메뉴 건너뛰기




Volumn 6, Issue 10, 2011, Pages

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

5,8,11 ICOSATRIENOIC ACID; ACYL COENZYME A DESATURASE; CHOLESTEROL; FATTY ACID; ISOENZYME; LONG CHAIN FATTY ACID; MESSENGER RNA; MONOUNSATURATED FATTY ACID; SATURATED FATTY ACID; SPHINGOLIPID; TRIACYLGLYCEROL; DIHOMO GAMMA LINOLENIC ACID; DRUG DERIVATIVE; ISOPROTEIN;

EID: 80055042204     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024777     Document Type: Article
Times cited : (104)

References (36)
  • 3
    • 11444257052 scopus 로고    scopus 로고
    • Developmental origins of aging in brain and blood vessels: an overview
    • Finch CE, (2005) Developmental origins of aging in brain and blood vessels: an overview. Neurobiol Aging 26: 281-291.
    • (2005) Neurobiol Aging , vol.26 , pp. 281-291
    • Finch, C.E.1
  • 4
    • 11444256802 scopus 로고    scopus 로고
    • The epidemiologic study of dementia: a life-long quest?
    • Launer LJ, (2005) The epidemiologic study of dementia: a life-long quest? Neurobiol Aging 26: 335-340.
    • (2005) Neurobiol Aging , vol.26 , pp. 335-340
    • Launer, L.J.1
  • 5
    • 29044442270 scopus 로고    scopus 로고
    • A life-course approach to the aetiology of late-onset dementias
    • Whalley L, Dick F, McNeill G, (2006) A life-course approach to the aetiology of late-onset dementias. Lancet Neurology 5: 87-96.
    • (2006) Lancet Neurology , vol.5 , pp. 87-96
    • Whalley, L.1    Dick, F.2    McNeill, G.3
  • 6
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, et al. (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467-1472.
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3    George-Hyslop, P.H.4    Pericak-Vance, M.A.5
  • 7
    • 1242338183 scopus 로고    scopus 로고
    • Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
    • Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, et al. (2004) Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A 101: 2070-2075.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2070-2075
    • Cutler, R.G.1    Kelly, J.2    Storie, K.3    Pedersen, W.A.4    Tammara, A.5
  • 8
    • 23944501334 scopus 로고    scopus 로고
    • Alzheimer's disease-a dysfunction in cholesterol and lipid metabolism
    • Lukiw WJ, Pappolla M, Pelaez RP, Bazan NG, (2005) Alzheimer's disease-a dysfunction in cholesterol and lipid metabolism. Cell Mol Neurobiol 25: 475-483.
    • (2005) Cell Mol Neurobiol , vol.25 , pp. 475-483
    • Lukiw, W.J.1    Pappolla, M.2    Pelaez, R.P.3    Bazan, N.G.4
  • 9
    • 77958518079 scopus 로고    scopus 로고
    • Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease
    • Astarita G, Jung K, Berchtold N, Nguyen L, Gillen D, et al. (2010) Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One 5: e12538.
    • (2010) PLoS One , vol.5
    • Astarita, G.1    Jung, K.2    Berchtold, N.3    Nguyen, L.4    Gillen, D.5
  • 10
    • 54949130109 scopus 로고    scopus 로고
    • Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
    • Sanchez-Mejia R, Newman J, Toh S, Yu G, Zhou Y, et al. (2008) Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci 11: 1311-1318.
    • (2008) Nat Neurosci , vol.11 , pp. 1311-1318
    • Sanchez-Mejia, R.1    Newman, J.2    Toh, S.3    Yu, G.4    Zhou, Y.5
  • 11
    • 28644451007 scopus 로고    scopus 로고
    • Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin
    • Grimm MO, Grimm HS, Patzold AJ, Zinser EG, Halonen R, et al. (2005) Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol 7: 1118-1123.
    • (2005) Nat Cell Biol , vol.7 , pp. 1118-1123
    • Grimm, M.O.1    Grimm, H.S.2    Patzold, A.J.3    Zinser, E.G.4    Halonen, R.5
  • 12
  • 13
    • 47249089071 scopus 로고    scopus 로고
    • Role of stearoyl-CoA desaturase in human metabolic disease
    • Sampath H, Ntambi JM, (2008) Role of stearoyl-CoA desaturase in human metabolic disease. Future Lipidol 3: 163-173.
    • (2008) Future Lipidol , vol.3 , pp. 163-173
    • Sampath, H.1    Ntambi, J.M.2
  • 14
    • 33748477872 scopus 로고    scopus 로고
    • Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study
    • Corpeleijn E, Feskens EJ, Jansen EH, Mensink M, Saris WH, et al. (2006) Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study. Diabetologia 49: 2392-2401.
    • (2006) Diabetologia , vol.49 , pp. 2392-2401
    • Corpeleijn, E.1    Feskens, E.J.2    Jansen, E.H.3    Mensink, M.4    Saris, W.H.5
  • 15
    • 46049108007 scopus 로고    scopus 로고
    • Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity
    • Paillard F, Catheline D, Duff FL, Bouriel M, Deugnier Y, et al. (2008) Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity. Nutr Metab Cardiovasc Dis 18: 436-440.
    • (2008) Nutr Metab Cardiovasc Dis , vol.18 , pp. 436-440
    • Paillard, F.1    Catheline, D.2    Duff, F.L.3    Bouriel, M.4    Deugnier, Y.5
  • 16
    • 34547947590 scopus 로고    scopus 로고
    • Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity
    • Warensjo E, Ingelsson E, Lundmark P, Lannfelt L, Syvanen AC, et al. (2007) Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity. Obesity (Silver Spring) 15: 1732-1740.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 1732-1740
    • Warensjo, E.1    Ingelsson, E.2    Lundmark, P.3    Lannfelt, L.4    Syvanen, A.C.5
  • 17
    • 26244436986 scopus 로고    scopus 로고
    • Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men
    • Warensjo E, Riserus U, Vessby B, (2005) Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia 48: 1999-2005.
    • (2005) Diabetologia , vol.48 , pp. 1999-2005
    • Warensjo, E.1    Riserus, U.2    Vessby, B.3
  • 19
    • 0030260340 scopus 로고    scopus 로고
    • A noise and background reduction method for component detection in liquid chromatography/mass spectrometry
    • Windig W, Phalp J, Payne A, (1996) A noise and background reduction method for component detection in liquid chromatography/mass spectrometry. Anal Chem 68: 3602-3606.
    • (1996) Anal Chem , vol.68 , pp. 3602-3606
    • Windig, W.1    Phalp, J.2    Payne, A.3
  • 20
    • 26444598506 scopus 로고    scopus 로고
    • A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
    • Lukiw WJ, Cui JG, Marcheselli VL, Bodker M, Botkjaer A, et al. (2005) A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 115: 2774-2783.
    • (2005) J Clin Invest , vol.115 , pp. 2774-2783
    • Lukiw, W.J.1    Cui, J.G.2    Marcheselli, V.L.3    Bodker, M.4    Botkjaer, A.5
  • 22
    • 40449110086 scopus 로고    scopus 로고
    • ACAT as a drug target for Alzheimer's disease
    • Huttunen HJ, Kovacs DM, (2008) ACAT as a drug target for Alzheimer's disease. Neurodegener Dis 5: 212-214.
    • (2008) Neurodegener Dis , vol.5 , pp. 212-214
    • Huttunen, H.J.1    Kovacs, D.M.2
  • 23
    • 5144227934 scopus 로고    scopus 로고
    • The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease
    • Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, et al. (2004) The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron 44: 227-238.
    • (2004) Neuron , vol.44 , pp. 227-238
    • Hutter-Paier, B.1    Huttunen, H.J.2    Puglielli, L.3    Eckman, C.B.4    Kim, D.Y.5
  • 24
    • 16544376730 scopus 로고    scopus 로고
    • Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein
    • Puglielli L, Ellis BC, Ingano LA, Kovacs DM, (2004) Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein. J Mol Neurosci 24: 93-96.
    • (2004) J Mol Neurosci , vol.24 , pp. 93-96
    • Puglielli, L.1    Ellis, B.C.2    Ingano, L.A.3    Kovacs, D.M.4
  • 25
    • 33846057321 scopus 로고    scopus 로고
    • The metabolic syndrome and Alzheimer disease
    • Razay G, Vreugdenhil A, Wilcock G, (2007) The metabolic syndrome and Alzheimer disease. Arch Neurol 64: 93-96.
    • (2007) Arch Neurol , vol.64 , pp. 93-96
    • Razay, G.1    Vreugdenhil, A.2    Wilcock, G.3
  • 26
    • 0036846245 scopus 로고    scopus 로고
    • Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    • Attie AD, Krauss RM, Gray-Keller MP, Brownlie A, Miyazaki M, et al. (2002) Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res 43: 1899-1907.
