Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

Nature Medicine

Volumn 21, Issue 7, 2015, Pages 786-794

  Lemos, Dario R ^a   Babaeijandaghi, Farshad ^a   Low, Marcela ^a   Chang, Chih Kai ^a   Lee, Sunny T ^a   Fiore, Daniela ^b   Zhang, Regan Heng ^a   Natarajan, Anuradha ^a   Nedospasov, Sergei A ^c,d,e   Rossi, Fabio M V ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^d MOSCOW STATE UNIVERSITY   (Russian Federation)

^e German Rheumatism Research Center   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; NILOTINIB; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; CCR2 PROTEIN, MOUSE; CHEMOKINE RECEPTOR CCR2; COLLAGEN; MESSENGER RNA; NOTEXIN; PYRIMIDINE DERIVATIVE; SNAKE VENOM; TUMOR NECROSIS FACTOR ALPHA;

ADIPOGENIC PROGENITOR CELL; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL INFILTRATION; CHRONIC DISEASE; CONTROLLED STUDY; DNA FRAGMENTATION; EXTRACELLULAR MATRIX; FIBROGENESIS; LIMIT OF QUANTITATION; MONOCYTE; MOUSE; MUSCLE ATROPHY; MUSCLE INJURY; MUSCLE REGENERATION; MYOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; ADIPOGENESIS; ANIMAL; C57BL MOUSE; CELL COUNT; CELL SURVIVAL; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FEMALE; FIBROSIS; FLOW CYTOMETRY; GENETICS; INJURIES; MACROPHAGE; MALE; METABOLISM; MUSCULAR DISEASES; PATHOLOGY; REGENERATION; SKELETAL MUSCLE; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

MUS;

ADIPOGENESIS; ANIMALS; APOPTOSIS; CELL COUNT; CELL SURVIVAL; CHRONIC DISEASE; COLLAGEN; ELAPID VENOMS; FEMALE; FIBROSIS; FLOW CYTOMETRY; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, INBRED MDX; MONOCYTES; MUSCLE, SKELETAL; MUSCULAR DISEASES; PYRIMIDINES; RECEPTORS, CCR2; REGENERATION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84936889894     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3869     Document Type: Article

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