Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice

Journal of Biological Chemistry

Volumn 284, Issue 48, 2009, Pages 33466-33474

  Lerat, Hervé ^a   Kammoun, Hélène L ^b   Hainault, Isabelle ^b   Mérour, Emilie ^a   Higgs, Martin R ^a   Callens, Céline ^b   Lernon, Stanley M ^c   Foufelle, Fabienne ^b   Pawlotsky, Jean Michel ^a,d  

^a INSERM U955   (France)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC HEPATITIS; CYTOPATHIC EFFECT; ENDOPLASMIC RETICULUM STRESS; ER STRESS; HEPATITIS C VIRUS; HEPATOCELLULAR; HUMAN INFECTION; INFECTED PATIENTS; LIPID METABOLISMS; LIPOGENESIS; LIPOGENIC ENZYMES; LOW LEVEL; METABOLIC DEFECTS; NUCLEAR TRANSLOCATIONS; OPEN READING FRAME; PLASMA TRIGLYCERIDES; PROTEOLYTIC CLEAVAGE; STEROL REGULATORY ELEMENT-BINDING PROTEINS; TRANSGENIC MICE; WILD TYPES;

METABOLISM; PHYSIOLOGY; PROTEINS;

ENZYME INHIBITION;

STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; HEPATITIS C; LIPOGENESIS; MALE; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; FATTY LIVER; HEPACIVIRUS; HEPATITIS C; HUMANS; LIPOGENESIS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIGLYCERIDES; VIRAL PROTEINS;

HEPATITIS C VIRUS; MUS; MUS MUSCULUS;

EID: 70450245165     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.019810     Document Type: Article

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