    • (2002) J Lipid Res , vol.43 , pp. 1899-1907
    • Attie, A.D.1    Krauss, R.M.2    Gray-Keller, M.P.3    Brownlie, A.4    Miyazaki, M.5
  • 27
    • 51549107903 scopus 로고    scopus 로고
    • Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
    • Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, et al. (2008) Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134: 933-944.
    • (2008) Cell , vol.134 , pp. 933-944
    • Cao, H.1    Gerhold, K.2    Mayers, J.R.3    Wiest, M.M.4    Watkins, S.M.5
  • 28
    • 77957825925 scopus 로고    scopus 로고
    • Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dih ydrospiro[chromene-2,4′-piperidine] analogs
    • Uto Y, Ueno Y, Kiyotsuka Y, Miyazawa Y, Kurata H, et al. (2010) Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dih ydrospiro[chromene-2,4′-piperidine] analogs. Eur J Med Chem 45: 4788-4796.
    • (2010) Eur J Med Chem , vol.45 , pp. 4788-4796
    • Uto, Y.1    Ueno, Y.2    Kiyotsuka, Y.3    Miyazawa, Y.4    Kurata, H.5
  • 29
    • 69249213918 scopus 로고    scopus 로고
    • Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models
    • Issandou M, Bouillot A, Brusq JM, Forest MC, Grillot D, et al. (2009) Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models. Eur J Pharmacol 618: 28-36.
    • (2009) Eur J Pharmacol , vol.618 , pp. 28-36
    • Issandou, M.1    Bouillot, A.2    Brusq, J.M.3    Forest, M.C.4    Grillot, D.5
  • 30
    • 37249046860 scopus 로고    scopus 로고
    • Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions
    • Kalra SP, (2008) Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides 29: 127-138.
    • (2008) Peptides , vol.29 , pp. 127-138
    • Kalra, S.P.1
  • 31
    • 0033563109 scopus 로고    scopus 로고
    • Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites
    • Zhang L, Ge L, Parimoo S, Stenn K, Prouty SM, (1999) Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J 340 (Pt 1): 255-264.
    • (1999) Biochem J , vol.340 , Issue.PT 1 , pp. 255-264
    • Zhang, L.1    Ge, L.2    Parimoo, S.3    Stenn, K.4    Prouty, S.M.5
  • 32
    • 45849096807 scopus 로고    scopus 로고
    • Comparison of pig, sheep and chicken SCD5 homologs: Evidence for an early gene duplication event
    • Lengi AJ, Corl BA, (2008) Comparison of pig, sheep and chicken SCD5 homologs: Evidence for an early gene duplication event. Comp Biochem Physiol B Biochem Mol Biol 150: 440-446.
    • (2008) Comp Biochem Physiol B Biochem Mol Biol , vol.150 , pp. 440-446
    • Lengi, A.J.1    Corl, B.A.2
  • 33
    • 50449101908 scopus 로고    scopus 로고
    • Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder
    • McNamara RK, Jandacek R, Rider T, Tso P, Stanford KE, et al. (2008) Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res 160: 285-299.
    • (2008) Psychiatry Res , vol.160 , pp. 285-299
    • McNamara, R.K.1    Jandacek, R.2    Rider, T.3    Tso, P.4    Stanford, K.E.5
  • 34
    • 44849133291 scopus 로고    scopus 로고
    • The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity
    • McNamara RK, Liu Y, Jandacek R, Rider T, Tso P, (2008) The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins Leukot Essent Fatty Acids 78: 293-304.
    • (2008) Prostaglandins Leukot Essent Fatty Acids , vol.78 , pp. 293-304
    • McNamara, R.K.1    Liu, Y.2    Jandacek, R.3    Rider, T.4    Tso, P.5
  • 35
    • 0032871502 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
    • Ntambi JM, (1999) Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J Lipid Res 40: 1549-1558.
    • (1999) J Lipid Res , vol.40 , pp. 1549-1558
    • Ntambi, J.M.1
  • 36
    • 74949087610 scopus 로고    scopus 로고
    • Lipidomic analysis of biological samples by liquid chromatography coupled to mass spectrometry
    • Astarita G, Ahmed F, Piomelli D, (2009) Lipidomic analysis of biological samples by liquid chromatography coupled to mass spectrometry. Methods Mol Biol 579: 201-219.
    • (2009) Methods Mol Biol , vol.579 , pp. 201-219
    • Astarita, G.1    Ahmed, F.2    Piomelli, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.