Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 499-502

  Léger, Serge ^a   Black, W Cameron ^a   Deschenes, Denis ^a   Dolman, Sarah ^a   Falgueyret, Jean Pierre ^a   Gagnon, Marc ^a   Guiral, Sébastien ^a   Huang, Zheng ^a   Guay, Jocelyne ^a   Leblanc, Yves ^a   Li, Chun Sing ^a   Massé, Frédéric ^a   Oballa, Renata ^a   Zhang, Lei ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Bioavailable; Pyridazine; SCD inhibitor; Stearoyl CoA; Thiadiazole

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE INHIBITOR; MF 438; PYRIDAZINE DERIVATIVE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALOPECIA; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; METABOLIC DISORDER; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; ENZYME INHIBITORS; MICE; MICROSOMES, LIVER; PYRIDAZINES; RATS; STEAROYL-COA DESATURASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 72249113143     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.111     Document Type: Article

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