메뉴 건너뛰기




Volumn 32, Issue 18, 2014, Pages 1968-1976

Molecular genetics of clear-cell renal cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; ELONGIN C; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIK3CA PROTEIN; POLYBROMO 1 PROTEIN; PROTEIN; SET DOMAIN CONTAINING PROTEIN 2; TUBEROUS SCLEROSIS 1 PROTEIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; ANTINEOPLASTIC AGENT; BAP1 PROTEIN, HUMAN; HISTONE LYSINE METHYLTRANSFERASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PBRM1 PROTEIN, HUMAN; SET2 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN THIOLESTERASE; VHL PROTEIN, HUMAN;

EID: 84905403670     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2012.45.2003     Document Type: Article
Times cited : (247)

References (89)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, et al: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893-2917, 2010
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 5
    • 84879890360 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of clear cell renal cell carcinoma
    • Creighton CJ, Morgan M, Gunaratne PH, et al: Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499:43-49, 2013
    • (2013) Nature , vol.499 , pp. 43-49
    • Creighton, C.J.1    Morgan, M.2    Gunaratne, P.H.3
  • 6
    • 84880967722 scopus 로고    scopus 로고
    • Integrated molecular analysis of clear-cell renal cell carcinoma
    • Sato Y, Yoshizato T, Shiraishi Y, et al: Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet 45:860-867, 2013
    • (2013) Nat Genet , vol.45 , pp. 860-867
    • Sato, Y.1    Yoshizato, T.2    Shiraishi, Y.3
  • 7
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al: Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366:883-892, 2012
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 9
    • 84873441292 scopus 로고    scopus 로고
    • Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation
    • Tomasetti C, Vogelstein B, Parmigiani G: Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A 110:1999-2004, 2013
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1999-2004
    • Tomasetti, C.1    Vogelstein, B.2    Parmigiani, G.3
  • 10
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC: Clonal evolution in cancer. Nature 481:306-313, 2012
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 11
    • 84880898004 scopus 로고    scopus 로고
    • Cooperation and antagonism among cancer genes: The renal cancer paradigm
    • Peña-Llopis S, Christie A, Xie XJ, et al: Cooperation and antagonism among cancer genes: The renal cancer paradigm. Cancer Res 73:4173-4179, 2013
    • (2013) Cancer Res , vol.73 , pp. 4173-4179
    • Peña-Llopis, S.1    Christie, A.2    Xie, X.J.3
  • 12
    • 84862988411 scopus 로고    scopus 로고
    • BAP1 loss defines a new class of renal cell carcinoma
    • Peña-Llopis S, Vega-Rubín-de-Celis S, Liao A, et al: BAP1 loss defines a new class of renal cell carcinoma. Nat Genet 44:751-759, 2012
    • (2012) Nat Genet , vol.44 , pp. 751-759
    • Peña-Llopis, S.1    Vega-Rubín-de-Celis, S.2    Liao, A.3
  • 13
    • 85027954125 scopus 로고    scopus 로고
    • DNA methylation profiling in the clinic: Applications and challenges
    • Heyn H, Esteller M: DNA methylation profiling in the clinic: Applications and challenges. Nat Rev Genet 13:679-692, 2012
    • (2012) Nat Rev Genet , vol.13 , pp. 679-692
    • Heyn, H.1    Esteller, M.2
  • 16
    • 51049084870 scopus 로고    scopus 로고
    • Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
    • Nickerson ML, Jaeger E, Shi Y, et al: Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer Res 14:4726-4734, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 4726-4734
    • Nickerson, M.L.1    Jaeger, E.2    Shi, Y.3
  • 18
    • 0023181644 scopus 로고
    • Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
    • DOI 10.1038/327721a0
    • Zbar B, Brauch H, Talmadge C, et al: Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327:721-724, 1987 (Pubitemid 17085908)
    • (1987) Nature , vol.327 , Issue.6124 , pp. 721-724
    • Zbar, B.1    Brauch, H.2    Talmadge, C.3    Linehau, M.4
  • 19
    • 66349100709 scopus 로고    scopus 로고
    • Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney
    • Beroukhim R, Brunet JP, Di Napoli A, et al: Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res 69:4674-4681, 2009
    • (2009) Cancer Res , vol.69 , pp. 4674-4681
    • Beroukhim, R.1    Brunet, J.P.2    Di Napoli, A.3
  • 20
    • 70349880529 scopus 로고    scopus 로고
    • Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays
    • Chen M, Ye Y, Yang H, et al: Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays. Int J Cancer 125:2342-2348, 2009
    • (2009) Int J Cancer , vol.125 , pp. 2342-2348
    • Chen, M.1    Ye, Y.2    Yang, H.3
  • 21
    • 84873091765 scopus 로고    scopus 로고
    • The VHL/HIF axis in clear cell renal carcinoma
    • Shen C, Kaelin WG Jr: The VHL/HIF axis in clear cell renal carcinoma. Semin Cancer Biol 23:18-25, 2013
    • (2013) Semin Cancer Biol , vol.23 , pp. 18-25
    • Shen, C.1    Kaelin Jr., W.G.2
  • 22
    • 0033574737 scopus 로고    scopus 로고
    • Structure of the VHL-elonginC-elonginB complex: Implications for VHL tumor suppressor function
    • DOI 10.1126/science.284.5413.455
    • Stebbins CE, Kaelin WG Jr, Pavletich NP: Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function. Science 284:455-461, 1999 (Pubitemid 29289612)
    • (1999) Science , vol.284 , Issue.5413 , pp. 455-461
    • Stebbins, C.E.1    Kaelin Jr., W.G.2    Pavletich, N.P.3
  • 23
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela I, Tarpey P, Raine K, et al: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469:539-542, 2011
    • (2011) Nature , vol.469 , pp. 539-542
    • Varela, I.1    Tarpey, P.2    Raine, K.3
  • 25
    • 67650725820 scopus 로고    scopus 로고
    • The biology of chromatin remodeling complexes
    • Clapier CR, Cairns BR: The biology of chromatin remodeling complexes. Annu Rev Biochem 78:273-304, 2009
    • (2009) Annu Rev Biochem , vol.78 , pp. 273-304
    • Clapier, C.R.1    Cairns, B.R.2
  • 26
    • 79959653996 scopus 로고    scopus 로고
    • SWI/SNF nucleosome remodellers and cancer
    • Wilson BG, Roberts CW: SWI/SNF nucleosome remodellers and cancer. Nat Rev Cancer 11:481-492, 2011
    • (2011) Nat Rev Cancer , vol.11 , pp. 481-492
    • Wilson, B.G.1    Roberts, C.W.2
  • 28
    • 84878745222 scopus 로고    scopus 로고
    • Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
    • Kadoch C, Hargreaves DC, Hodges C, et al: Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet 45:592-601, 2013
    • (2013) Nat Genet , vol.45 , pp. 592-601
    • Kadoch, C.1    Hargreaves, D.C.2    Hodges, C.3
  • 29
    • 60249101576 scopus 로고    scopus 로고
    • Polybromo-1: The chromatin targeting subunit of the PBAF complex
    • Thompson M: Polybromo-1: The chromatin targeting subunit of the PBAF complex. Biochimie 91:309-319, 2009
    • (2009) Biochimie , vol.91 , pp. 309-319
    • Thompson, M.1
  • 30
    • 84873081430 scopus 로고    scopus 로고
    • Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation
    • Kapur P, Peña-Llopis S, Christie A, et al: Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation. Lancet Oncol 14:159-167, 2013
    • (2013) Lancet Oncol , vol.14 , pp. 159-167
    • Kapur, P.1    Peña-Llopis, S.2    Christie, A.3
  • 32
    • 79951834644 scopus 로고    scopus 로고
    • Wellcome Trust Sanger Institute
    • Wellcome Trust Sanger Institute: Catalog of Somatic Mutations in Cancer. http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/
    • Catalog of Somatic Mutations in Cancer
  • 34
    • 77956271441 scopus 로고    scopus 로고
    • Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
    • Burrows AE, Smogorzewska A, Elledge SJ: Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A 107:14280-14285, 2010
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14280-14285
    • Burrows, A.E.1    Smogorzewska, A.2    Elledge, S.J.3
  • 35
    • 84880962794 scopus 로고    scopus 로고
    • PBRM1 and BAP1 as novel targets for renal cell carcinoma
    • Brugarolas J: PBRM1 and BAP1 as novel targets for renal cell carcinoma. Cancer J 19:324-332, 2013
    • (2013) Cancer J , vol.19 , pp. 324-332
    • Brugarolas, J.1
  • 36
