Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype

Biotechnology and Bioengineering

Volumn 111, Issue 6, 2014, Pages 1210-1221

  Boehler, R M ^a   Kuo, R ^a   Shin, S ^a   Goodman, A G ^a   Pilecki, M A ^a   Leonard, J N ^a,b,c   Shea, L D ^a,b,c  

^a Northwestern University   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Gene delivery; IL 10; Lentivirus; Macrophage; Macrophage phenotype; Transduction efficiency

Indexed keywords

BACTERIOPHAGES; BIOLOGICAL MATERIALS; BIOMATERIALS; GENE TRANSFER; IMMUNE SYSTEM; POLARIZATION; RECOMBINANT PROTEINS; SCAFFOLDS (BIOLOGY);

GENE DELIVERY; IL-10; LENTIVIRUS; MACROPHAGE PHENOTYPES; TRANSDUCTION EFFICIENCY;

MACROPHAGES;

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; LIPOPOLYSACCHARIDE; RECOMBINANT INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN 10; RECOMBINANT PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW CELL; CELL DEATH; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LENTIVIRINAE; MACROPHAGE; MACROPHAGE ACTIVATION; PHENOTYPE; POLARIZATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; VIRAL GENE DELIVERY SYSTEM; VIRUS PARTICLE; ANIMAL; CELL LINE; GENETIC TRANSDUCTION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; SECRETION (PROCESS);

LENTIVIRUS;

ANIMALS; CELL LINE; HUMANS; INTERLEUKIN-10; LENTIVIRUS; MACROPHAGES; MICE; PHENOTYPE; RECOMBINANT PROTEINS; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899626586     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25175     Document Type: Article

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