Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells

Cell Death and Disease

Volumn 4, Issue 12, 2013, Pages

  Noto, A ^a   Raffa, S ^a,b,c   De Vitis, C ^a,d   Roscilli, G ^a,e   Malpicci, D ^a   Coluccia, P ^a   Di Napoli, A ^a,b   Ricci, A ^a,b   Giovagnoli, M R ^a,b   Aurisicchio, L ^e,f   Torrisi, M R ^a,b,c   Ciliberto, G ^g   Mancini, R ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Pasteur Institute   (Italy)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^e Takis srl   (Italy)

^f Grande Ospedale Metropolitano   (Italy)

^g NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

anoikis; cancer stem cells; lung cancer; SCD1 inhibition; tumor spheroids

Indexed keywords

A 939572; ACYL COENZYME A DESATURASE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 1A1; ANTINEOPLASTIC AGENT; GROWTH FACTOR; MF 438; MONOUNSATURATED FATTY ACID; OXYGENASE INHIBITOR; RNA; STEAROYL COENZYME A DESATURASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INITIATING CELL; CANCER STEM CELL; CARCINOGENICITY; CELL AGGREGATION; CELL DAMAGE; CELL GROWTH; CELL KILLING; CELL LINE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MALIGNANT PLEURA EFFUSION; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RNA INTERFERENCE; TUMOR SPHEROID; TUMOR XENOGRAFT;

ALDEHYDE DEHYDROGENASE; ANOIKIS; HUMANS; LUNG NEOPLASMS; NEOPLASTIC STEM CELLS; PLEURAL EFFUSION, MALIGNANT; STEAROYL-COA DESATURASE;

EID: 84891765373     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.444     Document Type: Article

References (40)

1. Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007; 7: 763-777
2. Igal RA. Stearoyl-CoA desaturase-1: A novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis 2010; 31: 1509-1515
3. Ntambi JM. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J Lipid Res 1999; 40: 1549-1558
4. Riboni L, Ghidoni R, Sonnino S, Omodeo-Salè F, Gaini SM, Berra B. Phospholipid content and composition of human meningiomas. Neurochem Pathol 1984; 2: 171-188
5. Zhang L, Ge L, Parimoo S, Stenn K, Prouty SM. Human stearoyl-CoA desaturase: Alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J 1999; 340: 255-264
6. Beiraghi S, Zhou M, Talmadge CB, Went-Sumegi N, Davis JR, Huang D et al. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4) (p13.1q21.1) in a family with cleft lip. Gene 2003; 309: 11-21
7. Robert J, Montaudon D, Hugues P. Incorporation and metabolism of exogenous fatty acids by cultured normal and tumoral glial cells. Biochim Biophys Acta 1983; 752: 383-395
8. Scaglia N, Chisholm JW, Igal RA. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: Role of AMPK. PLoS One 2009; 4: E6812
9. Mason P, Liang B, Li L, Fremgen T, Murphy E, Quinn A et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS One 2012; 7: E33823
10. Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ et al. Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol Cancer Res 2011; 9: 1551-1561
11. Hess D, Igal RA. Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells. Exp Biol Med (Maywood) 2011; 236: 707-713
12. Du X, Wang QR, Chan E, Merchant M, Liu J, French D et al. FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. Cancer Res 2012; 72: 5843-5855
13. Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avancès C et al. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther 2010; 9: 1740-1754
14. Luyimbazi D, Akcakanat A, McAuliffe PF, Zhang L, Singh G, Gonzalez-Angulo AM et al. Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Mol Cancer Ther 2010; 9: 2770-2784
15. Scaglia N, Igal RA. Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol 2008; 33: 839-850
16. von Roemeling CA, Marlow LA, Wei JJ, Cooper SJ, Caulfield TR, Wu K et al. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res 2013; 19: 2368-2380
17. Isabel E, Powell DA, Black WC, Chan CC, Crane S, Gordon R et al. Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett 2011; 21: 479-483
18. Léger S, Black WC, Deschenes D, Dolman S, Falgueyret JP, Gagnon M et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett 2010; 20: 499-502
19. Nguyen LV, Vanner R, Dirks P, Eaves CJ. Cancer stem cells: An evolving concept. Nat Rev Cancer 2012; 12: 133-143
20. Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA et al. A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cellderived tumors. Stem Cells 2009; 27: 18-28
21. Eramo A, Lotti F, Sette G, Pilozzi E, Biffoni M, Di Virgilio A et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 2008; 15: 504-514
22. Dontu G, Wicha MS. Survival of mammary stem cells in suspension culture: Implications for stem cell biology and neoplasia. J Mammary Gland Biol Neoplasia 2005; 10: 75-86
23. Akunuru S, James Zhai Q, Zheng Y. Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity. Cell Death Dis 2012; 3: E352
24. Bartucci M, Svensson S, Romania P, Dattilo R, Patrizii M, Signore M et al. Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy. Cell Death Differ 2012; 19: 768-778
25. Abdullah LN, Chow EK. Mechanisms of chemoresistance in cancer stem cells. Clin Transl Med 2013; 2: 1326-2-3
26. Deng S, Yang X, Lassus H, Liang S, Kaur S, Ye Q et al. Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 2010; 5: E10277
27. Sullivan JP, Spinola M, Dodge M, Raso MG, Behrens C, Gao B et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res 2010; 70: 9937-9948
28. Ucar D, Cogle CR, Zucali JR, Ostmark B, Scott EW, Zori R et al. Aldehyde dehydrogenase activity as a functional marker for lung cancer. Chem Biol Interact 2009; 178: 48-55
29. Moreb JS. Aldehyde dehydrogenase as a marker for stem cells. Curr Stem Cell Res Ther 2008; 3: 237-246
30. Mancini R, Giarnieri E, De Vitis C, Malanga D, Roscilli G, Noto A et al. Spheres derived from lung adenocarcinoma pleural effusions: Molecular characterization and tumor engraftment. PLoS One 2011; 6: E21320
31. Ricci A, De Vitis C, Noto A, Fattore L, Mariotta S, Cherubini E et al. TrkB is responsible for EMT transition in malignant pleural effusions derived cultures from adenocarcinoma of the lung. Cell Cycle 2013; 12: 1696-1703
32. Herbst RS, Heymach JV, Lippman SM. N Engl J Med. Lung Cancer 2008; 359: 1367-1380
33. Mani SA, GuoW, LiaoMJ, Eaton EN, Ayyanan A, Zhou AY et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-715
34. Garcia-Gonzalo FR, Izpisúa Belmonte JC. Albumin-Associated lipids regulate human embryonic stem cell self-renewal. PLoS One 2008; 3: E1384
35. Ben-David U, Gan QF, Golan-Lev T, Arora P, Yanuka O, Oren YS et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-Throughput screen. Cell Stem Cell 2013; 12: 167-167
36. Mauvoisin D, Charfi C, Lounis AM, Rassart E, Mounier C. Decreasing stearoyl-CoA desaturase-1 expression inhibits b-catenin signaling in breast cancer cells. Cancer Sci 2013; 104: 36-42
37. Giarnieri E, De Vitis C, Noto A, Roscilli G, Salerno G, Mariotta S et al. EMT markers in lung adenocarcinoma pleural effusion spheroid cells. J Cell Physiol 2013; 228: 8
38. Li T, Su Y, Mei Y, Leng Q, Leng B, Liu Z et al. ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest 2010; 90: 234-244
39. Kelm JM, Timmins NE, Brown CJ, Fussenegger M, Nielsen LK. Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng 2003; 83: 173-180
40. Vinci M, Gowan S, Boxall F, Patterson L, Zimmermann M, Court W et al. Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation. BMC Biol 2012 10-29