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • Dalgliesh GL, Furge K, Greenman C, et al: Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463:360-363, 2010
    • (2010) Nature , vol.463 , pp. 360-363
    • Dalgliesh, G.L.1    Furge, K.2    Greenman, C.3
  • 37
    • 84879466482 scopus 로고    scopus 로고
    • Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network
    • Hakimi AA, Ostrovnaya I, Reva B, et al: Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network. Clin Cancer Res 19:3259-3267, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 3259-3267
    • Hakimi, A.A.1    Ostrovnaya, I.2    Reva, B.3
  • 38
    • 38549139593 scopus 로고    scopus 로고
    • Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
    • DOI 10.1038/sj.emboj.7601967, PII 7601967
    • Edmunds JW, Mahadevan LC, Clayton AL: Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J 27:406-420, 2008 (Pubitemid 351161656)
    • (2008) EMBO Journal , vol.27 , Issue.2 , pp. 406-420
    • Edmunds, J.W.1    Mahadevan, L.C.2    Clayton, A.L.3
  • 39
    • 84856120332 scopus 로고    scopus 로고
    • Understanding the language of Lys36 methylation at histone H3
    • Wagner EJ, Carpenter PB: Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol 13:115-126, 2012
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 115-126
    • Wagner, E.J.1    Carpenter, P.B.2
  • 40
    • 84876943255 scopus 로고    scopus 로고
    • The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα
    • Li F, Mao G, Tong D, et al: The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell 153:590-600, 2013
    • (2013) Cell , vol.153 , pp. 590-600
    • Li, F.1    Mao, G.2    Tong, D.3
  • 41
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov LB, Nik-Zainal S, Wedge DC, et al: Signatures of mutational processes in human cancer. Nature 500:415-421, 2013
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 42
    • 84655176646 scopus 로고    scopus 로고
    • Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
    • Guo G, Gui Y, Gao S, et al: Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet 44:17-19, 2012
    • (2012) Nat Genet , vol.44 , pp. 17-19
    • Guo, G.1    Gui, Y.2    Gao, S.3
  • 44
    • 80052837898 scopus 로고    scopus 로고
    • Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma
    • Kucejova B, Peña-Llopis S, Yamasaki T, et al: Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma. Mol Cancer Res 9:1255-1265, 2011
    • (2011) Mol Cancer Res , vol.9 , pp. 1255-1265
    • Kucejova, B.1    Peña-Llopis, S.2    Yamasaki, T.3
  • 45
    • 71749110779 scopus 로고    scopus 로고
    • The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1
    • Machida YJ, Machida Y, Vashisht AA, et al: The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J Biol Chem 284:34179-34188, 2009
    • (2009) J Biol Chem , vol.284 , pp. 34179-34188
    • Machida, Y.J.1    Machida, Y.2    Vashisht, A.A.3
  • 46
    • 77957853061 scopus 로고    scopus 로고
    • The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression
    • Yu H, Mashtalir N, Daou S, et al: The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol 30:5071-5085, 2010
    • (2010) Mol Cell Biol , vol.30 , pp. 5071-5085
    • Yu, H.1    Mashtalir, N.2    Daou, S.3
  • 47
    • 67649634849 scopus 로고    scopus 로고
    • Defining the human deubiquitinating enzyme interaction landscape
    • Sowa ME, Bennett EJ, Gygi SP, et al: Defining the human deubiquitinating enzyme interaction landscape. Cell 138:389-403, 2009
    • (2009) Cell , vol.138 , pp. 389-403
    • Sowa, M.E.1    Bennett, E.J.2    Gygi, S.P.3
  • 48
    • 84899421896 scopus 로고    scopus 로고
    • Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low risk clear cell renal cell carcinoma
    • doi: 10.1002/cncr.28521 [epub ahead of print on December 30, 2013]
    • Joseph RW, Kapur P, Serie DJ, et al: Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low risk clear cell renal cell carcinoma. Cancer doi: 10.1002/cncr.28521 [epub ahead of print on December 30, 2013]
    • Cancer
    • Joseph, R.W.1    Kapur, P.2    Serie, D.J.3
  • 49
    • 78649700287 scopus 로고    scopus 로고
