Yang C., Xiao M.T., Liu L.X., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011, 19:17-30.