    • Frequent mutation of BAP1 in metastasizing uveal melanomas
    • Harbour JW, Onken MD, Roberson ED, et al: Frequent mutation of BAP1 in metastasizing uveal melanomas. Science 330:1410-1413, 2010
    • (2010) Science , vol.330 , pp. 1410-1413
    • Harbour, J.W.1    Onken, M.D.2    Roberson, E.D.3
  • 50
    • 79959694149 scopus 로고    scopus 로고
    • The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
    • Bott M, Brevet M, Taylor BS, et al: The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet 43:668-672, 2011
    • (2011) Nat Genet , vol.43 , pp. 668-672
    • Bott, M.1    Brevet, M.2    Taylor, B.S.3
  • 51
    • 80053385701 scopus 로고    scopus 로고
    • Germline BAP1 mutations predispose to malignant mesothelioma
    • Testa JR, Cheung M, Pei J, et al: Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet 43:1022-1025, 2011
    • (2011) Nat Genet , vol.43 , pp. 1022-1025
    • Testa, J.R.1    Cheung, M.2    Pei, J.3
  • 52
    • 80053386896 scopus 로고    scopus 로고
    • Germline mutations in BAP1 predispose to melanocytic tumors
    • Wiesner T, Obenauf AC, Murali R, et al: Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet 43:1018-1021, 2011
    • (2011) Nat Genet , vol.43 , pp. 1018-1021
    • Wiesner, T.1    Obenauf, A.C.2    Murali, R.3
  • 53
    • 84878846119 scopus 로고    scopus 로고
    • Germline BAP1 mutations predispose to renal cell carcinomas
    • Popova T, Hebert L, Jacquemin V, et al: Germline BAP1 mutations predispose to renal cell carcinomas. Am J Hum Genet 92:974-980, 2013
    • (2013) Am J Hum Genet , vol.92 , pp. 974-980
    • Popova, T.1    Hebert, L.2    Jacquemin, V.3
  • 54
    • 84884497841 scopus 로고    scopus 로고
    • A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma
    • Farley MN, Schmidt LS, Mester JL, et al: A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma. Mol Cancer Res 11:1061-1071, 2013
    • (2013) Mol Cancer Res , vol.11 , pp. 1061-1071
    • Farley, M.N.1    Schmidt, L.S.2    Mester, J.L.3
  • 55
    • 52049085265 scopus 로고    scopus 로고
    • BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization
    • Ventii KH, Devi NS, Friedrich KL, et al: BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res 68:6953-6962, 2008
    • (2008) Cancer Res , vol.68 , pp. 6953-6962
    • Ventii, K.H.1    Devi, N.S.2    Friedrich, K.L.3
  • 56
    • 64649106796 scopus 로고    scopus 로고
    • Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1
    • Misaghi S, Ottosen S, Izrael-Tomasevic A, et al: Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1. Mol Cell Biol 29:2181-2192, 2009
    • (2009) Mol Cell Biol , vol.29 , pp. 2181-2192
    • Misaghi, S.1    Ottosen, S.2    Izrael-Tomasevic, A.3
  • 57
    • 77952429798 scopus 로고    scopus 로고
    • Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
    • Scheuermann JC, de Ayala Alonso AG, Oktaba K, et al: Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 465:243-247, 2010
    • (2010) Nature , vol.465 , pp. 243-247
    • Scheuermann, J.C.1    De Ayala Alonso, A.G.2    Oktaba, K.3
  • 58
    • 77956222562 scopus 로고    scopus 로고
    • Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer
    • Sauvageau M, Sauvageau G: Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 7:299-313, 2010
    • (2010) Cell Stem Cell , vol.7 , pp. 299-313
    • Sauvageau, M.1    Sauvageau, G.2
  • 59
    • 77957154350 scopus 로고    scopus 로고
    • Throwing the cancer switch: Reciprocal roles of polycomb and trithorax proteins
    • Mills AA: Throwing the cancer switch: Reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer 10:669-682, 2010
    • (2010) Nat Rev Cancer , vol.10 , pp. 669-682
    • Mills, A.A.1
  • 60
    • 84866467141 scopus 로고    scopus 로고
    • Loss of the tumor suppressor BAP1 causes myeloid transformation
    • Dey A, Seshasayee D, Noubade R, et al: Loss of the tumor suppressor BAP1 causes myeloid transformation. Science 337:1541-1546, 2012
    • (2012) Science , vol.337 , pp. 1541-1546
    • Dey, A.1    Seshasayee, D.2    Noubade, R.3
  • 61
    • 79955934205 scopus 로고    scopus 로고
    • An emerging model for BAP1's role in regulating cell cycle progression
    • Eletr ZM, Wilkinson KD: An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys 60:3-11, 2011
    • (2011) Cell Biochem Biophys , vol.60 , pp. 3-11
    • Eletr, Z.M.1    Wilkinson, K.D.2
  • 62
    • 77949273931 scopus 로고    scopus 로고
    • Control of alpha-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activities
    • Kristie TM, Liang Y, Vogel JL: Control of alpha-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activities. Biochim Biochim Biophys Acta 1799:257-265, 2010
    • (2010) Biochim Biochim Biophys Acta , vol.1799 , pp. 257-265
    • Kristie, T.M.1    Liang, Y.2    Vogel, J.L.3
  • 63
    • 84887620736 scopus 로고    scopus 로고
    • Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma
    • Gossage L, Murtaza M, Slatter AF, et al: Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma. Genes Chromosomes Cancer 53:38-51, 2014
    • (2014) Genes Chromosomes Cancer , vol.53 , pp. 38-51
    • Gossage, L.1    Murtaza, M.2    Slatter, A.F.3
  • 64
    • 84893845225 scopus 로고    scopus 로고
    • BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma
    • Kapur P, Christie A, Raman JD, et al: BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma. J Urol 191:603-610, 2014
    • (2014) J Urol , vol.191 , pp. 603-610
    • Kapur, P.1    Christie, A.2    Raman, J.D.3
  • 65
    • 84857443037 scopus 로고    scopus 로고
    • The genetics of uveal melanoma: An emerging framework for targeted therapy
    • Harbour JW: The genetics of uveal melanoma: An emerging framework for targeted therapy. Pigment Cell Melanoma Res 25:171-181, 2012
    • (2012) Pigment Cell Melanoma Res , vol.25 , pp. 171-181
    • Harbour, J.W.1
  • 67
    • 77951727246 scopus 로고    scopus 로고
    • VHL-gene deletion in single renal tubular epithelial cells and renal tubular cysts: Further evidence for a cyst-dependent progression pathway of clear cell renal carcinoma in von Hippel-Lindau disease
    • Montani M, Heinimann K, von Teichman A, et al: VHL-gene deletion in single renal tubular epithelial cells and renal tubular cysts: Further evidence for a cyst-dependent progression pathway of clear cell renal carcinoma in von Hippel-Lindau disease. Am J Surg Pathol 34:806-815, 2010
    • (2010) Am J Surg Pathol , vol.34 , pp. 806-815
    • Montani, M.1    Heinimann, K.2    Von Teichman, A.3
  • 68
    • 65249180173 scopus 로고    scopus 로고
    • An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency
    • Ho L, Ronan JL, Wu J, et al: An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A 106:5181-5186, 2009
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5181-5186
    • Ho, L.1    Ronan, J.L.2    Wu, J.3
  • 69
    • 34249782070 scopus 로고    scopus 로고
    • SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation
    • DOI 10.1074/jbc.M610563200
    • Sohn DH, Lee KY, Lee C, et al: SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation. J Biol Chem 282:10614-10624, 2007 (Pubitemid 47093407)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.14 , pp. 10614-10624
    • Sohn, D.H.1    Lee, K.Y.2    Lee, C.3    Oh, J.4    Chung, H.5    Jeon, S.H.6    Seong, R.H.7
  • 71
    • 80053508297 scopus 로고    scopus 로고
    • A blueprint for advancing genetics-based cancer therapy
    • Sellers WR: A blueprint for advancing genetics-based cancer therapy. Cell 147:26-31, 2011
    • (2011) Cell , vol.147 , pp. 26-31
    • Sellers, W.R.1
  • 74
    • 84878532557 scopus 로고    scopus 로고
    • Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
    • Dibble CC, Manning BD: Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol 15:555-564, 2013
    • (2013) Nat Cell Biol , vol.15 , pp. 555-564
    • Dibble, C.C.1    Manning, B.D.2
  • 75
    • 17844369428 scopus 로고    scopus 로고
    • The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
    • DOI 10.1038/sj.onc.1204009
    • Benvenuto G, Li S, Brown SJ, et al: The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 19:6306-6316, 2000 (Pubitemid 32641844)
    • (2000) Oncogene , vol.19 , Issue.54 , pp. 6306-6316
    • Benvenuto, G.1    Li, S.2    Brown, S.J.3    Braverman, R.4    Vass, W.C.5    Cheadle, J.P.6    Halley, D.J.J.7    Sampson, J.R.8    Wienecke, R.9    DeClue, J.E.10
  • 76
    • 79955609641 scopus 로고    scopus 로고
    • Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death
    • Kucejova B, Sunny NE, Nguyen AD, et al: Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death. Oncogene 30:2147-2160, 2011
    • (2011) Oncogene , vol.30 , pp. 2147-2160
    • Kucejova, B.1    Sunny, N.E.2    Nguyen, A.D.3
  • 77
    • 84865800800 scopus 로고    scopus 로고
    • An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis
    • Mazhab-Jafari MT, Marshall CB, Ishiyama N, et al: An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis. Structure 20:1528-1539, 2012
    • (2012) Structure , vol.20 , pp. 1528-1539
    • Mazhab-Jafari, M.T.1    Marshall, C.B.2    Ishiyama, N.3
  • 78
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM: mTOR: From growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21-35, 2011
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 79
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • DOI 10.1038/sj.onc.1207542
    • Fingar DC, Blenis J: Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151-3171, 2004 (Pubitemid 38638827)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 80
    • 84877761058 scopus 로고    scopus 로고
    • mTOR kinase structure, mechanism and regulation
    • Yang H, Rudge DG, Koos JD, et al: mTOR kinase structure, mechanism and regulation. Nature 497:217-223, 2013
    • (2013) Nature , vol.497 , pp. 217-223
    • Yang, H.1    Rudge, D.G.2    Koos, J.D.3
  • 81
    • 77952243626 scopus 로고    scopus 로고
    • Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
    • Sato T, Nakashima A, Guo L, et al: Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. Oncogene 29:2746-2752, 2010
    • (2010) Oncogene , vol.29 , pp. 2746-2752
    • Sato, T.1    Nakashima, A.2    Guo, L.3
  • 82
    • 84905828884 scopus 로고    scopus 로고
    • Effective monotherapy despite intratumor heterogeneity: Clonal convergence within the PI3K pathway and sensitivity to mTOR inhibitors in patients with advanced renal cell carcinoma (RCC)
    • abstr 4573
    • Voss MH, Hakimi AA, Chen Y, et al: Effective monotherapy despite intratumor heterogeneity: Clonal convergence within the PI3K pathway and sensitivity to mTOR inhibitors in patients with advanced renal cell carcinoma (RCC). J Clin Oncol 31:302s 2013, (suppl; abstr 4573)
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Voss, M.H.1    Hakimi, A.A.2    Chen, Y.3
  • 84
    • 84867333656 scopus 로고    scopus 로고
    • Genome sequencing identifies a basis for everolimus sensitivity
    • Iyer G, Hanrahan AJ, Milowsky MI, et al: Genome sequencing identifies a basis for everolimus sensitivity. Science 338:221, 2012
    • (2012) Science , vol.338 , pp. 221
    • Iyer, G.1    Hanrahan, A.J.2    Milowsky, M.I.3
  • 85
    • 0033062412 scopus 로고    scopus 로고
    • Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes
    • DOI 10.1016/S0014-5793(99)00185-4, PII S0014579399001854
    • Tinton SA, Buc-Calderon PM: Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes. FEBS Lett 446:55-59, 1999 (Pubitemid 29127249)
    • (1999) FEBS Letters , vol.446 , Issue.1 , pp. 55-59
    • Tinton, S.A.1    Buc-Calderon, P.M.2
  • 86
    • 79955430863 scopus 로고    scopus 로고
    • MTORC1 signaling and hypoxia
    • Polunovsky VAA, Houghton PJJ (eds): Cancer Drug Discovery and Development, Humana Press
    • Brugarolas J: MTORC1 signaling and hypoxia, in Polunovsky VAA, Houghton PJJ (eds): mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Cancer Drug Discovery and Development, Humana Press, 2010, pp 75-97
    • (2010) MTOR Pathway and MTOR Inhibitors in Cancer Therapy , pp. 75-97
    • Brugarolas, J.1
  • 87
    • 79955389182 scopus 로고    scopus 로고
    • Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia
    • Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, et al: Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia. Mol Cell Biol 31:1870-1884, 2011
    • (2011) Mol Cell Biol , vol.31 , pp. 1870-1884
    • Wolff, N.C.1    Vega-Rubin-de-Celis, S.2    Xie, X.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.